Identification of SARS-CoV-2-against aptamer with high neutralization activity by blocking the RBD domain of spike protein 1

作     者：Ge Yang Ziyue Li Irfan Mohammed Liping Zhao Wei Wei Haihua Xiao Weisheng Guo Yongxiang Zhao Feng Qu Yuanyu Huang Ge Yang;Ziyue Li;Irfan Mohammed;Liping Zhao;Wei Wei;Haihua Xiao;Weisheng Guo;Yongxiang Zhao;Feng Qu;Yuanyu Huang

作者机构：School of Life ScienceAdvanced Research Institute of Multidisciplinary ScienceInstitute of Engineering MedicineKey Laboratory of Molecular Medicine and BiotherapyBeijing Institute of TechnologyBeijingChina State Key Laboratory of Biochemical EngineeringInstitute of Process EngineeringChinese Academy of SciencesBeijingChina Beijing National Laboratory for Molecular SciencesState Key Laboratory of Polymer Physics and ChemistryInstitute of ChemistryChinese Academy of SciencesBeijingChina Translational Medicine CenterKey Laboratory of Molecular Target&Clinical Pharmacology and the State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences&the Second Affiliated HospitalGuangzhou Medical UniversityGuangzhouChina National Center for International Research of Biological Targeting Diagnosis and TherapyGuangxi Key Laboratory of Biological Targeting Diagnosis and Therapy ResearchGuangxi Medical UniversityNanningGuangxiChina 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2021年第6卷第7期

页      面：1985-1988页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：This work was supported by the National Natural Science Foundation of China(21675012,21874010,21827810,31871003,and 31901053) the Beijing Nova Program from Beijing Municipal Science&Technology Commission(Z201100006820005) the Beijing-Tianjin-Hebei Basic Research Cooperation Project(19JCZDJC64100) the Young Elite Scientist Sponsorship Program of Beijing Association for Science and Technology(2020-2022) the Fundamental Research Funds for the Central Universities from Beijing Institute of Technology(2018CX01023) the Hunan Provincial Natural Science Foundation of China(2018JJ1019) the Hu-Xiang Young Talent Program(2018RS3094) the Natural Science Foundation of Guangdong Province(2019A1515010776) the Postdoctoral Science Foundation of China(2020M670169) Guangxi Key Research and Development Project(No.AB20117001) 

主　　题：death acute respiratory 

摘      要：Dear Editor,The ongoing outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)poses a great threat to the public health of people and the normal economic and social development around the *** of January 8,2021,more than 88 million people were infected with SARS-CoV-2,resulting in more than 1.9 million death.