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In-hospital direct costs for thromboembolism and bleeding in Chinese patients with atrial fibrillation

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Chronic Diseases and Translational Medicine 2018年第2期4卷 127-134页

作者： san-Shuai Chang Jia-Hui Wu Yi Liu Ting Zhang Xin Du Jian-Zeng Dong Gregory Y.H. Lip Chang-sheng Ma Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityNational Clinical Research Centre for Cardiovascular DiseasesBeijing 100029China Department of Cardiology Xuzhou Center HospitalXuzhouJiangsu 221000China University of Birmingham Institute of Cardiovascular Sciences City HospitalBirmingham B18 7QHUnited Kingdom

Objective: Limited data are available on the direct costs of hospitalization owing to thromboembolism and bleeding in patients with atrial fibrillation (AF) in China. Such data are essential for policy development, service planning, and cost-effectiveness analysis of new therapeutic strategies. This study aimed to provide detailed data regarding in-hospital direct costs for these pa-tients, compare the costs at different scenarios, and identify independent factors that may predict the costs. Methods: We collected data regarding in-hospital direct costs among patients with AF who were hospitalized owing to ischemic stroke (IS), transient ischemic attack (TIA), intracranial hemorrhage (ICH), or major gastrointestinal bleeding. All data were collected from 7 representative tertiary referral hospitals and 3 secondary care hospitals from December 2009 to October 2014. Results: In total, 312 eligible patients with thromboembolism and 143 patients with major bleeding were identified, and their hospital charts were reviewed. The median in-hospital direct costs were 17,857 Chinese Yuan (CNY) for IS and 16,589 CNY for TIA (equivalent to 2907 US dollars and 2701 US dollars, respectively). For patients with major bleeding, the costs were 27,924 CNY for ICH and 18,196 CNY for major gastrointestinal bleeding (equivalent to 4546 US dollars and 2962 US dollars, respec-tively). The direct costs were mainly driven by medications, which accounted for approximately 33.4%-36.1% in different groups of patients. The direct costs were highly related to the hospital level and National Institutes of Health Stroke Scale scores in patients with thromboembolism; in patients with ICH, the factors included hospital level, warfarin treatment before admission, and prior hospitalization for stroke. Conclusions: Given the high prevalence, AF-related thromboembolism and bleeding impose considerable economic burden on the Chinese society. Efforts to improve the management of AF may confer substantial e

关键词： Atrial fibrillation Ischemic stroke Bleeding In-hospital direct costs

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汽车B柱热成形技术的比较分析

塑性工程学报 2019年第3期26卷 70-76页

作者：王三省余海燕陈梦同济大学汽车学院上海201804 芜湖本特勒浦项汽车配件制造有限公司安徽芜湖241009

对乘用车B柱所使用的7种热成形技术进行了介绍,包括普通热成形、补丁板的热成形、与冷冲件拼接的热成形、软硬分区的热成形、不等厚板的热成形、激光拼焊板的热成形,带B柱的热成形门环等。阐述了不同热成形技术对材料、设备、热成形模... 详细信息

对乘用车B柱所使用的7种热成形技术进行了介绍,包括普通热成形、补丁板的热成形、与冷冲件拼接的热成形、软硬分区的热成形、不等厚板的热成形、激光拼焊板的热成形,带B柱的热成形门环等。阐述了不同热成形技术对材料、设备、热成形模具和成形前板料等的要求以及不同技术成形的B柱所能达到的碰撞性能和轻量化效果,进而从材料成本、技术难度、轻量化效果、碰撞安全性等角度,对比分析了7种热成形技术组合而成的11种热成形B柱的优劣,对未来热成形B柱的发展趋势进行了展望。分析结果表明,普通热成形B柱技术要求和成本最低,而碰撞性能、轻量化效果最好的为带B柱的热成形门环。

关键词：热成形 B柱轻量化碰撞安全

Discovery of Highly Oxidized Abietane Diterpenoids from the Roots of Euphorbia fischeriana with Anti-tumor Activities

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Chinese Journal of Chemistry 2021年第11期39卷 2973-2982页

作者： Jiang-Chun Wei Yu-Ning Gao Dong-Dong Wang Xiao-Yu Zhang san-Peng Fan Te-Ri-Gen Bao Xiao-Xu Gao Gao-sheng Hu An-Hua Wang Jing-Ming Jia School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyangLiaoning110016 China

Four previously undescribed ent-abietane diterpenoids(1—4),along with eleven known analogues(5—15),were isolated from the roots of wild Euphorbia *** gross structures were determined via extensive spectroscopic data,and the absolute configurations were elucidated by means of single-crystal X-ray diffraction analysis,Rh2(OCOCF3)4-induced CD spectrum and ECD *** cervical carcinoma inhibition activities counteract HeLa cells were screened by MTT assay,and the structure-activity relationships were further *** results demonstrated that 2(IC50 value at 3.75μmol/L)was more potent than *** underlying mechanism study revealed that 2 could distinctly induce apoptosis accompanied by increasing reactive oxygen species(ROS)production,Ca^(2+)influx and decreasing mitochondrial membrane ***,signal pathways including MAPKs/AKT might play a significant role in 2-induced cervical cancer cells death.

关键词： Euphorbia fischeriana Diterpenoids Structure elucidation Biological activity Anti-tumor

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静电式同位素辐射能量收集器的研究

物理学报 2014年第2期63卷 389-393页

作者：王翔张强陈然斌邓志强伞海生厦门大学物理与机电工程学院厦门361005 厦门大学萨本栋微纳米科学技术研究院厦门361005

针对目前无线传感网络节点对长寿命微能源的需求,提出了将同位素辐射能量转换为电能的静电式振动能量收集原理.该原理利用同位素63Niβ辐射能实现平行板悬浮-质量块结构的自由阻尼振动,并通过可变电容电路实现充-放电振荡循环,从而实现... 详细信息

针对目前无线传感网络节点对长寿命微能源的需求,提出了将同位素辐射能量转换为电能的静电式振动能量收集原理.该原理利用同位素63Niβ辐射能实现平行板悬浮-质量块结构的自由阻尼振动,并通过可变电容电路实现充-放电振荡循环,从而实现电能的转换.通过分析运动状态和能量转化过程,给出了结构的运动状态和能量输出方程,并使用Matlab/Simulink对输出特性进行了数值模拟和基于Ansys的结构优化设计.根据仿真和优化的结构尺寸设计出了满足最大平均输出功率的微电子机械器件结构.结果表明:所设计的结构在一阶固有频率为500 Hz,两极板间距离为75μm,外接电阻为90 k?时平均输出功率最大为0.416μW,转化效率8.25%.

关键词：能量收集同位素 63Ni 静电式振动能量

n型透明导电薄膜CdIn_2O_4电学性质的研究和大面积制备的最佳条件

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物理学报 2005年第4期54卷 1736-1741页

作者：伞海生陈冲何毓阳王君冯博学兰州大学磁学与磁性材料教育部重点实验室兰州730000

在Ar +O2 气氛中 ,采用射频反应溅射Cd In靶制备CdIn2 O4 薄膜 .制得的薄膜经x射线衍射 (XRD)检测为CdIn2 O4 和CdO相组成的多晶 .从理论上分析了热处理前后氧空位、掺杂点缺陷和富氧电子陷阱在影响膜的载流子浓度和电子散射中所起的重... 详细信息

在Ar +O2 气氛中 ,采用射频反应溅射Cd In靶制备CdIn2 O4 薄膜 .制得的薄膜经x射线衍射 (XRD)检测为CdIn2 O4 和CdO相组成的多晶 .从理论上分析了热处理前后氧空位、掺杂点缺陷和富氧电子陷阱在影响膜的载流子浓度和电子散射中所起的重要作用 .同时 ,对样品进行Hall效应、Seebeck效应测试并得出不同载流子浓度下的迁移率、有效质量、弛豫时间以及它们之间的相互关系 ,特别强调了弛豫时间的重要性 .为了提高导电膜的透射率 ,还分析了Burstein Moss漂移和带隙收缩对光带隙的影响 ,并在薄膜制备时选择了合适的衬底温度Ts≈ 2 80℃ .实验表明 ,在氧分压为 8%左右时制备的薄膜质量较好 ,热处理后的指标大约为迁移率 μH =31× 10 - 4m2 V·s ,电阻率 ρ =1 89× 10 - 5Ω·m .

关键词：透明导电薄膜射频反应溅射 CdIn2O4 电学性质导电机制带隙收缩

Caffeic acid ameliorates early and delayed brain injuries after focal cerebral ischemia in rats

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Acta Pharmacologica Sinica 2006年第9期27卷 1103-1110页

作者： Yu ZHOU san-hua FANG Yi-lu YE Li-sheng CHU Wei-ping ZHANG Meng-ling WANG Er-qing WEI~2 Department of Pharmacology,School of Medicine,Zhejiang University,Hangzhou 310031,China DepartmentofPharmacologySchoolofMedicine ZhejiangUniversityHangzhou310031China

Aim:To investigate the effects of caffeic acid on early and delayed injuries afterfocal cerebral ischemia in rats,and the possible relation to ***:Transient focal cerebral ischernia was induced by middlecerebral artery occlusion in Sprague-Dawley *** acid(10 and 50 mg/kg)was ip injected for 5 d after *** brain injuries were observed,and thelevels of cysteinyl leukotrienes and leukotriene B4in the brain tissue ***:Caffeic acid(50 mg/kg)ameliorated neurological dysfunctionand neuron loss,and decreased infarct volume 24 h after ischemia;it attenuatedbrain atrophy,infarct volume,and particularly astrocyte proliferation 14 d *** addition,it reduced the production of leukotrienes(5-lipoxygenasemetabolites)in the ischemic hemispheres 3 h and 7 d after ***:Caffeic acid has protective effect on both early and delayed injuries after focalcerebral ischemia in rats;and this effect may partly relate to 5-lipoxygenaseinhibition.

关键词： caffeic acid focal cerebral ischemia neuron astrocyte 5-lipoxygenase leukotriene

Particle-in-Cell Simulations of Fast Magnetic Reconnection in Laser-Plasma Interaction

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Chinese Physics Letters 2013年第4期30卷 122-125页

作者： ZHANG Ze-Chen LU Quan-Ming DONG Quan-Li LU san HUANG Can WU Ming-Yu sheng Zheng-Ming WANG Shui ZHANG Jie CAS Key Lab of Geoscience Environment University of Science and Technology of ChinaHefei 230026 School of Physics and Optoelectronic Engineering Ludong UniversityYantai 264025 Key Laboratory for Laser Plasmas(MoE and Department of Physics Shanghai Jiao Tong UniversityShanghai 200240

Recent experiments have observed magnetic reconnection in laser-produced high-energy-density(HED)plasma *** perform two-dimensional(2-D)particle-in-cell(PIC)simulations to investigate magnetic reconnection between two approaching HED plasma *** is found that the expanding velocity of the bubbles has a great influence on the process of magnetic *** the expanding velocity is small,a single X line reconnection is ***,when the expanding velocity is sufficiently large,we can observe a plasmoid in the vicinity of the X *** the same time,the structures of the electromagnetic field in HED plasma reconnection are similar to that in Harris current sheet reconnection.

关键词： expanding approaching sufficiently

Drug-coated balloons for the treatment of ostial left anterior descending or ostial left circumflex artery lesions:a patientlevel propensity score-matched analysis

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Journal of Geriatric Cardiology 2023年第10期20卷 716-727,I0001-I0005页

作者： Liang PAN Wen-Jie LU Zhan-Ying HAN san-Cong PAN Xi WANG Ying-Guang SHAN Meng PENG Xiao-Fei QIN Guo-Ju SUN Pei-sheng ZHANG Jian-Zeng DONG Chun-Guang QIU Department of Cardiovascular Medicine the First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Cardiology Jincheng People’s HospitalJinchengChina Department of Cardiology the Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

BACKGROUND Controversy exists as to the optimal treatment approach for ostial left anterior descending(LAD)or ostial left circumflex artery(LCx)***-coated balloons(DCB)may overcome some of the limitations of drug-eluting stents(DES).Therefore,we investigated the security and feasibility of the DCB policy in patients with ostial LAD or ostial LCx lesions,and compared it with the conventional DES-only *** We retrospectively enrolled patients with de novo ostial lesions in the LAD or LCx who underwent interventional *** were categorized into two groups based on their treatment approach:the DCB group and the DES *** treatment strategies in the DCB group involved the use of either DCB-only or hybrid strategies,whereas the DES group utilized crossover or precise stenting ***-year target lesion revascularization was the primary endpoint,while the rates of major adverse cardiovascular events,cardiac death,target vessel myocardial infarction,and vessel thrombosis were the secondary *** propensity score matching,we assembled a cohort with comparable baseline *** ensure result analysis reliability,we conducted sensitivity analyses,including interaction,and stratified *** Among the 397 eligible patients,6.25%of patients who were planned to undergo DCB underwent DES.A total of 108 patients in each group had comparable propensity scores and were included in the ***-year target lesion revascularization occurred in 5 patients(4.90%)and 16 patients(16.33%)in the DCB group and the DES group,respectively(odds ratio=0.264,95%CI:0.093–0.752,P=0.008).Compared with the DES group,the DCB group demonstrated a lower major adverse cardiovascular events rate(7.84%vs.19.39%,P=0.017).However,differences with regard to cardiac death,non-periprocedural target vessel myocardial infarction,and definite or probable vessel thrombosis between the groups were *** The utilization of

关键词： lesions balloon treatment

基于双层蚂蚁算法的半导体炉管制程批调度研究

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系统工程理论与实践 2005年第12期25卷 96-101页

作者：梁静钱省三马良上海理工大学管理学院上海200093

借助蚁群系统较强的路径寻优能力与并行搜索特点,设计了一种双层蚂蚁算法,解决了多品种晶圆批连续到达动态环境下非等效平行多机器的批调度问题.仿真实验表明,算法能得到较好的可行解,并优于其他启发式算法,对高负载的工作环境具有良好... 详细信息

借助蚁群系统较强的路径寻优能力与并行搜索特点,设计了一种双层蚂蚁算法,解决了多品种晶圆批连续到达动态环境下非等效平行多机器的批调度问题.仿真实验表明,算法能得到较好的可行解,并优于其他启发式算法,对高负载的工作环境具有良好的适用性.

关键词：批调度炉管蚂蚁算法总完工时间