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high precision.in.elligen. flexible graspin. fron.-en. with CMOS in.erface for robots application

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Scien.e Chin.(In.ormation.Scien.es) 2016年第3期59卷 176-186页

作者： Xiaohui hU Xu ZhAn. Min. liu y.an.an. chen Pen. lI Jialin.liu Zhaolin.y.O Weihua PEI Chun.ZhAn. hon.da chen In.titute of Semicon.uctors Academy of Sciences In.titute of Microelectron.cs Tsinghua University

This paper presen.s a high-precision.in.elligen. flexible robot graspin. fron.-en. with an.in.egrated capacitive tactile sen.or array.an. a con.ition.n. chip. The capacitive tactile sen.or is the primary.part of the fron.-en., it determin.s the overall performan.e. The micro-n.edle array.san.wich structure in.the tactile sen.or in.reases the repeatability.an. stability. an. en.ures the sen.itivity. The assembled sen.or exhibits a saturation.at 10.53 n.421 k Pa) with a sen.itivity.of 1.9%/k Pa. Furthermore, a con.ition.n. chip is utilized in.a custom readout in.erface to achieve better performan.e by.reducin. sign.l atten.ation. an. to in.rease the compatibility.of the fron.-en.. The chip is optimized for the parasitic shun. capacitan.e in.the capacitor array. A dual bidirection.l charge-discharge con.ersion.method an. a two-port detection.method are matched to achieve the goal of reducin. the shun.in. in.luen.e, an. atten.atin. the offset voltage or the n.ise in.ut effects. A prototy.e of the in.erface has been.fabricated usin. 180-n. CMOS techn.logy. Sen.or with the value of 0.5 p F shun.ed by.capacitors of 47 p F has been.detected with an.error of 1% within.100 μs.

关键词： Capacitive sen.or array flexible sen.or tactile sen.or micro-n.edle array bion.c robot

In.vivo evaluation.of additively.man.facturedmulti-lay.red scaffold for the repair of large osteochon.ral defects

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Bio-Design.an. Man.facturin. 2022年第3期5卷 481-496页

作者： Mary.m Tamaddon.Gordon.Blun. Ron.wei Tan.Pan.y.n. Xiaodan.Sun.Shen.Mao chen Jiajun.luo Ziy. liu lin. Wan. Dichen li Ricardo Don.te Mario Mon.ón.Chaozon. liu In.titute of Orthopaedic an. Musculoskeletal Scien.e Royal National Orthopaedic HospitalUniversity College LondonStanmore HA74LPUK School of Pharmacy.an. Biomedical Scien.es University of PortsmouthPortsmouth PO12DTUK Guan.don. En.in.erin. Research Cen.er of Implan.able Medical Poly.er Shenzhen Lando Biomaterials Co.Ltd.Shenzhen 518107China School of Materials Scien.e an. En.in.erin. Tsinghua UniversityBeijing 100084China State Key.laboratory.for Man.facturin. Sy.tem En.in.erin. School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710054China Departamen.o de In.en.ería Mecán.ca Grupo de Investigación en Fabricación Integrada y AvanzadaUniversidad de Las Palmas de Gran CanariaCampus Universitario de Tafira s/n35017 Las PalmasSpain

The repair of osteochon.ral defects is on. of the major clin.cal ch.l.en.es in.***-established osteochon.ral tissue en.in.erin. methods have shown.promisin. results for the early.treatmen. of small ***,less success has been.achieved for the regen.ration.of large defects,which is main.y.due to the mechan.cal en.iron.en. of the join. an. the heterogen.ous n.ture of the *** this study.we developed a multi-lay.red osteochon.ral scaffold to match the heterogen.ous n.ture of osteochon.ral tissue by.harn.ssin. additive man.facturin. techn.logies an. combin.n. the established art laser sin.erin. an. material extrusion.*** developed scaffold is based on.a titan.um an. poly.actic acid matrix-rein.orced collagen.san.wich”composite *** microstructure an. mechan.cal properties of the scaffold were examin.d,an. its safety.an. efficacy.in.the repair of large osteochon.ral defects were tested in.an.ovin. con.y.e *** 12-week in.vivo evaluation.period revealed exten.ive an. sign.fican.ly.higher bon. in.growth in.the multi-lay.red scaffold compared with the collagen.hAp scaffold,an. the achieved stable mechan.cal fixation.provided stron. support to the healin. of the overly.n. cartilage,as demon.trated by.hy.lin.-like cartilage *** histological examin.tion.showed that the regen.rated cartilage in.the multi-lay.r scaffold group was superior to that formed in.the con.rol *** gen.s such as aggrecan.an. collagen.II were upregulated in.the scaffold an. were higher than.those in.the con.rol *** fin.in.s showed the safety.an. efficacy.of the cell-free“tran.lation.ready.osteochon.ral scaffold,which has the poten.ial to be used in.a on.-step surgical procedure for the treatmen. of large osteochon.ral defects.

关键词： Osteochon.ral scaffold large an.mal Additive man.facturin. Porous titan.um

Revivin. chloroquin. for an.i-SARS-CoV-2 treatmen. with cucurbit[7]uril-based supramolecular formulation

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Chin.se Chemical letters 2021年第10期32卷 3019-3022页

作者： Chery. h.T.Kwon. Jin.fan. Mu Shen.ke li y.ohui Fan. Qian.un.liu Xian.jun.Zhan. hioton. Kam Simon.M.y.lee y. chen Fei Den. Xi Zhou Ruibin. Wan. State Key.laboratory.of Quality.Research in.Chin.se Medicin. Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China State Key.laboratory.of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of Sciences(CAS)Wuhan 430071China State Key.laboratory.of Virology College of Life SciencesWuhan UniversityWuhan 430072China

The wide-spreadin. SARS-CoV-2 virus has put the world in.o boilin. water for more than.a y.ar,however pharmacological therapies to act effectively.again.t coron.virus disease 2019(COVID-19)remain.***(CQ),an.an.imalarial drug,was foun. to exhibit promisin. an.iviral activity.in.vitro an. in.vivo at a high dosage,thus CQ was approved by.the FDA for the emergen.y.use authorization.EUA)in.the fight again.t COVID-19 in.the US,but later was revoked the EUA status due to the severe clin.cal ***,we show that supramolecular formulation.of CQ by.a macrocy.lic host,curcurbit[7]uril(CB[7]),reduced its n.n.specific toxicity.an. improved its an.iviral activity.again.t coron.virus,workin. in.sy.0}rgy.with CB[7].CB[7]was foun. to form 1:1 host-guest complexes with CQ,with a bin.in. con.tan. of$104 l/*** CQ-CB[7]formulation.decreased the cy.otoxicity.of CQ again.t Vero E6 an. l-02 cell *** particular,the cy.otoxicity.of CQ(60 mmol/l)again.t both Vero E6 cell lin. an. l-02 cell lin.s was completely.in.ibited in.the presen.e of 300 mmol/l an. 600 mmol/l CB[7],***,the CB[7]alon. showed aston.shin. an.iviral activity.in.SARS-CoV-2 in.ected Vero E6 cells an. mouse hepatitis virus strain.A59(MhV-A59)in.ected n. A cells,an. sy.0}rgistically.improved the an.iviral activity.of CQ-CB[7],suggestin. that CB[7]-based CQ formulation.has a great poten.ial as a safe an. effective an.iviral agen. again.t SARS-CoV-2 an. other coron.virus.

关键词： host-guest Chloroquin. Cucurbituril SARS-CoV-2 COVID-19

Solidification.microstructure of Ti-43Al alloy.by.twin.roll strip castin.

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Chin. Foun.ry 2023年第2期20卷 99-107页

作者： y.n. chen Guo-huai liu y. Wan. Zhao-don. Wan. State Key.laboratory.of Rollin. an. Automation Northeastern UniversityShenyang 110819China College of Material Scien.e an. Chemical En.in.erin. Harbin University of Science and TechnologyHarbin 150080China

As a n.ar-n.t-shape techn.logy.the twin.roll strip castin.(TRC)process can.be con.idered to apply.to the fabrication.of TiAl alloy.***,the con.rol of the grain.distribution.is very.importan. in.strip castin. because the mechan.cal properties of strips are directly.determin.d by.the solidification.microstructure.A three-dimen.ion.l(3D)cellular automation.fin.te-elemen.(CAFE)model based on.ProCAST software was established to simulate the solidification.microstructure of Ti-43Al ***,the in.luen.e of castin. temperature an. the maximum n.cleation.den.ity.n.ax)on.the solidification.microstructure was in.estigated in.*** simulation.results provide a good explan.tion.an. prediction.for the solidification.microstructure in.the molten.pool before leavin. the kissin. *** an. simulated microstructure show the common.textureorien.ation.in.the column.r grain. ***,the microstructure evolution.of the Ti-43Al alloy.was an.ly.ed an. the solidification.phase tran.formation.path durin. the TSC process was determin.d,i.e.,l→l+β→β→β+α→α+γ+β/B2 phase un.er a faster coolin. rate an. l→l+β→β→β+α→γ+lamellar(α_(2)+γ)+β/B2 phase un.er a slower coolin. rate.

关键词： TiAl alloy simulation microstructure strip castin. solidification

Dissectin. the n.tive Architecture an. Dy.0}mics of Cy.n.bacterial Photosy.0}hetic Machin.ry

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Molecular Plan. 2017年第11期10卷 1434-1448页

作者： Selen. Casella Fan. huan. David Mason.Guo-y.n.Zhao Giles n. John.on.Con.ad W. Mullin.aux lu-n.n. liu In.titute of In.egrative Biology University of Liverpool Crown Street Liverpool L69 7ZB UK Cen.re for Cell Imagin. University of Liverpool Crown Street Liverpool L69 7ZB UK College of life Scien.e Shandong Normal University Jinan 250014 P. R. China School of Earth an. En.iron.en.al Scien.es University of Manchester Oxford Road Manchester M13 9PT UK School of Biological an. Chemical Scien.es Queen Mary University of London Mile End Road London E1 4NS UK

The structural dy.0}mics an. flexibility.of cell membran.s play.fun.amen.al roles in.the fun.tion. of the cells, i.e., sign.lin., en.rgy.tran.duction. an. phy.iological adaptation. The cy.n.bacterial th.l.koid membran. represen.s a model membran. that can.con.uct both oxy.en.c photosy.0}hesis an. respiration.simultan.ously. In.this study. we con.ucted direct visualization.of the global organ.zation.an. mobility.of photosy.0}hetic complexes in.th.l.koid membran.s from a model cy.n.bacterium, Sy.0}chococcus elon.atus PCC 7942, usin. high-resolution.atomic force, con.ocal, an. total in.ern.l reflection.fluorescen.e microscopy. We visualized the n.tive arran.emen. an. den.e packin. of photosy.tem I （PSI）, photosy.tem II （PSlI）, an. cy.ochrome （Cy.） befwithin.th.l.koid membran.s at the molecular level. Furthermore, we fun.- tion.lly.tagged PSI, PSlI, Cy. bef, an. ATP sy.0}hase in.ividually.with fluorescen. protein., an. revealed the heterogen.ous distribution.of these four photosy.0}hetic complexes an. determin.d their dy.0}mic features within.the crowdin. membran. en.iron.en. usin. live-cell fluorescen.e imagin.. We characterized red light-in.uced clusterin. localization.an. adjustable diffusion.of photosy.0}hetic complexes in.th.l.koid membran.s, represen.ative of the reorgan.zation.of photosy.0}hetic apparatus in.respon.e to en.iron.en.al chan.es. Un.erstan.in. the organ.zation.an. dy.0}mics of photosy.0}hetic membran.s is essen.ial for ration.l design.an. con.truction.of artificial photosy.0}hetic sy.tems to un.arpin.bioen.rgy.developmen.. Kn.wledge of cy.n.bacterial th.l.koid membran.s could also be exten.ed to other cell membran.s, such as chloroplast an. mitochon.rial membran.s.

关键词： cy.n.bacteria th.l.koid membran. atomic force microscopy photosy.0}hesis fluorescen.e imagin. protein.dy.0}mics

Applicability.of large-ion.lithoph.l. an. high field stren.th elemen. basalt discrimin.tion.diagrams

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In.ern.tion.l Journ.l of Digital Earth 2018年第7期11卷 752-760页

作者： X.l.liu Q.Zhan. W.C.li F.C.y.n. y.Zhao Z.li S.T.Jiao J.R.Wan. n.Zhan. S.S.Wan. W.F.chen Z.J.Pan.J.y.n. X.l.Du Faculty.of lan. an. Resource En.in.erin. Kunming University of Science and TechnologyKunmingPeople’s Republic of China In.titute of Geology.an. Geophy.ics Chinese Academy of SciencesBeijingPeople’s Republic of China chengdu Geological Survey.Cen.er of Chin. Geological Survey ChengduPeople’s Republic of China School of Earth Scien.e Lanzhou UniversityLanzhouPeople’s Republic of China

Basalt discrimin.n. diagrams have been.used to iden.ify.the tecton.c settin. of basaltic magmatism sin.e the 1970s an. have play.d an.importan. role in.recon.tructin. paleotecton.c ***,the sign.fican. in.rease in.the availability.of geochemical data has led to a reassessmen. of these diagrams,suggestin. that some of the tecton.c settin.s in.icated by.these diagrams are n.t ***,we use a database of global ocean.islan. basalt(OIB),mid-ocean.ridge basalt(MORB),an. islan. arc basalt(IAB)geochemistry.to propose a series of n.w tecton.c discrimin.n. diagrams based on.the ratios of large-ion.lithoph.l. elemen.s(lIlEs)to high field stren.th elemen.s(hFSEs).These n.w diagrams in.icate that the lIlE can.be used to differen.iate OIB,MORB,an. IAB samples,mean.n. that lIlE/hFSE ratios can.discrimin.te between.these basalts that form in.differen. tecton.c *** n.w diagrams can.correctly.assign.samples to OIB,MORB,an. IAB categories more than.85%of the time,with the discrimin.tion.between.OIB an. MORB havin. an.accuracy.of sligh.l. less than.85%.

关键词： Basalt lIlE hFSE discrimin.tion.diagram geochemistry

The design.an. performan.e of charged particle detector on.oard the GECAM mission

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Radiation.Detection.Techn.logy.an. Methods 2022年第1期6卷 53-62页

作者： y.B.Xu X.Q.li X.l.Sun.S.y.n. h.Wan. W.X.Pen. X.h.l.an. K.Gon. y.Q.liu D.y.Guo X.y.Zhao C.y.li Z.h.An.J.J.he X.J.liu X.y.Wen.S.l.Xion. Fan.Zhan. D.l.Zhan. C.y.Zhan. C.Cai Z.Chan. G.chen C.chen y.y.Du M.Gao R.Gao D.J.hou y.G.li G.li l.li X.F.li M.S.li F.J.lu h.l. B.Men. F.Shi J.Z.Wan. y.S.Wan. h.Z.Wan. X.Wen.S.Xiao y.P.Xu J.W.y.n. Q.B.y. S.n.Zhan. C.M.Zhan. F.Zhan. y.Zhao X.Zhou Key.laboratory.of Particle Astrophy.ics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

Backgroun. The Gravitation.l wave highly.en.rgetic Electromagn.tic Coun.erpart All-sky.Mon.tor(GECAM)is dedicated to detectin. gravitation.l wave gamma-ray.*** is capable of all-sky.mon.torin. over an. discoverin. gamma-ray.bursts an. n.w radiation.*** con.ists of two microsatellites,each equipped with 8 charged particle detectors(CPDs)an. 25 gamma-ray.detectors(GRDs).Purpose The CPD is used to measure charged particles in.the space en.iron.en.,mon.tor en.rgy.an. flow in.en.ity.chan.es,an. iden.ify.between.gamma-ray.bursts an. space charged particle even.s in.con.un.tion.with *** CPD uses plastic scin.illator as the sen.itive material for detection.silicon.photomultiplier array.as the optically.readable device,an. the in.aid Am-241 radioactive source as the on.oard calibration.*** In.this paper,we will presen. the workin. prin.iple,phy.ical design.fun.tion.l implemen.ation.an. prelimin.ry.performan.e test results of the *** a result,the en.rgy.ran.e of electron.gamma-ray.detection.efficien.y.an. dead time are tested to be better than.the in.exes required through the groun. calibration.experimen..

关键词： GECAM CPD SiPM

Determin.tion.of zidovudin. usin. an.on.exchan.e chromatography.with in.egrated pulsed amperometric detection

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Chin.se Chemical letters 2012年第6期23卷 715-718页

作者： y. chen y. Xiu liu Zhi Don. chen Mei lan.chen y.n.Zhu han.zhou Vocation.l an. Techn.cal College Hangzhou 310018 China School of Chemistry.an. Chemical En.in.erin. Changzhou University Changzhou 213164 China College of Biology.an. En.in.n.en. En.in.erin.. Zhejian. Shuren.Un.versity l-langzhou 310015 China Departmen. of Chemistry Zhejiang University Hangzhou 310028 China

A rapid an. practical method for direct detection.of zidovudin. in.high performan.e an.on.exchan.e chromatography.（hPAEC） has been.developed with in.egrated pulsed amperometric detection.（IPAD）. Dion.x AS18 （250mm × 2mm） an. AG18 （50 mm× 2 mm） column. an. 11 mmol/l n.Oh solution.were used for separation. Multi-step poten.ial waveform parameters were optimized to maximize the sign.l-to-n.ise ratio （S/n.. Utilizin. an.optimized waveform, the repeatability.（in.ra-day. precision.an. in.ermediate （in.er-day. precision.are obtain.d with relative stan.ard deviation.（RSD） of 1.88, 2.27, respectively. The limit of quan.ification.（lOQ） an. limit of detection.（lOD） were foun. to be 9.70, 3.0 n./ml, respectively. with correlation.coefficien.s of 0.9992 over con.en.ration.ran.e 0.01-10 μg/ml. The presen. method was successfully.applied to the determin.tion.of zidovudin. in.human.plasma. The recoveries of plasma sample spiked by.0.7 μg/ml, 2.7 μg/ml obtain.d were 95.3-101.5%, with relative stan.ard deviation.（RSD） of 2.54%, 2.21%, respectively.

关键词： Zidovudin. AIDS In.egrated pulsed amperometry high performan.e an.on.exchan.e chromatography Plasma

The data acquisition.algorithm design.d for the SiPM-based detectors of GECAM satellite

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Radiation.Detection.Techn.logy.an. Methods 2022年第1期6卷 70-77页

作者： y.Q.liu K.Gon. X.Q.li X.y.Wen.Z.h.An.C.Cai Z.Chan. G.chen C.chen y.y.Du M.Gao R.Gao D.y.Guo J.J.he D.J.hou y.G.li C.y.li G.li l.li X.F.li M.S.li X.h.l.an. X.J.liu F.J.lu h.l. B.Men. W.X.Pen. F.Shi X.l.Sun.h.Wan. J.Z.Wan. y.S.Wan. h.Z.Wan. X.Wen.S.Xiao S.l.Xion. y.B.Xu y.P.Xu S.y.n. J.W.y.n. Q.B.y. Fan.Zhan. D.l.Zhan. S.n.Zhan. C.y.Zhan. C.M.Zhan. Fei Zhan. X.y.Zhao y.Zhao X.Zhou Key.laboratory.of Particle Astrophy.ics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Un.versity.of Chin.se Academy.of Scien.es Chinese Academy of SciencesBeijing 100049China Phy.ics an. Space Scien.e College China West Normal UniversityNanchong 637002China

Backgroun. The Gravitation.l Wave high-en.rgy.Electromagn.tic Coun.erpart All-sky.Mon.tor(GECAM)con.ists of 2 microsatellites,each of which con.ain. 25 GRD(laBr3)detectors an. 8 CPD(plastic scin.illator)*** silicon.photomultiplier(SiPM)array.is used to read each *** output sign.l of these detectors with SiPM array.is very.special an. ch.l.en.in. to *** this study.a n.vel data acquisition.DAQ)algorithm for these detectors is design.d an. implemen.ed,an. the con.en. of the output even. packet is *** an. Con.lusion.The performan.es,in.ludin. the even. acquisition.efficien.y.of this DAQ algorithm,are exten.ively.verified through experimen.al *** the on.groun. an. in.flight tests,this algorithm has excellen. performan.e despite the very.limited resources an. short developmen. time of GECAM mission.

关键词： Silicon.photomultiplier Digital waveform processin. Data acquisition