Nature:骨髓微环境发生突变可导致造血干细胞异常

作     者：Lei Dong, Wen-Mei Yu, Hong Zheng, Melinda Pauly, Muxiang Zhou Cheng-Kui Qu Mignon L. Loh Silvia T. Bunting Gang Huang Hal E. Broxmeyer David T. Scadden 

作者机构：Department of Pediatrics Division of Hematology/Oncology Aflac Cancer and Blood Disorders Center Children’s Healthcare of Atlanta Emory University School of Medicine Atlanta Georgia 30322 USA Department of Pediatrics Division of Pediatric Hematology-Oncology University of California at San Francisco San Francisco California 94122 USA Department of Pathology Children’s Healthcare of Atlanta Emory University Atlanta Georgia 30322 USA Division of Experimental Hematology and Cancer Biology Cincinnati Children' s Hospital University of Cincinnati Cincinnati Ohio 45229 USA Department of Microbiology and Immunology Indiana University School of Medicine Indianapolis Indiana 46202 USA Center for Regenerative Medicine and MGH Cancer Center Massachusetts General Hospital Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute Harvard University Boston Massachusetts 02114 USA 

出 版 物：《现代生物医学进展》 (Progress in Modern Biomedicine)

年 卷 期：2016年第16卷第35期

页      面：I0003-I0004页

核心收录：

学科分类：08[工学] 09[农学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

基　　金：National Institute of Diabetes and Digestive and Kidney Diseases  NIDDK  (R01DK105014) 

主　　题：造血干细胞 DNA突变 微环境 骨髓 异常 可导 国际学术期刊 白血病 

摘      要：白血病骨髓微环境中支持血液发育的某些DNA突变可以驱动周围造血干细胞形成白血病，来自艾默里大学温希普癌症研究所和亚特兰大儿童健康中心的研究人员在国际学术期刊Nature上公布了他们的最新研究进展。许多致癌突变都作用于细胞自身。让细胞自身生长更快。相比之下，努南综合征小鼠模型上可以观察到间接的邻近细胞效应，努南综合征是一种能够增加白血病患病风险的遗传紊乱。