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Protaetia brevitarsis larvae extract ameliorated obesity in high fat diet-fed mice by modulating gut microbiota and lipid metabolism

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Food Science and Human Wellness 2024年

作者： Zong-Qi Zhang Si-Cong Chen Qing-Lei Wang Chun-Qin Liu Jin-hua Xiao Da-Wei huang College of Life Sciences， Nankai University Hebei Key Laboratory of Soil Entomology， Cangzhou Academy of Agricultural and Forestry Sciences

Due to the rapid development of obesity and related metabolic diseases in the world， it is particularly important to explore the ability of novel materials in regulating obesity. In this study， C57BL/6J obese mice were used as objects， and 16S rRNA gene sequencing and lipidomics techniques were used to explore the regulatory effect and mechanism of the P. brevitarsis ethanol extract (50%， v/v) against obesity. Our results showed that P. brevitarsis extract could significantly reduce the body weight， triglyceride (TG)， total cholesterol (TC)， low-density lipoprotein cholesterol (LDL-C)， and pro-inflammatory cytokines (TNF-α， IFN-γ， and IL-6) levels of HFD-fed mice. Moreover， the P. brevitarsis extract changed the composition and relative abundance of its gut microbiota， especially increasing Akkermansia muciniphila. Meanwhile， the content of short-chain fatty acids (SCFAs) was increased， especially acetic acid and butyric acid， which leads to a decrease in the synthesis and accumulation of lipids in the liver. Furthermore， the P. brevitarsis extract also induced the difference in lipid synthesis in the liver by down-regulating the mRNA levels of SREPB-1C， FAS， and ACC. Therefore， this research provided preliminary work and reference for the development of P. brevitarsis as a functional food for anti-obesity.

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大豆花叶病毒CP基因密码子使用偏性分析

中国油料作物学报 2015年第2期37卷 148-153页

作者：黄赛花袁瑗王成坤任锐何卓伟智海剑南京农业大学大豆研究所国家大豆改良中心作物遗传与种质创新国家重点实验室江苏南京210095

大豆花叶病毒(soybean mosaic virus,SMV)外壳蛋白(coat protein,CP)是SMV基因组的结构蛋白,在SMV侵染大豆的过程中发挥着重要的作用。运用CUSP和Codon W等软件分析了大豆花叶病毒外壳蛋白的密码子的偏性,并与SMV基因组的密码子偏性进... 详细信息

大豆花叶病毒(soybean mosaic virus,SMV)外壳蛋白(coat protein,CP)是SMV基因组的结构蛋白,在SMV侵染大豆的过程中发挥着重要的作用。运用CUSP和Codon W等软件分析了大豆花叶病毒外壳蛋白的密码子的偏性,并与SMV基因组的密码子偏性进行了比较。结果表明,SMV CP偏好于以A/T结尾的密码子;与SMV基因组密码子偏性相比,发现只有8种氨基酸密码子偏性完全一致。ENC与GC3的相关性分析结果显示,CP的密码子使用偏好性受碱基组成等多种因素共同影响。聚类分析显示基于基因CDS序列的聚类结果与基于密码子偏性参数相对密码子使用度(RSCU)的聚类结果基本一致。通过分析CP密码子使用特性,为进一步研究其功能奠定基础。

关键词：大豆花叶病毒 CP基因密码子偏好性

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钱塘江河口弯道潮流场的数值模拟

浙江大学学报（理学版） 2007年第3期34卷 351-356页

作者：祝丽丽孙志林黄赛花夏珊珊孙平锋浙江大学水利与海洋工程系浙江杭州310028

钱塘江河口潮流错综复杂,依靠零星的实测潮流资料无法全面描述其流场特征.本文采用Deldt3D模型对钱塘江河口闻家堰至仓前河段的潮流场进行二维数值模拟,着重研究了河口弯道的流场特性.结果表明,河口弯道流场具有跟无潮河流弯道显著不同... 详细信息

钱塘江河口潮流错综复杂,依靠零星的实测潮流资料无法全面描述其流场特征.本文采用Deldt3D模型对钱塘江河口闻家堰至仓前河段的潮流场进行二维数值模拟,着重研究了河口弯道的流场特性.结果表明,河口弯道流场具有跟无潮河流弯道显著不同的特性,如弯道流速向下游递增;涨、落急主流线分歧;涨、落潮流对丁坝工程的响应不同,以及下游弯道水面横比降大于上游弯道.

关键词：潮流场数值模拟河口弯道钱塘江

Aspartoacylase suppresses prostate cancer progression by blocking LYN activation

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Military Medical Research 2024年第2期11卷 180-205页

作者： Hong Weng Kang-Ping Xiong Wang Wang Kai-Yu Qian Shuai Yuan Gang Wang Fang Yu Jun Luo Meng‑Xin Lu Zhong‑hua Yang Tao Liu Xing huang Hang Zheng Xing-huan Wang Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for Evidence‑Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Biological Repositories Zhongnan Hospital of Wuhan UniversityWuhan 430071China Hubei Key Laboratory of Tumor Biological Behaviors Wuhan 430071China Department of Pathology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for Pathology and Molecular Diagnostics Wuhan UniversityWuhan 430071China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan 430071China

Background:Globally,despite prostate cancer(PCa)representing second most prevalent malignancy in male,the precise molecular mechanisms implicated in its pathogenesis remain ***,elucidating the key molecular regulators that govern disease progression could substantially contribute to the establishment of novel therapeutic strategies,ultimately advancing the management of ***:A total of 49 PCa tissues and 43 adjacent normal tissues were collected from January 2017 to December 2021 at Zhongnan Hospital of Wuhan *** advanced transcriptomic methodologies were employed to identify differentially expressed mRNAs in *** expression of aspartoacylase(ASPA)in PCa was thoroughly evaluated using quantitative real-time PCR and Western blotting *** elucidate the inhibitory role of ASPA in PCa cell proliferation and metastasis,a comprehensive set of in vitro and in vivo assays were conducted,including orthotopic and tumor-bearing mouse models(n=8 for each group).A combination of experimental approaches,such as Western blotting,luciferase assays,immunoprecipitation assays,mass spectrometry,glutathione S-transferase pulldown experiments,and rescue studies,were employed to investigate the underlying molecular mechanisms of ASPA's action in *** Student‘s t-test was employed to assess the statistical significance between two distinct groups,while one-way analysis of variance was utilized for comparisons involving more than two groups.A two-sided P<0.05 was deemed to indicate statistical ***:ASPA was identified as a novel inhibitor of PCa *** expression of ASPA was found to be significantly down-regulated in PCa tissue samples,and its decreased expression was independently associated with patients’prognosis(HR=0.60,95%CI 0.40–0.92,P=0.018).Our experiments demonstrated that modulation of ASPA activity,either through gain-or loss-of-function,led to the suppression or enhancement of PCa cell proliferation,mig

关键词： Prostate cancer Aspartoacylase LYN JNK AP-1 C-Jun Phosphorylation

To explore the mechanism of Yigong San anti-gastric cancer and immune regulation

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1965-1994页

作者： Dou-Dou Lu Ling Yuan Zhao-Zhao Wang Jian-Jun Zhao Yu-hua Du Na Ning Guo-Qing Chen Shi-Cong huang Yi Yang Zhe Zhang Yi Nan School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Chinese Medical Gastrointestinal China-Japan Friendship HospitalBeijing 100029China Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Yigong San(YGS)is a representative prescription for the treatment of digestive disorders,which has been used in clinic for more than 1000 ***,the mechanism of its anti-gastric cancer and regulate immunity are still remains *** To explore the mechanism of YGS anti-gastric cancer and immune *** Firstly,collect the active ingredients and targets of YGS,and the differentially expressed genes of gastric ***,constructed a protein-protein interaction network between the targets of drugs and diseases,and screened hub *** the clinical relevance,mutation and repair,tumor microenvironment and drug sensitivity of the hub gene were ***,molecular docking was used to verify the binding ability of YGS active ingredient and hub *** Firstly,obtained 55 common targets of gastric cancer and *** Kyoto Encyclopedia of Genes and Genomes screened the microtubule-associated protein kinase signaling axis as the key pathway and IL6,EGFR,MMP2,MMP9 and TGFB1 as the hub *** 5 hub genes were involved in gastric carcinogenesis,staging,typing and prognosis,and their mutations promote gastric cancer ***,molecular docking results confirmed that the components of YGS can effectively bind to therapeutic *** YGS has the effect of anti-gastric cancer and immune regulation.

关键词： Gastric cancer Yigong San Mechanism Immune

Effect of quenching cooling rate on residual stress and microstructure evolution of 6061 aluminum alloy

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Journal of Central South University 2024年第7期31卷 2167-2180页

作者： huang Ke YI You-ping huang Shi-quan HE Hai-lin LIU Jie hua Hong-en TANG Yun-jian Research Institute of Light Alloy Central South UniversityChangsha 410083China State Key Laboratory of Precision Manufacturing for Extreme Service Performance Changsha 410083China School of Mechanical and Electrical Engineering Central South UniversityChangsha 410083China

In this study,the cooling rate was manipulated by quenching with water of different temperatures(30,60 and 100℃).Surface and internal residual stresses in the quenched 6061 aluminum alloy samples were measured using hole-drilling and crack compliance methods,***,the processability of the quenched samples was evaluated at cryogenic *** mechanical properties of the as-aged samples were assessed,and microstructure evolution was *** surface residual stresses of samples W30℃,W60℃and W100℃is−178.7,−161.7 and−117.2 MPa,respectively along x-direction,respectively;and−191.2,−172.1 and−126.2 MPa,respectively along *** sample quenched in boiling water displaying the lowest residual stress(~34%and~60%reduction in the surface and core).The generation and distribution of quenching residual stress could be attributed to the lattice distortion *** plasticity was also exhibited in the samples with relatively low quenching cooling rates at cryogenic *** strengthes of the as-aged samples are 291.2 to 270.1 MPa as the quenching water temperature increase from 30℃to 100℃.Fine and homogeneous β"phases were observed in the as-aged sample quenched with boiling water due to the clusters and Guinier-Preston zones(GP zones)premature precipitated during quenching process.

关键词： 6061 aluminum alloy residual stress cooling rate cryogenic cooling mechanical properties microstructure evolution

Active Magnetic Compensation Based on Parametric Resonance Magnetometer

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Journal of Shanghai Jiaotong university(Science) 2024年第2期29卷 280-289页

作者：郭阳李绍良黄艺明骆曼箬刘华 School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Institute of Spacefight Control Technology Shanghai Key Laboratory of Space Intelligent Control TechnologyShanghai Engineer Research Center of InertiaShanghai 201109China

Based on the parametric resonance magnetometer(PRM)theory,this paper establishes an experimen-tal system of *** experimental results are consistent with the theoretical predictions.A PRM has been developed with sensitivity of 0.5 pT/Hz^(1/2),which can detect the magnitude of residual magnetic field;furthermore,a proportion-integration-differentiation(PID)closed-loop magnetic compensation system of the residual magnetic field also has been *** with open-loop compensation,the PID closed-loop compensation reduces the average value of the residual magnetic field in the z-axis direction from 0.0244nT to-0.0023nT,and the mean-square error from 0.2083 nT to 0.0691 *** the same way,the average value of the residual magnetic field in the y-axis direction is reduced from 0.0816nT to-0.0042nT,and the mean-square error from 0.1316nT to 0.0461 *** magnitude of residual magnetic fields in both directions is decreased to the order of picotesla(pT).In addition,based on the signal waveforms of the magnetometer,a method of verifying the effect of magnetic compensation is proposed.

关键词： magnetometer parametric resonance nuclear magnetic resonance gyroscope magnetic compensa-tion proportion-integration-differentiation(PID)

Liver stiffness in hepatocellular carcinoma and chronic hepatitis patients:Hepatitis B virus infection and transaminases should be considered

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World Journal of Hepatology 2024年第7期16卷 1018-1028页

作者： Jia-Yao huang Jian-Yun Peng Hai-Yi Long Xian Zhong Yu-hua Xie Lu Yao Xiao-Yan Xie Man-Xia Lin Department of Medical Ultrasonics The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Liver condition is a crucial prognostic factor for patients with hepatocellular carcinoma(HCC),but a convenient and comprehensive method to assess liver condition is *** stiffness(LS)measured by two-dimensional shear wave elastography may help in assessing liver fibrosis and liver *** hepatitis B(CHB)is an important risk factor for HCC progression,but LS was found to be less reliable in assessing liver fibrosis following hepatitis viral *** hypothesize that the status of hepatitis virus infection would affect the accuracy of LS in assessing the liver *** To test the feasibility and impact factors of using LS to assess liver condition in patients with HCC and *** A total of 284 patients were retrospectively recruited and classified into two groups on the basis of serum CHB virus hepatitis B virus(HBV)-DNA levels[HBV-DNA≥100.00 IU/mL as Pos group(n=200)and40 U/L),the correlations between LS and liver condition indices were not significant(P>0.05).CONCLUSION LS was significantly correlated with most liver condition indices in patients with CHB and ***,these correlations varied according to differences in HBV-DNA and transaminase concentrations.

关键词： Liver function Liver stiffness Elastography Chronic hepatitis B Hepatocellular carcinoma

基于高输入阻抗偶极子的低剖面宽带双极化基站天线

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电子学报 2024年第7期52卷 2300-2306页

作者：黄河马瑞华西安电子科技大学空间科学与技术学院陕西西安710126

本文提出了一种低剖面的宽带双极化基站天线.该天线由两个相互交叉的扇形偶极子演变而来.首先,在扇形偶极子末端增加环形窄微带和金属化通孔,使天线端口输入阻抗增大,达到降低天线高度的目的 .然后,增大扇形偶极子臂的张角,产生第二谐振... 详细信息

本文提出了一种低剖面的宽带双极化基站天线.该天线由两个相互交叉的扇形偶极子演变而来.首先,在扇形偶极子末端增加环形窄微带和金属化通孔,使天线端口输入阻抗增大,达到降低天线高度的目的 .然后,增大扇形偶极子臂的张角,产生第二谐振点,提高天线带宽.该双极化天线工作在2.17~2.7 GHz频段,可提供22%的带宽.而且,由于两个偶极子围绕几何中心高度对称,该天线在工作频带内可以获得较高的隔离度和交叉极化鉴别度,其中隔离度仿真值可达51 dB,0°交叉极化鉴别度仿真值可达48 dB.该天线的峰值增益仿真值高达9.6 dBi.综上所述,该天线具有高隔离、高交叉极化鉴别度和高增益等优点,在基站系统中具有良好的应用前景.

关键词：基站天线双极化天线偶极子天线输入阻抗低剖面天线宽带天线

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