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Effects of SMO Preservation Solution on Apoptosis and Energy Metabolism in Canine Kidneys during Cold Preservation

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器官移植内科学杂志 2007年第4期2卷 218-222页

作者： Qincheng han Xiongwei zhu Zhihua Zhou Youhua zhu Organ Transplantation Institution of PLA Changzheng Hospital Second Military Medical UniversityShanghai 200003 China

Objective To investigate the effects of SMO preservation solution on apoptosis and energy metabolism in canine kidneys during cold preservation. Methods The model of simple cold preservation of isolated canine kidney was set up. The kidneys were flushed and preserved with 0-4℃HTK preservation solution (HTK group), 0-4℃UW preservation solution (UW group) and 0-4℃SMO preservation solution (SMO group). Samples of kidney cortex were obtained at the 48h, 72h of cold preservation. The histopathology, apoptosis index (AI) and tissue energy metabolism of cortex cells were evaluated. Results The pathological damage of preserved canine kidneys in SOM group was similar to that in UW group at each time point and milder than that in HTK group at 48 and 72h. There was no significant difference at 24 h between the AI in SMO group and HTK group (P>0.05). The AI in SMO group was lower than that in HTK group and there was significant difference at 48 and 72h (P0.05). At each time point, there was no significant difference between the Na^+-K^+ ATPase activities of UW group and SMO group (P>0.05) and at 24 and 48h between SMO group and HTK group (P>0.05). Na^+-K^+ ATPase activity in SMO group was significantly higher than that in HTK group at 72h (Phanges, reducing cell apoptosis and slowing down the suppression of Na^+-K^+ ATPase activity.

关键词：新陈代谢保存液细胞凋亡低温保存技术

Jetting of a near-wall cavitation bubble induced by another tandem bubble

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Journal of Hydrodynamics 2024年第3期36卷 444-456页

作者： Hui han Jing-zhu Wang Jian-lin Huang Peng-bo Bai Yong-gang Chen Yi-wei Wang Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing100190China School of Engineering Science University of Chinese Academy of SciencesBeijing100049China Guangdong Aerospace Research Academy Guangzhou511458China School of Future Technology University of Chinese Academy of SciencesBeijing100049China Jianghuai Advance Technology Center Hefei230088China

Double bubbles near a rigid wall surface collapse to produce a significant jet impact,with potential applications in surface cleaning and ultrasonic ***,the dynamic behaviors of near-wall bubbles remain *** this study,we investigate the jetting of a near-wall bubble induced by another tandem *** define two dimensionless standoff distances,γ_(1),γ_(2),to represent the distances from the center of the near-wall bubble to the rigid wall and the center of controlling bubble to the center of the near-wall bubble,*** observations reveal three distinct jetting regimes for the near-wall bubble:transferred jetting,double jetting,and directed *** further investigate the jetting mechanism,numerical simulations are conducted using the compressibleInterFoam solver in the open-source framework of OpenFOAM.A detailed analysis shows that the transferred jet flow is caused by the pinch-off resulting from the axial contraction velocity at the lower end of the near-wall bubble being greater than the vertical contraction velocity,leading to a maximum jet velocity of 682.58 m/*** the case of double jetting,intense stretching between the controlling bubble and the wall leads to a pinch-off and a double jetting with a maximum velocity of 1096.29 m/*** directed jet flow is caused by the downward movement of the high-pressure region generated by the premature collapse of the controlling bubble,with the maximum jet velocity reaching 444.62 m/s.

关键词： Jetting of near-wall bubble controlling bubble impact velocity

Constructing globally consecutive 3D conductive network using P-doped biochar cotton fiber for superior performance of silicon-based anodes

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Journal of Materials Science & Technology 2024年第6期173卷 181-191页

作者： Jun Cao Jianhong Gao Kun Wang zhuoying Wu Xinxin zhu han Li Min Ling Chengdu Liang Jun Chen Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China Institute of Zhejiang University-Quzhou Zheda Road 99Quzhou 324000China

The inferior conductivity and drastic volume expansion of silicon still remain the bottleneck in achieving high energy density Lithium-ion Batteries(LIBs).The design of the three-dimensional structure of electrodes by compositing silicon and carbon materials has been employed to tackle the above challenges,however,the exorbitant costs and the uncertainty of the conductive structure persist,leaving ample room for ***,silicon nanoparticles were innovatively composited with eco-friendly biochar sourced from cotton to fabricate a 3D globally consecutive conductive *** network serves a dual purpose:enhancing overall electrode conductivity and serving as a scaffold to maintain electrode *** conductivity of the network was further augmented by introducing P-doping at the optimum doping temperature of 350℃.Unlike the local conductive sites formed by the mere mixing of silicon and conductive agents,the consecutive network can affirm the improvement of the conductivity at a macro ***,first-principle calculations further validated that the rapid diffusion of Li^(+)is attributed to the tailored electronic microstructure and charge rearrangement of the *** prepared consecutive conductive Si@P-doped carbonized cotton fiber anode outperforms the inconsecutive Si@Graphite anode in both cycling performance(capacity retention of 1777.15 mAh g^(-1) vs.682.56 mAh g^(-1) after 150 cycles at 0.3 C)and rate performance(1244.24 mAh g^(-1) vs.370.28 mAh g^(-1) at 2.0 C).The findings of this study may open up new avenues for the development of globally interconnected conductive networks in Si-based anodes,thereby enabling the fabrication of high-performance LIBs.

关键词： 3D conductive network Biochar carbon-silicon anode Heteroatoms doping strategy DFT calculation Lithium-ion battery

Potential Value of Datura stramonium Agglutinin-recognized Glycopatterns in Urinary Protein on Differential Diagnosis of Diabetic Nephropathy and Nondiabetic Renal Disease

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Chinese Medical Journal 2018年第2期131卷 180-187页

作者： Xiao-Li Yang han-Jie Yu han-Yu zhu Ying Zheng Qiu-Xia han Guang-Yan Cai Xiang-Mei Chen 'Department of Nephrology Chinese People's Liberation Army General Hospital Chinese People's Liberation Army Institute of NephrologyState Key Laboratory of Kidney Diseases (2011DAVO0088) National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Diseases Beijing 100853 China Laboratory for Functional Glycomics College of I'ifeSciences Northwest University Xi'an Shaanxi 710069 China Department of Nephrology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan 450052 China

Background： Diabetic nephropathy （DN） is the most common and serious microvascular complication of diabetes. To date, the gold standard for identifying DN and nondiabetic renal disease （NDRD） is a renal biopsy; however, there is currently no reliable diagnostic marker to identify DN and NDRD in a noninvasive manner. This study aimed to investigate the different glycopatterns in urine specimens of DN patients and NDRD patients for a differential diagnosis. Methods： In total, 19 DN patients and 18 NDRD patients who underwent renal biopsies between March 2015 and March 2016 at the Chinese People＇s Liberation Army General Hospital were enrolled in this study. A lectin microarray was used to investigate the glycopatterns in the urinary protein of the 37 patients. Ratio analysis and one-way analysis of variance were used to screen altered glycopatterns. Then, the altered glycopatterns between the DN and NDRD groups were verified by a urinary protein microarray among another 32 patients （15 with DN and 17 with NDRD）, and receiver operating characteristic （ROC） curve analysis was used to determine the diagnostic value of the altered glycopatterns in differentiating DN and NDRD. Finally, lectin blotting was used to evaluate the altered glycosylation in protein level. Results： The result of lectin microarrays revealed that the relative abundance of the （13-1,4）-linked N-acetyI-D-glucosamine （GlcNAc） recognized by lectin Datura stramonium agglutinin （DSA） was significantly higher in urinary protein in DN patients than that in NDRD patients （fold change 〉1.50, P 〈 0.001）. Subsequently, the results of urinary protein microarrays were consistent with lectin microarrays （P 〈 0.05）. Furthermore, the ROC curve showed that glycopatterns could effectively distinguish DN from NDRD patients （area under the ROC curve = 0.94, P 〈 0.001）. DSA lectin blotting showed that glycoproteins, with a molecular weight of approximately 50,000, demonstrated a difference in urine samples between DN pat

关键词： Diabetic Nephropathy: Glycopattern NondiabeticRenal Disease, Urinary Protein

Implications for fault reactivation and seismicity induced by hydraulic fracturing

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Petroleum Science 2024年第2期21卷 1081-1098页

作者： Zi-han Sun Ming-Guang Che Li-Hong zhu Shu-Juan Zhang Ji-Yuan Lu Chang-Yu Jin Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines School of Resources and Civil Engineering and Key Laboratory of Liaoning Province on Deep Engineering and Intelligent TechnologyNortheastern UniversityShenyang110819LiaoningChina Research Institute of Petroleum Exploration&Development PetroChina Company LimitedBeijing100084China The Exploration and Development Research Institute of Daqing Oilfield Limited Company Daqing163458HeilongjiangChina

Evaluating the physical mechanisms that link hydraulic fracturing(HF) operations to induced earthquakes and the anticipated form of the resulting events is significant in informing subsurface fluid injection operations. Current understanding supports the overriding role of the effective stress magnitude in triggering earthquakes, while the impact of change rate of effective stress has not been systematically addressed. In this work, a modified critical stiffness was brought up to investigate the likelihood, impact,and mitigation of induced seismicity during and after hydraulic fracturing by developing a poroelastic model based on rate-and-state fraction law and linear stability analysis. In the new criterion, the change rate of effective stress was considered a key variable to explore the evolution of this criterion and hence the likelihood of instability slip of fault. A coupled fluid flow-deformation model was used to represent the entire hydraulic fracturing process in COMSOL Multiphysics. The possibility of triggering an earthquake throughout the entire hydraulic fracturing process, from fracturing to cessation, was investigated considering different fault locations, orientations, and positions along the fault. The competition between the effects of the magnitude and change rate of effective stress was notable at each fracturing stage. The effective stress magnitude is a significant controlling factor during fracturing events, with the change rate dominating when fracturing is suddenly started or stopped. Instability dominates when the magnitude of the effective stress increases(constant injection at each fracturing stage) and the change rate of effective stress decreases(the injection process is suddenly stopped). Fracturing with a high injection rate, a fault adjacent to the hydraulic fracturing location and the position of the junction between the reservoir and fault are important to reduce the Coulomb failure stress(CFS) and enhance the critical stiffness as

关键词： Hydraulic fracturing Coulomb failure stress Rate-and-state fraction model Linear stability analysis Critical stiffness Seismically induced fault

Recent progresses in the development of tubular segmented-in-series solid oxide fuel cells:Experimental and numerical study

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 427-442页

作者： Shuo han Tao Wei Sijia Wang Yanlong zhu Xingtong Guo Liang He Xiongzhuang Li Qing Huang Daifen Chen School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037China

Solid oxide fuel cells(SOFCs)have attracted a great deal of interest because they have the highest efficiency without using any noble metal as catalysts among all the fuel cell ***,traditional SOFCs suffer from having a higher volume,current leakage,complex connections,and difficulty in gas *** solve these problems,Rolls-Royce has fabricated a simple design by stacking cells in series on an insulating porous support,resulting in the tubular segmented-in-series solid oxide fuel cells(SIS-SOFCs),which achieved higher output *** work systematically reviews recent advances in the structures,preparation methods,perform-ances,and stability of tubular SIS-SOFCs in experimental and numerical ***,the challenges and future development of tubular SIS-SOFCs are also *** findings of this work can help guide the direction and inspire innovation of future development in this field.

关键词： solid oxide fuel cell segmented-in-series tubular experimental study numerical study

A Tabletop Nano-CT Image Noise Reduction Network Based on 3-Dimensional Axial Attention Mechanism

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Computers, Materials & Continua 2024年第7期80卷 1711-1725页

作者： Huijuan Fu Linlin zhu ChunhuiWang Xiaoqi Xi Yu han Lei Li Yanmin Sun Bin Yan Henan Key Laboratory of Imaging and Intelligent Processing PLA Strategic Support Force Information Engineering UniversityZhengzhou450000China

Nano-computed tomography(Nano-CT)is an emerging,high-resolution imaging ***,due to their low-light properties,tabletop Nano-CT has to be scanned under long exposure conditions,which the scanning process is *** 3D reconstruction data,this paper proposed a lightweight 3D noise reduction method for desktop-level Nano-CT called AAD-ResNet(Axial Attention DeNoise ResNet).The network is framed by theU-net *** encoder and decoder are incorporated with the proposed 3D axial attention mechanism and residual dense *** layer of the residual dense block can directly access the features of the previous layer,which reduces the redundancy of parameters and improves the efficiency of network *** 3D axial attention mechanism enhances the correlation between 3D information in the training process and captures the long-distance *** can improve the noise reduction effect and avoid the loss of image structure *** results show that the network can effectively improve the image quality of a 0.1-s exposure scan to a level close to a 3-s exposure,significantly shortening the sample scanning time.

关键词： Deep learning tabletop Nano-CT image denoising 3D axial attention mechanism

A wide load-range OTA using a digitally assisted compensating technique

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Science China(Information Sciences) 2024年第7期67卷 343-344页

作者： Haolin han Shubin LIU Yi SHEN Hongzhi LIANG Yue CAO Longjie ZHONG Zhangming zhu School of Microelectronics Xidian University

To keep pace with rapid advancements in high-quality liquid crystal displays (LCDs), there has been a growing focus on the development of low-power, high-speed output drivers in recent years. An LCD column driver typically compromises registers, data latches [1], digital-to-analog converters [2],and output buffers.

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Function and regulation of muscle stem cells in skeletal muscle development and regeneration:a narrative review

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Journal of Bio-X Research 2021年第3期4卷 89-96页

作者： han zhu Xin Lin Yarui Diao Departments of Pediatrics and Cellular&Molecular Medicine Pediatric Diabetes Research CenterSanford Consortium for Regenerative MedicineUniversity of CalformiaSan DiegoLa JollaCA Department of Cell Biology Duke University Medical CenterDurhamNCUSA Regeneration Next Iitiative Duke University Medical CenterDurhamNCUSA Department of Orthopedic Surgery Duke University Medical CenterDurhamNCUSA

Skeletal muscle plays an essential role in generating the mechanical force necessary to support the movement of our body and daily exercise. Compared with cardiac and smooth muscle, in mammals, skeletal muscle exhibits remarkable regenerative capacity in response to damage. Muscle stem cells, also known as satellite cells, directly contribute to regeneration. Here, we review primary and secondary myogenesis processes with a focus on muscle stem cells, as well as the function and regulation of muscle stem cells in adult muscle regeneration in mammals.

关键词： muscle stem cell satellite cell skeletal muscle development skeletal muscle regeneration stem cell niche