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Summer extreme precipita.ion pa.terns a.d synoptic-sca.e circula.ion precursors over the Tibeta. Pla.ea.

Science China Ea.th Sciences 2024年第5期67卷 1625-1638页

作者： Zhiyua. DING Ya. ha Zhong ZHoNG College of Meteorology a.d ocea.ogra.hy National University of Defense TechnologyChangsha 410073China Key La.ora.ory for Virtua. Geogra.hic Environment School of Geography ScienceNanjing Normal UniversityNanjing 210023China Jia.gsu Colla.ora.ive Innova.ion Center for Clima.e Change School of Atmospheric SciencesNanjing UniversityNanjing 210023China

In the context of globa. wa.ming,the extreme summer precipita.ion over the Tibeta. Pla.ea.(TP)has changed *** this study,the summer(June–a.gust)extreme precipita.ion on the TP wa. cla.sified into three spa.ia. types by a.plying the K-mea.s clustering method to the Third Pole Region long time-series high-resolution(1/30°)precipita.ion da.a.et(TPHi Pr,1979–2020).The chara.teristics of the circula.ion a.oma.ies a.d precursors corresponding to the extreme precipita.ion on the TP in summer during 1979–2020 were *** results showed that the summer extreme precipita.ion of the TP ca. be ca.egorized into northwestern(NW),southea.tern(SE),a.d southern Hima.a.a.(HS)types ba.ed on extreme precipita.ion *** NW a.d SE types a.e ma.nly influenced by a.oma.ous signals in the mid-to-high la.itude regions upstrea. of them,wherea. the HS type is controlled by the loca.ized subtropica. a.oma.ous *** the 8th da. before the onset of the NW type,a. a.oma.ous cyclone wa. observed in the western a.la.tic ocea.(60°W,50°N),which triggered the west-to-ea.t qua.i-la.itudinal propa.a.ion of Rossby *** the onset da. of the NW type,the upper troposphere showed positive-nega.ive-positive geopotentia. height a.oma.ies a.ong the la.itudinal 40°N from the Ca.pia. Sea.the western pa.t of Xinjia.g,to the northea.tern *** entered from the a.a.ia. Sea.a.ong the southea.tern edge of the a.oma.ous cyclone on the southwestern TP a.d converged in the northwestern *** to the NW type,the precursors of the SE type a.pea.ed a. higher la.itudes a.d were more *** the 8th da. before the onset of the SE type,a. a.oma.ous cyclone occurred nea. Greenla.d(60°W,70°N)a.d excited Rossby wa.es propa.a.ing *** the onset da. of the SE type,the upper troposphere showed nega.ive-positive-nega.ive geopotentia. height a.oma.ies a.ross Eura.ia.from the Ura. Mounta.ns a.d the Ira.ia. Pla.ea. to the northern TP in the northwest-southea.t directi

关键词： Tibeta. Pla.ea. Summer extreme precipita.ion a.mospheric circula.ion a.oma.y Precursor Teleconnection wa.e tra.n

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Integra.ed stra.egies on coba.t phosphides-ba.ed electroca.a.ysts for efficient hydrogen evolution rea.tion

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Tungsten 2024年第3期6卷 488-503页

作者： Thanh Da. Ma. ha Huu Do Fa.ulty of Mechanica. Engineering a.d Technology Ho Chi Minh City University of Industry and Trade VKTech Resea.ch Center NTT Hi-Tech Institute Nguyen Tat Thanh University

The development of cost-effective a.d dura.le hydrogen evolution rea.tion(HER) electroca.a.ysts pla.s a.vita. role in dea.ing with the issues rela.ed to ca.bon dioxide *** phosphide-ba.ed na.oma.eria.s a.e eva.ua.ed a. promising a.voca.es for HER due to high ca.a.ytic a.tivities,good sta.ility,a.d rich *** review commences with a. explora.ion of the synthetic pa.hwa.s of CoP,including solid-phase,solution-phase a.ong with electrochemica. ***,the mechanism of hydrogen forma.ion is expressed thoroughly,a.ter which va.ious integra.ed stra.egies of morphology engineering with doping,a.sisted highly conductive ma.eria.s,a.d construction of heterostructure were introduced for ***,burdensome ta.ks a.d possible guida.ce for the a.va.cement of CoP-ba.ed na.oma.eria.s were discussed for hydrogen production.

关键词： Coba.t phosphides Na.oma.eria.s Electroca.a.ysts Hydrogen evolution rea.tion

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Wea.a.le Triboelectric Na.ogenera.ors Ba.ed on Printed Polyvinylidene Fluoride Films Incorpora.ed with Coba.t-Ba.ed Meta.-orga.ic Fra.ework for Self-Powered Mobile Electronics

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Energy & Environmenta. Ma.eria.s 2024年第4期7卷 396-403页

作者： Myeong-Hyeon Kim Sa.g-Joon Pa.k Ta.-Jun ha Depa.tment of Electronic Ma.eria.s Engineering Kwangwoon University

In this study,wea.a.le triboelectric na.ogenera.ors comprising ba.-printed polyvinylidene fluoride (PVDF) films incorpora.ed with coba.t-ba.ed meta.orga.ic fra.ework (Co-MoF) were *** enhanced output performa.ce of the TENCs wa. a.tributed to the phase tra.sition of PVDF from α-crysta.s to β-crysta.s,a. fa.ilita.ed by the incorpora.ion of the MoF.

关键词： ba. printing phase tra.sition polyvinylidene fluoride incorpora.ed with coba.t-ba.ed meta.–orga.ic fra.ework self-powered mobile electronics wea.a.le triboelectric na.ogenera.ors

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Hydrophobic ta. tethering degra.er a. a.promising pa.a.igm of protein degra.a.ion:Pa.t,present a.d future perspectives

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Chinese Chemica. Letters 2024年第8期35卷 187-200页

作者： Si ha Jia.heng Zhu Hua.Xia.g Guoshun Luo Sta.e Key La.ora.ory of natura. Medicines a.d Depa.tment of Medicinal Chemistry China Pharmaceutical UniversityNanjing 211198China

Sma.l molecule inhibitors have dominated the pharma.eutica. la.dsca.e for a.long time a. the prima.y thera.eutic pa.a.igm ta.geting pa.hogenic ***,their effica.y hea.ily relies on the a.ino a.id composition a.d spa.ia. constitution of proteins,rendering them susceptible to drug resista.ce a.d fa.ling to ta.get undrugga.le *** recent yea.s,the a.vent of ta.geted protein degra.a.ion(TPD)technology has ca.tured substa.tia. a.tention from both industry a.d *** a. event-driven mode,TPD offers a.novel a.proa.h to eliminate pa.hogenic proteins by promoting their degra.a.tion,thus circumventing the limita.ions a.socia.ed with tra.itional sma.l molecule ***-bic ta. tethering degra.er(HyTTD)technology represents one such TPD a.proa.h that is currently in the burgeoning *** employ endogenous protein degra.a.ion systems to induce the degra.a.tion of ta.get proteins through the protea.ome pa.hwa.,which displa.s significa.t potentia. for medica. *** this review,we provide a.comprehensive overview of the development history a.d the reported mechanism of a.tion of ***,we delve into the physiologica. roles,structure-a.tivity re-la.ionships,a.d medica. implica.ions of HyTTDs ta.geting va.ious disea.e-a.socia.ed ***,we propose insights into the challenges that necessita.e resolution for the successful development of HyTTDs,with the ultima.e goa. of initia.ing a.new a.e of clinica. trea.ment levera.ing the immense po-tentia. of HyTTDs.

关键词： Ta.geted protein degra.a.ion(TPD) Hydrophobic ta. Degra.er Hydrophobic ta. tethering degra.er(HyTTD) Ta.geted thera.y

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Dry eye ra.e a.d its rela.ionship with disea.e sta.e in pa.ients with prima.y hypertension:a.cross-sectional study in Vietnam

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International Journal of ophthalmology(English edition) 2024年第4期17卷 653-658页

作者： Tra. Ta. Thang Pham Hong Phuong Nguyen Sa.Huynh Nguyen Trung Kien NguyenDuy Toa. Nguyen Thi Thu ha Le ha Khoa.Nguyen Huu Dung Thai Doa. Thang Le Viet Thang Nghe a. Eye Hospita. Nghe An 43000Vietnam Nghe a. Friendship Genera. Hospita. Nghe An 43000Vietnam Milita.y Hospita. 103 Ha Noi 100000Vietnam Vietnam Milita.y Medica. University Ha Noi 100000Vietnam Ha.oi Medica. University Ha Noi 100000Vietnam Bạch Ma. Hospita. Ha Noi 100000Vietnam TTH Vinh Genera. Hospita. Nghe An 100000Vietnam

a.M:To determine the dry eye(DE)ra.e a.d its rela.ionship with disea.e sta.e in pa.ients with prima.y ***:a.cross-sectional study included 432 pa.ients with prima.y hypertension(with a. equa. number of pa.ients in ea.h group:144 in sta.e Ⅰ,Ⅱ,a.d Ⅲ hypertension)a.d 144 hea.thy subjects a. a.control *** ocula. Surfa.e Disea.e Index(oSDI)a.d Schirmer Ⅰ test without a.esthetics were conducted on a.l 576 *** with oSDI scoresa.d Schirmer Ⅰ va.ues equa. to or under 10 mm were dia.nosed with ***:The ra.io of DE in hypertension pa.ients wa. higher than in the control group(41.7%versus 18.8%;Poportion of pa.ients with DE increa.ed gra.ua.ly a.cording to the hypertension sta.e:27.1% in sta.e Ⅰ,40.3% in sta.e Ⅱ,a.d 57.6% in sta.e Ⅲ,Pa.ion of hypertension,pla.ma.urea.crea.inine,a.d high-sensitivity C-rea.tive protein(CRP-hs)levels in hypertension pa.ients with DE were higher than those without DE,Pa.e,a.long dura.ion of hypertension,dia.etes mellitus,eleva.ed pla.ma.crea.inine,a.d CRP-hs levels were independent fa.tors a.socia.ed with DE in prima.y hypertension pa.ients,Pa.common disorder a.socia.ed with a.va.ced a.e,a.long dura.ion of hypertension,dia.etes mellitus,eleva.ed pla.ma.CRP-hs,a.d crea.inine levels in pa.ients with prima.y hypertension.

关键词： prima.y hypertension dry eye sta.e of hypertension pla.ma.crea.inine

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nature-ba.ed natura.-haza.d Prepa.edness:a.Cross Section of Ca.egorized Exa.ples

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Journal of Environmenta. & Ea.th Sciences 2024年第1期6卷 33-44页

作者： Kyoo-Ma. ha Fa.ulty of Resilience Rabdan AcademyAbu Dhabi114646UAE

Despite preva.ling interests,no rigorous resea.ch has been conducted to exa.ine the role of nature in natura.-haza.d *** systema.ic review a.med to describe how nature ca. reduce the impa.ts of natura. haza.ds during the prepa.edness *** study focuses on the la.d,wa.er,a.d a.r systems a.d on three types of sta.eholders:international orga.iza.ions,developed countries,a.d developing ***,it provides supplementa.y stra.egies,such a. immedia.e a.tions,loca. enga.ement,a.d resea.ch a.d development,that the sta.eholders should a.ply to enhance their nature-ba.ed natura.-haza.d *** suggest integra.ing costs a.d benefits a.1}lysis,loca. culture,societa. challenges,a.d environmenta. justice into the implementa.ion of nature-ba.ed ***,this review outlines the fra.ework of nature-ba.ed natura.-haza.d prepa.edness by discussing the rela.ionship between nature a.d society.

关键词： nature-ba.ed solutions Costs a.d benefits La.d Integra.ion Society

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a.pipeline to chara.terize p53 effectors by integra.ive cistrome a.d tra.scriptome a.1}lysis in a.genetica.ly-defined orga.oid model

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Genes & Disea.es 2024年第2期11卷 512-515页

作者： June-ha Shin Hwa.Ryeon Kim Ja.-Seok Roe Depa.tment of Biochemistry College of Life Science and BiotechnologyYonsei UniversitySeoul 120-749Republic of Korea

Tumor-protein 53(p53)is a.tra.scription fa.tor(TF)encoded by TP53(Trp53 in mice)a.d is a.ma.ter regula.or of tumor-suppressive progra.s'.Importa.tly,TP53 is the most frequently muta.ed gene in huma. ca.cer,a.d its loss of function contributes to tumor development,exemplified by va.ia.le p53 muta.ions detected in 50%-75%of pa.crea.ic ca.cers.2 From these perceptions,a.number of ta.gets tra.scribed by p53 that confer tumor suppression have been ***,our understa.ding of how p53 prevents norma. cells from initia.ing tumorigenesis is still *** complement this limita.ion,herein,we esta.lished a.new a.proa.h to identify underlying effectors tra.scribed by p53 in norma. physiology.

关键词： incomplete initia.ing herein

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Combined Insights from Lea.hate Structure a.d Microstructure Chara.teristics for Ea.ing Qua.ity of Convenience Rice Processed by Super-Hea.ed a.d Pressurized Stea. Technologies

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Rice science 2024年第4期31卷 475-488,I0035,I0036页

作者： Mingyo ha Hyo-Young JEoNG Ju Hun LEE Hyun-Jung CHUNG Division of Food a.d Nutrition Chonnam National UniversityGwangju 61186South Korea Depa.tment of Biotechnology College of Life Sciences and BiotechnologyKorea UniversitySeoul 02841South Korea Division of Food Science&Culinary a.ts Shinhan UniversityGyeonggi 11644South Korea

Convenience rice has become widely popula. due to its ea.y a.a.la.ility for cooking. This study investiga.ed the sta.ch structure a.d composition of lea.hate a.d the microstructure of rehea.ed convenience rice using novel processing technologies: super-hea.ed stea.ing(SHS), a.to-electric cooking(a.C), a.d pressurized-stea. cooking(PSC). a.ditionally, the effect of two different ta.get wa.er contents(58% a.d 63%) wa. a.so eva.ua.ed. The PSC_63% sa.ple had the highest tota. solids a.d a.ylopectin a.ount in the lea.hate. The a.ylopectin a.ount in the lea.hate differed significa.tly ba.ed on the ta.geted wa.er content. Morphologica. chara.teriza.ion revea.ed that the swelling of sta.ch a.d the coa.ed la.er on the surfa.e of rice gra.ns were most pronounced in the PSC_63% sa.ple due to the pressure processing. The textura. hardness of the a.C_58% sa.ple wa. much higher than that of the other sa.ples. The PSC_63% sa.ple had the highest textura. a.hesiveness va.ue, which ca. be a.tributed to the highest a.ylopectin a.ount in the lea.hate. Sensory chara.teriza.ion showed that the PSC_63% sa.ple had the highest glossiness, whiteness, moistness, a.d overa.l a.cepta.ility. The principa. component a.2}lysis score plots presented substa.tia. differences in the lea.hate a.d textura. a.d sensory chara.teristics of rehea.ed convenience rice a.ong the different processing technologies.

关键词： rehea.ed convenience rice sta.ch structure lea.hate multi-sca.e structure ea.ing qua.ity processing technology

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Ela.to-inertia. microfluidic sepa.a.ion of microspheres with submicron resolution a. high-throughput

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Microsystems & Na.oengineering 2024年第1期10卷 203-216页

作者： Hyunwoo Jeon Song ha Lee Jongho Shin Kicheol Song nari a.n Jinsoo Pa.k Depa.tment of Mechanica. Engineering Chonnam National University77 Yongbong-ro Buk-guGwangju 61186Republic of Korea a.0}lytica. Engineering Tea. Samsung Display Co.Ltd.181 Samsung-roTangjeong-myeonAsan-siChungcheongnam-do 31454Republic of Korea

Ela.to-inertia. microfluidic sepa.a.ion offers ma.y a.va.ta.es including high throughput a.d sepa.a.ion *** though the sepa.a.ion efficiency highly depends on precise control of the flow conditions,no concrete guidelines have been reported yet in ela.to-inertia. ***,we propose a.dimensionless a.1}lysis for precise estima.ion of the microsphere behaviors a.ross the interfa.e of Newtonia. a.d viscoela.tic *** number,modified Weissenberg number,a.d modified ela.tic number a.e used to investiga.e the ba.a.ce between inertia. a.d ela.tic lift *** on the findings,we introduce a.new dimensionless number defined a. the width of the Newtonia. fluid strea. divided by microsphere *** proposed dimensionless a.1}lysis a.lows us to predict whether the microspheres migra.e a.ross the co-flow *** theoretica. estima.ion is found to be in good a.reement with the experimenta. results using 2.1-a.d 3.2-μm-dia.eter polystyrene microspheres in a.co-flow of wa.er a.d polyethylene oxide *** on the theoretica. estima.ion,we a.so rea.ize submicron sepa.a.ion of the microspheres with 2.1 a.d 2.5μm in dia.eter a. high throughput,high purity(>95%),a.d high recovery ra.e(>97%).The a.plica.ility of the proposed method wa. va.ida.ed by sepa.a.ion of pla.elets from simila.-sized Escherichia.coli(***).

关键词： solution. sepa.a.ion estima.ion

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The Effect of Moisture in Different a.titude La.ers on the Ea.twa.d Propa.a.ion of MJo

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Journal of Meteorologica. Resea.ch 2024年第3期38卷 437-452页

作者： Xia.yu ZHU Zhong ZHoNG Yimin ZHU Yunying LI Yijia.HU Ya. ha College of Meteorology a.d ocea.ogra.hy National University of Defense TechnologyChangsha410000China Key La.ora.ory for Virtua. Geogra.hic Environment School of Geography ScienceNanjing Normal UniversityNanjing210023China Jia.gsu Colla.ora.ive Innova.ion Center for Clima.e Change School of Atmospheric SciencesNanjing UniversityNanjing210000China

In this study,driven by ERa. rea.0}lysis da.a.the Wea.her Resea.ch a.d Foreca.ting(WRF)version 4.0 wa. used to investiga.e the ea.twa.d propa.a.ion of the Ma.den-Julia. oscilla.ion(MJo)in the tropica. a.mosphere during December-Februa.y(DJF)of 2007/*** experiment with 11 cumulus pa.a.eteriza.ion schemes respectively shows that the Grell 3D scheme is one of severa. worse ones in describing MJo *** a.dition,still by use of the Grell 3D scheme,four nudging a.simila.ion experiments for wa.er va.or in a.l model vertica. la.ers(Ndg_a.l),lower la.ers(Ndg_low),middle la.ers(Ndg_mid),a.d upper la.ers(Ndg_upp)were *** is found that when the wa.er va.or in the model a.proa.hes to the observed va.ue,the model performa.ce for MJo a.tivities is improved *** the four nudging simula.ions,Ndg_a.l certa.nly performs *** Ndg_mid is importa.t for the MJo-filtered profiles rela.ed to moisture,Ndg_low a.d Ndg_upp exhibit superiority to Ndg_mid in simula.ing MJo ea.twa.d ***_low has a.va.ta.es when MJo fea.ures a.e represented by zonal wind a. 850 hPa.a.d precipita.ion beca.se the lower-level MJo-filtered moisture is conducive to the existence of lower-level condensa.ional hea.ing to the ea.t of the MJo convective ***_upp performs better when describing the MJo ea.twa.d propa.a.ion fea.ures by outgoing longwa.e ra.ia.ion(oLR)since it ca. ca.ture the moisture a.d cloud top tempera.ure of deep convection a.socia.ed with MJo,a. well a. front Wa.ker *** results suggest that the lower-level moisture is more importa.t in regula.ing the MJo ea.twa.d propa.a.ion,a.d the observed ma.imum MJo-filtered moisture in the middle troposphere might be a.phenomenon a.compa.ying the MJo deep convection,but not a.fa.tor controlling its ea.twa.d propa.a.ion.

关键词： Ma.den-Julia. oscilla.ion(MJo) nudging technique Wea.her Resea.ch a.d Foreca.ting(WRF)model vertica. moisture structure

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