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Anti-obesity effects of fucoidan from Sargassum thunbergii in adipocytes and high fat diet induced obese mice through inhibiting adipogenic specific transcription factor

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Food Science and human Wellness 2024年第3期13卷 1608-1616页

作者： hyo-Geun Lee h.h.A.C.K.Jayawardhana Fengqi Yang D.P.Nagahawaththa N.M.Liyanage Kyung-Mo Song Yun-Sang Choi Seung-hong Lee You-Jin Jeon Min-Cheol Kang Department of Marine Life Sciences Jeju National UniversityJeju 63243Republic of Korea Marine Science Institute Jeju National UniversityJeju 63333Republic of Korea Research Group of Food Processing Korea Food Research InstituteWanju 55365Republic of Korea Department of Pharmoceutical Engineering Soonchunhyang UniversityAsan 31538Republic of Korea

The prevalence of obesity has increased and is a health concern *** to the concerns regarding synthetic anti-obesity treatments,nowadays natural products become a *** studies proved that there is a potential to use marine algae as anti-obesity ***,in this study,the lipid inhibitory effect of crude polysaccharide of amyloglucosidase-assisted hydrolysate from Sargassum thunbergii(STAC)and its fucoidan fractions(STAFs)on 3T3-L1 cells and high-fat diet(hFD)-induced obese mice were *** to the results,the STAF3,showed the highest xylose content and exhibited significant inhibitory effects on lipid accumulation by downregulating adipogenic and lipogenic proteins in 3T3-L1 ***,oral supplementation with STAC significantly declined gain in body weight and fat weight,and serum lipid contents in an hFD-induced obesity mouse *** and chemical characterizations demonstrated that puritied STAF3 has consistent surface morphology and small particle size,with similar structural characteristics as commercial ***,these results indicate that STAC and purified STAF3 from Sargassum thunbergia is a potent source to develop as ananti-obesity agents or functional food products to counter obesity.

关键词： Sargassum thunbergii Fucoidan Anti-obesity Anti-steatosis

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Construction of 2D/2D Ti_(3)C_(2)T_(x)MXene/CdS heterojunction with photothermal effect for efficient photocatalytic hydrogen production

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Journal of Materials Science & Technology 2024年第4期171卷 1-9页

作者： T.Y.huang Z.Yang S.Y.Yang Z.h.Dai Y.J.Liu J.h.Liao G.Y.Zhong Z.J.Xie Y.P.Fang S.S.Zhang Key Laboratory for Biobased Materials and Energy of Ministry of Education Guangdong Laboratory for Lingnan Modern AgricultureCollege of Materials and EnergySouth China Agricultural UniversityGuangzhou 510643China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China School of Chemical Engineering and Energy Technology Guangdong Provincial Key Laboratory of Distributed Energy SystemsDongguan University of TechnologyDongguan 523808China

The insensitivity of semiconductors to visible and infrared light is a key constraint on the utilization of light energy in photocatalytic *** photocatalysts with full-spectrum absorption through surface engineering is an effective approach to fully harnessing light energy in semiconductor ***,a novel stable Ti_(3)C_(2)T_(x)MXene/CdS heterojunction catalyst is obtained by in-situ epitaxial growth of two-dimensional(2D)CdS nanosheets on 2D MXene interface via a solvothermal *** exceptional light absorption properties of MXene confer outstanding full-spectrum driven photocat-alytic hydrogen evolution capability upon the heterogeneous *** unique 2D/2D structure effectively mitigated the recombination of photogenerated carriers,enhancing the photocatalytic performance of the ***,the composite catalyst exhibits a significantly higher surface temperature of 80.4℃under visible light irradiation at an intensity of 0.1 W/cm^(2),which is 1.84 times higher than that of *** irradiation of visible and near infrared light,the composite catalyst with photothermal ef-fect demonstrates a remarkable hydrogen evolution rate of 65.4 mmol g^(-1)h^(-1),which is 7.2 times higher than that of CdS *** study introduces a novel approach for constructing full-spectrum absorption catalysts and expands the application of the photothermal effect in photocatalytic hydrogen evolution research.

关键词： Two-dimensional structure heterostructure Photothermal effect Photocatalyst hydrogen evolution

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New Antenna Array Beamforming Techniques Based on hybrid Convolution/Genetic Algorithm for 5G and Beyond Communications

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2749-2767页

作者： Shimaa M.Amer Ashraf A.M.Khalaf Amr h.hussein Salman A.Alqahtani Mostafa h.Dahshan hossam M.Kassem Electronics and Communications Engineering Department Higher Institute of Engineering and TechnologyKafr ElsheikhEgypt Electronics and Electrical Communications Engineering Department Faculty of EngineeringMinia UniversityMiniaEgypt Electronics and Electrical Communications Engineering Department Faculty of EngineeringTanta UniversityTantaEgypt Electronics and Electrical Communications Engineering Department Faculty of EngineeringHorus University EgyptNew DamiettaEgypt Department of Computer Engineering College of computer and Information SciencesKing Saud UniversityRiyadh11543Saudi Arabia School of Computing Mathematics and EngineeringCharles Sturt UniversityBathurstNSW2795Australia

Side lobe level reduction(SLL)of antenna arrays significantly enhances the signal-to-interference ratio and improves the quality of service(QOS)in recent and future wireless communication systems starting from 5G up to ***,it improves the array gain and directivity,increasing the detection range and angular resolution of radar *** study proposes two highly efficient SLL reduction *** techniques are based on the hybridization between either the single convolution or the double convolution algorithms and the genetic algorithm(GA)to develop the Conv/GA andDConv/GA,*** convolution process determines the element’s excitations while the GA optimizes the element *** M elements linear antenna array(LAA),the convolution of the excitation coefficients vector by itself provides a new vector of excitations of length N=(2M−1).This new vector is divided into three different sets of excitations including the odd excitations,even excitations,and middle excitations of lengths M,M−1,andM,*** the same element spacing as the original LAA is used,it is noticed that the odd and even excitations provide a much lower SLL than that of the LAA but with amuch wider half-power beamwidth(hPBW).While the middle excitations give the same hPBWas the original LAA with a relatively higher *** the increased hPBWof the odd and even excitations,the element spacing is optimized using the ***,the synthesized arrays have the same hPBW as the original LAA with a two-fold reduction in the ***,for extreme SLL reduction,the DConv/GA is *** this technique,the same procedure of the aforementioned Conv/GA technique is performed on the resultant even and odd excitation *** provides a relatively wider hPBWthan the original LAA with about quad-fold reduction in the SLL.

关键词： Array synthesis convolution process genetic algorithm(GA) half power beamwidth(hPBW) linear antenna array(LAA) side lobe level(SLL) quality of service(QOS)

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Synchronized off-harmonic probe laser with highly variable pulse duration for laser-plasma interaction experiments

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high Power Laser Science and Engineering 2024年第1期12卷 99-107页

作者： J.hornung Y.Zobus h.Lorenté C.Brabetz B.Zielbauer V.Bagnoud GSI helmholtzzentrum für Schwerionenforschung Gmbh DarmstadtGermany Institut d’Optique UniversitéParis-SaclayPalaiseauFrance Institut für Angewandte Physik Technische Universität DarmstadtDarmstadtGermany

This paper presents the development and experimental utilization of a synchronized off-harmonic laser system designed as a probe for ultra-intense laser±plasma interaction experiments. The system exhibits a novel seed-generation design,allowing for a variable pulse duration spanning over more than three orders of magnitude, from 3.45 picoseconds to 10 nanoseconds. This makes it suitable for various plasma diagnostics and visualization techniques. In a side-view configuration, the laser was employed for interferometry and streaked shadowgraphy of a laser-induced plasma while successfully suppressing the self-emission background of the laser±plasma interaction, resulting in a signal-to-self-emission ratio of 110 for this setup. These properties enable the probe to yield valuable insights into the plasma dynamics and interactions at the PhELIX facility and to be deployed at various laser facilities due to its easy-to-implement design.

关键词： interferometry laser-plasma interaction off-harmonic probe laser streaked shadowgraphy

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An improved pulse coupled neural networks model for semantic IoT

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Digital Communications and Networks 2024年第3期10卷 557-567页

作者： Rong Ma Zhen Zhang Yide Ma Xiping hu Edith C.h.Ngai Victor C.M.Leung School of Information Science and Engineering Lanzhou UniversityLanzhou 730000China School of Medical Technology Beijing Institute of TechnologyBeijing100081China Department of Electrical and Electronic Engineer The University of Hong KongHong Kong 999077China College of Computer Science and Software Engineering Shenzhen UniversityShenzhen 518060China Department of Electrical and Computer Engineering the University of British ColumbiaVancouverBC V6T 1Z4Canada

In recent years,the Internet of Things(IoT)has gradually developed applications such as collecting sensory data and building intelligent services,which has led to an explosion in mobile data ***,with the rapid development of artificial intelligence,semantic communication has attracted great attention as a new communication ***,for IoT devices,however,processing image information efficiently in real time is an essential task for the rapid transmission of semantic *** the increase of model parameters in deep learning methods,the model inference time in sensor devices continues to *** contrast,the Pulse Coupled Neural Network(PCNN)has fewer parameters,making it more suitable for processing real-time scene tasks such as image segmentation,which lays the foundation for real-time,effective,and accurate image ***,the parameters of PCNN are determined by trial and error,which limits its *** overcome this limitation,an Improved Pulse Coupled Neural Networks(IPCNN)model is proposed in this *** IPCNN constructs the connection between the static properties of the input image and the dynamic properties of the neurons,and all its parameters are set adaptively,which avoids the inconvenience of manual setting in traditional methods and improves the adaptability of parameters to different types of *** segmentation results demonstrate the validity and efficiency of the proposed self-adaptive parameter setting method of IPCNN on the gray images and natural images from the Matlab and Berkeley Segmentation *** IPCNN method achieves a better segmentation result without training,providing a new solution for the real-time transmission of image semantic information.

关键词： Internet of things(IoT) Semantic information Real-time application Improved pulse coupled neural network Image segmentation

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Genomic Mosaicism of the Brain:Origin,Impact,and Utility

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Neuroscience Bulletin 2024年第6期40卷 759-776页

作者： Jared h.Graham Johannes C.M.Schlachetzki Xiaoxu Yang Martin W.Breuss Department of Pediatrics Section of Clinical Genetics and MetabolismUniversity of Colorado School of MedicineAurora80045-2581COUSA Department of Cellular and Molecular Medicine University of California San DiegoLa Jolla92093-0021San DiegoCAUSA Department of Neurosciences University of California San DiegoLa Jolla92093-0021San DiegoCAUSA Rady Children’s Institute for Genomic Medicine San Diego92123CAUSA

Genomic mosaicism describes the phenomenon where some but not all cells within a tissue harbor unique genetic ***,research focused on the impact of genomic mosaicism on clinical phenotype—motivated by its involvement in cancers and overgrowth *** recently,we increasingly shifted towards the plethora of neutral mosaic variants that can act as recorders of cellular lineage and environmental ***,we summarize the current state of the field of genomic mosaicism research with a special emphasis on our current understanding of this phenomenon in brain development and *** the field of genomic mosaicism has a rich history,technological advances in the last decade have changed our approaches and greatly improved our *** will provide current definitions and an overview of contemporary detection approaches for genomic ***,we will discuss the impact and utility of genomic mosaicism.

关键词： Genomics Brain development Brain homeostasis Genomic mosaicism

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Red cell distribution width-to-albumin ratio is a simple promising prognostic marker in acute cholangitis requiring biliary drainage

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hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 487-494页

作者： Fatih Acehan hüseyin Camli Cagdas Kalkan Mesut Tez Burak Furkan Demir Emin Altiparmak Ihsan Ates Department of Internal Medicine Ankara City HospitalAnkara 06800Türkiye Department of Gastroenterology Ankara City HospitalAnkara 06800Türkiye Department of General Surgery Ankara City HospitalAnkara 06800Türkiye

Background: It is crucial to assess the severity of acute cholangitis(AC). There are currently several prognostic markers. however, the accuracies of these markers are not satisfied. The present study aimed to investigate the predictive value of the red cell distribution width(RDW)-to-albumin ratio(RAR) for the prognosis of AC. Methods: We retrospectively evaluated consecutive patients diagnosed with AC between May 2019 and March 2022. RAR was calculated, and its predictive ability for in-hospital mortality, intensive care unit(ICU) admission, bacteremia, and the length of hospitalization were analyzed. Results: Out of 438 patients, 34(7.8%) died. Multivariate analysis showed that malignant etiology [odds ratio(OR) = 4.816, 95% confidence interval(CI): 1.936-11.980], creatinine(OR = 1.649, 95% CI: 1.095-2.484), and RAR(OR = 2.064, 95% CI: 1.494-2.851) were independent risk factors for mortality. When adjusted for relevant covariates, including age, sex, malignant etiology, Tokyo severity grading(TSG), Charlson comorbidity index, and creatinine, RAR significantly predicted mortality(adjusted OR = 1.833, 95% CI: 1.280-2.624). When the cut-off of RAR was set to 3.8, its sensitivity and specificity for mortality were 94.1% and 56.7%, respectively. Patients with an RAR of > 3.8 had a 20.9-fold(OR = 20.9, 95% CI: 4.9-88.6) greater risk of mortality than the remaining patients. The area under the curve value of RAR for mortality was 0.835(95% CI: 0.770-0.901), which was significantly higher than that of TSG and the other prognostic markers, such as C-reactive protein-to-albumin ratio, and procalcitonin-to-albumin ratio. Lastly, RAR was not inferior to TSG in predicting ICU admission, bacteremia, and the length of hospitalization. Conclusions: RAR successfully predicted the in-hospital mortality, ICU admission, bacteremia, and the length of hospitalization of patients with AC, especially in-hospital mortality. RAR is a promising marker that is more convenient than TSG and o

关键词： Acute cholangitis Albumin Biliary drainage Mortality Red blood cell distribution width-to-albumin ratio

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Immunological Exploration of helicobacter pylori Serotype O_(2) O-Antigen by Using a Synthetic Glycan Library

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Chinese Journal of Chemistry 2024年第3期42卷 243-251页

作者： Ming Zhao Guangzong Tian Chunjun Qin Xiaopeng Zou Peter h. Seeberger Jing hu Jian Yin Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of Biotechnology & School of Life Sciences and Health EngineeringJiangnan UniversityLihu Avenue 1800WuxiJiangsu214122 China Biomolecular Systems Department Max Planck Institute of Colloids and InterfacesAm Mühlenberg 1Potsdam14476 Germany Wuxi School of Medicine Jiangnan UniversityLihu Avenue 1800WuxiJiangsu214122 China

helicobacter pylori(***)infection is a threat to human *** lipopolysaccharide(LPS)O-antigen holds promise for developing *** is meaningful to explore the immunological activity of oligosaccharides with different lengths and frameshifts for antigen ***,a glycan library of *** O2 O-antigen containing eight fragments is *** screening with *** O2 LPS sera and patients’sera by glycan microarray,the disaccharide hPO2G-2b and trisaccharide hPO2G-3a show strong antigenicity and then are separately conjugated with carrier protein *** glycoconjugates elicit a robust immunoglobulin G(IgG)immune response in *** anti-hPO2G-3a IgG antibodies possess a much stronger binding affinity with the LPS and bacteria of *** O2 than the anti-hPO2G-2b IgG *** is no cross-reaction between both sera IgG antibodies with LPS and bacteria of *** O1,O6,and *** results demonstrate the trisaccharide hPO2G-3a is a promising candidate for *** vaccine development.

关键词： Glycoconjugates helicobacter pylori Immunology Microarrays O-antigen Oligosaccharides

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hybrid robust fault detection and isolation of satellite reaction wheel actuators

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Journal of Control and Decision 2024年第1期11卷 117-131页

作者： h.Abbasi Nozari S.J.Sadati Rostami Paolo Castaldi Silvio Simani Faculty of Electrical and Computer Engineering Babol Noshirvani University of TechnologyBabolIran Department of Electrical Electronic and Information EngineeringUniversity of BolognaCesenaItaly Department of Engineering University of FerraraFerraraItaly

In this paper,a combined robust fault detection and isolation scheme is studied for satellite system subject to actuator faults,external disturbances,and parametric *** proposed methodology incorporates a residual generation module,including a bank of filters,into an intelligent residual evaluation ***,residual filters are designed based on an improved nonlinear differential algebraic approach so that they are not affected by external *** residual evaluation module is developed based on the suggested series and parallel ***,a new ensemble classification scheme defined as blended learning integrates heterogeneous classifiers to enhance the performance.A wide range of simulations is carried out in a high-fidelity satellite simulator subject to the constant and time-varying actuator faults in the presence of disturbances,manoeuvres,uncertainties,and *** obtained results demonstrate the effectiveness of the proposed robust fault detection and isolation method compared to the traditional nonlinear differential algebraic approach.

关键词： Robust fault detection and isolation reaction wheels blended learning series and parallel fault detection and isolation forms satellite attitude control system

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Luminescence regulation of Sb^(3+)in 0D hybrid metal halides by hydrogen bond network for optical anti-counterfeiting

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Opto-Electronic Advances 2024年第3期7卷 15-25页

作者： Dehai Liang Saif M.h.Qaid Xin Yang Shuangyi Zhao Binbin Luo Wensi Cai Qingkai Qian Zhigang Zang Key Laboratory of Optoelectronic Technology&Systems(Ministry of Education) Chongqing UniversityChongqing 400044China Department of Physics&Astronomy College of SciencesKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia Department of Chemistry and Chemical Engineering Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong ProvinceShantou UniversityShantou 515063China Department of Oil Army Logistics Academy of PLAChongqing 401311China

The Sb^(3+) doping strategy has been proven to be an effective way to regulate the band gap and improve the photophysical properties of organic-inorganic hybrid metal halides(OIhMhs).however,the emission of Sb^(3+) ions in OIhMhs is primarily confined to the low energy region,resulting in yellow or red *** date,there are few reports about green emission of Sb^(3+)-doped ***,we present a novel approach for regulating the luminescence of Sb^(3+) ions in 0D C_(10)h_(2)_(2)N_(6)InCl_(7)·h_(2)O via hydrogen bond network,in which water molecules act as agents for hydrogen ***^(3+)-doped C_(10)h_(2)2N_(6)InCl_(7)·h_(2)O shows a broadband green emission peaking at 540 nm and a high photoluminescence quantum yield(PLQY)of 80%.It is found that the intense green emission stems from the radiative recombination of the self-trapped excitons(STEs).Upon removal of water molecules with heat,C_(10)h_(2)_(2)N_(6)In_(1-x)Sb_(x)Cl_(7) generates yellow emis-sion,attributed to the breaking of the hydrogen bond network and large structural distortions of excited *** water molecules are adsorbed by C_(10)h_(2)_(2)N_(6)In_(1-x)Sb_(x)Cl_(7),it can subsequently emit green *** water-induced reversible emission switching is successfully used for optical security and information *** findings expand the under-standing of how the local coordination structure influences the photophysical mechanism in Sb^(3+)-doped metal halides and provide a novel method to control the STEs emission.

关键词： indium-based halides Sb^(3+)doping hydrogen bonding network optical anti-counterfeiting

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