Secondary structure changes of ox-LDL by photoirradiation in an optofluidic resonator

作     者：Yuxi Shang Hailang Dai Daopeng qai jinmao Gu Meng Zhang Qiheng Wei Xianfeng Chen 尚宇晞;戴海浪;戴道鹏;顾进茂;张萌;魏麒恒;陈险峰

作者机构：State Key Laboratory of Advanced Optical Communication Systems and NetworksSchool of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Department of CardiologyRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200240China The Affiliated Hospital of Tianjin Chinese Medical InstituteTongji UniversityShanghai 200092China Shanghai Research Center for Quantum SciencesShanghai 201315China Jinan Institute of Quantum TechnologyJinan 250101China Collaborative Innovation Center of Light Manipulation and ApplicationsShandong Normal UniversityJinan 250358China 

出 版 物：《Chinese Optics Letters》 (中国光学快报（英文版）)

年 卷 期：2022年第20卷第3期

页      面：89-94页

核心收录：

学科分类：080904[工学-电磁场与微波技术] 070207[理学-光学] 1002[医学-临床医学] 07[理学] 0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 0803[工学-光学工程] 0702[理学-物理学] 10[医学] 

基　　金：This work was supported by the National Key R&D Program of China(No.2018YFA0306301) the National Natural Science Foundation of China(NSFC)(Nos.11734011,11764020,and 12104298) the China Postdoctoral Science Foundation(Nos.2020M681275 and 2021T140452) the Foundation for Shanghai Municipal Science and Technology Major Project(No.2019SHZDZX01-ZX06) 

主　　题：atherosclerosis ox-LDL optofluidic resonator photoirradiation 

摘      要：Atherosclerotic cardio-cerebral vascular disease is the most common disease that threatens human *** researches indicated that oxidatively modified low-density lipoprotein[ox-LDL]is a key pathogenic factor of ***,we report the change of the secondary structure of ox-LDL caused by photoirradiation in an optofluidic *** content ratios of amphipathic o-helices and β-sheets of ox-LDL are changed under laser beam ilumination,resulting in an increasing binding rate of ox-LDL and ox-LDL *** findings may provide a potential way for clinical athero-sclerosis treatment and prompt recovery rate of atherosclerotic cardio-cerebral vascular disease by optical technology and immunotherapy.