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High-throughput single-сell sequencing in cancer research

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Signal Transduction and Targeted Therapy 2022年第6期7卷 1899-1918页

作者： Qingzhu Jia Han Chu Zheng Jin haixia long Bo Zhu Institute of Cancer Xinqiao HospitalArmy Medical UniversityChongqing 400037China Chongqing Key Laboratory of Immunotherapy Chongqing 400037China Center of Growth Metabolism and AgingKey Laboratory of Bio-Resources and Eco-EnvironmentCollege of Life SciencesSichuan UniversityChengdu 610064China Research Institute GloriousMed Clinical Laboratory Co.LtdShanghai 201318China

With advances in sequencing and instrument technology,bioinformatics analysis is being applied to batches of massive cells at single-cell ***-throughput single-cell sequencing can be utilized for multi-omics characterization of tumor cells,stromal cells or infiltrated immune cells to evaluate tumor progression,responses to environmental perturbations,heterogeneous composition of the tumor microenvironment,and complex intercellular interactions between these ***,single-cell sequencing of T cell receptors,alone or in combination with single-cell RNA sequencing,is useful in the fields of tumor immunology and *** insights obtained from single-cell analysis are critically important for exploring the biomarkers of disease progression or antitumor treatment,as well as for guiding precise clinical decision-making for patients with malignant *** this review,we summarize the clinical applications of single-cell sequencing in the fields of tumor cell evolution,tumor immunology,and tumor ***,we analyze the tumor cell response to antitumor treatment,heterogeneity of the tumor microenvironment,and response or resistance to immune checkpoint *** limitations of single-cell analysis in cancer research are also discussed.

关键词： instrument precise utilized

Mechanism and effects of extramedullary hematopoiesis on anti-tumor immunity

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Cancer Biology & Medicine 2023年第7期20卷 477-482页

作者： Zefang Chen Xinyu Cheng Li Yang Xiaoming Cheng Bo Zhu haixia long Institute of Cancer Xinqiao HospitalThird Military Medical UniversityChongqing 400037China School of Pharmacy and Bioengineering Chongqing University of TechnologyChongqing 400054China Department of Respiratory Disease Xinqiao HospitalThird Military Medical UniversityChongqing 400037China

Cancer immunotherapy is a preferred strategy for boosting anti-tumor immunity to eliminate malignant cells and is considered a major breakthrough in the field of cancer treatment however,immunosuppressive cells in the tumor microenvironment(TME)pose a major obstacle to the efficacy of *** cells,such as tumor-a ssociated macrophages(TAMs)and myeloid-derived suppressor cells(MDSCs).

关键词： immunity immunotherapy Cancer

A potential ethnic difference in the association between 5-HTTLPR polymorphisms and the brain default mode network

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Chinese Science Bulletin 2014年第13期59卷 1355-1361页

作者： haixia long Bing Liu Bing Hou Chao Wang Keith M. Kendrick Chunshui Yu Tianzi Jiang Brainnetome Center Institute of Automation Chinese Academy of Sciences National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Key Laboratory for NeuroInformation of Ministry of Education School of Life Science and Technology University of Electronic Science and Technology of China Department of Radiology Tianjin Medical University General Hospital Queensland Brain Institute University of Queensland Brisbane QLD 4072 Australia

The serotonin-transporter-linked polymorphic region(5-HTTLPR)is associated with mood *** association is thought to be due to amygdala hyperresponsiveness to negative emotional stimuli as a result of reduced frontal cortical *** Caucasians,the short form is associated with this effect,but in Han Chinese we recently found that the long form is *** receptors have rich expression in default mode network(DMN)regions and the recent studies have found an association between the short form of the 5-HTTLPR and DMN functional connectivity(FC)in *** present study has investigated whether there may also be anethnic difference in this influence of 5-HTTLPR on the *** recruited 233 young Han Chinese subjects and calculated the resting-state default-network *** study found that the L carriers had decreased FC in the bilateral medial prefrontal cortex,right parahippocampal gyrus,left middle temporal gyrus,and increased FC in left precuneus(Pcu)compared to *** PCC-Pcu FC in L carriers was significantly negatively correlated with the depression *** findings,therefore,suggest that there is also a difference between Caucasian and Han Chinese subjects in the association between the different forms of the5-HTTLPR and DMN functional connectivity.

关键词：网络表多态性关联种族差异大脑中国汉族消极情绪前额叶皮质

DeepSVDNet:A Deep Learning-Based Approach for Detecting and Classifying Vision-Threatening Diabetic Retinopathy in Retinal Fundus Images

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Computer Systems Science & Engineering 2024年第2期48卷 511-528页

作者： Anas Bilal Azhar Imran Talha Imtiaz Baig Xiaowen Liu haixia long Abdulkareem Alzahrani Muhammad Shafiq College of Information Science and Technology Hainan Normal UniversityHaikou571158China Department of Creative Technologies Air UniversityIslamabadPakistan School of Life Science and Technology University of Electronic Science and Technology of China UESTCChengduChina School of Science and Technology University of Management and Technology UMTLahorePunjabPakistan Faculty of Computer Science&Information Technology Al Baha UniversityAl BahaSaudi Arabia School of Information Engineering Qujing Normal UniversityQujingChina

Artificial Intelligence(AI)is being increasingly used for diagnosing Vision-Threatening Diabetic Retinopathy(VTDR),which is a leading cause of visual impairment and blindness ***,previous automated VTDR detection methods have mainly relied on manual feature extraction and classification,leading to *** paper proposes a novel VTDR detection and classification model that combines different models through majority *** proposed methodology involves preprocessing,data augmentation,feature extraction,and classification *** use a hybrid convolutional neural network-singular value decomposition(CNN-SVD)model for feature extraction and selection and an improved SVM-RBF with a Decision Tree(DT)and K-Nearest Neighbor(KNN)for *** tested our model on the IDRiD dataset and achieved an accuracy of 98.06%,a sensitivity of 83.67%,and a specificity of 100%for DR detection and evaluation tests,*** proposed approach outperforms baseline techniques and provides a more robust and accurate method for VTDR detection.

关键词： Diabetic retinopathy(DR) fundus images(FIs) support vector machine(SVM) medical image analysis convolutional neural networks(CNN) singular value decomposition(SVD) classification

Tumor-Induced Erythroid Precursor-Differentiated Myeloid Cells Mediate Immunosuppression and Curtail Anti-PD-1/PD-L1 Treatment Efficacy

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Tumor-Induced Erythroid Precursor-Differentiated Myeloid Cel...

Authors' response to “Maternal age as a potential explanation of the role of the L allele of the serotonin transporter gene in anxiety and depression in Asians”

第十四届全国免疫学学术大会

作者： haixia long Qingzhu jia Bo zhu Institute of Cancer Xinqiao Hospital Third Military Medical University

Despite the unprecedented success of immune checkpoint inhibitors(ICIs) in cancer therapy, it remains a prevailing clinical need to identify additional mechanisms informing efficacy and predict the drug resistance. Here, we characterized an erythroid-myeloid hybrid cell population that abundant in established tumors, sharing surface markers and gene signatures of erythroid and myeloid cells, which we term erythroid differentiated myeloid cells(EDMCs). Further, in vivo lineage tracking and single cell transcriptomic analyses confirmed that tumors hijack erythroid progenitors to produce immunosuppressive EDMCs instead of red blood cells. A variety of functional assays revealed multiple immunosuppressive impacts from EDSCs to curtail T cell-mediated anti-tumor responses. Consequently, the EDMCs content within tumor tissues negatively associated with T cell inflammation for majority of human cancers;and, EDMCs enrichment, in accordance with anemia manifestation, predicts the poor prognosis in various cohort of patients undergoing ICIs therapy. Our findings reveal a feed-forward mechanism by which tumors exploit anemia signal-triggered erythropoiesis for myeloid trans-differentiation and immunosuppression.

关键词： Cancer immunotherapy Extramedullary erythropoiesis Erythroid progenitors Myeloid-derived suppressor cells(MDSCs) Trans-differentiation

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Neuroscience Bulletin 2014年第3期30卷 536-537页

作者： haixia long Bing Liu Bing Hou Chao Wang Jin Li Tianzi Jiang Brainnetome Center Institute of Automation Chinese Academy of Sciences National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Key Laboratory for NeuroInformation of Ministry of Education School of Life Science and Technology University of Electronic Science and Technology of China Queensland Brain Institute University of Queensland

In the letter to the editor, Dr. Comings et al. proposed a potential explanation of our findings that the L allele rather than S allele of 5-HTTLPR was associated with higher anxiety levels and reduced amygdala-prefrontal cortex （PFC） connectivity in Han Chinese[1], which demonstrated an ＇allele reversal＇ in the genetics of the 5-HTTLPR gene in Asians versus Caucasians. The authors alleged that this ＇allele reversal＇ might simply result from maternal age and suggested that we test this on our datasets. Unfortunately,

关键词： In Maternal age as a potential explanation of the role of the L allele of the serotonin transporter gene in anxiety and depression in Asians response to Authors gene

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直面当下:俄罗斯青少年体育的教育目标指向

比较教育研究 2017年第7期39卷 95-100页

作者：龙海霞内江师范学院教育科学学院四川内江641112

从20世纪90年代俄罗斯独立以来,在社会经济转型过程中,国家面临诸多社会问题,如国内新的政治与经济形势、国际的压力与挑战、猖獗的分裂主义与恐怖主义活动、青少年的轻贱生命与违法行为等。新的形势和时代需求,尤其是青少年教育的紧迫... 详细信息

从20世纪90年代俄罗斯独立以来,在社会经济转型过程中,国家面临诸多社会问题,如国内新的政治与经济形势、国际的压力与挑战、猖獗的分裂主义与恐怖主义活动、青少年的轻贱生命与违法行为等。新的形势和时代需求,尤其是青少年教育的紧迫性,促使国家在体育实践领域采取了多种增进健康的举措,加强了体育爱国主义教育,并对原国家体育管理机构进行了适应性变革,以强化青少年政治素质的培养。这些措施的贯彻体现了俄罗斯青少年体育教育目标新的侧重。

关键词：俄罗斯青少年体育体育爱国主义教育健康生活方式

群智能算法优化XGBoost的信贷风险预测

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计算机工程与应用 2023年第23期59卷 305-310页

作者：朱丽华龙海侠安阳工学院计算机科学与信息工程学院河南安阳455000 海南师范大学信息科学技术学院海口571158

为改善极端梯度提升(extreme gradient boosting,XGBoost)集成算法的信贷风险预测准确率,提出了一种改进的麻雀算法(improved sparrow search algorithm based on golden sine search,Cauchy mutation and oppositionbased learning,GCOSSA)来优化XGBoost参数。采用黄金正弦搜索策略来更新发现者位置,既增强全局搜索能力又增强局部搜索能力;在算法中引入反向学习策略和柯西变异进行扰动来扩大搜索领域改善陷入局部最优,同时使用贪婪规则确定最优解;将改进的算法用6个基准函数进行测试,并对SSA和GCOSSA进行对比,评估GCOSSA寻优性能;用GCOSSA优化XGBoost参数。在数据集上测试,并与网格搜索寻优、SSA及其混合正余弦改进算法(improved sparrow search algorithm based on sine and cosine,ISSA)方法进行对比。结果表明改进后的GCOSSA优化XGBoost参数,在信贷风险预测中准确率更高。

关键词：麻雀搜索算法黄金正弦搜索反向学习柯西变异极端梯度提升(XGBoost)

Subsequent strategies and underlying mechanism of acquired resistance to PD-1 axis inhibitors in advanced non-small cell lung cancer

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Chinese Medical Journal 2024年第7期137卷 880-882页

作者： Huilan Wang Xinyu Cheng Fan Yang Lu Chen Anmei Zhang Liangzhi Zhong haixia long Bo Zhu Zhongyu Wang Institute of Cancer Xinqiao HospitalThird Military Medical UniversityChongqing 400037China Chongqing Key Laboratory of Immunotherapy Chongqing 400037China

To the Editor:With the widespread application of immune checkpoint inhibitors(ICIs)in clinical practice,acquired resistance(AR)to programmed death-1(PD-1)/programmed death ligand 1(PD-L1)axis inhibitors in advanced nonsmall cell lung cancer(NSCLC)develops and limits the durability of *** is a clinical condition in which a patient initially responds to ICIs but relapses and progresses after a period of *** rates of AR have not been routinely reported in lung cancer but typically range from 12.9%to 64%.[1]However,studies on subsequent management strategies and the mechanism of AR to PD-1/PD-L1 axis inhibitors in lung cancer are *** main exploratory strategies are immunotherapy rechallenge and the combination of ICIs with other therapies,including local therapy,chemotherapy,antiangiogenetic treatment,and cytotoxic T lymphocyte antigen 4(CTLA-4)inhibitors.[2]The purpose of this study was to characterize the clinical patterns of AR and compare different subsequent therapies and outcomes in NSCLC patients after AR to PD-1/PD-L1 ***,we explored the underlying mechanism of AR by analyzing the alterations in next-generation sequencing(NGS)data before and after AR.

关键词： routine alterations resistance