检索结果-南通市图书馆

Mechanism and recent updates on insulin-related disorders

世界临床病例杂志 2023年第25期11卷 5840-5856页

作者： Shashank Kumar Sabyasachi Senapati Neetu Bhattacharya Amit Bhattacharya Shashank Kumar Maurya hadiya husain Jasvinder Singh Bhatti Abhay Kumar Pandey Department of Biochemistry Central University of PunjabBathinda 151401PunjabIndia Department of Human Genetics and Molecular Medicine Central University of PunjabBathinda 151401PunjabIndia Department of Zoology Dyal Singh CollegeUniversity of DelhiNew Delhi 110003India Department of Zoology Ramjas CollegeUniversity of DelhiNew Delhi 110007India Department of Zoology University of DelhiNew Delhi 110007India Department of Zoology University of LucknowLucknow 226007India Department of Biochemistry University of AllahabadAllahabad(Prayagraj)211002India

Insulin,a small protein with 51 amino acids synthesized by pancreatic β-cells,is crucial to sustain glucose homeostasis at biochemical and molecular *** metabolic dysfunctions are related to insulin-mediated altered glucose *** of the significant pathophysiological conditions linked to the insulin associated disorder is diabetes mellitus(DM)(type 1,type 2,and gestational).Insulin resistance(IR)is one of the major underlying causes of metabolic disorders despite its association with several physiological *** syndrome(MS)is another pathophysiological condition that is associated with IR,hypertension,and ***,several other pathophysiological disorders/diseases are associated with the insulin malfunctioning,which include polycystic ovary syndrome,neuronal disorders,and *** are an uncommon type of pancreatic β-cell-derived neuroendocrine tumor that makes up 2% of all pancreatic *** revealed that different biochemical events,molecular signaling pathways,microRNAs,and microbiota act as connecting links between insulin disorder and associated pathophysiology such as DM,insuloma,neurological disorder,MS,and *** this review,we focus on the insulin-related disorders and the underlying mechanisms associated with the pathophysiology.

关键词： Insulin disorder Diabetes Metabolic syndrome Neurological disorder Obesity Cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A rare complication of measles infection presented with subacute sclerosing panencephalitis: Report of two cases in India

引用

Asian Pacific Journal of Tropical Medicine 2024年第4期17卷 184-187页

作者： Razeen Fatima Amir husain Iram Tabish Department of Medicine JN Medical CollegeAMUAligarhIndia

Rationale:Subacute sclerosing panencephalitis(SSPE)is a progressive neurological disorder caused by persistent measles virus *** predominantly affects children and *** symptoms usually develop 6-15 years after measles infection and ultimately leading to death in many *** concerns:Patient 1 presented with cognitive decline and myoclonus and the Patient 2 presented with diminution of vision with myoclonic ***:Based on the clinical features with a characteristic electroencephalogram pattern and the presence of a high titer of anti-measles IgG in serum and cerebrospinal fluid,these patients were diagnosed as ***:Antiepileptics were started for controlling myoclonus along with supportive ***:Both patients were discharged on antiepileptics and supportive ***:Whenever there are unusual clinical manifestations with unknown vaccination status,SSPE can be suspected and the cerebrospinal fluid should be examined for anti-measles *** case study also highlights the importance of universal coverage of measles *** reduce the incidence of measles and associated deaths,it is important to maintain a high level of immunization coverage for the measles vaccine and to strengthen all the integral components of the national immunization program.

关键词： Subacute sclerosing panencephalitis Measles Myoclonus Electroencephalogram Cerebrospinal fluid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current updates on the epidemiology,pathogenesis and development of small molecule therapeutics for the treatment of Ebola virus infections

引用

Asian Pacific Journal of Tropical Medicine 2024年第7期17卷 285-298,I0001-I0007页

作者： Shah Alam Khan Neelima Shrivastava MdJawaid Akhtar Aftab Ahmad Asif husain Department of Pharmaceutical Chemistry College of PharmacyNational University of Science and TechnologyPO Box 620Postal code 130MuscatSultanate of Oman Centre of Molecular Medicine and Diagnostics(COMMAND) Saveetha Dental College&HospitalsSaveetha Institute of Medical&Technical SciencesSaveetha UniversityChennai 600077India Department of Pharmaceutical Chemistry School of Pharmaceutical Education and ResearchJamia HamdardNew Delhi-110062India Department of Health Information Technology the Applied CollegeKing Abdulaziz UniversityJeddah-21589Kingdom of Saudi Arabia

Ebola virus disease(EVD)is a rare,highly contagious and a deadly disease with a variable fatality rate ranging from 30%to 90%.Over the past two decades,Ebola pandemic has severely affected the sub-Sahara region including Democratic Republic of the Congo(DRC),and *** causative agents of the most EVD cases are three distinct species out of six Ebolaviruses namely Zaire Ebolavirus(ZEBOV),Sudan Ebolavirus(SUDV)and Bundibugyo Ebolavirus(BDBV).In recent years,significant strides have been made in therapeutic ***,the US Food and Drug Administration has approved two monoclonal antibodies:InmazebTM(REGN-EB3)and Ansuvimab or ***,many small molecules are currently in the developmental stage,promising further progress in medical *** the critical need for preventive measures,this review provides an in-depth analysis of the licensed Ebola vaccines-Ervebo and the combination of Zabdeno(***)and Mvabea(MVA-BN-Filo)as well as the vaccines which are currently being tested for their efficacy and safety in clinical *** vaccines might play an important role in curbing the spread and mitigating the impact of this lethal *** current treatment landscape for EVD encompasses both nutritional(supportive)and drug *** review comprehensively details the origin,pathogenesis,and epidemiology of EVD,shedding light on the ongoing efforts to combat this devastating *** explores small molecules in various stages of the development,discusses patents filed or granted,and delves into the clinical and supportive therapies that form the cornerstone of EVD *** review aims to provide the recent developments made in the design and synthesis of small molecules for scientific community to facilitate a deeper understanding of the disease and fostering the development of effective strategies for prevention,treatment,and control of EVD.

关键词： Ebola Epidemic Vaccine Ebola virus diseas

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Case of Refractory Thrombocytopenia in Pregnancy Associated with May-Heglin Anomaly after Repeated Platelet Transfusions

引用

Open Journal of Obstetrics and Gynecology 2024年第7期14卷 1083-1090页

作者： Aalaa A. Wahab Marzooq Aseel Ahmed husain Aayat Jaaffar Naseeb Salmaniya Medical Complex Manama Bahrain

May-Heglin Anomaly is an autosomal dominant disorder characterized by macrothrombocytopenia with a platelet function that is usually preserved. Platelets play an essential role in hemostasis. During pregnancy, a woman is susceptible to complications, including postpartum hemorrhage. Monitoring patients’ hemostatic functions and observing the patient’s clinical picture to maintain patient safety is paramount, while avoiding unnecessary therapeutic measures. This case report presents a rare instance of May-Heglin Anomaly (MHA) in a 35-year-old pregnant patient, with refractory thrombocytopenia despite receiving multiple platelet transfusions. Initially referred to as gravida 5 para 4 with severe thrombocytopenia at 28 weeks gestation, throughout her pregnancy, she was closely monitored and received over 40 units of platelets, which failed to increase her platelet count significantly. She delivered a healthy baby via vaginal delivery at 38 weeks, with her platelet count still critically low. This report highlights the challenges of managing MHA in pregnancy, the inefficacy of standard thrombocytopenia treatments such as platelet transfusion in MHA patients, and the importance of tailored management strategies to ensure maternal and fetal safety.

关键词： Platelets Pregnancy Macrothrombocytopenia MHA

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exploiting open source omics data to advance pancreas research

引用

Journal of Pancreatology 2024年第1期7卷 21-27页

作者： Gayathri Swaminathan Toshie Saito Sohail Z.husain Division of Gastroenterology Hepatology and NutritionDepartment of PediatricsStanford University School of MedicineStanfordCA

The"omics"revolution has transformed the biomedical research landscape by equipping scientists with the ability to interrogate complex biological phenomenon and disease processes at an unprecedented *** volume of"big"data generated by the different omics studies such as genomics,transcriptomics,proteomics,and metabolomics has led to the concurrent development of computational tools to enable in silico analysis and aid data *** the intensive resources and high costs required to generate and analyze big data,there has been centralized,collaborative efforts to make the data and analysis tools freely available as"Open Source,"to benefit the wider research *** research studies have contributed to this"big data rush"and have additionally benefitted from utilizing the open source data as evidenced by the increasing number of new research findings and publications that stem from such *** this review,we briefly introduce the evolution of open source omics data,data types,the"FAIR"guiding principles for data management and reuse,and centralized platforms that enable free and fair data accessibility,availability,and provide tools for omics data *** illustrate,through the case study of our own experience in mining pancreatitis omics data,the power of repurposing open source data to answer translationally relevant questions in pancreas research.

关键词： Gene expression Omics Open source data Pancreatitis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hydrocarbon Potential of the Triassic-Jurassic Sediments in Southeast Sulawesi, Indonesia, Based on Lithofacies and Geochemical Analysis

引用

Open Journal of Geology 2024年第8期14卷 723-745页

作者： Muhammad Sulhuzair Burhanuddin Shun Chiyonobu Takuto Ando Anggi Yusriani Ratna husain Suryawan Asfar Graduate School of International Resources Sciences Akita University Akita Japan Geological Department of Hasanuddin University Makassar Indonesia Geoservices Laboratory South Jakarta Indonesia Geological Department of Haluoleo University Kendari Indonesia

Triassic-Jurassic carbonates widely distributed in Eastern Indonesia are believed as oils source rock. The Mesozoic Tokala Formation exhibit source rock potential, as evidenced by high contents of organic matter. Recent exploration has been conducted in southeastern Sulawesi, targeting the Mesozoic intervals. Therefore, in this study, we attempted to determine source rock potential of Tokala Formation outcropped in southeastern Sulawesi area and its capability to generate hydrocarbon. Five distinct lithofacies were delineated, emphasizing lithological and mineralogical features: foraminifera wackestone (FW), lime mudstone (LM), massive bioturbated calcareous-argillaceous shale (MBCAS), weakly laminated argillaceous-calcareous shale (WLACS), and strongly laminated calcareous-argillaceous shale (SLCAS). Subsequent analyses showed that carbonate-rich samples (FW and LM facies, >50% CaO) had poor source rock potential. Conversely, shale facies with moderate carbonate content (WLACS, MBCAS, and SLCAS, 15% - 50% CaO) had good to excellent source rock characteristics, qualifying them as preferable source rock. In addition, levels of SiO2 and Al2O3 should not be neglected, as these constituents play important roles in clay mineral adsorption. Laminated shale facies with moderate CaO content tended to be more promising as source rock than bioturbated facies. The shale facies of Tokala Formation indicate prospective source rock horizon.

关键词： Source Rock Triassic-Jurassic Source Rock Lithofacies Southeastern Sulawesi Tokala Formation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Development of innovative tripartite partnership for China’s engagement in global health: recommendations from China-Tanzania Cooperation Project on Malaria Control

引用

贫困所致传染病(英文) 2024年第2期13卷 1-3页

作者： Ma Xuejiao Lu Shenning Ding Wei Deng Shanying Wang Duoquan Xiao Ning Mlacha Yeromin husain Lewis Zhou Xiaonong National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector Biology WHO Collaborating Center for Tropical Diseases National Center for International Research On Tropical Diseases Shanghai China University of Hong Kong Hong Kong China School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai China Ifakara Health Institute Dar-es-Salaam Tanzania Institute of Development Studies Brighton UK

Tripartite partnership, compared with the bilateral model, is envisioned as an opportunity to foster stronger and more trusting partnerships [1]. However, China has historically been characterized as principally reliant on bilateral engagement in global health [2]. The China-Tanzania Cooperation Project on Malaria Control was conducted by National Institute of Parasitic Diseases at China CDC and Chinese Center for Tropical Diseases Research, Ifakara Health Institute in Tanzania and funding agencies from 2015 to 2022, with an aim to explore the applicability of Chinese experience on malaria control to reduce malaria disease burden in the local context of Tanzania. In the tripartite project funded by the former UK Department for International Development (DFID) and later the Bill & Melinda Gates Foundation (BMGF), China's partners were expected to share the extensively parallel practices achieved from the control and elimination of malaria for over 70 years, UK's partners were to deliver resources and design global health strategies, while Tanzanian local staff collaborated with triangular partners to ensure the project implementation [3]. In the project, the trilateral cooperation has transparent management mechanism to ensure the concrete management and implementation of the project [4] (Additional file 1: Figure S1). This Brief is to provide recommendations for China's engagement in global health by distilling the experience from the innovative tripartite partnership of the project.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

A rare presentation of unicentric Castleman's disease in the thigh:A case report and review of literature

引用

World Journal of Clinical Cases 2024年第19期12卷 4003-4009页

作者： Sultan AlSheikh Abdulmajeed Altoijry husain Al-Mubarak Ofays Dakkam Alsallum Fadi Alakeel Tariq Alanezi Division of Vascular Surgery Department of SurgeryCollege of MedicineKing Saud UniversityRiyadh 11322Saudi Arabia Division of Vascular Surgery Department of SurgeryKing Khalid Hospital NajranNajran 11321Saudi Arabia Department of Pathology College of MedicineKing Saud UniversityRiyadh 11322Saudi Arabia

BACKGROUND Castleman's disease(CD)is a rare lymphoproliferative,emulating both benign and malignant *** diagnosis of CD is formulated upon the combination of clinical and laboratory criteria and ultimately confirmed by histopathological *** to its rarity,CD presents a challenge in treatment selection,with available options encompassing surgery,chemotherapy,and autologous stem cell ***,studies suggest that surgical resection of the lesion is the most effective treatment modality,especially for unicentric CD(UCD).CASE SUMMARY Here,we describe the case of a 25-year-old woman who presented with painless left thigh swelling for 10 *** had been following a low-fat diet to lose weight and had normal laboratory *** resonance imaging revealed a wellcircumscribed,demarcated cystic lesion located in the left inguinal region with eccentrically positioned signal void vascular structures,measuring 4.3 cm×3 cm×3.2 cm,likely of lymphoid *** patient underwent surgical resection,and the final histopathology showed a vascular proliferation and hyalinization of the vessel walls,along with atretic germinal centers traversed by penetrating vessels,consistent with *** patient was discharged home one day after the procedure in good condition,with a follow-up appointment scheduled in our outpatient *** Although surgical resection is the mainstay for UCD,a multidisciplinary approach is needed due the lack of specific diagnostic features and treatments.

关键词： Castleman’s disease Lymph nodes Surgical resection Lymphoproliferative disorder Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Potential of plant polyphenol oxidases in the decolorization and removal of textile and non-textile dyes

引用

Journal of Environmental Sciences 2007年第4期19卷 396-402页

作者： AMJAD ALI Khan QAYYUM husain Department of Biochemistry Faculty of Life Science Aligarh Muslim UniversityAligarh-202 002India.

In this study an effort has been made to use plant polyphenol oxidases; potato （Solanum tuberosum） and brinjal （Solanum melongena）, for the treatment of various important dyes used in textile and other industries. The ammonium sulphate fractionated enzyme preparations were used to treat a number of dyes under various experimental conditions. Majority of the treated dyes were maximally decolorized at pH 3.0. Some of the dyes were quickly decolorized whereas others were marginally decolorized. The initial first hour was sufficient for the maximum decolorization of dyes. The rate of decolorization was quite slow on long treatment of dyes. Enhancement in the dye decolorization was noticed on increasing the concentration of enzymes. The complex mixtures of dyes were treated with both preparations of polyphenol oxidases in the buffers of varying pH values. Potato polyphenol oxidase was significantly more effective in decolorizing the dyes to higher extent as compared to the enzyme obtained from brinjal polyphenol oxidase. Decolorization of dyes and their mixtures, followed by the formation of an insoluble precipitate, which could be easily removed simply by centrifugation.

关键词： decolorization textile dyes polyphenol oxidases potato brinjal wastewater treatment removal of dyes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental and parametrical investigation of pre-stressed ultrahigh-performance fiberreinforced concrete railway sleepers

引用

Frontiers of Structural and Civil Engineering 2023年第3期17卷 411-428页

作者： Sayed AHMED Hossam ATEF Mohamed husain Department of Structural Engineering Faculty of EngineeringZagazig UniversityZagazig 44519Egypt Track Work Department National Authority for TunnelsCairo 11522Egypt

In this study,ultrahigh-performance fiber-reinforced concrete(UHPFRC)used in a type B70 concrete sleeper is investigated experimentally and *** main parameters investigated are the steel fiber volume fractions(0%,0.5%,1%,and 1.5%).Under European standards,35 UHPFRC sleepers are subjected to static bending tests at the center and rail seat sections,and the screw on the fastening system is pulled *** first cracking load,failure load,failure mode,crack propagation,load–deflection curve,load–crack width,and failure load from these tests are measured and compared with those of a control sleeper manufactured using normal concrete *** accuracy of the parametric study is verified ***,the results of the study are applied to UHPFRC sleepers with different concrete volumes to investigate the effects of the properties of UHPFRC on their *** and parametric study results show that the behavior of UHPFRC sleepers improves significantly when the amount of steel fiber in the mix is *** manufactured using UHPFRC with a steel fiber volume fraction of 1%and a concrete volume less than 25%that of standard sleeper B70 can be used under the same loads and requirements,which contributes positively to the cost and surrounding environment.

关键词： pre-stressed concrete sleeper ultrahigh performance fiber-reinforced concrete pull-out test static bending test steel fiber aspect ratio volume fraction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：