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Science China Chemistry 2024年第6期67卷 1881-1903页

作者： Dayang Wang Xiaohua Li Huanchen Yao Xin liu Yan Gao hailin Cong Bing Yu Youqing Shen College of Chemistry and Chemical Engineering College of Life SciencesCollege of Materials Science and EngineeringInstitute of Biomedical Materials and EngineeringQingdao UniversityQingdao266071China State Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao UniversityQingdao266071China School of Materials Science and Engineering Shandong University of TechnologyZibo255000China Key Laboratory of Biomass Chemical Engineering of Ministry of Education Center for Bionanoengineeringand Department of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China

Nanomedicine delivery technology plays an important role in modern medicine and has shown good therapeutic effects in scientific research.Polysaccharides have the characteristics of wide sources,excellent biocompatibility,and non-toxicity.In addition,there are multifunctional groups on the main chain of polysaccharides,which can be surface-modified or functionalized to have targeting ability through specific sugar parts.Amphiphilic polysaccharide micelles with good biocompatibility,degradability,high safety,easy structural modification,and special core-shell structure are regarded as ideal carriers for nanomedicines.Therefore,this review is focused on the hydrophobic modification designs of polysaccharides,the preparation methods and characteristics of micelles,and the applications of amphiphilic polysaccharide micelles in the field of biomedicine.It is expected to provide some ideas and inspiration for the design of polysaccharide drug carriers.

关键词： polysaccharide hydrophobic modification micelle drug delivery biomedicine

Distributed Robust Containment Control of Linear Heterogeneous Multi-Agent Systems:An Output Regulation Approach

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IEEE/CAA Journal of Automatica Sinica 2022年第5期9卷 864-877页

作者： Wenchao Huang hailin liu Jie Huang College of Electrical Engineering and Automation Fuzhou UniversityFuzhou 350108China College of Electrical Engineering and Automation Fuzhou UniversityFuzhou 350108 School of Automation Sicience and Engineering South China University of TechnologyGuangzhou 510641China IEEE

In this paper,we consider the robust output containment problem of linear heterogeneous multi-agent systems under fixed directed networks.A distributed dynamic observer based on the leaders’measurable output was designed to estimate a convex combination of the leaders’states.First,for the case of followers with identical state dimensions,distributed dynamic state and output feedback control laws were designed based on the state-coupled item and the internal model compensator to drive the uncertain followers into the leaders’convex hull within the output regulation framework.Subsequently,we extended theoretical results to the case where followers have nonidentical state dimensions.By establishing virtual errors between the dynamic observer and followers,a new distributed dynamic output feedback control law was constructed using only the states of the compensator to solve the robust output containment problem.Finally,two numerical simulations verified the effectiveness of the designed schemes.

关键词： Containment control internal model principle multi-agent systems observer technique output regulation

The burgeoning importance of PIWI-interacting RNAs in cancer progression

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Science China(Life Sciences) 2024年第4期67卷 653-662页

作者： Xinpei Deng Tianle Liao Jindong Xie Da Kang Yiwei He Yuying Sun Zhangling Wang Yongluo Jiang Xuan Miao Yixuan Yan hailin Tang Lewei Zhu Yutian Zou Peng liu State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China School of Medicine Sun Yat-sen UniversityShenzhen 518107China Key Laboratory of Cardiovascular and Cerebrovascular Medicine Nanjing Medical UniversityNanjing 211166China Guanghua School of Stomatology Sun Yat-sen UniversityGuangzhou 510062China The First People’s Hospital of Foshan Foshan 528000China

PIWI-interacting RNAs(pi RNAs)are a class of small noncoding RNA molecules that specifically bind to piwi protein family members to exert regulatory functions in germ cells.Recent studies have found that pi RNAs,as tissue-specific molecules,both play oncogenic and tumor suppressive roles in cancer progression,including cancer cell proliferation,metastasis,chemoresistance and stemness.Additionally,the atypical manifestation of pi RNAs and PIWI proteins in various malignancies presents a promising strategy for the identification of novel biomarkers and therapeutic targets in the diagnosis and management of tumors.Nonetheless,the precise functions of pi RNAs in cancer progression and their underlying mechanisms have yet to be fully comprehended.This review aims to examine current research on the biogenesis and functions of pi RNA and its burgeoning importance in cancer progression,thereby offering novel perspectives on the potential utilization of pi RNAs and piwi proteins in the management and treatment of advanced cancer.

关键词： PIWI-interacting RNAs/piRNAs cancer progression metastasis chemoresistance stemness

CircMYBL2 facilitates hepatocellular carcinoma progression by regulating E2F1 expression

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Oncology Research 2024年第6期32卷 1129-1139页

作者： JUNZHE YI BINBIN LI XIAOMIN YIN LINGRUI liu CAILU SONG YING ZHAO MANBO CAI hailin TANG DONG CHEN NING LYU State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou510060China Department of Medical Oncology The Third People’s Hospital of YongzhouYongzhou425000China Department of Radiotherapy The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang421001China Center of Hepato-Pancreato-Biliary Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou510080China

Circular RNAs(circRNAs)have been recognized as pivotal regulators in tumorigenesis,yet the biological functions as well as molecular mechanisms of the majority of circRNAs in hepatocellular carcinoma(HCC)remain elusive.We sought to unveil the expression profile and biological role of circMYBL2 in HCC.Initial microarray analyses were conducted to probe the expression profile of circMYBL2 in HCC cells,and qRT‒PCR analysis was then performed in HCC cell lines and tissues,revealing significant upregulation of circMYBL2.Subsequent experiments were conducted to evaluate the biological function of circMYBL2 in HCC progression.Furthermore,bioinformatics analysis,qRT‒PCR analysis,luciferase reporter assays,and western blot analysis were employed to investigate the interplay among circMYBL2,miR-1205,and E2F1.CircMYBL2 was found to exhibit marked upregulation in tumor tissues as well as HCC cell lines.Elevated expression of circMYBL2 increased the proliferation and migration of HCC cells,whereas circMYBL2 knockdown elicited contrasting effects.Mechanistically,our results indicated that circMYBL2 promoted E2F1 expression and facilitated HCC progression by sponging miR-1205.Our findings revealed that circMYBL2 contributed to HCC progression through the circMYBL2/miR-1205/E2F1 axis,suggesting the potential of circMYBL2 as a novel target for HCC treatment or a prognostic biomarker for HCC.

关键词： Circular RNAs circMYBL2 miR-1205 E2F1 Hepatocellular carcinoma

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基于人机协同决策的运输调度优化研究

交通运输系统工程与信息 2024年第2期24卷 136-148页

作者：刘涛尤海林西南交通大学交通运输与物流学院成都611756 西南交通大学综合交通大数据应用技术国家工程实验室成都611756 西南交通大学系统科学与工程研究院成都611756 宜宾西南交通大学研究院四川宜宾644000

为求解带柔性约束的运输调度问题,本文提出一个基于逆差函数的人机协同决策方法。该方法主要包括两个阶段,第1阶段,借助数学规划模型,利用计算机的强大计算能力,快速求解得到问题的一个可行解;第2阶段,借助逆差函数模型,利用人类自身的... 详细信息

为求解带柔性约束的运输调度问题,本文提出一个基于逆差函数的人机协同决策方法。该方法主要包括两个阶段,第1阶段,借助数学规划模型,利用计算机的强大计算能力,快速求解得到问题的一个可行解;第2阶段,借助逆差函数模型,利用人类自身的知识与经验,在考虑柔性约束的情形下,进一步优化第1阶段的可行解。两个阶段通过逆差函数图像构成的图形用户界面进行实时交互,实现人机协同决策。通过网约定制公交车辆调度和民航飞机调度两个案例问题的求解,验证基于逆差函数的人机协同决策方法的有效性。计算结果表明:该方法可实现车次链/航班链的自动化构建和空驶车次的自动化插入,有助于求解带有复杂柔性约束的运输调度问题。

关键词：系统工程人机协同决策逆差函数运输调度交互式优化

Overexpression of MECP2 in the Suprachiasmatic Nucleus Alters Circadian Rhythm and Induces Abnormal Social Behaviors

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Neuroscience Bulletin 2021年第12期37卷 1713-1717页

作者： hailin liu Zilong Qiu Center for Excellence in Brain Science and Intelligence Technology Institute of NeuroscienceState Key Laboratory of NeuroscienceCAS Key Laboratory of Primate NeurobiologyChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai 201210China National Clinical Research Center for Aging and Medicine Huashan HospitalFudan UniversityShanghai 200040China

Dear Editors,Autism spectrum disorder is a highly heritable neurodevel-opmental disorder and is often associated with sleep disorders and dysregulation of the circadian rhythm[1,2].Whether neural circuits governing the circadian rhythm are causally associated with social behaviors remains to be determined.In this work,we used mice with MECP2 duplication as a model of autism to investigate whether regulation of the circadian rhythm is connected to social behaviors.

关键词： MECP2 rhythm connected

Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K/Akt/mTOR pathway

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Science China Life Sciences 2024年

作者： Kumar Ganesan Cong Xu Jianming Wu Bing Du Qingqing liu Yue Sui Cailu Song Jinhui Zhang hailin Tang Jianping Chen School of Chinese Medicine LKS Faculty of Medicine The University of Hong Kong School of Pharmacy Southwest Medical University Education Ministry Key Laboratory of Medical Electrophysiology Sichuan Key Medical Laboratory of New Drug Discovery and Druggability EvaluationLuzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica Southwest Medical University College of Food Science South China Agricultural University State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for Cancer Sun Yat-sen University Cancer Center

The spreading of cancer cells from the primary tumor site to other parts of the body, known as metastasis, is the leading cause of cancer recurrence and mortality in patients with triple-negative breast cancer(TNBC). Overexpression of epidermal growth factor receptor(EGFR)is observed in approximately 70% of TNBC patients. EGFR is crucial for promoting tumor metastasis and associated with poor prognosis.Therefore, it is vital to identify effective therapeutic strategies targeting EGFR inhibition. Ononin, an isoflavonoid found in various plants,such as clover and soybeans, has been shown to have anticancer properties in several cancers. In the present study, we aimed to investigate the effects of ononin on TNBC lung metastasis and the associated molecular pathways. We used various assays, including cell viability,colony formation, Transwell, wound healing, ELISA, Western blotting, and staining techniques, to achieve this objective. The results demonstrated that ononin effectively suppressed cellular proliferation and induced apoptosis, as evidenced by the cell viability assay, colony formation assay, and expression of apoptosis markers, and reduced the metastatic capabilities of TNBC cells. These effects were achieved through the direct suppression of cell adhesion, invasiveness and motility. Furthermore, in TNBC xenograft lung metastatic models, ononin treatment significantly reduced tumor growth and lung metastasis. Additionally, ononin reversed the epithelial-mesenchymal transition(EMT) by downregulating the expression of EMT markers and matrix metalloproteinases, as confirmed by Western blot analysis. Furthermore, ononin treatment reduced EGFR phosphorylation and suppressed the PI3K, Akt, and mTOR signaling pathways, which was further confirmed using EGFR agonists or inhibitors. Importantly, ononin treatment did not exert any toxic effects on liver or kidney function. In conclusion, our findings suggest that ononin is a safe and potentially therapeutic treatment for TNBC metastasis that targets the EGFRmediated

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中国党政组织关系的具体形态和生成逻辑

政治学研究 2024年第2期 63-79,M0004,M0005页

作者：刘鹏李海林中国人民大学公共管理学院北京市100872

党政关系是党和国家机构改革和中国国家治理体系的核心,但落实到具体的党政组织结构上,现有研究呈现出宏观分合形态和具体组织形式的脱节,以及缺乏对不同组织形式内在逻辑的探讨。本文设定了衡量党政组织关系分合程度的具体标准,以“分... 详细信息

党政关系是党和国家机构改革和中国国家治理体系的核心,但落实到具体的党政组织结构上,现有研究呈现出宏观分合形态和具体组织形式的脱节,以及缺乏对不同组织形式内在逻辑的探讨。本文设定了衡量党政组织关系分合程度的具体标准,以“分设-合一”维度依次分析了党政组织关系的五种不同形态:党委领导下的党政分设、统领协调、归口领导、合署办公、合并设立,总结了其概念、特征、演进和分布;基于这一维度,分析了影响党政关系分合的四种影响因素,认为党的领导越趋向全面系统化、党政机构协调成本降低空间越大、政府机构业务综合性战略性越强、工作政治性越强而导致党政责任边际模糊,则党政组织越倾向合一,同时在不同自主性强度的改革中,这种分合关系会在政府纵向层级间呈现差异化特征;最后提出了对未来我国党政关系分合模式的优化建议。

关键词：党政组织关系统领协调归口领导合署办公合并设立

装配式建筑示范城市政策对建筑业的碳减排效应及其作用机制研究

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环境科学学报 2024年第2期44卷 464-476页

作者：安敏刘明仿吴海林三峡大学三峡库区生态环境教育部工程研究中心宜昌443002 三峡大学三峡大学水利与环境学院宜昌443002 三峡大学三峡大学经济与管理学院宜昌443002

装配式建筑是一种低碳的建筑方式,中国政府从2017年开始进行装配式建筑示范城市试点工作,研究装配式建筑示范城市政策带来的碳减排效应,有助于加深社会对装配式建筑的认知,从而推动装配式建筑在建筑领域中稳步前进.以“装配式建筑示范... 详细信息

装配式建筑是一种低碳的建筑方式,中国政府从2017年开始进行装配式建筑示范城市试点工作,研究装配式建筑示范城市政策带来的碳减排效应,有助于加深社会对装配式建筑的认知,从而推动装配式建筑在建筑领域中稳步前进.以“装配式建筑示范城市”为切入点,基于2011—2019年我国16个装配式建筑示范城市和18个非示范城市的面板数据,借助双重差分模型评估了装配式建筑示范城市政策对于建筑业的碳减排效应及其作用机制.研究发现,相比非示范城市,示范城市建筑业的碳排放强度降低了约23.3%,意味着装配式建筑示范城市建设给建筑业带来的减排效果较为显著.机制分析发现,示范城市主要是通过减少建筑业能源消耗、提升绿色创新技术水平等途径来抑制建筑业的碳排放水平,其中,装配式建筑示范城市政策的实行显著降低了城市建筑业19.2%的能源消耗强度,同时提高了其4.91%的绿色创新水平.此外,异质性分析发现,装配式建筑示范城市建设对行政等级高的城市的碳减排效应大于行政等级较低的城市,城市行政等级在装配式建筑示范城市政策推行中具有影响力.本研究可为装配式建筑示范城市政策的科学评价提供量化依据,为降低建筑业碳排放提供重要的经验和启示.

关键词：装配式建筑示范城市建筑业碳减排双重差分模型政策效应

Effects of Alexithymia to Stigma of Patients with Lymphedema

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Journal of Cancer Therapy 2024年第4期15卷 201-211页

作者： Qiaoling Zhong Huizhen Zhang Liping Zhang Qinghua Luo Huiting Zhang Feng liu hailin Tang Na Li Lijuan Zhang State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer Center Guangzhou China

BACKGROUND: Secondary lymphedema is one of the common complications after malignant tumor surgery. It is a chronic and complex disease. Once lymphedema occurs, there will be discomfort such as limb swelling, pain, numbness and tension, which will eventually lead to changes in the appearance of the affected limb and will seriously affect the quality of life and require lifelong treatment and psychosocial support. This study investigated the current situation of stigma and alexithymia in patients with lymphedema, and discussed the impact of alexithymia on stigma in patients with lymphedema. AIMS: To understand the current situation of stigma and alexithymia in patients with lymphedema, and to analyze the influence of alexithymia on stigma. METHODS: 195 patients with lymphedema in a hospital were selected by convenient sampling. General information questionnaire, Toronto Alexithymia Scale and social impact scale were used to investigate respectively, to study the general situation, stigma and alexithymia of the respondents. RESULTS: The results showed that the total score of stigma in 195 patients with lymphedema was (60.36 ± 11.08), and the total score of alexithymia was (56.53 ± 8.43). Multiple linear regression analysis showed that alexithymia and family relationship were the influencing factors of stigma in patients with lymphedema. CONCLUSIONS: The patients with lymphedema have obvious stigma, and alexithymia and family relationship are the influencing factors.

关键词： Alexithymia Lymphedema Stigma Influence Factor