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VPS13D affects epileptic seizures by regulating mitochondrial fission and autophagy in epileptic rats

Genes & Diseases 2024年第6期11卷 452-465页

作者： Jian Wang Fan zhang Zhong Luo haiqing zhang Changyin Yu Zucai Xu Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou 563000China Department of Neurology Affliated Aerospace Hospital of Zunyi Medical UniversityZunyiGuizhou 563000China Department of Clinical Medicine Zunyi Medical and Pharmaceutical CollegeZunyiGuizhou 563000China

Abnormal mitochondrial dynamics can lead to seizures,and improved mitochon-drial dynamics can alleviate *** protein sorting 13D(VPS13D)is closely associ-ated with regulating mitochondrial homeostasis and ***,further investigation is required to determine whether VPS13D affects seizures by influencing mitochondrial dy-namics and *** aimed to investigate the influence of VPS13D on behavior in a rat model of acute epileptic ***,we established an acute epileptic seizure rat model and employed the CRISPR/CAS9 technology to construct a lentivirus to silence the Vps13d ***,we used the HT22 mouse hippocampal neuron cell line to establish a stable strain with suppressed expression of Vps13d in ***,we performed quantitative prote-omic and bioinformatics analyses to confirm the mechanism by which VPS13D influences mito-chondrial dynamics and autophagy,both in vitro and in vivo using the experimental acute epileptic seizure *** found that knockdown of Vps13d resulted in reduced seizure la-tency and increased seizure frequency in the experimental *** staining and western blot analysis revealed a significant increase in mitochondrial dynamin-related pro-tein 1 expression following Vps13d ***,we observed a significant reduction in LC3Il protein expression levels and the LC31/LC3l ratio(indicators for autophagy)accompa-nied by a significant increase in P62 expression(an autophagy adaptor protein).The proteomic analysis confirmed the up-regulation of P62 protein ***,we propose that VPS13D plays a role in modulating seizures by influencing mitochondrial dynamics and autophagy.

关键词： Autophagy Mitochondrial dynamics Mitochondrial fission Seizures VPS13D

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Environmental subsidies and companies’environmental investments

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Economic and Political Studies 2021年第4期9卷 477-496页

作者： Jianbo Song haiqing zhang Zihao Su Business School Renmin University of ChinaBeijingChina Management School Harbin Institute of TechnologyHarbinChina

Environmental subsidies are important means for the government to promote companies to fulfil environmental protection *** a text analysis method,this study obtains the data on government subsidies for environmental protection of Ashare listed companies in China from 2007 to *** estimates show that the subsidies received by companies promote their environmental ***,analyst tracking and internal control enhance the positive effect of subsidies on the companies’environmental *** above results are still valid after testing the Heckman two-stage model and the Propensity-Score-Matching and Difference-in-Difference *** paper provides evidential support for the effectiveness of government subsidies and explores feasible ways to improve the efficiency of government subsidies based on the corporate governance channels.

关键词： Environmental subsidies environmental investments analyst tracking internal control

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Does Education Still Pay Off in Rural China:Revisit the Impact of Education on Off-farm Employment and Wages

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China & World Economy 2008年第2期16卷 50-65页

作者： haiqing zhang Linxiu zhang Renfu Luo Qiang Li Ph.D. candidate Center for Chinese Agricultural Policy Institute of Geographical Sciences and Natural Resources Research Chinese Academy of Sciences Beijing China Professor and Deputy Director Center for Chinese Agricultural Policy Institute of Geographical Sciences and Natural Resources Research Chinese Academy of Sciences Beijing China Post Doctoral Researcher Center for Chinese Agricultural Policy Institute of Geographical Sciences and Natural Resources Research Chinese Academy of Sciences Beijing China Lecturer School of Economics and Management Beijing Forestry University Beijing China

The present study considers how education affects off-farm job participation and wages. We use a nationally representative dataset from a survey conducted in 5 provinces, 101 villages and 808 households by the authors in early 2005. The empirical results show that educational attainment, skill training and years of experience of rural residents have positive, statistically significant effects on off-farm employment. The average return to a year of education is 7percent, which is higher than those observed in previous studies. We also find the return to an additional year of schooling to be higher for post-junior high schooling than for junior high and below schooling： 11.8 versus 3.2 percent. We conclude that not only does education still pays off in rural China, but also the rate of return to education is increasing over time.

关键词： off-farm employment retums to education rural labor force

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Independent and Combined Associations of Sleep Duration, Bedtime, and Polygenic Risk Score with the Risk of Hearing Loss among Middle-Aged and Old Chinese: The Dongfeng–Tongji Cohort Study

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Research 2024年第1期2023卷 721-733页

作者： Miao Liu haiqing zhang Zhichao Wang Tingting Mo Xuefeng Lai Yaling He Minghui Jiang Meian He Weijia Kong Tangchun Wu Xiaomin zhang Department of Occupational and Environmental Health Ministry of Education Key Laboratory of Environment and Healthand State Key Laboratory of Environmental Health(Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Otorhinolaryngology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina

Evidence available on the independent and combined associations of sleep duration,bedtime,and genetic predisposition with hearing loss was *** present study included 15,827 participants from the Dongfeng–Tongji cohort *** risk was characterized by polygenic risk score(PRS)based on 37 genetic loci related to hearing *** conducted multivariate logistic regression models to assess the odds ratio(OR)for hearing loss with sleep duration and bedtime,as well as the joint association and interaction with *** showed that hearing loss was independently associated with sleeping≥9 h/night compared to the recommended 7 to9:00 *** 10:00 *** to those with bedtime>10:00 *** 11:00 p.m.,with estimated ORs of 1.25,1.27,and 1.16,respectively.

关键词： Middle hearing fen

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Vertical,capacitive microelectromechanical switches produced via direct writing of copper wires

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Microsystems & Nanoengineering 2016年第1期2卷 249-255页

作者： Zhiran Yi Jianjun Guo Yining Chen haiqing zhang Shuai zhang Gaojie Xu Minfeng Yu Ping Cui Zhejiang Key Laboratory of Additive Manufacturing Materials Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China D.Guggenheim School of Aerospace Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Nano Science and Technology Institute University of Science and Technology of ChinaSuzhou 215123China

Three-dimensional(3D)direct writing based on the meniscus-confined electrodeposition of copper metal wires was used in this study to develop vertical capacitive microelectromechanical *** microelectromechanical switches reduce the form factor and increase the area density of such devices in integrated *** studied the electromechanical characteristics of such vertical switches by exploring the dependence of switching voltage on various device structures,particularly with regard to the length,wire diameter,and the distance between the two wires.A simple model was found to match the experimental measurements made in this *** found that the electrodeposited copper microwires exhibit a good elastic modulus close to that of bulk *** optimizing the 3D structure of the electrodes,a volatile electromechanical switch with a sub-5 V switching voltage was demonstrated in a vertical microscale switch with a gap distance as small as 100 nm created with a pair of copper wires with diameters of~1μm and heights of 25μ*** study establishes an innovative approach to construct microelectromechanical systems with arbitrary 3D microwire structures for various applications,including the demonstrated volatile and nonvolatile microswitches.

关键词： microelectromechanical switch direct writing copper microwire

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Executive function during transient ischemic attacks

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Neural Regeneration Research 2007年第3期2卷 142-145页

作者： Jianhua Zhao Tong Li Yanxia Liu Ping zhang haiqing Yan Department of Neurology the First Affiliated Hospital of Xinxiang Medical College Xinxiang 453100 Henan Province China

BACKGROUND： Recent researches demonstrate that damage of executive function is an early manifestation of vascular cognitive disorder. OBJECTIVE： To investigate the executive functions of patients with transient ischemic attack （TIA）. DESIGN： Case control. SETTING： Department of Neurology, the First Affiliated Hospital of Xinxiang Medical College. PARTICIPANTS： A total of 83 TIA patients （46 males and 37 females, aged 32 - 74 years） were selected from Department of Neurology, the First Affiliated Hospital of Xinxiang Medical College from July 2005 to December 2006. The diagnosis of TIA was established by the criteria of cerebrovascular diseases made by the Fourth National Cerebrovascular Disease Meeting. In these cases, forty-five patients （54%） were involved in internal carotid artery, and thirty-eight patients （46%） were involved in vertebral basilar system. Fifty healthy adults （Control group： 28 males and 22 females, aged 32 - 74 years） were chosen from retiree in community and family of patients. All of them were right-handedness, without cerebrovascular disease, cerebral trauma, inborn oligophrenia, and heating and visual disorders; also they had no anxiety and depression nearly one week. In addition, all the subjects cooperated with examination. METHODS： After TIA diagnosis, all patients received neuropsychological examination, including attention and inhibition, working memory, flexibility, planning and diversion, based on Stroop tests （C and CW） and the Wisconsin card sorting tests （WCST）. ① WCST test： The edition revised by Nelson was used. We would take the times of sorting, incorrect response, persistent incorrect response, and randomly incorrect response as the index of evaluation.② Stroop tests： The edition revised by Trenarry was used and this test had two types： form color and form color-word. Their incorrect response and response time were recorded for data analysis in the end. MAIN OUTCOME MEASURES： Results of WCST test and Stroop tests. RESULTS： A

关键词： ischemic attack, transient neuropsychological tests case control studies

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Genomic structure of metabotropic glutamate receptor 7 and comparison of genomic structures of extracellular domains of mGluR family

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Chinese Science Bulletin 2002年第16期47卷 1330-1336页

作者： Qingfa Wu Wei Dong Xiaohua Qi Weidong Bao Yuxin Niu Yiling zhang haiqing zhang Chong Chen Bin Liu Songnian Hu et al. Chinese Acad Sci Inst Genet Beijing Gen Inst Ctr Human Genome Beijing 100101 Peoples R China

Metabotropic glutamate receptor 7, coupled with a chemical neurotransmitter L-glutamate, plays an important role in the development of many psychiatric and neurological disorders. To study the biological and genetic mechanism of the mGluR7-related diseases, a physical map covering the full-length mGluR7 genomic sequence has been constructed through seed clone screening and fingerprinting database searching. These BAC clones in the physical map have been sequenced with shotgun strategy and assembled by Phred-Phrap-Consed software; the error rate of the final genoniic sequence is less than 0.01%. mGluR7 spans 880 kb genoniic region, the GC content and repeat content of mGluR7 genoniic sequence are 38% and 37.5% respectively. mGluR7 has a typical 'house-keeping' promoter and consists of 11 exons, with introns ranging from 6 kb to 285 kb. mGluR7a and mGluR7b are two known alternatively splicing variants. Comparing the genomic structures of extracellular domains of mGluR family, their genomic structures can

关键词： metabotropic glutamate receptor physical map genome exon intron extracellular domain.

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采用分布参数模型的CO_2微通道蒸发器数值模拟

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西安交通大学学报 2012年第1期46卷 42-47,119页

作者：张海清郭蓓西安交通大学能源与动力工程学院西安710049

采用有限元分析方法为跨临界CO2空调系统的微通道蒸发器建立了二维分布参数仿真模型,比较分析了适用于不同制冷剂侧的换热关联式,并为此提出了一种修正的换热关联式,以期为微通道蒸发器模型能够获得很好的预测结果.模型中考虑了干、湿... 详细信息

采用有限元分析方法为跨临界CO2空调系统的微通道蒸发器建立了二维分布参数仿真模型,比较分析了适用于不同制冷剂侧的换热关联式,并为此提出了一种修正的换热关联式,以期为微通道蒸发器模型能够获得很好的预测结果.模型中考虑了干、湿工况以及制冷剂进出集液管产生的压力损失对制冷剂侧换热和流动特性的影响.对比分析得出:微通道蒸发器的制冷量和压降在制冷剂侧仿真、实验的相对误差分别小于8.2%和10%,表明所建模型可作为CO2微通道蒸发器的优化设计的理论依据.

关键词：二氧化碳微通道蒸发器分布参数模型数值模拟

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Synthesis of perylene-bridged bis(dibenzo-24-crown-8) and its assembly behavior with a fullerene-based secondary dibenzylammonium salt

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Science China Chemistry 2010年第9期53卷 1982-1986页

作者： YAO haiqing,zhang HengYi,HAN Min,DING ZhiJun,zhang ZhiJun & LIU Yu State Key Laboratory of Elemento-Organic Chemistry Department of Chemistry,Nankai University,Tianjin 300071,China State Key Laboratory of Elemento-Organic Chemistry Department of Chemistry Nankai University Tianjin China

This paper reports the synthesis of a perylene-bridged bis(crown ether) through the condensation reaction between primary amine-armed dibenzo-24-crown-8 and 3,4,9,10-perylenetetracarboxylic *** with a perylene moiety at the wheel and a fullerene unit in the middle of the axle was prepared,which was evidenced by 1H NMR and fluorescence *** investigations show that the formation and disassociation of the pseudorotaxane can be controlled by the alternating addition of KPF6 and 18-crown-6,following the change of the florescence intensity of perylene.

关键词： crown ether perylene fullerene pseudorotaxane

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焦炭塔顶挥发线应力和腐蚀问题探讨

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炼油技术与工程 2007年第4期37卷 25-29页

作者：张海清荆门炼化工程设计有限公司湖北省荆门市448000

分析了焦化装置焦炭塔顶挥发线运行时二次应力超标现象的产生原因,由于挥发线管道自重很大,易产生一次应力超标。另外,由于原料硫含量大幅度增加,碳钢材质的管道腐蚀严重。结合生产经验和分析计算,认为可以通过采用新的配管形式来降低... 详细信息

分析了焦化装置焦炭塔顶挥发线运行时二次应力超标现象的产生原因,由于挥发线管道自重很大,易产生一次应力超标。另外,由于原料硫含量大幅度增加,碳钢材质的管道腐蚀严重。结合生产经验和分析计算,认为可以通过采用新的配管形式来降低挥发线的二次应力;合理设置支架防止一次应力超标;提高挥发线管道材质,以有效抵抗腐蚀。

关键词：焦化装置焦炭塔顶挥发线二次应力一次应力腐蚀

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