CDH1 germline mutation in hereditary gastric carcinoma

作     者：Hal-DanWang JunRen LianZhang 

作者机构：CenterofClinicalOncolugyandInternationalCollaborativeGrouponHereditaryGastricCarcinomaXijingHospitaltheFourthMilitaryMedicalUniversityXi'an710032ShaanxiProvinceChina PekingUniversitySchoolofOncologyBeijing100036China 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2004年第10卷第21期

页      面：3088-3093页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by the Teaching and Research Award Program for Outstanding Young Teachers Ministry of Education P R China No.TRAPOYT99-016 

主　　题：CDH1 种系 基因突变 遗传性 胃癌 肿瘤 HGC 发病机理 

摘      要：This paper provides a bird s-eye view both in preclinical and clinical aspects of E-cadherin germline gene (CDH1) in gastric cancer patients and their families. E-cadherin, a product of CDH1 gene, belonging to the functionally related trans-membrane glycoprotein family, is responsible for the Ca^2+-dependent cell-cell adhesion mechanism and contributes to dissociation followed by acquisition of cell motility, which usually occurs in the first step of cancer irwasion and metastasis. CDH1 gene germline mutation is common in many types of carcinoma, and occurs very frequent in hereditary gastric carcinoma (HGC) patients and their families. Recently, more and more researches support that E-cadherin plays an important role in the differentiation, growth and invasion of HGC. So it is of great value to clarify its mechanisms both for understanding HGC pathogenesis and for clinical therapy, especially in China, where there are a high risk population of gastric cancer and a high HGC incidence rate. In this paper, recent researches on CDH1 gene mutation, especially its role in tumor genesis and progress of HGC, are reviewed, and advances in evaluation of its mutation status for HGC diagnosis, therapy and prognosis, are also discussed briefly.