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Engineering T cells for immunotherapy of primary human hepatocellular carcinoma

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Journal of Genetics and Genomics 2020年第1期47卷 1-15页

作者： Leidy DCaraballo Galva Lun Cai Yanxia Shao yukai he Georgia Cancer Center.Medical College of Georgia Augusta University.AugustaGA.30912USA Department of Medicine.Medical College of Georgia Augusta UniversityAugustaGA30912USA

Liver cancers, majority of which are primary hepatocellular carcinoma(HCC), continue to be on the rise in the world. Furthermore, due to the lack of effective treatments, liver cancer ranks the 4th most common cause of male cancer deaths. Novel therapies are urgently needed. Over the last few years,immunotherapies, especially the checkpoint blockades and adoptive cell therapies of engineered T cells,have demonstrated a great potential for treating malignant tumors including HCC. In this review, we summarize the current ongoing research of antigen-specific immunotherapies including cancer vaccines and adoptive cell therapies for HCC. We briefly discuss the HCC cancer vaccine and then focus on the antigen-specific T cells genetically engineered with the T cell receptor genes(TCRTs) and the chimeric antigen receptor genes(CARTs). We first review the current options of TCRTs and CARTs immunotherapies for HCC, and then analyze the factors and parameters that may help to improve the design of TCRTs and CARTs to enhance their antitumor efficacy and safety. Our goals are to render readers a panoramic view of the current stand of HCC immunotherapies and provide some strategies to design better TCRTs and CARTs to achieve more effective and durable antitumor effects.

关键词： Immunotherapy hepatocellular carcinoma T cell receptor Chimeric antigen receptor T cell engineering Gene transfer

Postharvest Variations of Rice Physicochemical Traits and Volatile Compounds under Granary Conditions During Long-Time Storage

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Rice science 2023年第2期30卷 92-95,I0007-I0009页

作者： HU Hao LIU Xingquan he yukai JIN Jiande WU Fenghua HUANG Shiwen ZHANG Jiaojiao College of Food and health Zhejiang Agriculture and Forest UniversityHangzhou 311300China China National Rice Research Institute Hangzhou 310006China Zhejiang Province Grain Reserve Management Co.LTD Hangzhou 310006China

Rice quality is influenced by many factors,viz.,temperature,humidity,atmosphere and storage *** uncover quality variations of rice after postharvest,we estimated the physicochemical properties and volatile compounds of an indica rice Zhongzheyou 8 under granary conditions(20ºC-25ºC in summer and 10ºC-15ºC in other seasons)for three years.

关键词： Traits humidity harvest

A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells(TCR-T cells)against hepatocellular carcinoma

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2215-2230页

作者： Wei Zhu Zhiming Zhang Jinzhang Chen Xiaolan Chen Lei Huang Xiaoyong Zhang Xuan Huang Na Ma Weikang Xu Xuan Yi Xinyu Lu Xin Fu Siwei Li Guoheng Mo Yiyue Wang Guosheng Yuan Mengya Zang Qi Li Xiaotao Jiang Yajing he Sha Wu yukai he Yongyin Li Jinlin Hou State Key Laboratory of Organ Failure Research Guangdong Provincial Key Laboratory of Viral Hepatitis ResearchDepartment of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhouChina Institute of Cellular Medicine Newcastle University Medical SchoolNewcastleUK Department of Pathology The First People’s Hospital of FoshanFoshanChina Dermatology Hospital Southern Medical UniversityGuangzhouChina Department of Immunology School of Basic Medical SciencesSouthern Medical UniversityGuangzhouChina Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhouChina Key Laboratory of Proteomics of Guangdong Province Demonstration Center for Experimental Education of Basic Medical Sciences of ChinaGuangzhouChina Medical College of Georgia Augusta University112015th StreetAugustaGAUSA

Strategies to improve T cell therapy efficacy in solid tumors such as hepatocellular carcinoma(HCC)are urgently *** common cytokine receptorγchain(γc)family cytokines such as IL-2,IL-7,IL-15 and IL-21 play fundamental roles in T cell development,differentiation and effector *** study aims to determine the combination effects of IL-21 in T cell therapy against HCC and investigate optimized strategies to utilize the effect of IL-21 signal in T cell *** antitumor function of AFP-specific T cell receptor-engineered T cells(TCR-T)was augmented by exogenous IL-21 in vitro and in ***-21 enhanced proliferation capacity,promoted memory differentiation,downregulated PD-1 expression and alleviated apoptosis in TCR-T after activation.A novel engineered IL-21 receptor was established,and TCR-T armed with the novel engineered IL-21 receptors(IL-21R-TCR-T)showed upregulated phosphorylated STAT3 expression without exogenous IL-21 ***-21R-TCR-T showed better proliferation upon activation and superior antitumor function in vitro and in ***-21R-TCR-T exhibited a less differentiated,exhausted and apoptotic phenotype than conventional TCR-T upon repetitive tumor antigen *** novel IL-21 receptor in our study programs powerful TCR-T and can avoid side effects induced by IL-21 systemic *** novel IL-21 receptor creates new opportunities for next-generation TCR-T against HCC.

关键词： hepatocellular TCR utilize

人民银行分支行管理体制改革的动力研究——基于进化博弈的复制动态模型

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南方金融 2008年第2期 23-26页

作者：何裕锴中国人民银行广州分行广东广州510120

作为博弈理论的新发展,进化博弈论已成为当代主流经济学的核心内容和最重要的前沿领域之一。本文运用进化博弈论中的复制动态模型对人民银行分支行管理体制改革的发展轨迹进行模拟,分析人民银行分支行进一步深化管理体制改革的动力机制... 详细信息

作为博弈理论的新发展,进化博弈论已成为当代主流经济学的核心内容和最重要的前沿领域之一。本文运用进化博弈论中的复制动态模型对人民银行分支行管理体制改革的发展轨迹进行模拟,分析人民银行分支行进一步深化管理体制改革的动力机制,得出以下主要结论:第一,鼓励首创和宽容失败的体制环境是人民银行分支行参与改革的先决条件;第二,改革收益递增与机会主义行为利益递减是人民银行分支行改革持续深入的激励相容约束条件;第三,政策支持与经验推广是人民银行分支行改革效用的倍增器。

关键词：人民银行分支行改革动力进化博弈论复制动态模型

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异香豆素类衍生物的卤化烷氧基化反应

精细化工 2022年第4期39卷 859-864页

作者：孙慧敏何玉凯曹阳江苏海洋大学江苏省海洋药物筛选重点实验室江苏连云港222005

以N-溴代丁二酰亚胺(NBS)、N-氯代丁二酰亚胺(NCS)分别为溴代、氯代试剂,醇类化合物作为反应原料及溶剂,实现了异香豆素类衍生物3,4-位的卤化烷氧基化反应。室温(25℃)下即可在3,4-位之间发生加成反应,合成具有潜在药理活性的异色满-1-... 详细信息

以N-溴代丁二酰亚胺(NBS)、N-氯代丁二酰亚胺(NCS)分别为溴代、氯代试剂,醇类化合物作为反应原料及溶剂,实现了异香豆素类衍生物3,4-位的卤化烷氧基化反应。室温(25℃)下即可在3,4-位之间发生加成反应,合成具有潜在药理活性的异色满-1-酮类衍生物。对4-溴-3-甲氧基-3-苯基异色满-1-酮(Ⅳa)的合成反应条件进行了优化。结果表明,当n(NBS)∶n[3-苯基-4H-异色满-1-酮(Ⅲa)]=2.0∶1、Ⅲa 0.09 mmol、甲醇为2 mL时,在25℃下反应7 h,产物Ⅳa的收率为90%。在上述最佳反应条件下,也可高收率(80%~90%)得到异色满-1-酮类衍生物。产物结构经^(1)HNMR、^(13)CNMR和HRMS确定。

关键词：异香豆素类衍生物卤化烷氧基化异色满-1-酮类衍生物加成反应精细化工中间体

Subcloning and Expression of Human Papillomavirus Type 16 E2 Gene in ***

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Journal of Medical Colleges of PLA(China) 1989年第2期4卷 163-168页

作者：何玉凯徐钤 Department of Biochemistry First Military Medical UnioersityGuangzhou

By using molccular doning technique,the E2 gene of human papillomavirus type 16 wasexpressed in *** 3.2 kb fragment containing the E2 gene was cut out from HPV16 genomeand blunted with nuelease *** plasmid pBD2 DNA was linearized with Hind Ⅲ and bluntedwith nuclasc S1 *** ligation,thc ligsted DNA was used to transform *** BMH *** positive colonies were screened by in situ hybridization technique,and proceedcd to DNA analy-sis and proton *** purified expressed protein was used to run immunoclctrophoreesis withantiserum against *** concktudcd that thc expressed protcin was a fusion protein ofbeta-galae-sidasc-E2 protein.

关键词： human papillomavirus transactivation cell transformation cloning and expression rocombinant DNA

Gadd45 proteins are important for the function of gamma delta T cellsand tumor immune surveillance

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Gadd45 proteins are important for the function of gamma delt...

不同价格变量下中央银行员工岗位双向选择的博弈分析

2007医学前沿论坛暨第十届全国肿瘤药理与化疗学术会议

作者： Songguang Ju Changyou Li Yani Zhao yukai he Lin Liu Binfeng Lu University of Pittsburgh School of Medicine and Cancer Institute

＜正＞The stress responsive growth arrest and DNA damage-inducible protein 45（Gadd45）gene family consists of three members,namely Gadd45a,Gadd45b and ***45b and Gadd45g are predominantly expressed in TH1 ***45b and ...

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海南金融 2007年第3期 13-15,29页

作者：何裕锴中国人民银行广州分行广东广州510120

本文用博弈论的方法就中央银行员工岗位双向选择的机制进行分析。试述在不同价格变量下,制度安排所产生的截然不同的政策效果,进而揭示出不同政策效果背后利益根源及价值取向所发生的变化,并提出解决的理论方向和激励相容约束的基本条件。

关键词：中央银行组织行为价格双向选择博弈

王平采用培元固本消瘿散结法治疗瘿病经验撷菁

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湖北中医杂志 2024年第3期46卷 18-21页

作者：贺宇楷王平湖北中医药大学中医学院湖北武汉430061 湖北中医药大学老年医学研究所湖北武汉430065

瘿病,亦称瘿气、瘿瘤,是一类以颈前喉结两旁结块肿大为主要临床特征的疾病。西医中单纯性甲状腺肿、甲状腺结节、甲状腺功能亢进症、甲状腺炎、甲状腺腺瘤、甲状腺癌均属本病范畴。根据我国甲状腺疾病流行病学调查,各类甲状腺疾病患病... 详细信息

瘿病,亦称瘿气、瘿瘤,是一类以颈前喉结两旁结块肿大为主要临床特征的疾病。西医中单纯性甲状腺肿、甲状腺结节、甲状腺功能亢进症、甲状腺炎、甲状腺腺瘤、甲状腺癌均属本病范畴。根据我国甲状腺疾病流行病学调查,各类甲状腺疾病患病率高达50.96%,甲状腺功能异常患病率达15.22%[1]。这类疾病不仅对患者个人身心健康创剧痛深,还为社会带来沉重负担。

关键词：瘿病培元固本中医治疗王平名医经验