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Biosafety chemistry and biosafety materials:A new perspective to solve biosafety problems

Biosafety and Health 2022年第1期4卷 15-22页

作者： Yingjie Yu Jianxun Ding Yunhao Zhou haihua xiao Guizhen Wu State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing 100029China Key Laboratory of Polymer Eco-materials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China c Jilin Biomedical Polymers Engineering Laboratory Changchun 130022China Beijing National Laboratory for Molecular Sciences State Key Laboratory of Polymer Physics and ChemistryInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

Coronavirus disease 2019(COVID‐19)has rapidly swept around the globe since its emergence near ***,people have failed to fully understand its origin or *** as an international biosafety incident,COVID‐19 has again encouraged worldwide attention to reconsider the importance of biosafety due to the adverse impact on personal well‐being and social *** countries have already taken measures to advocate progress in biosafety‐relevant research,aiming to prevent and solve biosafety problems with more advanced techniques and ***,we propose a new concept of biosafety chemistry and reiterate the notion of biosafety materials,which refer to the interdisciplinary integration of biosafety and chemistry or *** attempt to illustrate the exquisite association that chemistry and materials science possess with biosafety‐science,and we hope to provide a pragmatic perspective on approaches to utilize the knowledge of these two subjects to handle specific biosafety issues,such as detection and disinfection of pathogenic microorganisms,personal protective equipment,vaccine adjuvants and specific drugs,etc..In addition,we hope to promote multidisciplinary cooperation to strengthen biosafety research and facilitate the development of biosafety products to defend national security in the future.

关键词： Biosafety Chemistry Material science Biosafety chemistry Biosafety materials

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Advanced biosafety materials for prevention and theranostics of biosafety issues

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Biosafety and Health 2022年第2期4卷 59-60页

作者： Jianxun Ding haihua xiao Xuesi Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China Beijing National Laboratory for Molecular Sciences State Key Laboratory of Polymer Physics and ChemistryInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Since its global outbreak in 2020,the coronavirus disease 2019(COVID-19)has been a severe threat to life and health and aroused worldwide concern about biosafety[1].Capitalizing on this,various disciplines,such as mathematics,physics,biology,chemistry,material science,and computer science,have been urged to develop novel protocols for the prevention and theranostics of biosafety *** particular,chemistry and material science have been addressed to provide unique strategies for solving biosafety issues,such as infections by pathogenic microorganisms like viruses or *** on this,a new field termed“biosafety materials”has emerged.

关键词： prevention safety computer

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Biosafety materials:Ushering in a new era of infectious disease diagnosis and treatment with the CRISPR/Cas system

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Biosafety and Health 2022年第2期4卷 70-78页

作者： Yuquan Zhang Ziyue Li Julien Milon Essola Kun Ge Xuyan Dai Huining He haihua xiao Yuhua Weng Yuanyu Huang School of Life Science School of Medical TechnologyAdvanced Research Institute of Multidisciplinary ScienceKey Laboratory of Molecular Medicine and BiotherapyKey Laboratory of Medical Molecule Science and Pharmaceutics EngineeringBeijing Institute of TechnologyBeijing 100081China Key Laboratory of Analytical Science and Technology of Hebei Province College of Chemistry and Environmental ScienceKey Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of EducationHebei UniversityBaoding 071000China Hunan Agricultural University Changsha 410128China Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics School of PharmacyTianjin Medical UniversityTianjin 300070China Beijing National Laboratory for Molecular Science State Key Laboratory of Polymer Physical and ChemistryInstitute of ChemistryChinese Academy of ScienceBeijing 100190China School of Materials and the Environment Beijing Institute of TechnologyZhuhai 519085China

Despite multiple virus outbreaks over the past decade,including the devastating coronavirus disease 2019(COVID-19)pandemic,the lack of accurate and timely diagnosis and treatment technologies has wreaked havoc on global *** clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated proteins(Cas)system has the potential to address these critical needs for tackling infectious diseases to detect viral nucleic acids and inhibit viral *** review summarizes how the CRISPR/Cas system is being utilized for the treatment and diagnosis of infectious diseases with the help of biosafety materials and highlights the design principle and in vivo and in vitro efficacy of advanced biosafety materials used to deal with virus attacks.

关键词： Biosafety materials CRISPR/Cas SARS-CoV-2 Diagnosis Infectious disease

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UM15 reinforces a lymphocyte-mimicking nanotrap for precise HIV-1 inhibition

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Nano Research 2023年第7期16卷 9906-9920页

作者： Jinbang Zhang Zhengyang Li Jiaxin Li Hui Li Junwei Che Te Zhao Pengfei Zou Jingwan Han Yang Yang Meiyan Yang Yuli Wang Wei Gong haihua xiao Zhiping Li Lin Li Chunsheng Gao State key Laboratory of Toxicology and Medical Countermeasure Beijing Institute of Pharmacology and ToxicologyBeijing 100039China Pharmaceutical College Henan UniversityKaifeng 475001China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China School of Public Health and Health Management Gannan Medical UniversityGanzhou 341000China Institute of Chemistry Chinese Academy of SciencesBeijing 100190China

Even the potential of T cell-mimicking nanotrap for long term viral control due to its overcoming of human immunodeficiency virus(HIV)genetic diversity and viral resistance,the robust HIV inhibition was not expected because these nanotraps displayed no obvious advantages compared with the infinite host ***,a glycoprotein 120(gp120)-targeting polypeptide UM15 reinforced lymphocyte-mimicking nanotrap was constructed,and its improved HIV-1 inhibiting efficacy was *** to the results,the constructed nanotraps exhibited evident escaping ability from uptake of the mononuclear phagocyte system and highly improved binding ability with gp120 *** constructed nanotraps neutralized all tested HIV-1 pseudo typed viruses with IC80 of 21.0μg/mL,and inhibited both X4-tropic and R5-tropic HIV-1 with IC80 of 34.4 and 20.6μg/mL,*** 40%of gp120 was observed to be shed from pseudo virus,and above 40%bystander T cells were prevented from gp120-induced death by the constructed *** safety of the constructed nanotraps was confirmed both in vitro and in ***,the constructed nanotraps could specifically neutralize free HIV-1,selectively bind with gp120 expressing HIV-1 infected cells,cause gp120 shedding,inhibit gp120-induced bystander T cell killing on the premise of safety,and were considered as promising therapeutic agents for precise inhibition of HIV.

关键词： nanotrap lymphocyte membrane UM15 human immunodeficiency virus-1(HIV-1) glycoprotein 120(gp120)

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Genome-wide analysis identify novel germline genetic variations in ADCY1 influencing platinum-based chemotherapy response in nonsmall cell lung cancer

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Acta Pharmaceutica Sinica B 2022年第3期12卷 1514-1522页

作者： Chenxue Mao Juan Chen Ting Zou Yuankang Zhou Junyan Liu Xi Li Xiangping Li Min Li Pinhua Pan Wei Zhuo Yang Gao Shuo Hu Desheng xiao Lin Wu Zhan Wang Heng Xu Wen Yang Yingjie Xu haihua xiao Kazuhiko Hanada Wei Zhang Honghao Zhou Jiye Yin Zhaoqian Liu Departments of Clinical Pharmacology and Pharmacy Hunan Key Laboratory of Pharmacogeneticsand National Clinical Research Center for Geriatric DisordersXiangya HospitalCentral South UniversityChangsha 410008China Institute of Clinical Pharmacology Engineering Research Center of Applied Technology of PharmacogenomicsMinistry of EducationCentral South UniversityChangsha 410078China Department of Respiratory Xiangya HospitalCentral South UniversityChangsha 410008China Department of Thoracic Surgery Xiangya HospitalCentral South UniversityChangsha 410008China Department of Nuclear Medicine Xiangya HospitalCentral South UniversityChangsha 410008China Department of Pathology Xiangya HospitalCentral South UniversityChangsha 410014China Department of Thoracic Medicine Hunan Cancer HospitalChangsha 410014China Department of Medical Oncology Lung Cancer and Gastrointestinal UnitHunan Cancer HospitalChengdu 610000China State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengdu 610000China Department of Molecular and Cellular Biochemistry School of MedicineShanghai Jiaotong UniversityShanghai 200025China Beijing National Laboratory for Molecular Sciences State Key Laboratory of Polymer Physics and ChemistryInstitute of ChemistryChinese Academy of SciencesBeijing 100190China Department of Pharmacometrics and Pharmacokinetics Meiji Pharmaceutical University Tokyo 204-8588Japan

To explore the pharmacogenomic markers that affect the platinum-based chemotherapy response in non-small-cell lung carcinoma(NSCLC),we performed a two-cohort of genome-wide association studies(GWAS),including 34 for WES-based and 433 for microarray-based analyses,as well as two independent validation *** integrating the results of two studies,the genetic variations related to the platinum-based chemotherapy response were further determined by fine-mapping in 838 samples,and their potential functional impact were investigated by eQTL analysis and in vitro cell *** found that a total of 68 variations were significant at P<1×10^(-3)in cohort 1 discovery stage,of which 3 SNPs were verified in 262 independent samples.A total of541 SNPs were significant at P<1×10^(-4)in cohort 2 discovery stage,of which 8 SNPs were verified in 347 independent *** the validated SNPs in two GWAS,ADCY1 gene was verified in both independent *** results of fine-mapping showed that the G allele carriers of ADCY1rs2280496 and C allele carriers of rs189178649 were more likely to be resistant to platinum-based *** conclusion,our study found that rs2280496 and rs189178649 in ADCY1 gene were associated the sensitivity of platinum-based chemotherapy in NSCLC patients.

关键词： Pharmacogenomics NSCLC Platinum GWAS WES ADCY1 Precious medicine SNPs

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Identification of SARS-CoV-2-against aptamer with high neutralization activity by blocking the RBD domain of spike protein 1

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Signal Transduction and Targeted Therapy 2021年第7期6卷 1985-1988页

作者： Ge Yang Ziyue Li Irfan Mohammed Liping Zhao Wei Wei haihua xiao Weisheng Guo Yongxiang Zhao Feng Qu Yuanyu Huang School of Life Science Advanced Research Institute of Multidisciplinary ScienceInstitute of Engineering MedicineKey Laboratory of Molecular Medicine and BiotherapyBeijing Institute of TechnologyBeijingChina State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijingChina Beijing National Laboratory for Molecular Sciences State Key Laboratory of Polymer Physics and ChemistryInstitute of ChemistryChinese Academy of SciencesBeijingChina Translational Medicine Center Key Laboratory of Molecular Target&Clinical Pharmacology and the State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences&the Second Affiliated HospitalGuangzhou Medical UniversityGuangzhouChina National Center for International Research of Biological Targeting Diagnosis and Therapy Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy ResearchGuangxi Medical UniversityNanningGuangxiChina

Dear Editor,The ongoing outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)poses a great threat to the public health of people and the normal economic and social development around the *** of January 8,2021,more than 88 million people were infected with SARS-CoV-2,resulting in more than 1.9 million death.

关键词： death acute respiratory

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Efficient hepatic delivery and protein expression enabled by optimized mRNA and ionizable lipid nanoparticle

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Bioactive Materials 2020年第4期5卷 1053-1061页

作者： Tongren Yang Chunhui Li xiaoxia Wang Deyao Zhao Mengjie Zhang Huiqing Cao Zicai Liang haihua xiao Xing-Jie Liang Yuhua Weng Yuanyu Huang School of Life Science Advanced Research Institute of Multidisciplinary ScienceInstitute of Engineering MedicineKey Laboratory of Molecular Medicine and BiotherapyBeijing Institute of TechnologyBeijing100081China Institute of Molecular Medicine Peking UniversityBeijing100871China Suzhou Ribo Life Science Co.Ltd. Jiangsu215300China Beijing National Laboratory for Molecular Science State Key Laboratory of Polymer Physical and ChemistryInstitute of ChemistryChinese Academy of ScienceBeijing100190China Chinese Academy of Sciences(CAS)Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaBeijing100190China School of Materials and the Environment Beijing Institute of TechnologyZhuhai519085China Department of Radiation Oncology The First Affiliated Hospital of Zhengzhou UniversityErqiZhengzhou450000China

mRNA is a novel class of therapeutic modality that holds great promise in vaccination,protein replacement therapy,cancer immunotherapy,immune cell engineering ***,optimization of mRNA molecules and efficient in vivo delivery are quite important but challenging for its broad *** we present an ionizable lipid nanoparticle(iLNP)based on iBL0713 lipid for in vitro and in vivo expression of desired proteins using codon-optimized *** encoding luciferase or erythropoietin(EPO)were prepared by in vitro transcription and formulated with proposed iLNP,to form iLP171/mRNA *** was revealed that both luciferase and EPO proteins were successfully expressed by human hepatocellular carcinoma cells and *** maximum amount of protein expression was found at 6 h *** expression efficiency of EPO with codon-optimized mRNA was significantly higher than that of unoptimized ***,no toxicity or immunogenicity was observed for these mRNA ***,our study provides a useful and promising platform for mRNA therapeutic development.

关键词： mRNA therapy Lipid nanoparticle mRNA delivery Erythropoietin Codon optimization

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免疫连续记忆故障诊断方法

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机械工程学报 2023年第24期59卷 34-45页

作者：张宏利兰超刘树林肖海华蒋伦常孙欣上海大学机电工程与自动化学院上海200444

故障样本少且难以获得是制约智能诊断系统发展的关键问题,基于生物免疫系统的克隆、变异及连续学习等众多智能机理,提出了一种具备新增故障样本在线连续学习能力的免疫连续记忆算法(Immune continuous memory,ICM)。算法采用高斯函数计... 详细信息

故障样本少且难以获得是制约智能诊断系统发展的关键问题,基于生物免疫系统的克隆、变异及连续学习等众多智能机理,提出了一种具备新增故障样本在线连续学习能力的免疫连续记忆算法(Immune continuous memory,ICM)。算法采用高斯函数计算空间任一点故障样本(抗原)出现可能性的大小称为细胞因子浓度,并根据细胞因子浓度大小提出尺度可变B细胞(Scale variable B cells,SVB)概念,模拟生物免疫克隆变异机理针对任一抗原形成数量较多但识别能力更强的成熟B细胞,进而提出一种记忆细胞优选策略,对成熟B细胞数目进行优化,形成数量较少且能够识别所有训练抗原的记忆B细胞群用于数据分类。构建记忆B细胞群条件更新机制,对新增抗原进行持续学习,形成识别能力更强的记忆B细胞集,实现ICM的连续学习功能。经标准数据集仿真表明,所提出的ICM算法在同等条件下与其它算法相比具有较好的分类性能。经往复压缩机气阀诊断试验证明,ICM算法能够通过不断更新记忆细胞提高其诊断性能,是一种有效的连续学习故障算法。

关键词：故障诊断连续学习生物免疫系统优选记忆细胞

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基于多维关联规则的车辆故障码解耦方法研究

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汽车工程 2024年第1期46卷 161-169页

作者：胡杰卿海华魏敏耿黄政张潇陈林武汉理工大学现代汽车零部件技术湖北省重点实验室现代零部件技术湖北省协同创新中心新能源与智能网联车湖北工程技术研究中心武汉430070 上汽通用五菱汽车股份有限公司柳州545000

本文提出一种针对车辆复杂耦合故障的故障码(DTC)解耦方法。首先由车辆故障自诊断原理及故障信号传播过程分析故障码的复杂关联性,结合关联规则技术挖掘故障码间强关联关系,并定义故障码多维关联规则;其次由故障码数据集特征,改进适用... 详细信息

本文提出一种针对车辆复杂耦合故障的故障码(DTC)解耦方法。首先由车辆故障自诊断原理及故障信号传播过程分析故障码的复杂关联性,结合关联规则技术挖掘故障码间强关联关系,并定义故障码多维关联规则;其次由故障码数据集特征,改进适用于故障码多维关联规则挖掘的FP-Growth算法;最后由多维关联规则构建故障码关联知识图谱,结合图论实现复杂故障码解耦。结果表明,该方法能有效降低故障码的数量及复杂度,提升基于故障码检修故障的效率。

关键词：故障码解耦多维关联规则知识图谱

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Biomedical polymers: synthesis, properties, and applications

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Science China Chemistry 2022年第6期65卷 1010-1075页

作者： Wei-Hai Chen Qi-Wen Chen Qian Chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao Chengqiang Tang Jinqiang Wang Lei Wang Meng-Hua Xiong Lichen Yin Kuo Zhang Zhanzhan Zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He Jian Ji Xiqun Jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei Sun Hao Wang Jun Wang haihua xiao Fu-Jian Xu Zhiyuan Zhong Xian-Zheng Zhang Xuesi Chen Key Laboratory of Biomedical Polymers of Ministry of Education&Department of Chemistry Wuhan UniversityWuhan430072China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou215123China School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional MaterialsTianjin UniversityTianjin300350China Key Laboratory of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical Technology) Ministry of EducationBeijing Laboratory of Biomedical MaterialsCollege of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing100029China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials of Ministry of EducationCollege of ChemistryNankai UniversityTianjin300071China Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China Jinhua Institute of Zhejiang University Jinhua321299China Zhejiang Key Laboratory of Smart BioMaterials and Center for Bionanoengineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou311215China State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science and Laboratory of Advanced MaterialsFudan UniversityShanghai200438China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nano-scienceNational Center for Nanoscience and Technology(NCNST)Beijing100190China School of Biomedical Sciences and Engineering Guangzhou International CampusSouth China University of TechnologyGuangzhou510006China Institute of Functional Nano and So

Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation.

关键词： biomedical polymer nanomedicine cancer therapy drug delivery bioimaging and biosensing tissue engineering regenerative medicine cytotoxicity biocompatibility

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