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Rehabilitative Ultrasound Imaging within Clinical Practice

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中国运动医学杂志 2009年第5期28卷 572-574页

作者： Noelle m. Selkow med ATC 3rd Year Doctoral Student University of Virginia

Introduction Rehabilitative Ultrasound Imaging(RUSI)is on the rise among clinical rehabilitation of patients with varying *** use of real-time ultrasound has increased the effectiveness of clinical techniques,improved... 详细信息

关键词：复原超声成像临床实践 RUSI 运动医学

CLINICAL STUDY OF LASERNEEDLE ACUPUNCTURE

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World Journal of Acupuncture-moxibustion 2001年第4期11卷 43-49页

作者： med. m. Weber Facharzt für Allgemeinmedizin, Lnsstr. 10, 37697 Lauenfrde, Germany Facharzt fǖr Allgemeinmedizin L(o)nsstr. 10 37697 Lauenf(o)rde Germany

We are reporting over 500 acupuncture cases, a wide range of illnesses ranging from orthopedic, internal, neurological and psychological diseases, all of which were treated with a newly developed and therefore available Laserneedle system. This system was highly successful in treatment of a variety of illnesses including HWS, BWS and LWS Syndromes, gonarthritis, coxarthritis, rhizarthrosis, periarthritis of the shoulder, epicondylitis humeri radialis, tendinitis, fibromyalgia and PCP, morbus Bechterew, paralysis after stroke, migraine and other headache syndrome, tinnitus, trigeminal neuralgia, gastropathy, bronchial asthma, AVK, mental depression and other psychovegatative burnout syndrome by using both body acupoints and otopoints. Treatment was made by simultaneously using 8 Laserneedles which were not pricked into, but stuck onto the skin. The Laserneedles emit red and infrared Laserrays with a high energy output, so that perceptible, vegetative stimulation can be detected at the acupunctrured sites. We found out, that especially in the therapy resistant, long standing cases and cases with chronic back and spine problems, considerable improvements in easing pain and increasing mobility could be made. Recognizable success was made by using Laserneedles in cases suffering from psychological illnesses, especially psychosomatic related Burnout syndrome and cases of exhaustion. Usually after 2～3 treatments, efficient success was made, without any side effects what so ever.

关键词： Laserneedle system Body acupoints and otopoints Various diseases

Geophysics Contribution for the Determination of Aquifers with a Case Study

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International Journal of Geosciences 2012年第1期3卷 117-125页

作者： Latifa Ouadif Lahcen Bahi Ahmed Akhssas Khadija Baba med menzhi 3GE Laboratory Mohammadia Engineering School Mohammed V Agdal University Rabat Morocco

The determination and monitoring of aquifer formations on the eastern border of moroccan Gharb basin are very difficult because of their spatial and temporal variation. To delimit these formations, a geophysical survey of 52 geoelectric soundings was performed with a mesh of 500 m and electrodes distance between 1000 m and 3000 m. Geoelectric sections and resistivity maps show a horst and graben structure. The correlation of existing oil drillings shows that the Jurassic and Neogene formations are both affected by normal faults causing Jurassic deposits collapse with local thickening of the miocene deposits, and reverse faults delimiting tectonic slices due to tension caused by prerifaine nappe advance. This fact confirms the generated structure by the resistivity method. The isobath map of resistant formations's roof show average depths extending from 400 to 800 m for calcareous sandstone that are potential aquifers while oil drillings indicate over 1000 m depths.

关键词： Aquifer Prerifaine Nappe Resistivity method Geophysical Survey Gharb Basin

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自己的肌肤自己救

自己的肌肤自己救

mechanisms for progression of cervical squamous premalignant lesions:Implications in cervical cancer screening

2020年

作者： medPartner美的好朋友医疗团队

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Mechanisms for progression of cervical squamous premalignant...

Tissue inhibitor of metalloproteinase-1 protects mCF-7 breast cancer cells from paclitaxel-induced apoptosis by decreasing the stability of cyclin B1

第八次全国妇产科学学术会议

作者： Jian Yu Rao, m. D., Associate Professor Dept. of Pathology and Lab med Jonsson Comprehensive Cancer Center University of California at Los Angeles

morphological changes of cervical squamous premalignant lesions have been well defined in the past. These changes include the gradual progression from HPV - associated koilocytie atypia,, to low grade dysplasia, to high grade dysplasia, to carcinoma in situ, and eventually invasive carcinoma. Cytological and histological monitoring by Papsmear and cervical biopsy, coupled with colposcopic examination as well as cone/leep biopsy,have been a successful strategy in reducing the incidence of cervical squamous cell carcinoma. While the latency from HPV infection to cancer is long (around 15 to 20 years), and only a small group of women with HPV infection eventually develop

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南京医科大学学报（自然科学版） 2010年第5期30卷 720-720页

作者： Wang,T Lv,JH Zhang,XF Li,CJ han,X Sun,YJ Nanjing med Univ,Key Lab Human Funct Genom Jiangsu Prov,Nanjing 210029,Peoples R China Nanjing med Univ,Dept Cell Biol & med Genet,Nanjing 210029,Peoples R China Nanjing Univ,Sch med,Nanjing 210008,Peoples R China Nanjing med Univ,Ctr Canc,Nanjing 210029,Peoples R China

Paclitaxel(PTX) is a very effective drug in treating *** disturbs microtubule dynamics and impairs the transition of cells from metaphase to anaphase in mitosis,leading to cell death by ***,the effectiveness of PTX in cancer chemotherapy is hampered by drug resistance in some *** inhibitor of metalloproteinase-1(TImP-1) is well known to be capable of inhibiting *** tumor tissue TImP-1 levels have been significantly associated with a poor response to *** hypothesized that TImP-1 could reduce the sensitivity of breast cancer cells to PTX by inhibiting *** test this hypothesis,we first examined the effects of TImP-1 on the apoptosis induced by PTX and investigated the effects of TImP-1 on the expression and stability of cyclin B1 that critically regulates the metaphase to anaphase transition during mitosis in mCF-7 breast cancer *** data demonstrate that TImP-1 could significantly decrease the sensitivity of mCF-7 cells to PTX-induced apoptosis,attenuate mitotic blockage in G(2) /m,and enhance the degradation of cyclin *** further investigate whether the inhibitory effect of TImP-1 on PTX-induced apoptosis is mediated by lowering levels of cyclin B1,a cyclin B1-expression plasmid was transfected into clone overexpressing *** levels of PTX-induced apoptosis were then *** data showed that the TImP-1-based decrease in PTX-induced apoptosis was reversed by cyclin *** data indicate that TImP-1 can protect breast cancer cells from PTX-induced apoptosis by decreasing the stability of cyclin B1.

关键词：肺癌癌细胞临床化疗

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膝关节前髁解剖的性别差异

中华骨科杂志 2010年第3期30卷 I0018-I0023页

作者： Thomas K. Fehring, mD Susan m. Odum, med CCRC, Josh Hughes, BS Bryan D. Springer, mD Walter B. Beaver Jr., mD 张伟滨(译) 王青禾(译) Investigation performed at the OrthoCarolina Hip and Knee Center Charlotte North Carolina 上海瑞金医院骨科 200025

背景：膝关节前髁解剖形态存在明显性别差异的观点已使存全膝关节假体设计时专门为女性患者设计了薄型前髁假体。我们通过对自己的患者进行观察，发现前髁的解剖形态变异很大，不仅取决于患者的性别，还取决于患者的身材、身高和人种。... 详细信息

背景：膝关节前髁解剖形态存在明显性别差异的观点已使存全膝关节假体设计时专门为女性患者设计了薄型前髁假体。我们通过对自己的患者进行观察，发现前髁的解剖形态变异很大，不仅取决于患者的性别，还取决于患者的身材、身高和人种。鉴于所发现的膝关节前髁解剖存在较大变异，我们试图明确是否真正存在前髁解剖的性别差异。方法：我们对212例随机挑选患者的mRI（男112例，女100例）进行评估。前髁定义为膝关节间隙以上10mm的股骨前侧皮质前方的骨性区域。前髁的内、外侧高度直接从mRI两个层面的标记值读出，以毫米为单位。经计算得出的髁高横径比用来确定患者的身材对前髁的大小是否有影响。

关键词：解剖形态性别差异全膝关节女性患者假体设计形态变异膝关节间隙 mRI

酪氨酸激酶抑制剂BIBFll20治疗特发性肺纤维化的有效性

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中华结核和呼吸杂志 2012年第3期35卷 197-197页

作者： Richeldi L Costabel U Selman m et a1．NEngl J med 北京大学第一医院呼吸内科 100034

背景和目的：特发性肺纤维化（IPF）是一种进行性发展的、病死率很高的肺部疾病。研究结果显示，被数种酪氨酸激酶受体激活的信号通路参与了肺纤维化的过程，因此有人提出抑制这些受体有可能减慢IPF的进展。方法：在一项为期12个月的Ⅱ... 详细信息

背景和目的：特发性肺纤维化（IPF）是一种进行性发展的、病死率很高的肺部疾病。研究结果显示，被数种酪氨酸激酶受体激活的信号通路参与了肺纤维化的过程，因此有人提出抑制这些受体有可能减慢IPF的进展。方法：在一项为期12个月的Ⅱ期临床试验中，我们在IPF患者中评价了4种不同口服剂量的酪氨酸激酶抑制剂BIBFll20与安慰剂相比的有效性和安全性。主要研究终点为用力肺活量（FVC）的年下降率，次要终点包括急性加重的次数、生活质量[用圣乔治呼吸问卷（SGRQ）测定]和肺总量等。结果：共432例IPF患者随机分组后，分别接受BIBFll20的4种剂量之一（50mg1次／d，50mg2次／d，100mg2次／d，或150mg2次／d）或安慰剂。在接受150mg2次／d组中，FVC每年下降0．06L，而安慰剂组每年下降0．19L（多重校正的封闭检验P=0．06，分层检验P=0．01）。与安慰剂相比，该剂量还使急性加重的发生率降低（每100人中分别为15．7次／年、2．4次／年，P=0．02），使SGRQ评分（根据0-100评分量表进行评价，分数越低表明生活质量越好）小幅下降，而安慰剂组SGRQ评分增加（分别为-0．66、5．46，P=0．007）。150mg2次／d组与安慰剂组比较，胃肠道症状（导致150mg20：／d组停药比安慰剂组多）和肝脏转氨酶升高更为常见。结论：与安慰剂相比，酪氨酸酶抑制剂B1BFll20（150mg，2次／d）可降低IPF患者肺功能的年下降率，减少急性加重的次数以及改善生活质量。

关键词：酪氨酸激酶抑制剂特发性肺纤维化有效性圣乔治呼吸问卷酪氨酸酶抑制剂治疗 Ⅱ期临床试验口服剂量

Target blood pressure in diabetes patients with hypertension——What is the accumulated evidence in 2011?

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第8期12卷 611-623页

作者： Peter m.NILSSON Department of Clinical Sciences Lund UniversityUniversity Hospital

There is overwhelming evidence that hypertension is an important risk factor for both macrovascular and microvascular complications in patients with diabetes,but the problem remains to identify appropriate goals for preventive therapies.A number of guidelines (the European Society of Cardiology (ESC)/European Association for the Study of Diabetes (EASD) 2007,the Joint National Committee (JNC)-Ⅶ 2003,the American Diabetes Association (ADA) 2011) have for example advocated a blood pressure goal of less than 130/80 mmHg,but this suggestion has been challenged by findings in recent trials and meta-analyses (2011).The European Society of Hypertension (ESH) therefore recommends a systolic blood pressure goal of "well below" 140 *** on evidence from both randomized controlled trials (hypertension optimal treatment (HOT),action in diabetes and vascular disease:preterax and diamicron mR controlled evaluation (ADVANCE),action to control cardiovascular risk in diabetes (ACCORD)) and observational studies (ongoing telmisartan alone and in combination with ramipril global endpoint trial (ONTARGET),international verapamil-trandolapril study (INVEST),treat to new targets (TNT),and the National Diabetes Register (NDR)),it has been shown that the benefit for stroke reduction remains even at lower achieved blood pressure levels,but the risk of coronary events may be uninfluenced or even increased at lower systolic blood pressure *** a recent meta-analysis,it was therefore concluded that the new recommended goal should be 130-135 mmHg systolic blood pressure for most patients with type 2 *** risk factors should also be controlled with a more ambitious strategy applied in the younger patients with shorter diabetes duration,but a more cautious approach in the elderly and frail patients with a number of vascular or non-vascular *** patients from East Asia,such as China,the stroke risk is relatively higher than the risk of coronary *** must al

关键词： Blood pressure Cardiovascular Diabetes Goal Hypertension Treatment