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Dual activation and C-C coupling on single atom catalyst for CO_(2) photoreduction

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npj Computational Materials 2023年第1期9卷 110-117页

作者： u-li sun Cun-biao Lin Wei Zhang Qing Chen Wen-xian Chen xiao-nian Li Gui-lin Zhuang h-PSI Computational Chemistry Lab Institute of Industrial CatalysisState Key Laboratory Breeding Base of Green-Chemical Synthesis TechnologyCollege of Chemical EngineeringZhejiang University of TechnologyHangzhou 310032PR China Surface Lab 10 Institute of PhysicsChinese Academy of SciencesBeijingPR China

An excellent single-atomic photocatalyst,Ti@C_(4)N_(3),is theoretically found to effectively convert CO_(2) to C_(2)h_(6) by density functional theory(DFT)calculations and non-adiabatic molecular dynamics(NAMD)*** Ti@C_(4)N_(3) photocatalyst has remarkable stability both thermally,chemically,and ***,it has strong absorption properties(λ=327.77 and 529.61 nm),suitable band positions,and a long photogenerated electron lifetime(τ_(e)=38.21 ps),allowing photogenerated electrons to migrate to the ***,the high-valence active site effectively activates two CO_(2) through dual activation:Under light irradiation,the weakly adsorbed CO_(2) undergoes photo-induced activation by the photoelectron of conduction band minimum(CBM);without light,the high Lewis acidity of the Ti site induces CO_(2) activation through back-donatingπ-*** simulation results uncovered that dual activation of CO_(2) is attributed to the thermal and photonic ***,two activated CO_(2) species under light easily couple to form oxalate with the barrier of 0.19 eV,and further reduced to C_(2)h_(6) with a low activation energy of 1.09 eV.

关键词： activation catalyst coupling

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一个15例患病的法布雷病家系分析

中华内科杂志 2024年第10期63卷 1001-1006页

作者：杨钧岚姜佳楠韦致远彭思琪王彬王凤梅孙丽何伟明张晓良东南大学医学院南京210009 东南大学附属中大医院肾脏科南京210009 江苏省盱眙县人民医院肾内科淮安211700 江苏省中医院、南京中医药大学附属医院肾内科南京210009

患者(先证者)男,28岁。因皮疹22年,尿检异常14年入东南大学附属中大医院肾内科,基因检测示α-半乳糖苷酶A基因(GLA基因)存在c.735G>A(***245*)半合子突变;α-半乳糖苷酶A(αgalactosidase A,α-Gal A)活性为0.36μmol·L^(-1)·h^(-1),... 详细信息

患者(先证者)男,28岁。因皮疹22年,尿检异常14年入东南大学附属中大医院肾内科,基因检测示α-半乳糖苷酶A基因(GLA基因)存在c.735G>A(***245*)半合子突变;α-半乳糖苷酶A(αgalactosidase A,α-Gal A)活性为0.36μmol·L^(-1)·h^(-1),脱乙酰基三己糖酰基鞘脂醇(Lyso-GL-3)为71.09 ng/ml;肾组织穿刺活检病理示,肾小球足细胞弥漫泡沫变性;患者存在左心室肥厚及蛋白尿;诊断为法布雷病。对其家系进行筛查发现15例(男性4例,女性11例)患法布雷病,3例疑似存在突变(男性1例,女性2例)。患病成员均有不同程度的Lyso-GL-3沉积及α-Gal A酶活性下降,但临床表型存在异质性。6例患者(男性2例,女性4例)进行了酶替代治疗(每两周静脉滴注阿加糖苷酶β1 mg/kg),1例患者出现一过性四肢抽搐伴头晕。3例患者进行酶替代治疗1年后,Lyso-GL-3下降,尿蛋白减少,心功能改善,周围神经症状及血管角质瘤减轻,但肾功能仍在进行性恶化。通过分析该家系基因型、临床表型及预后,强调了家系筛查在早期诊断并治疗法布雷病患者的重要性,提高临床医生对其的诊疗水平。

关键词：法布里病基因突变 GLA基因酶替代治疗

Crosslink between lipids and acute uveitis：a lipidomic analysis

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International Journal of Ophthalmology(English edition) 2018年第5期11卷 736-746页

作者： hai-Yan Wang Yi Wang Yuan Zhang Jing Wang Shu-Yu xiong Qian sun Department of Ophthalmology Shanghai First People's Hospital Affiliated to Jiaotong University Shanghai 200080China Shanghai Key Laboratory of Ocular Fundus Disease Shanghai 200080 China Shanghai Engineering Center for Visual Science and Photomedicine Shanghai 200080 China Department of Chemistry Fudan University Shanghai 200030 China Department of Institutes of Biomedical Sciences Fudan University Shanghai 200030 China

AIM：To explore the roles of phospholipids and sphingolipids in the inflammatory process of ***：Aqueous humor（Ah） and the retina were obtained from endotoxin-induced uveitis（EIU） rats during the acute inflammation stage（24 h after endotoxin injection）.Lipids were extracted using a modified Bligh and Dyer method and subjected to mass spectrometric identification using class-specific lipid standards and ratiometric *** intensity analysis was performed to evaluate the amount change of common lipids between the EIU and control ***：Unique lipid species encompassing all five phospholipid classes were found in both control and the EIU Ah and *** with the significantly increased level of lysophospholipids in the EIU Ah and retina,we found that the ratio of lysophospholipids to total phospholipids was significantly increased *** also detected a significant increase in 18：0 lysophosphatidylcholine levels in the EIU group（fold change =6.4 in Ah and 3.8 in retina）.Cer240,Cer241,and SM240 levels remarkably increased in the EIU *** C12 ceramide-1-phosphate（C12 C-1-P）,C16 C-1-P,C24 C-1-P,and upregulated Cer160,Cer240,SM120,and SM240 were found in EIU retina.C-1-P was believed to restore homeostasis by inhibiting nuclear factor kappa B（NF-κB） ***,we still found elevated NF-κB levels in the EIU ***：A variety of lipids might have played a critical role in EIU *** topical application of these protective lipids or inhibition of these pro-inflammatory lipids may be useful therapeutic strategies for the resolution of EIU.

关键词： lipidomics mass spectrometry uveitis phospholipid sphingolipid

A Facile Photo-cross-linking Method for Polymer Gate Dielectrics and Their Applications in Fully Solution Processed Low Voltage Organic Field-effect Transistors on Plastic Substrate

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Chinese Journal of Polymer Science 2018年第8期36卷 918-924页

作者： Ying Liu Jia-Qing Zhao Wen-Jian sun Yu-Kun huang Su-Jie Chen xiao-Jun Guo Qing Zhang Shanghai Key Laboratory of Electrical Insulation and Thermal Aging Department of Polymer Science and EngineeringSchool of Chemistry and Chemical EngineeringShanghai Jiao Tong University Department of Electronic Engineering School of Electronic Information and Electrical EngineeringShanghai Jiao Tong University

A simple and effective photochemical method was developed for cross-linking of polymer gate dielectrics. Laborious synthetic processes for functionalizing polymer dielectrics with photo-cross-linkable groups were avoided. The photo-cross-linker, BBP-4, was added into host polymers by simple solution blending process, which was capable of abstracting hydrogen atoms from polymers containing active C--h groups upon exposure to ultraviolet （UV） radiation. The cross-linking can be completed with a relatively long wavelength UV light （365 nm）. The approach has been applied to methacrylate and styrenic polymers such as commercial poly（methylmethacrylate）（PMMA）, poly（iso-butylmethacrylate）（PiBMA） and poly（4-methylstyrene）（PMS）. The cross-linked networks enhanced dielectric properties and solvent resistance of the thin films. The bottom-gate organic field-effect transistors （OFETs） through all solution processes on plastic substrate were fabricated. The OFET devices showed low voltage operation and steep subthreshold swing at relatively small gate dielectric capacitance.

关键词： Organic field-effect transistors Solution processed Polymer dielectric Cross-linking Photochemistry

支链脂肪酸在脂多糖诱导下猪小肠上皮细胞炎性反应中缓解作用的研究

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动物营养学报 2024年第9期36卷 5935-5948页

作者：张思琦王安琪周思彤孙丽华王勇吕静仪张淑枝刘洋辛杭书东北农业大学动物科学技术学院哈尔滨150030 广州优百特科技有限公司广州511300 沈阳禾丰反刍动物饲料有限公司沈阳110164 北大荒完达山乳业股份有限公司哈尔滨150001

本试验旨在研究支链脂肪酸(BCFA)对脂多糖(LPS)诱导下的猪小肠上皮细胞(IPEC-J2细胞)抗氧化、抗炎、抗凋亡及缓解屏障功能能力的影响。采用单因素试验设计,分为8组:对照组、LPS诱导组、iso-C14∶0+LPS组、iso-C15∶0+LPS组、iso-C16∶0+... 详细信息

本试验旨在研究支链脂肪酸(BCFA)对脂多糖(LPS)诱导下的猪小肠上皮细胞(IPEC-J2细胞)抗氧化、抗炎、抗凋亡及缓解屏障功能能力的影响。采用单因素试验设计,分为8组:对照组、LPS诱导组、iso-C14∶0+LPS组、iso-C15∶0+LPS组、iso-C16∶0+LPS组、iso-C17∶0+LPS组、anteiso-C15∶0+LPS组、anteiso-C17∶0+LPS组,每组3个重复。在正式开始试验之前,分别获得6种BCFA单体(iso-C14∶0、iso-C15∶0、iso-C16∶0、iso-C17∶0、anteiso-C15∶0、anteiso-C17∶0)和LPS处理IPEC-J2细胞的最适条件。通过CCK-8法测定IPEC-J2细胞活性、活性氧(ROS)检测试剂盒检测IPEC-J2细胞ROS含量、实时荧光定量PCR检测各BCFA单体对IPEC-J2细胞的影响。结果表明:1)通过梯度试验,最终确定分别用1.5μmol/L浓度的6种BCFA单体处理细胞24 h,用10μg/mL浓度的LPS分别处理各组细胞24 h,建立细胞炎性模型。2)检测6种BCFA单体对LPS诱导下IPEC-J2细胞活性的影响发现,与LPS组相比,BCFA预处理可以显著缓解由LPS刺激引起的IPEC-J2细胞存活率的降低(Px蛋白(BAx)基因相对表达量均显著降低(P<0.05),添加BCFA后,B淋巴细胞瘤-2(BCL-2)基因相对表达量均显著高于LPS组(P<0.05)。综上所述,BCFA可以减少IPEC-J2细胞内ROS的集聚,调节炎症细胞因子分泌,抑制TLR4/NF-κB信号通路的过度激活,还可以提高紧密连接相关基因表达,调节凋亡基因的表达,进而明显缓解LPS诱导下IPEC-J2细胞的炎症反应。

关键词：支链脂肪酸脂多糖 IPEC-J2细胞炎症损伤

Cu-catalyzed deoxygenative gem-hydroborylation of aromatic aldehydes and ketones to access benzylboronic esters

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Chinese Journal of Catalysis 2018年第11期39卷 1725-1729页

作者： Lu Wang Wei sun Chao Liu State Key Laboratory for Oxo Synthesis and Selective Oxidation Suzhou Research Institute of Lanzhou Institute of Chemical Physics(LICP)LICPChinese Academy of SciencesLanzhou 730000GansuChina University of Chinese Academy of Sciences Beijing 100049China

Organoboron compounds are widely used in synthetic chemistry,pharmaceutical chemistry and material *** various organoboron compounds,benzylboronic esters are unique and highly reactive,making them suitable benzylation *** present,the synthetic methods for the syntheses of benzylboronic esters are still insufficient to meet their *** is necessary to develop novel and practical methods for their *** this work,a novel copper‐catalyzed deoxygenative gem‐hydroborylation of aromatic aldehydes and ketones has been *** direct and operationally simple protocol provides an effective approach for the synthesis of a variety of primary and secondary benzylboronates,in which broad functional group tolerance was *** available B2pin2(pin=pinacol)was used as the boron source and alcoholic proton was applied as the hydride source.

关键词： homogeneous catalysis Copper catalysis Deoxygenative gem‐hydroborylation Aromatic aldehydes Aromatic ketones

Study of the effects of nesfatin-1 on gastric function in obese rats

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World Journal of Gastroenterology 2017年第16期23卷 2940-2947页

作者： Guo-Tao Yang hong-Ying Zhao Yu Kong Ning-Ning sun Ai-Qin Dong Department of Third Neurology Cangzhou Central HospitalCangzhou Clinical Medical School of Hebei Medical UniversityCangzhou 061001Hebei ProvinceChina Department of Elderly Internal Medicine Cangzhou Central HospitalCangzhou Clinical Medical School of Hebei Medical UniversityCangzhou 061001Hebei ProvinceChina Department of Second Digestion Cangzhou Central HospitalCangzhou Clinical Medical School of Hebei Medical UniversityCangzhou 061001Hebei ProvinceChina Department of First Digestion Cangzhou Central HospitalCangzhou Clinical Medical School of Hebei Medical UniversityCangzhou 061001Hebei ProvinceChina

AIM To investigate the effects of nesfatin-1 on gastric function in obese rats. METhODS The obese rat model was induced by a high-fat diet. The gastric emptying rate and gastric acid secretory capacity of the rats were determined after treatment with different drug concentrations of nesfatin-1 and administration routes. Based on this, the expression of h+/K+-ATPase was measured using RT-PCR and western blot to preliminarily explore the mechanism of gastric acid secretion changes. RESULTS Body weight, body length, and Lee's index of the rats significantly increased in the high-fat dietinduced obese rat model. Two hours after lateral intracerebroventricular injection of nesfatin-1, the gastric emptying rate and gastric acid secretory capacity of rats decreased. Four hours after injection, both were restored to normal levels. In addition, the expression of h+/K+-ATPase decreased and moved in line with changes in gastric acid secretory capacity. Thisin vivo experiment revealed that intracerebroventricular injection of nesfatin-1, rather than intravenous injection, could suppress gastric function in obese rats. Moreover, its effect on the gastric emptying and gastric acid secretory capacity of rats is dose-dependent within a certain period of *** Through this research, we provide a theoretical basis for further studies on nesfatin-1, a potential antiobesity drug.

关键词： Obesity Nesfatin-1 h^+/K^+-ATPase

Classification and comparison of physical and chemical properties of corn stalk from three regions in China

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International Journal of Agricultural and Biological Engineering 2014年第6期7卷 98-106页

作者： Wang Lu Liu Ronghou sun Chen Cai Wenfei Tao Yiwei Yin Renzhan Mei Yuanfei Biomass Energy Engineering Research Center School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Urban Agriculture(South) Ministry of AgricultureShanghai 200240China

Corn stalk samples from Anhui,Jiangxi and Shanghai were used as test *** physical,chemical and thermo-chemical engineering characteristics were *** similarities and differences in properties of corn stalk from the three regions were determined using SIMCA-P and SPSS software in order to obtain a proper energy utilization method of corn *** results show that the corn stalk from Shanghai has significant differences from the samples of Jiangxi and *** particular,the following properties of corn stalk from Shanghai such as the contents of cellulose,calcium(Ca),iron(Fe),crude ash,volatile matter,carbon(C),nitrogen(N),and oxygen(O)are significantly different from those of Jiangxi and Anhui samples(Phile other properties such as the contents of magnesium(Mg),copper(Cu),zinc(Zn),moisture,hydrogen(h),and sulfur(S)have no significant difference among samples of three *** with the corn stalk in Anhui and Jiangxi,the Shanghai samples are more suitable for the production of ethanol because of their higher ratio of cellulose to hemi-cellulose *** of its high content of ash and low calorific value,the Shanghai corn stalk is suitable for the gasification process instead of for direct combustion or bio-oil *** research can provide a reference for raw material selection for biomass energy production and utilization.

关键词： corn stalk physical and chemical properties bioenergy principal components analysis partial least squares discriminant analysis

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米诺地尔搽剂体外透皮一致性研究

中国医院药学杂志 2024年第9期44卷 1030-1037页

作者：吕晨羲游蓉丽刘艳之罗钢杨戎沈悦孙艳玉陆洋李建伟北京中医药大学中药学院北京102488 北京振东光明药物研究院有限公司北京100085 山西振东安欣生物制药有限公司山西晋中030619 长治医学院药学系山西长治046013

目的:比较5%米诺地尔搽剂试验制剂和参比制剂透皮作用的一致性。方法:以巴马香猪皮肤作为透皮渗透的材料,选用立式改良Franz扩散池测定米诺地尔搽剂的渗透规律,采用液相色谱-串联质谱法(LC-MS/MS)分别测定接收液中药物的渗透总量和猪皮... 详细信息

目的:比较5%米诺地尔搽剂试验制剂和参比制剂透皮作用的一致性。方法:以巴马香猪皮肤作为透皮渗透的材料,选用立式改良Franz扩散池测定米诺地尔搽剂的渗透规律,采用液相色谱-串联质谱法(LC-MS/MS)分别测定接收液中药物的渗透总量和猪皮中药物的滞留量随时间的变化关系。结果:试验制剂和参比制剂在巴马香猪皮肤中24 h米诺地尔的累积渗透量分别为(49 721±29 707) ng·cm^(–2)和(45 372±23 755) ng·cm^(–2);平均渗透速率分别为(2 352±1 309) ng·cm^(–2)·h^(–1)和(2 182±1 080) ng·cm^(–2)·h^(–1);皮肤滞留量分别为(218 276±137 675) ng·g^(–1)和(188 040±49 523) ng·g^(–1);试验制剂与参比制剂在累积渗透量约为总透过量一半时(12 h)的平均渗透速率分别为(2 172±1 330) ng·cm^(–2)·h^(–1)和(1 947±1 037) ng·cm^(–2)·h^(–1)。结论:5%米诺地尔搽剂试验制剂与参比制剂的透皮渗透程度和速率符合外用制剂的一致性要求,且在猪皮内药物滞留特征相似。

关键词：米诺地尔搽剂液相色谱-串联质谱法体外透皮 Franz扩散池