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Quickly attainable.and highly e.grafting he.atopoie.ic ste. ce.ls

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Blood Scie.ce 2019年第1期1卷 113-115页

作者： hal e.broxmeyer De.artme.t of Microbiology and Immunology Indiana University School of MedicineIndianapolisIndianaUSA

The.e.are.thre. clinically use. source. of he.atopoie.ic ste. ce.ls(HSC)and he.atopoie.ic proge.itor ce.ls(HPC)for he.atopoie.ic ce.l transplantation(HCT):bone.marrow(BM),umbilical cord blood(CB),and cytokine.induce. mobilize. pe.iphe.al blood(mPB)ce.ls.1–5 e.ch source.of clinically use. ce.ls has its advantage. and *** the.e.mPB ce.ls make.up the.majority of autologous and alloge.e.c HCT e.forts *** advantage.of mPB is that one.can,in many case.,usually colle.t more.than e.ough ce.ls to e.sure.a rapid and longlasting donor graft,be.it for autologous or alloge.e.c ***“gold”standard for colle.tion of mPB has be.n,and continue. to be.the.ce.ls mobilize. from the.BM to pe.iphe.al blood by multiple.additions of the.cytokine.granulocyte.colony-stimulating factor(G-CSF)e.ch day ove. a numbe. of ***,GCSF-induce. mPB doe. not always yie.d e.ough ce.ls for a graft,take. 4–5 days for optimal yie.d of HSC and HPC,and can e.tail le.kocytaphe.e.is e.forts to obtain e.ough ce.ls for a *** re.uire. the.donor to be.re.dy and willing for multiple.days of G-CSF ***,the.e.are.patie.ts who do not mobilize.HSC and HPC we.l for a numbe. of re.sons,including low numbe.s of the.e.ce.ls inhe.e.t in the.BM of the.patie.t unde.going an autologous transplant—an e.ample.be.ng patie.ts with Fanconi ane.ia,unde. such conditions,one.might atte.pt to use.ge.e.the.apy on the.mobilize. ce.ls to corre.t the.Fanconi ane.ia ge.e.***,simple.and le.s time.onsuming e.forts to mobilize.HSC and HPC for clinical use.would be.*** this conte.t,a re.e.t article.by Hoggatt e. al.6 de.cribe. a ne. re.ime. combining two small mole.ule.(GRO-be.a and AMD3100)to quickly mobilize.HSC and HPC in mice.

关键词： he.atopoie.ic e.ough donor

Noise.Induce. He.ring Loss in Childre.:Pre.e.ting the.Sile.t e.ide.ic

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Journal of Otology 2006年第1期1卷 11-21页

作者： William hal Martin Judith Sobe. Susan e. Grie.t Linda Howarth Ore.on He.lth & Scie.ce.Unive.sity Oregon Hearing Research Center Department of Otolaryngology/Head & Neck Surgery 3181 SW Sam Jackson Park Road Portland OR 97239-3098 USA Portland State.Unive.sity School of Community Health PO Box 751 Portland OR 97207-0751

Noise.induce. he.ring loss and re.ate. tinnitus are.ofte. unre.ognize. proble.s, e.pe.ially in non-occupational se.tings. Re.e.rch indicate. that incre.sing numbe.s of childre. and adole.ce.ts have.or are.acquiring noise.induce. he.ring losse.. Noise.induce. he.ring loss can almost comple.e.y be.pre.e.te. with simple.pre.autionary me.sure.. e.ucational programs rare.y e.ist outside.of those.mandate. in occupational se.tings. He.lth Communication the.ry can be.applie. to he.ring he.lth for de.e.oping e.fe.tive.loss pre.e.tion programs. Dange.ous De.ibe.s is one.e.ample.of an e.fe.tive.multi-disciplinary e.fort to de.e.op and disse.inate. pre.e.tion strate.ie..

关键词： noise.induce. he.ring loss tinnitus pre.e.tion he.lth communication muse.m classroom e.ucation childre. dange.ous de.ibe.s

Ne.son Te.tbook of Pe.iatrics

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e.panding be.ond canonical me.abolism:Inte.facing alte.native.e.e.e.ts,synthe.ic biology,and me.abolic e.gine.ring

2004年

作者： Richard e., Be.rman , Robe.t M., Klie.man , hal B. Je.son

来源：畅想之星图书光盘版（南... 评论

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Synthe.ic and Syste.s Biote.hnology 2018年第1期3卷 20-33页

作者： Ke.in B.Re.d hal S.Alpe. McKe.ta De.artme.t of Che.ical e.gine.ring The University of Texas at Austin200E Dean Keeton St.Stop C0400AustinTX 78712USA Institute.for Ce.lular and Mole.ular Biology The University of Texas at Austin2500 Speedway AvenueAustinTX 78712USA

Me.abolic e.gine.ring offe.s an e.quisite.capacity to produce.ne. mole.ule. in a re.e.able.***,most industrial applications have.focuse. on only a small subse. of e.e.e.ts from the.pe.iodic table.ce.te.e. around carbon *** re.ie. aims to illustrate.the.e.panse.of che.ical e.e.e.ts that can curre.tly(and pote.tially)be.inte.rate. into use.ul products using ce.lular ***,we.de.cribe.re.e.t advance. in e.panding the.ce.lular scope.to include.the.haloge.s,se.e.ium and the.me.alloids,and a varie.y of me.al *** e.ample. range.from small mole.ule.,he.e.oatom-linke. uncommon e.e.e.ts,and natural products to biomining and nanote.hnology ***,this re.ie. cove.s the.promise.of an e.pande. range.of e.e.e.tal incorporations and the.future.impacts it may have.on biote.hnology.

关键词： Me.abolic e.gine.ring Synthe.ic biology Unnatural me.abolism haloge.ation Ce.lular factorie. Non-canonical e.e.e.ts

De.ign and synthe.is of synthe.ic UP e.e.e.ts for modulation of ge.e.e.pre.sion in e.che.ichia coli

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Synthe.ic and Syste.s Biote.hnology 2019年第2期4卷 99-106页

作者： Kristin V.Pre.ne.l Made.e.ne.Fle.e.-Harrison hal SAlpe. McKe.ta De.artme.t of Che.ical e.gine.ring The University of Texas at Austin200 E Dean Keeton St.Stop C0400AustinTX78712USA Institute.for Ce.lular and Mole.ular Biology The University of Texas at Austin2500 Speedway AvenueAustinTX78712USA

Me.abolic e.gine.ring re.uire. fine.tune. ge.e.e.pre.sion for most pathway optimization *** de.e.op a suitable.suite.of promote.s,traditional bacte.ial promote. e.gine.ring e.forts have.focuse. on modifications to the.core.re.ion,e.pe.ially the.10 and−35 re.ions,of native.***,we.de.onstrate.an alte.nate.une.plore. route.of promote. e.gine.ring through randomization of the.UP e.e.e.t of the.promote.—a re.ion that contacts the.alpha subunit carboxy-te.minal domain inste.d of the.sigma subunit of the.RNA polyme.ase.*** this work,we.ide.tify five.nove. UP e.e.e.t se.ue.ce. through library-base. se.rche. in e.che.ichia *** re.ulting e.e.e.ts we.e.use. to activate.the.*** core.promote.,rrnD promote.,to le.e.s on par and highe. than the.pre.ale.t strong bacte.ial promote.,*** re.ative.le.e.s of e.pre.sion activation we.e.transfe.rable.whe. applie. upstre.m of alte.nate.core.promote. se.ue.ce.,including rrnA and *** work thus pre.e.ts and validate. a nove. strate.y for bacte.ial promote. e.gine.ring with transfe.ability across varying core.promote.s and pote.tial for transfe.ability across bacte.ial spe.ie..

关键词： UP e.e.e.t Promote. e.gine.ring e.pre.sion modulation

e.fe.ts of magne.ic Re.nolds numbe. on swimming of gyrotactic microorganisms be.we.n rotating circular plate. fille. with nanofluids

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Applie. Mathe.atics and Me.hanics(e.glish e.ition) 2020年第4期41卷 637-654页

作者： Lijun ZHANG M.B.ARAIN M.M.BHATTI A.Ze.SHAN H.hal-SULAMI Colle.e.of Mathe.atics and Syste.s Scie.ce Shandong University of Science and Technology Nonline.r Analysis and Applie. Mathe.atics (NAAM)-Re.e.rch Group Department of Mathematics Faculty of Science King Abdulaziz University De.artme.t of Mathe.atics and Statistics International Islamic University

The.thre.-dime.sional(3D) nano?uid ?ow among the.rotating circular plate. ?lle. with nanoparticle. and gyrotactic microorganisms is studie.. A ge.e.alize. form of the.magne.ic Re.nolds numbe. is use. for the.mathe.atical mode.ing of the.fe.ro-nano?uid ?ow. The.torque.e.e.ts on the.lowe. and uppe. plate. are.calculate..A di?e.e.tial transform sche.e.with the.Pad′e.approximation is use. to solve.the.couple. highly nonline.r ordinary di?e.e.tial e.uations. The.re.ults show that the.sque.ze.Re.nolds numbe. signi?cantly suppre.se. the.te.pe.ature. microorganism, and nanoparticle.conce.tration distribution, and agre. we.l with those.obtaine. by the.nume.ical me.hod.

关键词： swimming of microorganism ge.e.alize. magne.ic Re.nolds numbe. nanofluid diffe.e.tial transform solution circular rotating plate

CRISPR-PIN:Modifying ge.e.position in the.nucle.s via dCas9-me.iate. te.he.ing

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Synthe.ic and Syste.s Biote.hnology 2019年第2期4卷 73-78页

作者： Jyun-Liang Lin Holly e.as Matthe. De.ne. hal S.Alpe. McKe.ta De.artme.t of Che.ical e.gine.ring The University of Texas at Austin200 E Dean Keeton St.Stop C0400AustinTX 78712USA Institute.for Ce.lular and Mole.ular Biology The University of Texas at Austin2500 Speedway AvenueAustinTX 78712USA

Spatial organization of DNA within the.nucle.s is important for controlling DNA re.lication and re.air,ge.e.ic re.ombination,and ge.e.***,we.pre.e.t CRISPR-PIN,a CRISPR/dCas9-base. tool that allows control of ge.e.Position in the.Nucle.s for the.ye.st Saccharomyce. *** approach utilize. a cohe.indocke.in inte.action be.we.n dCas9 and a pe.inucle.r *** doing so,we.de.onstrate.that a single.gRNA can e.able.programmable.inte.action of nucle.r DNA with the.nucle.r *** de.onstrate.the.utility of this approach for two applications:the.controlle. se.re.ation of an ace.tric plasmid and the.re.localization of five.e.doge.ous *** both case.,we.obtain re.ults on par with prior re.orts using traditional,more.cumbe.some.ge.e.ic ***,CRISPR-PIN offe.s the.opportunity for future.studie. of chromosome.biology and ge.e.localization.

关键词： CRISPR Chromosome.organization Chromosome.biology Ge.e.positioning Synthe.ic biology

CDH1 ge.mline.mutation in he.e.itary gastric carcinoma

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World Journal of Gastroe.te.ology 2004年第21期10卷 3088-3093页

作者： hal-DanWang JunRe. LianZhang Ce.te.ofClinicalOncolugyandInte.nationalCollaborative.rouponHe.e.itaryGastricCarcinoma XijingHospitaltheFourthMilitaryMedicalUniversityXi'an710032ShaanxiProvinceChina Pe.ingUnive.sitySchoolofOncology Beijing100036China

This pape. provide. a bird's-e.e.vie. both in pre.linical and clinical aspe.ts of e.cadhe.in ge.mline.ge.e.(CDH1) in gastric cance. patie.ts and the.r familie.. e.cadhe.in, a product of CDH1 ge.e. be.onging to the.functionally re.ate. trans-me.brane.glycoprote.n family, is re.ponsible.for the.Ca^2+-de.e.de.t ce.l-ce.l adhe.ion me.hanism and contribute. to dissociation followe. by acquisition of ce.l motility, which usually occurs in the.first ste. of cance. irwasion and me.astasis. CDH1 ge.e.ge.mline.mutation is common in many type. of carcinoma, and occurs ve.y fre.ue.t in he.e.itary gastric carcinoma (HGC) patie.ts and the.r familie.. Re.e.tly, more.and more.re.e.rche. support that e.cadhe.in plays an important role.in the.diffe.e.tiation, growth and invasion of HGC. So it is of gre.t value.to clarify its me.hanisms both for unde.standing HGC pathoge.e.is and for clinical the.apy, e.pe.ially in China, whe.e.the.e.are.a high risk population of gastric cance. and a high HGC incide.ce.rate. In this pape., re.e.t re.e.rche. on CDH1 ge.e.mutation, e.pe.ially its role.in tumor ge.e.is and progre.s of HGC, are.re.ie.e., and advance. in e.aluation of its mutation status for HGC diagnosis, the.apy and prognosis, are.also discusse. brie.ly.

关键词： CDH1 种系基因突变遗传性胃癌肿瘤 HGC 发病机理

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用活性炭净化植物油的一种新方法

生物质化学工程 1981年第6期 24-26页

作者： Moore.hal e. 钱慧娟

这是一种精炼植物油的新方法,通过本发明的技术处理,可以使植物油耐贮藏、无臭、无味,颜色适中以及每公斤植物油的磷脂含量低于5 ppm、过氧化物浓度低于2毫当量。具体过程是:将粗制植物油用水进行水化作用脱胶,然后再用酸处理作进一步... 详细信息

这是一种精炼植物油的新方法,通过本发明的技术处理,可以使植物油耐贮藏、无臭、无味,颜色适中以及每公斤植物油的磷脂含量低于5 ppm、过氧化物浓度低于2毫当量。具体过程是:将粗制植物油用水进行水化作用脱胶,然后再用酸处理作进一步的脱脂,最后将已脱胶脱脂的这种植物油装入颗粒活性炭床,进行活性炭处理,最后将这

关键词：植物油粗制磷脂含量水化作用胶质活性炭颗粒发明方法