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Poly（N-isopropylacrylamide）/alginate Copolymer Hydrogel Grafted Fabrics Embedding of Berberine Nanosuspension: Preparation Evaluation in Vitro and in Vivo

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Poly（N-isopropylacrylamide）/alginate Copolymer Hydrogel Gr...

2013年中国药学大会暨第十三届中国药师周

作者： He Xu Xu-Dong yuan Bao-De Shen Jin Han Qing-yuan Lv Ling Dai Ming-Gui Lin Chao Yu Jin-Xia Bai hai-long yuan Department of Pharmacy 302 Military Hospital of China School of Pharmacy Chengdu University of Traditional Chinese Medicine School of Science Monmouth University Institute of Tuberculosis 309 Military Hospital of China

In the present studies, a novel hydrogel-grafted fabrics embedding of berberine nanosuspension was developed for the treatment of infected wound. Hydrogel-grafted fabrics （HGFs） was prepared by graft copolymerization of N-isopropylacrylamide （NIAAm） and alginate using ceric ammonium nitrate as initiator. Berberine nanosuspension was prepared and embedded in the HGFs to achieve sustained drug release. The prepared HGFs embedding of berberine nanosuspension was characterized by Fourier transform infrared spectroscopy （FT-IR）, scanning electron microscopy （SEM）, and swelling degree studies. FT-IR revealed that berberine was embedded into the matrix of HGFs, rather than on the surface. SEM showed that a thin hydrogel layer was formed on the surface of nonwoven fibers. The swelling study showed that HGFs was water absorbing with reversible temperature sensitivity. The drug release study demonstrated that HGFs could be used as a sustained drug delivery system of hydrophobic compounds. The berberine nanosuspension embedded HGFs was further investigated in an animal infected wound model and was found to be a very promising wound healing dressing for the treatment and healing of infected wounds.

关键词： Hydrogel PNIAAm Hydrogel grafted fabrics Berberine Nanosuspension wound dressing

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浅谈刑事侦查中的“网上追逃”的优势及完善

政法学刊 2001年第4期18卷 65-67页

作者：龙海元深圳市人民警察学校公安业务教研室广东深圳518000

１９９９年中国警方首次展开“网上追逃”，取得了重大成绩。“网上追逃”是历次严打斗争的继续，通过网上作战，进一步增强了广大民警的科技意识，公安信息网络建设在实战中得到空前加强。

关键词：网络追逃专项斗争特征完善措施

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论谈判在反恐怖劫持人质行动中的价值

政法学刊 2005年第1期22卷 66-68页

作者：龙海元深圳市警察学校广东深圳518053

保证人质及其他人的生命安全是警方处置恐怖劫持人质事件追求的目的。谈判是其中一个非常重要的环节。能够尽量避免恐怖劫持事件事态的恶化和升级,最大限度地保全人质、行动警员、恐怖劫持分子以及一些无辜人的生命,亦具公众安全心理安... 详细信息

保证人质及其他人的生命安全是警方处置恐怖劫持人质事件追求的目的。谈判是其中一个非常重要的环节。能够尽量避免恐怖劫持事件事态的恶化和升级,最大限度地保全人质、行动警员、恐怖劫持分子以及一些无辜人的生命,亦具公众安全心理安抚效应,体现了现代生活的价值理念。对警方不得不实施的武力解救行动来说。

关键词：谈判反恐怖劫持人质事件生命安全最大限度安全心理价值理念现代生活警方保全警员武力

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当前反恐怖公安理论培训的探析

政法学刊 2003年第3期20卷 79-80页

作者：龙海元深圳市人民警察学校广东深圳518000

恐怖分子有计划、有步骤、秘密地训练,活动隐蔽突然,恐怖活动不断加剧,手段十分残忍。对反恐怖公安理论的研究,要坚持与时俱进,不断探索反恐怖斗争的特点和规律,用最新的理论和方法指导未来反恐怖斗争的实践。

关键词：反恐怖公安理论学习培训

Fast dissolving sublingual films of methylphenidate hydrochloride for cancer-related fatigue management:Formulation and in vitro/in vivo evaluation

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Fast dissolving sublingual films of methylphenidate hydrochl...

中国药学会第十三届青年药学科研成果交流会

作者： Cheng-ying Shen Li-hong Zhang Bao-de Shen Ping-hua Xu Na Wu Juan Zheng hai-long yuan Department of Pharmacy Air Force General Hospital of PLA Jiangxi University of Traditional Chinese Medicine

Objective:The purpose of this study was to formulate Methylphenidate hydrochloride（MPH） as oral fast dissolving sublingual films（OFDSFs） in a trial to improve its bioavailability and patient ***:The MPH-OFDSFs were prepared by casting method and evaluated for their film thickness,mechanical properties,in vitro disintegration and *** content uniformity and stability were also *** verify the advantages of the OFDSFs,the pharmacokinetic properties were investigated and compared with oral solution of ***:The prepared MPH-OFDSFs showed desired mechanical properties and film *** drug content of MPH-OFDSFs was within 85%-115%.The films were found to be stable for 4 months when stored at 40℃ and 75%*** vitro release studies suggested a rapid disintegration,in which most of MPH was released 99.00 ± 0.49%of drug within 3 *** absorption of MPH from sublingual administration of MPH films in rats resulted in 4.57-fold increased in bioavailability as compared to oral administration of pure drug ***:These results suggest that the fast dissolving sublingual film containing MPH is likely to become one of the choices for treatment of cancer-related fatigue（CRF）.

关键词： Methylphenidate hydrochloride Fast dissolving film Sublingual films Cancer-related fatigue Pharmacokinetics

A Simultaneous Determination of Seven Principal Compounds in Liuwei Wuling Tablet Using HPLC-DAD

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A Simultaneous Determination of Seven Principal Compounds in...

2015年中国药学大会暨第十五届中国药师周

作者： Ling Cheng Juan-juan Li Gang Shen Ling Qiu Juan Zheng Li-hong Zhang Na Wu Jin Han hai-long yuan Pharmacy College Chengdu University of Traditional Chinese Medicine 302 Hospital of PLA&PLA Institute of Chinese Materia Medica

An effective high-performance liquid chromatography method coupled with diode array detection（HPLC-DAD） was established for the simultaneous determination of seven major bioactive compounds in Liuwei Wuling Tablet（LWWLT）, including forsythoside A, specnuezhenide, phillyrin schisandrin, schisantherin A, deoxyschizandrin and schisandrin B. The chromatographic separation was obtained on an Inertsil? ODS-3 column（250 mm×4.6 mm, 5 μm） at 25℃ with a gradient system of 0.1% phosphoric acid and acetonitrile. The wavelength of detector was set at 230 nm. The following parameters including specificity, linearity, limit of detection（LOD）, limit of quantification（LOQ）, precision, stability, repeatability and recovery were tested for evaluating the established analytical method. Calibration curves for seven compounds showed good linear regressions, with correlation coefficients exceeding 0.999 within the test concentration range. The limits of detection and quantification of each compound were in the range of 0.03-0.28 μg/mL and 0.11-0.87 μg/mL, respectively. The relative standard deviation values of precision, stability and repeatability were less than 2.34%. The average recovery yields of all seven constituents ranged from 96.71-103.9%. The above validated quantificationmethod was successfully applied for the analysis of ten batches of commercial LWWLT. These results would give a support for quality control and the further pharmacology study of LWWLT.

关键词： simultaneous determination seven bioactive constituents Liuwei Wuling Tablet HPLC-DAD

Influence of drug physicochemical characteristics on in vitro transdermal absorption of hydrophobic drug nanosuspensions

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Influence of drug physicochemical characteristics on in vitr...

LAMOST Time-Domain survey:first results of four K2 plates

2014年中国药学大会暨中国药师周

作者： Cheng-ying Shen Bao-de Shen Gang Shen Juan Zheng Xiao-rong Li Hong-yan Min Jin Han hai-long yuan Department of Pharmacy 302 Military Hospital

The purpose of this paper was to study the influence of drug physicochemical characteristics on in vitro transdermal absorption of hydrophobic drug *** drug nanosuspensions,which were same in stabilizer and similar in particle size,were produced by high pressure homogenization *** analysis showed there was no difference in the crystalline state between drug microsuspension and *** vitro permeation study demonstrated that the permeation rate of drug nanosuspension was higher than that of drug *** analysis between drug physicochemical properties and Jss revealed that log P and p Ka were factors that influence the in vitro transdermal absorption of hydrophobic drug nanosuspensions and drugs with log P value around 3 and p Ka value around 7 would gain higher Jss in this paper.

关键词： Nanosuspension Drug physicochemical characteristics Transdermal absorption Permeation rate Correlation analysis

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Research in Astronomy and Astrophysics 2021年第11期21卷 213-232页

作者： Song Wang Hao-Tong Zhang Zhong-Rui Bai hai-long yuan Mao-Sheng Xiang Bo Zhang Wen Hou Fang Zuo Bing Du Tan-Da Li Fan Yang Kai-Ming Cui Yi-Lun Wang Jiao Li Mikhail Kovalev Chun-Qian Li Hao Tian Wei-Kai Zong Heng-Geng Han Chao Liu A-Li Luo Jian-Rong Shi Jian-Ning Fu Shao-Lan Bi Zhan-Wen Han Ji-Feng Liu Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Max-Planck Institute for Astronomy Konigstuhl 17D-69117 HeidelbergGermany Department of Astronomy Beijing Normal UniversityBeijing 100875China School of Physics and Astronomy University of BirminghamBirmingham B152TTUK Stellar Astrophysics Centre Department of Physics and AstronomyAarhus UniversityNy Munkegade 120DK-8000 Aarhus CDenmark College of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China Yunnan Astronomical Observatory Chinese Academy of SciencesKunming 650216China Key Lab of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China WHU-NAOC Joint Center for Astronomy Wuhan UniversityWuhan 430072China

From Oct.2019 to Apr.2020,LAMOST performed a time-domain(TD)spectroscopic survey of four K2 plates with both low-and medium-resolution *** low-resolution spectroscopic survey acquired 282 exposures(≈46.6 h)over 25 nights,yielding a total of about 767000 spectra,and the medium-resolution survey took 177 exposures(≈49.1 h)over 27 nights,collecting about 478000 *** than 70%/50%of low-resolution/medium-resolution spectra have signal-to-noise ratio higher than *** determine stellar parameters(e.g.,Teff,log g,[Fe/H])and radial velocity(RV)with different methods,including LASP,DD-Payne and *** general,these parameter estimations from different methods show good agreement,and the stellar parameter values are consistent with those of *** use the Gaia DR2 RV values to calculate a median RV zero point(RVZP)for each spectrograph exposure by exposure,and the RVZP-corrected RVs agree well with the APOGEE *** stellar evolutionary and spectroscopic masses are estimated based on the stellar parameters,multi-band magnitudes,distances and extinction ***,we construct a binary catalog including about 2700 candidates by analyzing their light curves,fitting the RV data,calculating the binarity parameters from medium-resolution spectra and cross-matching the spatially resolved binary catalog from Gaia *** LAMOST TD survey is expected to represent a breakthrough in various scientific topics,such as binary systems,stellar activity,stellar pulsation,etc.

关键词： astronomical database:miscellaneous catalogs stars:fundamental parameters binaries:general binaries:spectroscopic

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乙酰阿魏酸薄荷醇酯的合成与表征

化学试剂 2017年第2期39卷 203-206页

作者：张海龙鲍远志翁士兵柴多里合肥工业大学化学与化工学院安徽合肥230009 六安市捷通达化工有限责任公司安徽六安237158

以香兰素和乙酸酐为原料、无水乙酸钠为催化剂,采用Perkin反应合成乙酰阿魏酸,再与氯化亚砜反应合成乙酰阿魏酰氯后,以三聚磷酸钠为缚酸剂与薄荷醇反应合成标题化合物,收率78.5%。采用FT-IR、~1HNMR、^(13)CNMR、元素分析、MS对目标化... 详细信息

以香兰素和乙酸酐为原料、无水乙酸钠为催化剂,采用Perkin反应合成乙酰阿魏酸,再与氯化亚砜反应合成乙酰阿魏酰氯后,以三聚磷酸钠为缚酸剂与薄荷醇反应合成标题化合物,收率78.5%。采用FT-IR、~1HNMR、^(13)CNMR、元素分析、MS对目标化合物进行表征并确认产物的结构。

关键词：香兰素薄荷醇三聚磷酸钠乙酰阿魏酸薄荷醇酯