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Prognostic factors and predictors of postoperative adjuvant transcatheter arterial chemoembolization benefit in patients with resected hepatocellular carcinoma

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World Journal of Gastroenterology 2020年第10期26卷 1042-1055页

作者： Ming-Yu Chen Sarun Juengpanich jia-hao hu Win Topatana jia-Sheng Cao Chen-hao Tong jian Lin Xiu-Jun Cai Department of General Surgery Sir Run-Run Shaw HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina School of Medicine Zhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Engineering Research Center of Cognitive Healthcare of Zhejiang Province Hangzhou 310000Zhejiang ProvinceChina Department of General Surgery Shaoxing People’s HospitalZhejiang UniversityShaoxing 312000Zhejiang ProvinceChina Department of General Surgery Longyou People’s HospitalQuzhou 314400Zhejiang ProvinceChina

BACKGROUND Postoperative adjuvant transcatheter arterial chemoembolization (PA-TACE) has improved overall survival (OS) in patients with hepatocellular carcinoma (HCC).However,the prognostic and predictive factors remain *** To assess the prognostic factors and the predictors of PA-TACE benefit for OS in patients with resected *** Univariate and multivariate analyses were performed to identify the potential prognostic factors for *** order to assess the predictive factors of PA-TACE benefit,the interaction variables between treatments for each subgroup were evaluated using the Cox proportional hazards regression *** A total of 378 patients (PA-TACE vs surgery alone,189:189) from three centerswere included after a propensity-score 1:1 matching *** to the group receiving surgery alone,PA-TACE prolonged the OS rate in patients with resected HCC (P <0.001).The Barcelona Clinic Liver Cancer system and ferritinto-hemoglobin ratio (FHR) were used as the prognostic factors for OS in both *** (P=0.023) and microscopic vascular invasion (MVI)(P=0.002) were also identified in the PA-TACE group,while gender (P=0.027),hepatitis B virus(P=0.034) and albumin-bilirubin grade (P=0.027) were also selected in the surgery alone *** addition,PA-TACE resulted in longer OS than surgery alone across subgroups [all hazard ratios (PA-TACE-to-surgery alone)<1].Notably,a significantly prolonged OS following PA-TACE was observed in patients with high FHR (P=0.038) and without MVI (P=0.048).CONCLUSION FHR and Barcelona Clinic Liver Cancer stages were regarded as prognostic factors for ***,high FHR and the absence of MVI were important predictive factors,which can be used to assist clinicians in selecting which patients could achieve a better OS with PA-TACE.

关键词： Postoperative adjuvant transcatheter arterial chemoembolization Hepatocellular carcinoma Prognostic factors Predictive factors Overall survival

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Biologic therapy for Crohn’s disease over the last 3 decades

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World Journal of Clinical Cases 2022年第2期10卷 594-606页

作者： Ji-Liang Shen Zheng Zhou jia-Sheng Cao Bin Zhang jia-hao hu jia-Ying Li Xiao-Ming Liu Sarun Juengpanich Ming-Song Li Xu Feng Department of General Surgery Sir Run-Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016Zhejiang ProvinceChina Department of Gastroenterology Nan Fang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Gastroenterology Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Despite the overload of publications on Crohn’s disease(CD),no comprehensive analysis of biologic therapy for CD has been *** To determine knowledge gaps and identify areas of interest of biologic therapy for *** The top 100 highest-cited original articles were identified from January 1991 to December 2020 in the Clarivate Analytics Web of Science Core Collection *** conducted a bibliometric analysis of biologic therapy for CD based on total citations,summarized the bibliographic information of the articles related to CD biologic therapy,and explored the research *** The top 100 highest-cited original articles were identified with total citations ranging from 307 to *** 2000s(Period II,n=66)yielded the most influential original articles and saw the most dramatic *** the top 10 countries,including 8 European countries and 2 North American countries,the United States(n=37)and Belgium(n=20)contributed the most *** the top 10 institutions,the University Hospital Gasthuisberg in Belgium(n=23),the University of Chicago in the United States(n=20),and the Mayo Clinic in the United States(n=17)published the most *** authors,Rutgeerts P in Belgium(n=32),Sandborn WJ in the United States(n=23),and Feagan BG in Canada(n=18)published the highest number of *** cooperation relationships between the United States and Europe were most ***(impact factor=22.682)published the most articles on biologic therapy for CD(n=32)with 17654 total ***-tumor necrosis factor biologics and monoclonal antibodies were the most studied *** The bibliometric analysis emphasized the key contributions to the development of the specialized *** data would provide useful research insights into biologic therapy for CD for clinicians and researchers.

关键词： Biologic therapy Crohn’s disease Bibliometric analysis Most influential Insight

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Mediation Effects of Placental Inflammatory Transcriptional Biomarkers on the Sex-Dependent Associations between Maternal Phthalate Exposure and Infant Allergic Rhinitis: A Population-Based Cohort Study

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Biomedical and Environmental Sciences 2022年第8期35卷 711-721页

作者： WANG jian Qing LI Zhi Juan GAO hui SHENG Jie LIANG Chun Mei hu Ya Bin XIA Xun huANG Kun WANG Su Fang Zhu Peng hao jia hu TAO Fang Biao Department of Maiernal Child and Adolescent HealthSchool of Public HealthAnhui Medical UniversityHefei 230032AnhuiChina MOE Key Laboratory of Popularion Health across Life Cycle Hefei 230032AnhuiChina NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract Hefei 230032AnhuiChina Anhui Provincial Key Laboratory of Population Health and Aristogenics Anhui Medical UniversityHefei 230032AnhuiChina The Fourth Affiliated Hospital Anhui Medical UniversiyHefei 230022AnhuiChina Department of Pediatrics First Afiliated Hospital of Anhui Medical UniversityHefei 230022AnhuiChina

Objective Prenatal phthalate exposure has been associated with placental inflammatory factors and infant allergic rhinitis(AR).However,the results are *** designed a population-based cohort study to examine the effects of placental inflammatory biomarkers on the sex-dependent associations between maternal phthalate exposure and infant *** A total of 2,348 pregnant women from Ma’anshan,Anhui Province,China,who were screened before antenatal visits and met the inclusion criteria,were included in the present *** assessed AR in their offspring aged 36 months with a *** PCR was performed to measure placental inflammatory factor m *** independent samples t-test and multivariable logistic regression were used to determine the associations between infant AR and maternal *** Childhood AR may be related to education and family monthly income(P = 0.01).The phthalate metabolites,mono(2-ethylhexyl) phthalate(MEHP),mono(2-ethyl-5-hydroxyl) phthalate(MEHHP),in pregnant women were associated with a significantly increased risk for infant AR in males[P < 0.05;odds ratio(OR):1.285;95% confidence interval(CI):1.037-1.591,and OR:1.232,95% CI:1.008-1.507,respectively],but not ***,irritably-increased expression levels of HO-1 and IL-4 were associated with AR in male infants(OR:1.175;95% CI:1.038-1.329 and OR:1.181;95% CI:1.056-1.322,respectively).The association between maternal urinary MEHHP and placental HO-1 was marginally significant according to mediation *** The associations of maternal MEHHP and MEOHP levels with fetal AR in males were *** HO-1 was a fractional mediator in the associations between MEHHP and ***,the placenta should be further investigated as a potential mediator of maternal exposure-induced disease risk in children.

关键词： Phthalate Infants Allergic rhinitis Inflammation Sex difference

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Laparoscopic surgery for early gallbladder carcinoma:A systematic review and meta-analysis

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World Journal of Clinical Cases 2020年第6期8卷 1074-1086页

作者： Xu Feng jia-Sheng Cao Ming-Yu Chen Bin Zhang Sarun Juengpanich jia-hao hu Win Topatana Shi-Jie Li Ji-Liang Shen Guang-Yuan Xiao Xiu-Jun Cai Hong Yu Department of General Surgery Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Department of General Surgery Jiaxing Hospital of Traditional Chinese MedicineJiaxing 314000Zhejiang ProvinceChina

BACKGROUND There is a controversy as to whether laparoscopic surgery leads to a poor prognosis compared to the open approach for early gallbladder carcinoma (GBC)We hypothesized that the laparoscopic approach is an alternative for early *** To identify and evaluate the safety and feasibility of laparoscopic surgery in the treatment of early *** A comprehensive search of online databases,including MEDLINE (PubMed),Cochrane libraries,and Web of Science,was performed to identify noncomparative studies reporting the outcomes of laparoscopic surgery and comparative studies involving laparoscopic surgery and open surgery in early GBC from January 2009 to October 2019.A fixed-effects meta-analysis was performed for 1-and 5-year overall survival and postoperative complications,while 3-year overall survival,operation time,blood loss,the number of lymph node dissected,and postoperative hospital stay were analyzed by random-effects *** The review identified 7 comparative studies and 8 non-comparative studies.1068 patients (laparoscopic surgery:613;open surgery:455) were included in the meta-analysis of 1-,3-,and 5-year overall survival with no significant differences observed [(HR=0.54;95%CI:0.29-1.00;12=0.0%;P=0.051),(HR=0.75;95%CI:0.34-1.65;I^2=60.7%;P=0.474),(HR=0.71;95%CI:0.47-1.08;I^2=49.6%;P=0.107),respectively].There were no significant differences in operation time[weighted mean difference (WMD)=18.69;95%CI:-19.98-57.36;I^2=81.4%;P=0.343],intraoperative blood loss (WMD=-169.14;95%CI:-377.86-39.57;I2=89.5%;P=0.112),the number of lymph nodes resected (WMD=0.12;95%CI:-2.95-3.18;I^2=73.4%;P=0.940),and the complication rate (OR=0.69;95%CI:0.30-1.58;I2=0.0%;P=0.377) between the two groups,while patients who underwent laparoscopic surgery had a reduced length of hospital stay (WMD=-5.09;95%CI:-8.74--1.45;I2=91.0%;P=0.006).CONCLUSION This systematic review and meta-analysis confirms that laparoscopic surgery is a safe and feasible alternative to open sur

关键词： Laparoscopic surgery Open surgery Early gallbladder carcinoma Survival Meta-analysis

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Adhesive cryogel particles for bridging confined and irregular tissue defects

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Military Medical Research 2023年第6期10卷 763-777页

作者： Yao-Ting Xue Ming-Yu Chen jia-Sheng Cao Lei Wang jia-hao hu Si-Yang Li Ji-Liang Shen Xin-Ge Li Kai-Hang Zhang Shu-Qiang hao Sarun Juengpanich Si-Bo Cheng Tuck-Whye Wong Xu-Xu Yang Tie-Feng Li Xiu-Jun Cai Wei Yang Department of Engineering Mechanics Zhejiang UniversityHang‑zhou 310027China Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Zhejiang UniversityHangzhou 310027China Center for X‑Mechanics Department of Engineering MechanicsZhejiang Univer‑sityHangzhou 310027China Department of General Surgery Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China Soft Intelligent Materials Co. LtdSuzhou 215123China School of Biomedical Engineering and Health Sciences and Advanced Membrane Technology Research Centre Universiti Teknologi Malaysia81310 SkudaiMalaysia

Background Reconstruction of damaged tissues requires both surface hemostasis and tissue *** with damage resulting from physical trauma or surgical treatments may have arbitrary surface topographies,making tissue bridging *** This study proposes a tissue adhesive in the form of adhesive cryogel particles(ACPs) made from chitosan,acrylic acid,1-ethyl-3-(3-dimethylaminopropyl) carbodiimide(EDC) and N-hydroxysuccinimide(NHS).The adhesion performance was examined by the 180-degree peel test to a collection of tissues including porcine heart,intestine,liver,muscle,and *** of ACPs was evaluated by cell proliferation of human normal liver cells(LO2)and human intestinal epithelial cells(Caco-2).The degree of inflammation and biodegradability were examined in dorsal subcutaneous rat *** ability of ACPs to bridge irregular tissue defects was assessed using porcine heart,liver,and kidney as the ex vivo ***,a model of repairing liver rupture in rats and an intestinal anastomosis in rabbits were established to verify the effectiveness,biocompatibility,and applicability in clinical *** ACPs are applicable to confined and irregular tissue defects,such as deep herringbone grooves in the parenchyma organs and annular sections in the cavernous *** formed tough adhesion between tissues[(670.9±50.1) J/m^(2) for the heart,(607.6±30.0) J/m^(2) for the intestine,(473.7±37.0) J/m^(2) for the liver,(186.1±13.3) J/m^(2) for the muscle,and(579.3±32.3) J/m^(2) for the stomach].ACPs showed considerable cytocompatibility in vitro study,with a high level of cell viability for 3 d[(98.8±1.2)%for LO2 and(98.3±1.6)%for Caco-2].It has comparable inflammation repair in a ruptured rat liver(P=0.58 compared with suture closure),the same with intestinal anastomosis in rabbits(P=0.40 compared with suture anastomosis).Additionally,ACP-based intestinal anastomosis(less than 30 s) was remarkably faster than the convention

关键词： Tissue reconstruction Wet adhesion Adhesive hydrogel Bioadhesive

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Artificial intelligence in gastroenterology and hepatology:Status and challenges

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World Journal of Gastroenterology 2021年第16期27卷 1664-1690页

作者： jia-Sheng Cao Zi-Yi Lu Ming-Yu Chen Bin Zhang Sarun Juengpanich jia-hao hu Shi-Jie Li Win Topatana Xue-Yin Zhou Xu Feng Ji-Liang Shen Yu Liu Xiu-Jun Cai Department of General Surgery Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Zhejiang University School of Medicine Zhejiang UniversityHangzhou 310058Zhejiang ProvinceChina School of Medicine Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina College of Life Sciences Zhejiang UniversityHangzhou 310058Zhejiang ProvinceChina

Originally proposed by John McCarthy in 1955,artificial intelligence(AI)has achieved a breakthrough and revolutionized the processing methods of clinical medicine with the increasing workloads of medical records and digital *** are paying attention to AI technologies for various diseases in the fields of gastroenterology and *** review will illustrate AI technology procedures for medical image analysis,including data processing,model establishment,and model ***,we will summarize AI applications in endoscopy,radiology,and pathology,such as detecting and evaluating lesions,facilitating treatment,and predicting treatment response and prognosis with excellent model *** current challenges for AI in clinical application include potential inherent bias in retrospective studies that requires larger samples for validation,ethics and legal concerns,and the incomprehensibility of the output ***,doctors and researchers should cooperate to address the current challenges and carry out further investigations to develop more accurate AI tools for improved clinical applications.

关键词： Artificial intelligence Gastroenterology Hepatology Status Challenges

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Towards prenatal biomonitoring in Nanjing, China： lead and cadmium levels in the duration of pregnancy

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Chinese Medical Journal 2013年第16期126卷 3107-3111页

作者： LIU Kang-sheng MAO Xiao-dong hao jia-hu SHI Juan DAI Chun-fang CHEN Wen-jun Department of Clinical Laboratory State Key Laboratory ofReproductive Medicine Nanjing Matemity and Child Health CareHospital Affiliated to Nanjing Medical University Nanjing Jiangsu210029 China Department of Endocrine Jiangsu Province Academy of TraditionalChinese Medicine Nanjing Jiangsu 210028 China Department of Nutrition and Food Hygiene School of Public Healthof Anhui Medical University Hefei Anhui 230032 China Department of Maternity and Child Health Care Nanjing Maternity and Child Health CareHospital Nanjing Jiangsu 210004 China Departmentof Obstetrics Nanjing Maternity and Child Health CareHospital Nanjing Jiangsu 210004 China

Background Prenatal lead and cadmium exposure will not only influence the mother＇s organ systems,but also will provide an environment that may influence the fetus and neonate in a harmful *** the present study,we detected the blood lead levels （BLLS） and cadmium levels for the duration of pregnancy and 6-12 weeks after delivery and to analyze the influencing factors of BLLs in healthy pregnant *** A cohort study survey was carried *** recruited 174 healthy pregnant women without pregnancy or obstetric complications or abnormal pregnancy outcomes as the gravida group,and 120 healthy non-pregnant women as the control *** The lead concentrations in the three pregnancy trimesters and in the postpartum period were：（5.98±2.43）,（5.54±2.01）,（5.59±1.97）,and （6.76±1.74） μg/dl; and （6.75±2.13） μg/dl in the control *** cadmium concentrations in the three pregnancy trimesters and postpartum period were 1.61±0.45,1.63±0.46,1.64±0.49,and 1.67±*** found that the BLLs in the gravida group were lower than in the control group during all three ***,supplement nutritional elements （dietary supplements and nutritional （food） elements）,and the time of house painting could affect BLLs in pregnant ***-related occupations,using cosmetics,and living in a house painted more recently than one year previously are risk factors of high BLLs among pregnant women,while calcium,iron,zinc,and milk supplements are protective *** These findings may help people,especially pregnant women,to reduce lead exposure via supplements of calcium,iron,zinc,and milk or avoiding contacting risk factors.

关键词： blood lead levels blood cadmium levels pregnancy lead exposure

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皮质下缺血性抑郁症患者5-羟色胺转运体基因启动子区基因多态性和认知功能研究

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中华老年医学杂志 2011年第6期30卷 441-445页

作者：梁栋郝加虎孙中武安徽医科大学第一附属医院神经内科 230022 安徽医科大学公共卫生学院

目的探讨皮质下缺血性抑郁症（SID）患者5-羟色胺转运体基因启动子区（5-HTTLPR）基因多态性分布特征和认知功能及其之间关系。方法运用汉密尔顿抑郁量表（HAMD）、简易智能状态检查量表（MMSE）、蒙特利尔量表（MoCA）对所有被试者进... 详细信息

目的探讨皮质下缺血性抑郁症（SID）患者5-羟色胺转运体基因启动子区（5-HTTLPR）基因多态性分布特征和认知功能及其之间关系。方法运用汉密尔顿抑郁量表（HAMD）、简易智能状态检查量表（MMSE）、蒙特利尔量表（MoCA）对所有被试者进行抑郁和认知功能评定。运用多聚酶链式反应-限制性片段长度多态性技术（PCR—RFLP）检测60例SID患者与60例健康老年对照者5-HTTLPR基因多态性的分布频率。结果SID组与对照组比较，5-HTTLPR基因型频率及等位基因频率差异均有统计学意义（χ2=7．833及χ2=6．290，均P〈0．05），SID患者ss等位基因型频率（58．3％）显著高于对照组（23．3％）；S等位基因频率（68．3％）也显著高于对照组（52．5％）。SID组MoCA总分（23．63士1．59）分，低于对照组的（27．25±1．59）分，差异具有统计学意义（χ2=12．44，P〈0．01）。结论5HTTLPR的SS基因型可能是SID的易感基因。SS纯合子可能是SID特别是女性发病的危险因子；等位基因I。及其纯合子可能是SID抑郁症状的保护因子。SID患者存在一定的认知功能损害。

关键词：抑郁症脑缺血血清素基因表达多态性,限制性片段长度认知障碍

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中国儿童青少年抑郁症状性别差异的流行病学调查

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中华流行病学杂志 2013年第9期34卷 893-896页

作者：王熙孙莹安静郝加虎陶芳标安徽医科大学公共卫生学院儿少卫生与妇幼保健学系安徽人口健康与优生省级实验室合肥230032

目的了解中国儿童青少年抑郁症状的流行特征和性别差异。方法采取整群抽样，在全国9个协作地区选取9．0～18．9岁汉族城乡各年龄组儿童青少年男女生各50人，每个地区最低样本量为2000人。采用儿童抑郁量表（CDI）评定小学四年级至高中... 详细信息

目的了解中国儿童青少年抑郁症状的流行特征和性别差异。方法采取整群抽样，在全国9个协作地区选取9．0～18．9岁汉族城乡各年龄组儿童青少年男女生各50人，每个地区最低样本量为2000人。采用儿童抑郁量表（CDI）评定小学四年级至高中三年级青少年的抑郁症状，评估第二性征（男女童阴毛、女童乳房和男童外生殖器）发育指标。结果中国青少年抑郁症状总检出率为14．81％，男女生抑郁症状检出率分别为15．35％和14．43％。农村地区儿童青少年抑郁症状检出率（16．41％）高于城市（13．23％）。10、11岁组男生抑郁症状检出率均高于同龄女生（χ2=11．625，P〈0．005；χ2=5．807，P〈0．005），17岁组女生抑郁症状检出率（21．5％）高于同龄男生（17．26％）（χ2=6．192，P〈0．005）。仅在Tanner发育Ⅱ期，男生抑郁检出率（18．4％）高于女生（15．8％），差异有统计学意义（χ2=6．593，P〈0．005）。结论在特殊年龄段和特定发育阶段，中国儿童青少年抑郁症状检出率存在性别差异，但还需要进一步纵向研究加以证实。

关键词：抑郁症状性别差异儿童青少年

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孕期亚临床甲状腺功能减退对胎儿及儿童发育的影响及相关机制

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实用儿科临床杂志 2010年第11期25卷 860-863页

作者：刘芳陶芳标郝加虎安徽医科大学公共卫生学院儿少卫生与妇幼保健学系合肥230032 安徽人口健康与优生省级实验室合肥230032

孕期亚临床甲状腺功能减退影响胎儿及儿童发育,主要表现在神经心理、妊娠结局及行为等方面,其中神经心理发育包括脑、智力和认知发育;不良妊娠结局有低出生体质量、早产及宫内发育迟缓;不良行为表现包括焦虑/抑郁,注意力问题和攻击行为... 详细信息

孕期亚临床甲状腺功能减退影响胎儿及儿童发育,主要表现在神经心理、妊娠结局及行为等方面,其中神经心理发育包括脑、智力和认知发育;不良妊娠结局有低出生体质量、早产及宫内发育迟缓;不良行为表现包括焦虑/抑郁,注意力问题和攻击行为综合征等。现从甲状腺素的角度出发,介绍孕期亚临床甲状腺功能减退对胎儿及儿童发育的影响及相关机制。

关键词：甲状腺功能减退神经心理神经系统儿童发育

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