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A lysosomal-targeted Pt(Ⅱ) metallacycle for NIR-Ⅱ fluorescence imaging guided highly efficient tumor immunogenic cell death

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Science China Chemistry 2024年第11期67卷 3508-3509页

作者： Qihang Ding Shuai Zhang Jong Seung Kim Department of Chemistry Korea UniversitySeoul 02841Republic of Korea Department of Medical Oncology Harbin Medical University Cancer HospitalHarbin 150040China

Cisplatin, carboplatin, and oxaliplatin are well-known firstline antineoplastic drugs that have been approved worldwide. Recently, the successful integration of chemotherapy and immunotherapy in clinical trials has hi... 详细信息

关键词： drugs chemotherapy Cisplatin death

Distillability of Sudden death in Qutrit-Qutrit Systems under Global Mixed Noise

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Chinese Physics Letters 2019年第5期36卷 17-21页

作者： Bing-Bing Chai Jin-Liang Guo College of Physics and Materials Science Tianjin Normal UniversityTianjin 300387

Considering the influences of collective dephasing, multilocal qutrit-flip, local qutrit-flip, and the combination of global mixed noise, we study the dynamics of entanglement and the phenomenon of distillability of sudden death (DSD) in a qutrit-qutrit system under various decoherent noises. It is shown that the system always undergoes DSD when it interacts with multilocal and local qutrit-flip noise, and the time-determined bound entangled state is more dependent on different noises. Comparing with the cases of global mixed and collective dephasing noise,we conclude that the qutrit-flip noise is responsible for the DSD.

关键词： Distillability of Sudden death in Qutrit-Qutrit Systems under Global Mixed Noise

An overview of end-of-life issues in a cardiology department. Is the mode of death worse in the cardiac intensive care unit?

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Journal of Geriatric Cardiology 2019年第6期16卷 482-489页

作者： Lourdes Vicent Vanesa Bruna Carolina Devesa Jorge García-Carreno Iago Sousa-Casasnovas Miriam Juárez Francisco Fernández-Avilés Manuel Martínez-Sellés Servicio de Cardiología Hospital Universitario Gregorio Maranon CIBERCV Madrid Spain Universidad Complutense de Madrid Madrid Spain Universidad Europea de Madrid Madrid Spain

Introduction Cardiovascular (CV) diseases are the most common causes of death and causes frequent hospital admissions.[1] The increase in life expectancy and the appearance of new treatments,[2] is changing in the clinical profile of CV disease, with a rise in chronic processes and concomitant comorbidities.[ 3] These changes are probably reflected in the current profile of patients admitted to cardiology departments, and in their causes of mortality.

关键词： Cardiovascular death Mortality Withdraw of life-sustaining therapies

Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis

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Acta Pharmaceutica Sinica B 2020年第8期10卷 1397-1413页

作者： Xiaowei Zhang Ping Zhang Lin An Ningyuan Sun Liying Peng Weiwei Tang Dingyuan Ma Jun Chen State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China Department of Pharmacognosy School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009China Department of Prenatal Diagnosis Nanjing Maternity and Child Health Care HospitalWomen’s Hospital of Nanjing Medical UniversityNanjing 210004China

Pyroptosis is a form of programmed cell death,and recently described as a new molecular mechanism of chemotherapy drugs in the treatment of ***,a derivative of phenanthrenequinone isolated from the root of Salvia miltiorrhiza Bunge,has been shown to possess anti-cancer ***,we found that miltirone inhibited the cell viability of either HepG2 or Hepa1-6 cells,and induced the proteolytic cleavage of gasdermin E(GSDME)in each hepatocellular carcinoma(HCC)cell line,with concomitant cleavage of caspase *** out GSDME switched miltirone-induced cell death from pyroptosis to ***,the induction effects of miltirone on GSDMEdependent pyroptosis were attenuated by si RNA-mediated caspase three silencing and the specific caspase three inhibitor Z-DEVD-FMK,*** effectively elicited intracellular accumulation of reactive oxygen species(ROS),and suppressed phosphorylation of mitogen-activated and extracellular signal-regulated kinase(MEK)and extracellular regulated protein kinases 1/2(ERK1/2)for pyroptosis ***,miltirone significantly inhibited tumor growth and induced pyroptosis in the Hepa1-6 mouse HCC syngeneic *** results provide a new insight that miltirone is a potential therapeutic agent for the treatment of HCC via GSDME-dependent pyroptosis.

关键词： death drugs chemotherapy GSD treatment

Vacuolar processing enzyme positively modulates plant resistance and cell death in response to Phytophthora parasitica infection

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Journal of Integrative Agriculture 2023年第5期22卷 1424-1433页

作者： GAO Xian-xian TANG Ya-ling SHI Qing-yao WEI Yu-shu WANG Xiao-xue SHAN Wei-xing QIANG Xiao-yu State Key Laboratory of Crop Stress Biology for Arid Areas/College of Agronomy Northwest A&F UniversityYangling 712100P.R.China

Oomycete, particularly Phytophthora species, causes the most devastating crop diseases, such as potato late blight,and threatens the sustainable crop production worldwide. Our previous studies identified Resistance to Phytophthora parasitica 1(RTP1) as a negative regulator of Arabidopsis resistance to multiple biotrophic pathogens and RTP1 lossof-function plants displayed rapid cell death and reactive oxygen species(ROS) production during early colonization of P. parasitica. In this study, we aim to decipher the mechanism of RTP1-mediated cell death, and identify a member of vaculoar processing enzymes(VPEs), γVPE, playing a role in rtp1-mediated resistance to P. parasitica and cell death occurrence. Our results showed up-regulation of the expression of γVPE as well as increased VPE/caspase 1-like protease activity in P. parasitica-infected rtp1 mutant plants. Besides, we found that the VPE/caspase 1-like protease activity was required for the cell death occurrence in Arabidopsis plants during the infection of P. parasitica as well as rtp1-mediated resistance to P. parasitica. Further pathogenicity assays on either Arabidopsis γvpe mutant plants or leaves of Nicotiana benthamiana with transient overexpression of γVPE demonstrated γVPE could positively affect plant resistance to P. parasitica. Together, our studies suggest that γVPE might function as an important regulator of plant defense and cell death occurrence in response to P. parasitica infection, and VPE/caspase 1-like protease activity is required for rtp1-mediated resistance to P. parasitica.

关键词： cell death caspase 1 plant resistance Phytophthora parasitica RTP1 susceptibility factor vacuolar processingenzyme

Individual and joint effects of borderline ankle-brachial index and high plasma total homocysteine on all-cause death in hypertensive adults

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Journal of Geriatric Cardiology 2022年第7期19卷 522-530页

作者： Jun-Pei LI Tian-Yu CAO Xiao-Yuan ZHA Yun YU Zi-Heng TAN Zai-Hua CHENG Hua-Bo YING Wei ZHOU Lin-Juan ZHU Tao WANG Li-Shun LIU Hui-Hui BAO Xiao HUANG Xiao-Shu CHENG Department of Cardiology the Second Affiliated Hospital of Nanchang UniversityNanchangChina University of California Santa BarbaraCAUSA Rancheng Community Health Service Center WuyuanChina Center for Prevention and Treatment of Cardiovascular Diseases the Second Affiliated Hospital of Nanchang UniversityNan-changChina Graduate School at Shenzhen Tsinghua UniversityShenzhenChina

BACKGROUND The cardiovascular hazards of total homocysteine(tHcy)are long *** addition,despite the acknow-ledgment on the importance of low ankle-brachial index(ABI)(<0.9),borderline ABI(0.91-0.99)was once commonly **... 详细信息

BACKGROUND The cardiovascular hazards of total homocysteine(tHcy)are long *** addition,despite the acknow-ledgment on the importance of low ankle-brachial index(ABI)(death in hypertensive *** This study included 10,538 participants from China H-type Hypertension Registry *** was described into two groups:normal ABI(1.00-1.40)and borderline *** level was also divided into two groups:deaths were observed in the 1.7 years follow-up *** ABI has a higher predicted risk of death than normal ABI(HR=1.87,95%CI:1.17-3.00)after adjusting for potential *** with tHcy leveldeath risk than those with low tHcy,nevertheless,no significant different between borderline and normal ABI among those with low tHcy *** Borderline ABI and tHcy level both have independent predictive value on all-cause *** combined group of borderline ABI and high tHcy has highest risk factor of outcomes,which suggested the mutual additive value of border-line ABI and *** attention should be given to the importance of borderline ABI in hypertensive population,especially with elevated tHcy level.

关键词： hypertensive death ankle

Relationship of body fat and left ventricular hypertrophy with the risk of all-cause death in patients with coronary artery disease

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Journal of Geriatric Cardiology 2022年第3期19卷 218-226页

作者： Bao-Tao HUANG Lu YANG Bo-Sen YANG Fang-Yang HUANG Qian-Feng XIAO Xiao-Bo PU Yong PENG Mao CHEN Department of Cardiology West China HospitalSichuan UniversityChengduSichuanChina Department of Cardiology West China HospitalSichuan University/West China School of NursingSichuan UniversityChengduSichuanChina

BACKGROUND Left ventricular hypertrophy(LVH)is prevalent in obese ***,both of LVH and obesity is as-sociated with subclinical LV *** study aims to investigate the interplay between body fat and LVH in relation to all-cause death in patients with coronary artery disease(CAD).METHODS In this retrospective cohort study,a total of 2243 patients with angiographically proven CAD were *** fat and LV mass were calculated using established *** were grouped according to body fat percentage and pres-ence or absence of ***-proportional hazard models were used to observe the interaction effect of body fat and LVH on all-cause *** Of 2243 patients enrolled,560(25%)had a higher body fat percentage,and 1045(46.6%)had *** a median follow-up of 2.2 years,the cumulative mortality rate was 8.2%in the group with higher body fat and LVH,2.5%in those with lower body fat and no LVH,5.4%in those with higher body fat and no LVH,and 7.8%in those with lower body fat and LVH(log-rank Pdeath(HR=3.49,95%CI:1.40-8.69,P=0.007)compared with those with lower body fat and no LVH;in contrast,patients with higher body fat and no LVH had no statistically significant difference in risk of death compared with those with lower body fat and no LVH(HR=2.03,95%CI:0.70-5.92,P=0.195).CONCLUSION A higher body fat percentage was associated with a different risk of all-cause death in patients with CAD,strat-ified by coexistence of LVH or *** body fat was significantly associated with a greater risk of mortality among patients with LVH but not among those without LVH.

关键词： patients death ventricular

Role of hydrogen peroxide in stress-induced programmed cell death during somatic embryogenesis in Fraxinus mandshurica

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Journal of Forestry Research 2019年第3期30卷 767-777页

作者： Ling Yang Cheng Wei Chao Huang Hongnan Liu Dongyan Zhang Hailong Shen Yuhua Li State Key Laboratory of Tree Genetics and Breeding School of Forestry Northeast Forestry University

We examined how reactive oxygen species, in the form of hydrogen peroxide (H2O2), affect osmotic stress–induced programmed cell death during somatic embryogenesis from cotyledon explants of Manchurian ash (Fraxinus mandshurica Rupr.). We found that substantial osmotic stress was essential for Manchurian ash somatic cells to obtain embryogenic competence. The explant cells displayed hallmarks of programmed cell death, chromatin condensation, and DNA fragmentation to oligonucleotides during somatic embryogenesis. Increasing concentrations of plant growth regulators and sucrose in the medium increased osmotic stress thereby inducing H2O2 accumulation in the explant cells. We found that H2O2 concentration was significantly decreased in explant cells when the induction medium was modified, i.e., when reducing the concentration of sucrose, which reduces the osmotic pressure of the medium, or by withdrawing plant growth regulators at mid-culture. These treatments also decreased the proportion of explant cells undergoing programmed cell death. Accordingly, a decreased rate of somatic embryo induction was observed. These results show that PCD occurred during tissue browning and death of some explant cells during somatic embryogenesis in F. mandshurica. The ROS contributed to PCD in abiotic stress stimulated F. mandshurica cells.

关键词： Manchurian ash Somatic embryos Programmed cell death Reactive oxygen species Osmotic stress

Role of axon resealing in retrograde neuronal death and regeneration after spinal cord injury

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Neural Regeneration Research 2019年第3期14卷 399-404页

作者： William Rodemer Michael E.Selzer Shriners Hospital Pediatric Research (Center Center for Neural Repair and Rehabilitation) Department of Neurology the Lewis Katz School of Medicine at Temple University

Spinal cord injury leads to persistent behavioral deficits because mammalian central nervous system axons fail to regenerate. A neuron's response to axon injury results from a complex interplay of neuron-intrinsic and environmental factors. The contribution of axotomy to the death of neurons in spinal cord injury is controversial because very remote axotomy is unlikely to result in neuronal death, whereas death of neurons near an injury may reflect environmental factors such as ischemia and inflammation. In lampreys, axotomy due to spinal cord injury results in delayed apoptosis of spinal-projecting neurons in the brain, beyond the extent of these environmental factors. This retrograde apoptosis correlates with delayed resealing of the axon, and can be reversed by inducing rapid membrane resealing with polyethylene glycol. Studies in mammals also suggest that polyethylene glycol may be neuroprotective, although the mechanism(s) remain unclear. This review examines the early, mechanical, responses to axon injury in both mammals and lampreys, and the potential of polyethylene glycol to reduce injury-induced pathology. Identifying the mechanisms underlying a neuron's response to axotomy will potentially reveal new therapeutic targets to enhance regeneration and functional recovery in humans with spinal cord injury.

关键词： axon resealing regeneration retrograde neuronal death spinal cord injury sea lamprey PEG mitochondrial dysfunction calcium signaling