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Friction 2024年第7期12卷 1580-1598页

作者： Yuzhen LIU Jae-Ho han Shusheng XU Young Chan JUNG Dae-eun KIM State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Department of Mechanical Engineering Yonsei UniversitySeoul03722Republic of Korea Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai 264000China Yantai Zhongke Research Institute of Advanced Materials and Green Chemical Engineering Yantai 264000China

The outstanding tribological performance of transition metal dichalcogenides(TMDs)is attributed to their unique sandwich microstructure and low interlayer shear *** advantageous structure allows TMDs to demonstrate exceptional friction reduction ***,the incorporation of TMDs and amorphous carbon(a-C)in multi-layer structures shows excellent potential for further enhancing tribological and anti-oxidation *** carbon,known for its high ductility,chemical inertness,and excellent wear resistance,significantly contributes to the overall performance of these multi-layer *** gain an in-depth understanding of the tribological mechanism and evolution of TMDs’multi-layer coatings,a dual in-situ analysis was carried out using a tribometer equipped with a 3D laser microscope and a Raman *** innovative approach allowed for a comprehensive evolution of the tribological,topographical,and tribochemical characteristics of both single-layer WS_(2)and multi-layer WS_(2)/C coatings in real *** findings from the dual in-situ tribotest revealed distinct failure characteristics between the single-layer WS_(2)coating and the multi-layer WS_(2)/C *** single-layer WS_(2)coating predominantly experienced failure due to mechanical removal,whereas a combination of mechanical removal and tribochemistry primarily influenced the failure of the multi-layer WS_(2)/C *** tribological evolution process of these two coatings can be classified into four stages on the basis of their tribological behavior:the running-in stage,stable friction stage,re-deposition stage,and lubrication failure *** stage represents a distinct phase in the tribological behavior of the coatings and contributes to our understanding of their behavior during sliding.

关键词： In-situ analysis multi-layer coating tribology tribochemistry

Intracellular zinc signaling via Kruppel-like transcription factor 6 promotes HuD expression in pancreatic β cell

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Genes & Diseases 2024年第4期11卷 24-27页

作者： Seongho Cha Chongtae Kim Myeongwoo Jung Seungyeon Ryu Sukyoung han Wook Kim eun Kyung Lee Department of Biochemistry Department of Biomedicine&Health SciencesCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Catholic Institute for Visual Science College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Molecular Science&Technology Ajou UniversitySuwon 16499South Korea

Dysfunction of pancreaticβcells caused by zinc deficiency is related to the pathogenesis of diabetes.1 Impaired zinc homeostasis in diabetes is associated with reduced zinc transporters.2 Down-regulation of HuD,an es... 详细信息

关键词： βcell homeostasis zinc

Long-term outcomes of very low birth weight infants with intraventricular hemorrhage:a nationwide population study from 2011 to 2019

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World Journal of Pediatrics 2024年第7期20卷 692-700页

作者： Joonsik Park Sook-Hyun Park Yu-ra Kwon So Jin Yoon Joo Hee Lim Jung Ho han Jeong eun Shin Ho Seon eun Min Soo Park Soon Min Lee Department of Pediatrics Yonsei University College of Medicine211 Eonjuro GangnamguSeoul 06273Republic of Korea

Background Advancements in neonatal care have increased preterm infant survival but paradoxically raised intraventricular hemorrhage(IVH)*** study explores IVH prevalence and long-term outcomes of very low birth weight(VLBW)infants in Korea over a *** Using Korean National Health Insurance data(NHIS,2010-2019),we identified 3372 VLBW infants with IVH among 4,129,808 live ***-related claims data,encompassing diagnostic codes,diagnostic test costs,and administered procedures were sourced from the NHIS *** results of the developmental assessments are categorized into four groups based on standard deviation(SD)*** characteristics and complications were compared among the *** regression models were employed to identify significant changes in the incidence of complications and to calculate odds ratios with corresponding 95%confidence intervals for each risk factor associated with mortality and morbidity in ***-term growth and development were compared between the two groups(years 2010-2013 and 2014-2017).Results IVH prevalence was 12%in VLBW and 16%in extremely low birth weight(ELBW)*** the past decade,IVH rates increased significantly in ELBW infants(P=0.0113),while mortality decreased(P=0.0225).Major improvements in certain neurodevelopmental outcomes and reductions in early morbidities have been observed among VLBW infants with *** percent of the population received surgical treatments such as external ventricular drainage(EVD)or a ventriculoperitoneal(VP)shunt,with the choice of treatment methods remaining consistent over *** IVH with surgical intervention group exhibited higher incidences of delayed development,cerebral palsy,seizure disorder,and growth failure(height,weight,and head circumference)up to 72 months of age(P<0.0001).Surgical treatments were also significantly associated with abnormal developmental screening test *** The neurodevelopmental outcomes of infa

关键词： Cerebral intraventricular hemorrhage Developmental Hydrocephalus Mortality Posthemorrhagic ventricular dilatation Surgery

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弓形虫韩国KI-1分离株的生物学特性鉴定

中国寄生虫学与寄生虫病杂志 2006年第3期24卷 183-186页

作者：林爱芬申银希朴在焕韩银泽蔡钟一温州医学院附属台州医院中心实验室临海317000 韩国国立首尔大学寄生虫学和热带医学教研室

目的研究弓形虫韩国KI-1分离株的生物学特性。方法分别将弓形虫韩国KI-1株与国际标准RH株进行下列实验:透射电镜观察虫体的形态,不同浓度的速殖子接种BALB/c小鼠观察其毒力,蛋白质印迹(Westernblotting)分析弓形虫抗原与抗弓形虫单抗Tg... 详细信息

目的研究弓形虫韩国KI-1分离株的生物学特性。方法分别将弓形虫韩国KI-1株与国际标准RH株进行下列实验:透射电镜观察虫体的形态,不同浓度的速殖子接种BALB/c小鼠观察其毒力,蛋白质印迹(Westernblotting)分析弓形虫抗原与抗弓形虫单抗Tg563和抗新孢子虫单抗12B4反应,PCR-限制性片段长度多态(PCR-RFLP)技术分析其基因型,检测SAG1和ROP1基因编码区的序列。结果弓形虫韩国KI-1株的形态、毒力与RH株相似。KI-1和RH抗原仅与抗弓形虫单抗Tg563反应,而不与抗新孢子虫单抗12B4反应。PCR-RFLP技术分析表明,KI-1株属基因型I型弓形虫虫株。KI-1株与RH株相比,SAG1和ROP1基因均各有7个核苷酸及6个氨基酸差异。结论KI-1株为基因型I型弓形虫强毒株,与RH株间存在一定的基因差异。

关键词：弓形虫蛋白质印迹法 PCR 限制性片段长度多态(RFLP) 基因测序

Value of glucose transport protein 1 expression in detecting lymph node metastasis in patients with colorectal cancer

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World Journal of Clinical Cases 2024年第5期12卷 931-941页

作者： Hongsik Kim Song-Yi Choi Tae-Young Heo Kyeong-Rok Kim Jisun Lee Min Young Yoo taek-Gu Lee Joung-Ho han Department of Internal Medicine Chungbuk National University HospitalCheongju 28644South Korea Department of Pathology Chungnam National University College of MedicineDaejeon 35015South Korea Information and Statistics Chungbuk National UniversityCheongju 28644South Korea Department of Radiology College of MedicineChungbuk National UniversityChungbuk National University HospitalCheongju-si 28644South Korea Department of Nuclear Medicine School of MedicineInha UniversityIncheon 22332South Korea Department of Surgery Chungbuk National UniversityCollege of MedicineCheongju-si 28644South Korea Department of Internal Medicen Chungbuk National UniversityCollege of medicineCheongju-si 28644South Korea

BACKGROUND There are limited data on the use of glucose transport protein 1(GLUT-1)expre-ssion as a biomarker for predicting lymph node metastasis in patients with colorectal ***-1 and GLUT-3,hexokinase(HK)-II,and hypoxia-induced factor(HIF)-1 expressions may be useful biomarkers for detecting primary tumors and lymph node metastasis when combined with fluorodeoxyglucose(FDG)uptake on positron emission tomography/computed tomography(PET/CT).AIM To evaluate GLUT-1,GLUT-3,HK-II,and HIF-1 expressions as biomarkers for detecting primary tumors and lymph node metastasis with 18F-FDG-PET/*** This retrospective study included 169 patients with colorectal cancer who underwent colectomy and preoperative 18F-FDG-PET/CT at Chungbuk National University Hospital between January 2009 and May *** tissue cores from the central and peripheral areas of the tumors were obtained and were examined by a dedicated pathologist,and the expressions of GLUT-1,GLUT-3,HK-II,and HIF-1 were determined using immunohisto-chemical *** analyzed the correlations among their expressions,various clinicopathological factors,and the maximum standardized uptake value(SUVmax)of PET/*** GLUT-1 was found at the center or periphery of the tumors in 109(64.5%)of the 169 ***-1 positivity was significantly correlated with the SUVmax of the primary tumor and lymph nodes,regardless of the biopsy site(tumor center,P<0.001 and P=0.012;tumor periphery,P=0.030 and P=0.010,respectively).GLUT-1 positivity and negativity were associated with higher and lower sensitivities of PET/CT,respectively,for the detection of lymph node metastasis,regardless of the biopsy ***3,HK-II,and HIF-1 expressions were not significantly correlated with the SUVmax of the primary tumor and lymph *** GLUT-1 expression was significantly correlated with the SUVmax of 18F-FDG-PET/CT for primary tumors and lymph *** should consider GLUT-1 expression in preoperative endoscop

关键词： 18F-FDG-PET-CT Biomarker Colorectal neoplasms Glucose transporter type 1 Lymph node

M1-polarized macrophage-derived cellular nanovesicle-coated lipid nanoparticles for enhanced cancer treatment through hybridization of gene therapy and cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3169-3183页

作者： Ha eun Shin Jun-Hyeok han Seungyong Shin Ga-Hyun Bae Boram Son Tae-Hyung Kim Hee Ho Park Chun Gwon Park Wooram Park Department of Integrative Biotechnology Sungkyunkwan University(SKKU)SuwonGyeonggi 16419Republic of Korea Deparment of Inteligent Precision Healthcare Convergence SKKUSuwonGyeonggi 16419Republic of Korea Department of MetaBioHealth SKKU Institute for ConvergenceSKKUSuwonGyeonggi 16419Republic of Korea Department of Bioengineering Hanyang UniversitySeoul 04763Republic of Korea Department of Integrative Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Biomedical Engineering SKKUSuwonGyeonggi 16419Republic of Korea Korea Institute of Science and Technology(KIST) Seoul 02792Republic of Korea

Optimum genetic delivery for modulating target genes to diseased tissue is a major obstacle for profitable gene *** nanoparticles(LNPs),considered a prospective vehicle for nucleic acid delivery,have demonstrated efficacy in human use during the COVID-19 *** study introduces a novel biomaterial-based platform,M1-polarized macrophage-derived cellular nanovesicle-coated LNPs(M1-C-LNPs),specifically engineered for a combined gene-immunotherapy approach against solid *** dual-function system of M1-C-LNPs encapsulates Bcl2-targeting siRNA within LNPs and immune-modulating cytokines within M1 macrophage-derived cellular nanovesicles(M1-NVs),effectively facilitating apoptosis in cancer cells without impacting T and NK cells,which activate the intratumoral immune response to promote granule-mediating killing for solid tumor *** retention within tumor was observed upon intratumoral administration of M1-C-LNPs,owing to the presence of adhesion molecules on M1-NVs,thereby contributing to superior tumor growth *** findings represent a promising strategy for the development of targeted and effective nanoparticle-based cancer genetic-immunotherapy,with significant implications for advancing biomaterial use in cancer therapeutics.

关键词： Genetic-immunotherapy M1 macrophage-derived cellular nanovesicles Lipid nanoparticles(LNPs) Gene therapy siRNA Cancer immunotherapy Solid tumor Tumor microenvironment(TME)

影响间日疟原虫红内期短期体外培养的虫源因素研究

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中国血吸虫病防治杂志 2010年第1期22卷 56-58,I0007页

作者：陆凤高琪夏惠曹俊陶志勇朱国鼎周华云 han eun-taek 江文才王伟明顾亚萍李菊林江苏省寄生虫病防治研究所、江苏省寄生虫分子生物学重点实验室、江苏省寄生虫病学重点学科无锡214064 蚌埠医学院韩国江原大学医学院寄生虫学教研室

目的探讨影响红内期间日疟原虫短期体外培养的虫源因素。方法在间日疟流行区采集志愿者血样,以Mc-Coy’s5A为培养基,在含5%CO2的37℃培养箱中短期培养,分析间日疟原虫短期体外培养的影响因素。结果培养基可支持间日疟原虫完成1个无性周... 详细信息

目的探讨影响红内期间日疟原虫短期体外培养的虫源因素。方法在间日疟流行区采集志愿者血样,以Mc-Coy’s5A为培养基,在含5%CO2的37℃培养箱中短期培养,分析间日疟原虫短期体外培养的影响因素。结果培养基可支持间日疟原虫完成1个无性周期循环。导致间日疟原虫体外短期培养失败的因素包括含虫血置于室温时间过长(>4h)、期别单一(只见环状体)、病人服用抗疟药、服用抗生素药物、原虫密度过低。结论虫源是影响间日疟原虫短期体外培养的重要因素。

关键词：间日疟原虫培养红内期影响因素

Surgical Repair of Ventricular Septal Defect in Neonates: Indications and Outcomes

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Congenital Heart Disease 2024年第1期19卷 69-83页

作者： Jae Hong Lee Sungkyu Cho Jae Gun Kwak Hye Won Kwon Woong-han Kim Mi Kyoung Song Sang-Yun Lee Gi Beom Kim eun Jung Bae Department of Thoracic and Cardiovascular Surgery Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsanKorea Department of Thoracic and Cardiovascular Surgery Seoul National University Children’s HospitalSeoulKorea Department of Pediatrics Seoul National University Children’s HospitalSeoulKorea

Background:The optimal surgical timing and clinical outcomes of ventricular septal defect(VSD)closure in neo-nates remain *** aimed to evaluate the clinical outcomes of VSD closure in neonates(age≤30 days).Methods:We retrospectively reviewed 50 consecutive neonates who underwent VSD closure for isolated VSDs between August 2003 and June *** for the procedure included congestive heart failure/failure to thrive and pulmonary *** adverse events(MAEs)were deﬁned as the composite of all-cause mortality,reoperation,persistent atrioventricular block,and signiﬁcant(≥grade 2)valvular ***:The median age and body weight at operation were 26.0 days(interquartile range[IQR],18.8–28.3)and 3.7 kg(IQR,3.3–4.2),*** median follow-up duration was 110.4 months(IQR,56.8–165.0).Seven patients required preoperative respiratory support,andﬁve had signiﬁcant(≥grade 2)preoperative valvular *** early mortality occurred due to irreversible cardiogenic shock;no late mortality was *** reopera-tion was due to hemodynamically signiﬁcant residual VSD at 103.8 months *** overall survival,freedom from reoperation,and freedom from MAE at 15-years were 98.0%,96.3%,and 94.4%,***-operative mechanical ventilation was associated with a longer duration of postoperative mechanical ventilation(p<0.001)and a longer length of intensive care unit stay(p<0.001).Conclusions:VSD closure with favorable outcomes without morbidities is feasible even in ***,neonates requiring preoperative respiratory support may require careful postoperative management considering the long-term postoperative ***,surgical VSD closure might be indicated earlier in neonates with respiratory compromise.

关键词： Ventricular septal defect neonate early surgery neonatal surgery

Ni-NTA蛋白芯片技术检测间日疟原虫感染的体液免疫应答

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国际医学寄生虫病杂志 2011年第3期38卷 129-134页

作者：陈军虎王越坪井敬文韩银泽中国疾病预防控制中心寄生虫病预防控制所上海200025 200-701春川韩国国立江原大学医学院寄生虫学研究室浙江省医学科学院寄生虫病研究所杭州310013 790-8577松山日本爱媛大学无细胞技术研究中心和风险事业实验室

目的建立检测间日疟感染的Ni—NTA蛋白芯片技术。方法采用无细胞蛋白合成体系表达间日疟原虫重组蛋白，建立原位纯化重组蛋白和检测间t3疟原虫感染患者血清中抗体反应的M—NTA蛋白芯片技术。并对3个裂殖子表面蛋白（merozoitesurfacepro... 详细信息

目的建立检测间日疟感染的Ni—NTA蛋白芯片技术。方法采用无细胞蛋白合成体系表达间日疟原虫重组蛋白，建立原位纯化重组蛋白和检测间t3疟原虫感染患者血清中抗体反应的M—NTA蛋白芯片技术。并对3个裂殖子表面蛋白（merozoitesurfaceproteins，MSPs）MSP1-42、MSP8和MSP10的免疫应答进行分析。结果应用Ni—NTA蛋白芯片技术检测间日疟原虫感染患者血清抗体，鉴定出具有免疫原性的15个间日疟原虫蛋白，主要包括10个MSPs、2个Cys6蛋白以及其他3个未知蛋白，结果与以往报道的抗体芯片类似。MSP1-42、MSP8和MSP10依次识别出100．0％（20／20）、90．0％（18／20）和70．0％（14／20）的间日疟原虫感染患者血清，特异性均为100％（10／10），且曲线下面积（area under the curve，AUC）达到0．87—1．00。结论成功建立了检测间日疟原虫感染的Ni—NTA蛋白芯片技术。该方法有助于从间日疟原虫基因组中快速筛选鉴定具有免疫原性的蛋白以及应用于功能蛋白质组学研究。

关键词：间日疟原虫体液免疫蛋白芯片