检索结果-南通市图书馆

A neural m^(6)A pathway regulates behavioral aggregation in migratory locusts

Science China(Life Sciences) 2024年第6期67卷 1242-1254页

作者： Xianliang Huang Qing Li Yanan Xu Ang Li Shanzheng wang Yusheng Chen Chunrui Zhang Xia Zhang hailin wang Cong Lv Baofa Sun Shaoqin Li Le Kang Bing Chen School of Life Science Institutes of Life Science and Green DevelopmentHebei UniversityBaoding 071002China College of Plant Science and Technology Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute of Health Sciences Anhui UniversityHefei 230601China Beijing Institute of Genomics Chinese Academy of SciencesBeijing 100101China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100101China

RNA N6-methyladenosine(m^(6)A),as the most abundant modification of messenger RNA,can modulate insect behaviors,but its specific roles in aggregation behaviors remain unexplored.Here,we conducted a comprehensive molecular and physiological characterization of the individual components of the methyltransferase and demethylase in the migratory locust Locusta migratoria.Our results demonstrated that METTL3,METTL14 and ALKBH5 were dominantly expressed in the brain and exhibited remarkable responses to crowding or isolation.The individual knockdown of methyltransferases(i.e.,METTL3 and METTL14)promoted locust movement and conspecific attraction,whereas ALKBH5 knockdown induced a behavioral shift toward the solitary phase.Furthermore,global transcriptome profiles revealed that m^(6)A modification could regulate the orchestration of gene expression to fine tune the behavioral aggregation of locusts.In summary,our in vivo characterization of the m^(6)A functions in migratory locusts clearly demonstrated the crucial roles of the m^(6)A pathway in effectively modulating aggregation behaviors.

关键词： RNA methylation N^(6)-methyladenosine transcriptional orchestration aggregation behavior Locusta migratoria

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A neural mA pathway regulates behavioral aggregation in migratory locusts

引用

Science China Life Sciences 2024年

作者： Xianliang Huang Qing Li Yanan Xu Ang Li Shanzheng wang Yusheng Chen Chunrui Zhang Xia Zhang hailin wang Cong Lü Baofa Sun Shaoqin Li Le Kang Bing Chen Beijing Institute of Genomics Chinese Academy of Sciences College of Plant Science and Technology Huazhong Agricultural University State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of Zoology Chinese Academy of Sciences School of Life Science Institutes of Life Science and Green Development Hebei University Institute of Health Sciences Anhui University State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences

RNA N6-methyladenosine(m6A), as the most abundant modification of messenger RNA, can modulate insect behaviors, but its specific roles in aggregation behaviors remain unexplored. Here, we conducted a comprehensive molecular and physiological characterization of the individual components of the methyltransferase and demethylase in the migratory locust Locusta migratoria. Our results demonstrated that METTL3, METTL14 and ALKBH5 were dominantly expressed in the brain and exhibited remarkable responses to crowding or isolation. The individual knockdown of methyltransferases(i.e., METTL3 and METTL14) promoted locust movement and conspecific attraction, whereas ALKBH5 knockdown induced a behavioral shift toward the solitary phase. Furthermore, global transcriptome profiles revealed that m6A modification could regulate the orchestration of gene expression to fine tune the behavioral aggregation of locusts. In summary, our in vivo characterization of the m6A functions in migratory locusts clearly demonstrated the crucial roles of the m6A pathway in effectively modulating aggregation behaviors.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Tunnel bottleneck management with high-occupancy vehicle priority on intelligent freeways

引用

Transportation Safety and Environment 2024年第2期6卷 87-95页

作者： Jinyong Gao Juncheng Zeng Xinyuan wang Cheng Zhou hailin Zhang Jintao Lai Fujian Express way Group Co. LtdFuzhou 350000FujianChina Fujian Express way Science&Technology Innovation Research Institute Co. LtdFuzhou 350000FujianChina Beijing Baidu Netcom Science Technology Co. LtdBeijing 100000China Key Laboratory of Road and Traffic Engineering of the Ministry of Education Tongji UniversityShanghai 201804China

Tunnels on freeways,as one of the critical bottlenecks,frequently cause severe congestion and passenger delay.To solve the tunnel bottleneck problem,most of the existing research can be divided into two types.One is to adopt variable speed limits(VSLs)to regulate a predetermined speed for vehicles to get through a bottleneck smoothly.The other is to adopt high-occupancy vehicle(HOV)lane management.In HOV lane management strategies,all traffic is divided into HOVs and low-occupancy vehicles(LOVs).HOVs are vehicles with a driver and one or more passengers.LOVs are vehicles with only a driver.This kind of research can grant priority to HOVs by providing a dedicated HOV lane.However,the existing research cannot both mitigate congestion and maximize passenger-oriented benefits.To address the research gap,this paper leverages connected and automated vehicle(CAV)technologies on intelligent freeways and develops a tunnel bottleneck management strategy with a dynamic HOV lane(DHL).The strategy bears the following features:1)enables tunnel bottleneck management at a microscopic level;2)maximizes passenger-oriented benefits;3)grants priority to HOVs even when the HOV lane is open to LOVs;4)allocates right-of-way segments for HOVs and LOVs in real time;and 5)performs well in a mixed-traffic environment.The proposed strategy is evaluated through comparison against the non-control baseline and a VSL strategy.Sensitivity analysis is conducted under different congestion levels and penetration rates.The results demonstrate that the proposed strategy outperforms in terms of passenger-oriented delay reduction and HOVs’priority level improvement.

关键词： tunnel bottleneck high-occupancy vehicle(HOV) intelligent freeways right-of-way segment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hydrophobic modification of polysaccharides and the construction and properties of their micelles:a review of applications in the field of biomedicine

引用

Science China Chemistry 2024年第6期67卷 1881-1903页

作者： Dayang wang Xiaohua Li Huanchen Yao Xin Liu Yan Gao hailin Cong Bing Yu Youqing Shen College of Chemistry and Chemical Engineering College of Life SciencesCollege of Materials Science and EngineeringInstitute of Biomedical Materials and EngineeringQingdao UniversityQingdao266071China State Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao UniversityQingdao266071China School of Materials Science and Engineering Shandong University of TechnologyZibo255000China Key Laboratory of Biomass Chemical Engineering of Ministry of Education Center for Bionanoengineeringand Department of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China

Nanomedicine delivery technology plays an important role in modern medicine and has shown good therapeutic effects in scientific research.Polysaccharides have the characteristics of wide sources,excellent biocompatibility,and non-toxicity.In addition,there are multifunctional groups on the main chain of polysaccharides,which can be surface-modified or functionalized to have targeting ability through specific sugar parts.Amphiphilic polysaccharide micelles with good biocompatibility,degradability,high safety,easy structural modification,and special core-shell structure are regarded as ideal carriers for nanomedicines.Therefore,this review is focused on the hydrophobic modification designs of polysaccharides,the preparation methods and characteristics of micelles,and the applications of amphiphilic polysaccharide micelles in the field of biomedicine.It is expected to provide some ideas and inspiration for the design of polysaccharide drug carriers.

关键词： polysaccharide hydrophobic modification micelle drug delivery biomedicine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Novel Rolling and Fractional-ordered Grey System Model and Its Application for Predicting Industrial Electricity Consumption

引用

Journal of Systems Science and Systems Engineering 2024年第2期33卷 207-231页

作者： Wenhao Zhou hailin Li Zhiwei Zhang College of Business Administration Huaqiao UniversityQuanzhou 362021China College of Business Administration Capital University of Economics and BusinessBeijing 100070China

Accurate and reasonable prediction of industrial electricity consumption is of great significance for promoting regional green transformation and optimizing the energy structure.However,the regional power system is complicated and uncertain,affected by multiple factors including climate,population and economy.This paper incorporates structure expansion,parameter optimization and rolling mechanism into a system forecasting framework,and designs a novel rolling and fractional-ordered grey system model to forecast the industrial electricity consumption,improving the accuracy of the traditional grey models.The optimal fractional order is obtained by using the particle swarm optimization algorithm,which enhances the model adaptability.Then,the proposed model is employed to forecast and analyze the changing trend of industrial electricity consumption in Fujian province.Experimental results show that industrial electricity consumption in Fujian will maintain an upward growth and it is expected to 186.312 billion kWh in 2026.Compared with other seven benchmark prediction models,the proposed grey system model performs best in terms of both simulation and prediction performance metrics,providing scientific reference for regional energy planning and electricity market operation.

关键词： Electricity consumption grey system theory prediction model fractional order

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Study on the fast elimination of smoke particle based on electro-acoustic coupling agglomeration technology

引用

Particuology 2024年第5期88卷 1-10页

作者： Jie Feng Mingfeng Lu Kaige wang Kun Luo Mingzhou Yu Guangxue Zhang Jiangrong Xu Shuping Pan hailin Gu The Institute for Energy Engineering China Jiliang UniversityHangzhou310018China State Key Laboratory of Clean Energy Utilization Zhejiang UniversityHangzhou310027China Qingshanhu Energy Research Center Zhejiang UniversityHangzhou310017China Zhejiang Ecological Environment Monitoring Center Hangzhou310012China

Fire smoke,which consists large amounts of fine particles,is considered as the fatal factor in fires.In this study,a fast smoke particle elimination method based on electro-acoustic coupling agglomeration technology is proposed.First,the experimental results show that the electro-acoustic coupling agglomeration has higher smoke elimination efficiency compared to single-field.The smoke transmission is much less than 80%after 30s of single acoustic or electric field action,while the coupled field reaches 90%.Then,the effects of acoustic frequency,sound pressure level and voltage on the smoke elimination characteristics are discussed.It is found that the optimal acoustic frequency is 1.5kHz.While as the sound pressure level and voltage increase,the elimination efficiency first increases and then tends to stabilize,the critical values of the sound pressure level and voltage are 135 dB and 7kV.This indicates that there is an optimal combination of the three variables.Finally,through the theoretical analysis of particle movement and the micro-morphology of agglomerates,the particle agglomeration mechanism under the electro-acoustic coupling is analyzed.This study provides a new idea for the fast elimination of fire smoke particle.

关键词： Smoke particle Agglomeration Electro-acoustic coupling Smoke elimination

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sound event localization and detection based on deep learning

引用

Journal of Systems Engineering and Electronics 2024年第2期35卷 294-301页

作者： ZHAO Dada DING Kai QI Xiaogang CHEN Yu FENG hailin School of Mathematics and Statistics Xidian UniversityXi’an 710071China Science and Technology on Near-Surface Detection Laboratory Wuxi 214035China

Acoustic source localization(ASL)and sound event detection(SED)are two widely pursued independent research fields.In recent years,in order to achieve a more complete spatial and temporal representation of sound field,sound event localization and detection(SELD)has become a very active research topic.This paper presents a deep learning-based multioverlapping sound event localization and detection algorithm in three-dimensional space.Log-Mel spectrum and generalized cross-correlation spectrum are joined together in channel dimension as input features.These features are classified and regressed in parallel after training by a neural network to obtain sound recognition and localization results respectively.The channel attention mechanism is also introduced in the network to selectively enhance the features containing essential information and suppress the useless features.Finally,a thourough comparison confirms the efficiency and effectiveness of the proposed SELD algorithm.Field experiments show that the proposed algorithm is robust to reverberation and environment and can achieve higher recognition and localization accuracy compared with the baseline method.

关键词： sound event localization and detection(SELD) deep learning convolutional recursive neural network(CRNN) channel attention mechanism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neutrophil peptide 1 accelerates the clearance of degenerative axons during Wallerian degeneration by activating macrophages after peripheral nerve crush injury

引用

Neural Regeneration Research 2024年第8期19卷 1822-1827页

作者： Yuhui Kou Yusong Yuan Qicheng Li Wenyong Xie hailin Xu Na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina National Center for Trauma Medicine BeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina Department of Central Laboratory and Institute of Clinical Molecular Biology Peking University People’s HospitalBeijingChina

Macrophages play an important role in peripheral nerve regeneration,but the specific mechanism of regeneration is still unclear.Our preliminary findings indicated that neutrophil peptide 1 is an innate immune peptide closely involved in peripheral nerve regeneration.However,the mechanism by which neutrophil peptide 1 enhances nerve regeneration remains unclear.This study was designed to investigate the relationship between neutrophil peptide 1 and macrophages in vivo and in vitro in peripheral nerve crush injury.The functions of RAW 264.7 cells we re elucidated by Cell Counting Kit-8 assay,flow cytometry,migration assays,phagocytosis assays,immunohistochemistry and enzyme-linked immunosorbent assay.Axonal debris phagocytosis was observed using the CUBIC(Clear,Unobstructed Brain/Body Imaging Cocktails and Computational analysis)optical clearing technique during Wallerian degeneration.Macrophage inflammatory factor expression in different polarization states was detected using a protein chip.The results showed that neutrophil peptide 1 promoted the prolife ration,migration and phagocytosis of macrophages,and CD206 expression on the surfa ce of macrophages,indicating M2 polarization.The axonal debris clearance rate during Wallerian degeneration was enhanced after neutrophil peptide 1 intervention.Neutrophil peptide 1 also downregulated inflammatory factors interleukin-1α,-6,-12,and tumor necrosis factor-αin invo and in vitro.Thus,the results suggest that neutrophil peptide 1 activates macrophages and accelerates Wallerian degeneration,which may be one mechanism by which neutrophil peptide 1 enhances peripheral nerve regeneration.

关键词： axonal debris inflammatory factors macrophages neutrophil peptide 1 peripheral nerve injury peripheral nerve regeneration RAW 264.7 cells sciatic nerve Wallerian degeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Denoising Graph Inference Network for Document-Level Relation Extraction

引用

Big Data Mining and Analytics 2023年第2期6卷 248-262页

作者： hailin wang Ke Qin Guiduo Duan Guangchun Luo School of Computer Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China School of Computing and Artificial Intelligence Southwestern University of Finance and EconomicsChengdu 611130China

Relation Extraction(RE)is to obtain a predefined relation type of two entities mentioned in a piece of text,e.g.,a sentence-level or a document-level text.Most existing studies suffer from the noise in the text,and necessary pruning is of great importance.The conventional sentence-level RE task addresses this issue by a denoising method using the shortest dependency path to build a long-range semantic dependency between entity pairs.However,this kind of denoising method is scarce in document-level RE.In this work,we explicitly model a denoised document-level graph based on linguistic knowledge to capture various long-range semantic dependencies among entities.We first formalize a Syntactic Dependency Tree forest(SDT-forest)by introducing the syntax and discourse dependency relation.Then,the Steiner tree algorithm extracts a mention-level denoised graph,Steiner Graph(SG),removing linguistically irrelevant words from the SDT-forest.We then devise a slide residual attention to highlight word-level evidence on text and SG.Finally,the classification is established on the SG to infer the relations of entity pairs.We conduct extensive experiments on three public datasets.The results evidence that our method is beneficial to establish long-range semantic dependency and can improve the classification performance with longer texts.

关键词： Relation Eextraction(RE) document-level denoising linguistic knowledge attention mechanism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Circular RNAs in breast cancer diagnosis,treatment and prognosis

引用

Oncology Research 2024年第2期32卷 241-249页

作者： XIAOJIA HUANG CAILU SONG JINHUI ZHANG LEWEI ZHU hailin TANG Department of Breast Oncology Surgery Affiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhou510095China State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou510060China Department of Breast Surgery The First People’s Hospital of FoshanFoshan528000China

Breast cancer has surpassed lung cancer to become the most common malignancy worldwide.The incidence rate and mortality rate of breast cancer continue to rise,which leads to a great burden on public health.Circular RNAs(circRNAs),a new class of noncoding RNAs(ncRNAs),have been recognized as important oncogenes or suppressors in regulating cancer initiation and progression.In breast cancer,circRNAs have significant roles in tumorigenesis,recurrence and multidrug resistance that are mediated by various mechanisms.Therefore,circRNAs may serve as promising targets of therapeutic strategies for breast cancer management.This study reviews the most recent studies about the biosynthesis and characteristics of circRNAs in diagnosis,treatment and prognosis evaluation,as well as the value of circRNAs in clinical applications as biomarkers or therapeutic targets in breast cancer.Understanding the mechanisms by which circRNAs function could help transform basic research into clinical applications and facilitate the development of novel circRNA-based therapeutic strategies for breast cancer treatment.

关键词： CircRNA Breast cancer Diagnosis Treatment Biomarker

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：