Cu-catalyzed deoxygenative gem-hydroborylation of aromatic aldehydes and ketones to access benzylboronic esters

作     者：Lu Wang Wei Sun Chao Liu 王露;孙威;刘超

作者机构：State Key Laboratory for Oxo Synthesis and Selective OxidationSuzhou Research Institute of Lanzhou Institute of Chemical Physics(LICP)LICPChinese Academy of SciencesLanzhou 730000GansuChina University of Chinese Academy of SciencesBeijing 100049China 

出 版 物：《Chinese Journal of Catalysis》 (催化学报（英文）)

年 卷 期：2018年第39卷第11期

页      面：1725-1729页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：国家自然科学基金(91745110,21673261,21603245,21633013,21703265) 中科院兰州化物所“特聘人才”计划 中科院青年促进会(2018458) 中国化学会青年人才托举工程项目 中科院“西部之光”人才项目 

主　　题：Homogeneous catalysis Copper catalysis Deoxygenative gem‐hydroborylation Aromatic aldehydes Aromatic ketones 

摘      要：Organoboron compounds are widely used in synthetic chemistry,pharmaceutical chemistry and material *** various organoboron compounds,benzylboronic esters are unique and highly reactive,making them suitable benzylation *** present,the synthetic methods for the syntheses of benzylboronic esters are still insufficient to meet their *** is necessary to develop novel and practical methods for their *** this work,a novel copper‐catalyzed deoxygenative gem‐hydroborylation of aromatic aldehydes and ketones has been *** direct and operationally simple protocol provides an effective approach for the synthesis of a variety of primary and secondary benzylboronates,in which broad functional group tolerance was *** available B2pin2(pin=pinacol)was used as the boron source and alcoholic proton was applied as the hydride source.