检索结果-南通市图书馆

Enriched photosensitizer for deep-seated-tumor photodynamic therapy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Photonics Research 2024年第5期12卷 1024-1035页

作者： HONGRUI SHAN XUEQIAN WANG QIHENG WEI hailang dai XIANFENG CHEN State Key Laboratory on Fiber Optic Local Area Communication Networks and Advanced Optical Communication Systems Department of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Metal Matrix Composites Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsSchool of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center of Light Manipulations and Applications Shandong Normal UniversityJinan 250358China

Photodynamic therapy(PDT)is an innovative approach that utilizes photochemical reactions for non-invasive disease *** PDT is limited by the low penetration depth of visible light required for ***,we employed upconversion nanoparticles(UCNPs)to extend the activation wavelength of photosensitizers into the infrared range,enabling a treatment depth of over 10 ***,we also used the abundant amino groups of branched polyethyleneimine(PEI)with spatial structure to enhance the loading capacity of protoporphyrin(PPIX),and we ultimately improved skin tumor clearance ***,we achieved tumor-specific treatment by utilizing folic acid(FA)targeting and active enrichment of *** to cellular experimental results,we demonstrated the remarkable reactive oxygen species generation capability of the material and ultra-low dark ***,we investigated the apoptosis mechanism and demonstrated that the synthesized nanoparticle stimulates the up-regulation of apoptosis-associated proteins Bax/Bcl-2 and Cyto *** in vivo experiments involving intravenous injection in mouse tails,we investigated the anticancer efficacy of the nanoparticle,confirming its excellent PDT *** research provides a promising avenue for future non-invasive treatment of deep-seated tumors,offering a method for the treatment and management of specific cancers.

关键词： treatment utilize utilizing

Propagation dynamics of off-axis noncanonical vortices in a collimated Gaussian beam

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2019年第3期28卷 192-196页

作者： Cheng Yin Xuefen Kan hailang dai Minglei Shan Qingbang Han Zhuangqi Cao Jiangsu Key Laboratory of Power Transmission and Distribution Equipment Technology Hohai UniversityChangzhou 213022China The State Key Laboratory on Fiber Optic Local Area Communication Networks and Advanced Optical Communication Systems Shanghai JiaoTong UniversityShanghai 200240China

It is widely accepted that an off-axis noncanonical vortex moves across the free-space diffracting Gaussian beam without rotation. But our analysis shows that the vortex swirls a while before it approaches infinite. By neglecting the divergence of the host beam, we focus on this rotation characteristics of the vortices in linear homogeneous media. For the symmetrical host beam, it is found that the vortex moves along an elliptical trajectory, while the topological charge and the angular momentum of the vortex core relative to the beam axis are conserved. For the asymmetrical host beam, the vortex trajectory is rather complicated, since the noncanonical parameter varies as the light propagates, resulting in topological charge inversion. But we find that the vortices are always confined in a rectangular area, and the rotation direction is determined by the topological charge.

关键词： noncanonical optical vortex topological charge inversion

Enhancement of stimulated emission by a metallic optofluidic resonator

在线全文

学校读者我要写书评

暂无评论

Photonics Research 2018年第6期6卷 597-600页

作者： BEI JIANG hailang dai XIANFENG CHEN State Key Laboratory of Advanced Optical Communication Systems and Networks School of Physics and AstronomyShanghai Jiao Tong University Collaborative Innovation Center of IFSA (CICIFSA) Shanghai Jiao Tong University

Stimulated emission can be controlled by a material molecular energy band and the intensity of a pump laser, which can provide some population inversion and promote ground electron transition, respectively. We use a metallic optofluidic resonator to enhance stimulated emission intensity. The quality factor Q and the spontaneous emission coupling factor β of the metallic optofluidic resonator are discussed in detail to explain the enhancement mechanism. Experimental data demonstrate that the operated emission from rhodamin 6G solution can be observed due to the enhancement of stimulated emission from the optofluidic resonator.

关键词： Dye lasers Waveguides Resonators

Single-cell detection by enhancement of fluorescence in waveguides for cancer diagnosis and therapy

在线全文

学校读者我要写书评

暂无评论

Photonics Research 2021年第12期9卷 2381-2387页

作者： hailang dai HONGRUI SHAN ZHANGCHI SUN DAOPENG dai YUXI SHANG ZHUANGQI CAO XIANFENG CHEN State Key Laboratory of Advanced Optical Communication Systems and Networks School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Zhejiang Rongjun Hospital Jiaxing 314000China School of Pharmacy Shanghai Jiao Tong UniversityShanghai 200240China Department of Cardiology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200240China Collaborative Innovation Centre of Light Manipulations and Applications Shandong Normal UniversityJinan 250358China

Cancer is one of the most common diseases to threaten human *** individuals are diagnosed with malignant tumors via a single cell,medical workers are greatly advantageous to early diagnose and intervene in malignant tumors *** this paper,we propose a fluorescence detection map to rapidly distinguish whether the chromosomes of a cell are normal or abnormal by detecting the fluorescent intensity of a single ***,we draw a map from a single cell with an abnormal number of chromosomes that is monitored in real ***,this way offers precise and prompt detection of the surviving of cancer cells at or near the site of the tumor after treatments for cancer,which can achieve personalized cancer diagnosis and ***,cancer recurrences and metastasis can be effectively identified,utilizing this ultrasensitive detection method of an abnormal chromosome number.

关键词： diagnosis utilizing prompt

Detection of low-concentration EGFR with a highly sensitive optofluidic resonator

在线全文

学校读者我要写书评

暂无评论

Chinese Optics Letters 2017年第9期15卷 90-93页

作者： Jianfeng Shang hailang dai Yun Zou Xianfeng Chen State Key Laboratory of Advanced Optical Communication Systems and Networks Department of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Laboratory of Crime Science Evidence Shanghai Research Institute of Criminal Science and TechnologyShanghai 200083China

A hollow-core metal-cladding waveguide（HCMW） optofluidic resonator that works based on a free-space coupling technique is designed. An HCMW can excite ultra-high-order modes（UOMs） at the coupled angle, which can be used as an optofluidic resonator to detect alterations of the epidermal growth factor receptor（EGFR）concentration. Theoretical analysis shows that the UOMs excited in the HCMW have a highly sensitive response to the refractive index（RI） variation of the guiding layer. An EGFR solution with a 0.2 ng/mL alteration is detected, and the RI variation caused by the concentration alteration is about 2.5 × 10^（-3）.

关键词： Detection of low-concentration EGFR with a highly sensitive optofluidic resonator

Torque Reversals in Accreting Pulsars

在线全文

学校读者我要写书评

暂无评论

Torque Reversals in Accreting Pulsars

Secondary structure changes of ox-LDL by photoirradiation in an optofluidic resonator

中国天文学会高能分会2004年学术年会

作者： dai hailang Department of Astronomy Nanjing University

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Chinese Optics Letters 2022年第3期20卷 89-94页

作者： Yuxi Shang hailang dai Daopeng qai jinmao Gu Meng Zhang Qiheng Wei Xianfeng Chen State Key Laboratory of Advanced Optical Communication Systems and Networks School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Department of Cardiology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200240China The Affiliated Hospital of Tianjin Chinese Medical Institute Tongji UniversityShanghai 200092China Shanghai Research Center for Quantum Sciences Shanghai 201315China Jinan Institute of Quantum Technology Jinan 250101China Collaborative Innovation Center of Light Manipulation and Applications Shandong Normal UniversityJinan 250358China

Atherosclerotic cardio-cerebral vascular disease is the most common disease that threatens human *** researches indicated that oxidatively modified low-density lipoprotein[ox-LDL]is a key pathogenic factor of ***,we report the change of the secondary structure of ox-LDL caused by photoirradiation in an optofluidic *** content ratios of amphipathic o-helices and β-sheets of ox-LDL are changed under laser beam ilumination,resulting in an increasing binding rate of ox-LDL and ox-LDL *** findings may provide a potential way for clinical athero-sclerosis treatment and prompt recovery rate of atherosclerotic cardio-cerebral vascular disease by optical technology and immunotherapy.

关键词： atherosclerosis ox-LDL optofluidic resonator photoirradiation

在线全文

学校读者我要写书评

暂无评论

寰枢椎复合骨折三维有限元模型模拟分析

中华医学杂志 2018年第19期98卷 1484-1488页

作者：唐晓明柳超黄凯朱国太孙海浪戴健田纪伟南京医科大学附属上海一院临床医学院上海市第一人民医院骨科上海200080 上海市松江区中心医院骨科南京医科大学附属淮安第一医院

目的探索寰枢椎复合骨折三维有限元模型的临床应用。方法在正常全颈椎有限元模型的基础上，应用有限元ABAQUS6．12软件，建立4种不同类型的寰枢椎复合骨折的全颈椎有限元模型：C1（Jefferson）骨折＋C2（Ⅱ型骨折）、C1（Jefferson）骨... 详细信息

目的探索寰枢椎复合骨折三维有限元模型的临床应用。方法在正常全颈椎有限元模型的基础上，应用有限元ABAQUS6．12软件，建立4种不同类型的寰枢椎复合骨折的全颈椎有限元模型：C1（Jefferson）骨折＋C2（Ⅱ型骨折）、C1（Jefferson）骨折＋c2（Ⅲ型骨折）、C1（Jefferson）骨折＋C2（Hangman）骨折、c1（Jefferson）骨折＋C2（稳定性骨折）模型（FEM／fracture）（FEM／fracture），测量颈椎在前屈、后伸、侧屈、旋转等工况下活动度（ROM），并与正常全颈椎有限元模型测量结果进行比较。结果建立的寰枢椎复合骨折有限元模型几何相似性好，各个工况下活动度在不同节段有不同改变。C1骨折＋Ⅱ型齿状突骨折其C0/1、C1/2相对于正常模型前屈＋后伸、侧屈、旋转活动度明显增加，分别增加57．45％、29．34％、48．09％及95．49％、88．52％、36．71％；C，骨折＋Ⅲ型齿状突骨折其C0/1、C1/2节段分别增加47．01％、27．30％、45．31％及90．38％、27．30％、30．02％；C1骨折＋Hangman骨折其C0／1及C1／2分别增加32．68％、79．34％、77．62％及60．53％、81．20％、21．48％；C，骨折＋稳定性枢椎骨折其C0／1及C1/2分别增加15．00％、29．30％、8．47％及37．87％、75．57％、8．30％。结论不同类型寰枢椎复合骨折三维有限元模型能较好模拟临床实际情况，可对寰枢椎复合骨折的患者进行生物力学研究，寰枢椎复合骨折时比无损伤状态时有更大活动度，提示应进行手术处理。

关键词：寰枢椎骨折有限元生物力学

基于双折射MIM结构的增强光自旋霍尔效应研究

在线全文

学校读者我要写书评

暂无评论

江西师范大学学报（自然科学版） 2018年第1期42卷 52-56页

作者：殷澄王贤平阚雪芬戴海浪李建韩庆邦河海大学物联网工程学院江苏常州213022 上海交通大学物理与天文学院上海210094 江西师范大学物理与通信电子学院江西南昌330022

光自旋霍尔效应所产生的横向IF(Imbert-Fedorov)位移一般仅为亚波长量级,因此极大地限制了该效应在精密度量领域的应用.该文提出一种金属/双折射材料/金属(MIM)的多层结构,通过直接耦合方式激发该结构中的振荡模式,并利用双折射特性形... 详细信息

光自旋霍尔效应所产生的横向IF(Imbert-Fedorov)位移一般仅为亚波长量级,因此极大地限制了该效应在精密度量领域的应用.该文提出一种金属/双折射材料/金属(MIM)的多层结构,通过直接耦合方式激发该结构中的振荡模式,并利用双折射特性形成偏振相关的小角度共振,以此来增强光自旋霍尔效应.理论分析表明:上述设想可将可见光波段的横向IF位移增强到可以直接观察的亚毫米甚至毫米量级.

关键词：光自旋霍尔效应 MIM结构横向IF位移