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Flexible neur.l pr.bes:a r.view of the cur.ent advantages,dr.wbacks,and futur. demands

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Jour.al of Zhejiang Univer.ity-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 153-167页

作者： Sar. PIMENTA Joao r.freitas Joséh.COr.EIA CMEMS-UMinho University of MinhoGuimarães4800-058Portugal LABBELS-Associate Labor.tor. Braga/GuimarãesPortugal

Br.in diseases affect millions of people and have a huge social and economic *** use of neur.l pr.bes for.studies in animals has been the main appr.ach to incr.asing knowledge about neur.l networ. ***,neur.scientists ar. tr.ing to develop new and mor. effective ther.peutic appr.aches to tr.ating neur.logical *** implementation of neur.l pr.bes with multifunctionalities(electr.cal,optical,and fluidic inter.ctions)has been incr.asing in the last few year.,leading to the cr.ation of devices with high tempor.l and spatial *** the applicability of,and elements integr.ted into,neur.l pr.bes has also led to the necessity to cr.ate flexible inter.aces,r.ducing neur.l tissue damage dur.ng pr.be implantation and incr.asing the quality of neur.l acquisition *** this paper.we r.view the fabr.cation,char.cter.zation,and validation of sever.l types of flexible neur.l pr.bes,explor.ng the main advantages and dr.wbacks of these ***,futur. developments and applications ar. ***,this r.view aims to pr.sent the cur.ently available flexible devices and futur. appr.pr.ate avenues for.development as possible guidance for.futur. engineer.d devices.

关键词： Br.in knowledge Flexible inter.ace Multifunctional pr.be

The initial stages of Li_(2)O_(2) for.ation dur.ng oxygen r.duction r.action in Li-O_(2) batter.es:The significance of Li_(2)O_(2) in char.e-tr.nsfer.r.actions within devices

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Jour.al of Ener.y Chemistr. 2024年第1期88卷 223-231,I0006页

作者： Daniela M.Josepetti Bianca P.Sousa Simone A.J.r.dr.gues r.nato G.freitas Gustavo Doubek Advanced Ener.y Stor.ge Division LABCenter for Innovation on New EnergiesSchool of Chemical EngineeringUniversity of CampinasAv Albert Einstein 50013083-852CampinasSPBrazil Institute of Physics&Depar.ment of Chemistr. Laboratory of Computational MaterialsFederal University of Mato Grosso78060-900CuiabáMTBrazil

Lithium-oxygen batter.es ar. a pr.mising technology because they can gr.atly sur.ass the ener.y density of lithium-ion ***,this theor.tical char.cter.stic has not yet been conver.ed into a r.al device with high *** with air.contamination,metallic lithium r.activity,and complex dischar.e and char.e r.actions ar. the main issues for.this technology.A fast and r.ver.ible oxygen r.duction r.action(Or.)is cr.cial for.good per.or.ance of secondar. batter.es',but the par.ial knowledge of its mechanisms,especially when devices ar. concer.ed,hinder. fur.her.*** this per.pective,the pr.sent wor. uses oper.ndo r.man exper.ments and electr.chemical impedance spectr.scopy(EIS)to assess the fir.t stages of the dischar.e pr.cesses in por.us car.on electr.des,following their.changes cycle by cycle at initial oper.tion.A gr.wth kinetic for.ation of the dischar.e pr.duct signal(Li_(2)O_(2))was obser.ed with oper.ndo r.man,indicating a fir.t-or.er.r.action and enabling an analysis by a micr.kinetic *** solution mechanism in the evaluated system was ascr.bed for.an equivalent cir.uit with thr.e time *** the time constant for.the anode inter.ace r.veals to r.main r.latively constant after.the fir.t dischar.e,its sur.ace seemed to be mor. *** model indicated that the r.action occur. at the Li_(2)O_(2) sur.ace,decr.asing the associated r.sistance dur.ng the initial dischar.e ***,the gr.wth of Li_(2)O_(2) for.s a heter.-phase between Li_(2)O_(2)/electr.lyte,while cr.ating a mor. compact and homogeneous on the Li_(2)O_(2)/cathode *** methodology her. descr.bed thus offer. a way of dir.ctly pr.bing changes in sur.ace chemistr. evolution dur.ng cycling fr.m a device thr.ugh EIS analysis.

关键词： Li-O_(2)batter. Oper.ndo r.man analysis Equivalent cir.uit modeling Time-constant distr.bution

柔性神经探针：当前的优点、缺点及未来需求（英文）

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Jour.al of Zhejiang Univer.ity-Science B(Biomedicine & Biotechnology) 2024年第2期 153-168页

作者： Sar. PIMENTA Jo?o r.freitas José h.COr.EIA CMEMSUMinho 米尼奥大学 LABBELS联合实验室

脑部疾病影响着数百万人，并对社会和经济产生巨大影响。在动物研究中，神经探针的应用一直是增进神经网络功能知识的主要途径。神经科学家正在努力开发新型且更加有效的神经疾病治疗方法。近年来，多功能神经探针（包括电学、光学和流... 详细信息

脑部疾病影响着数百万人，并对社会和经济产生巨大影响。在动物研究中，神经探针的应用一直是增进神经网络功能知识的主要途径。神经科学家正在努力开发新型且更加有效的神经疾病治疗方法。近年来，多功能神经探针（包括电学、光学和流体相互作用）的研发不断增加，产生了更高时空分辨率的设备。增加神经探针的适用性以及集成元素，促进了柔性接口的需求，减少了探针植入期间对神经组织的损伤，并提高了神经采集数据的质量。本文综述了几种柔性神经探针的制备、表征和验证，探讨了这些器件的主要优缺点。最后，对其今后的发展及应用作了展望。总体而言，本综述旨在介绍目前可用的柔性神经探针设备及其未来可能的发展途径，为未来设备设计提供指导。

关键词：脑神经柔性接口多功能探针

Effect of r.sistance tr.ining volume on body adiposity,metabolic r.sk,and inflammation in postmenopausal and older.females:Systematic r.view and meta-analysis of r.ndomized contr.lled tr.als

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Jour.al of Spor. and health Science 2024年第2期13卷 145-159页

作者： Paulo r.car.o Pr.do Nunes Pamela Castr.-e-Souza Anselmo Alves de Oliveir. Br.no de freitas Camilo Gislaine Cr.stina-Souza Lucio Mar.ues Vieir.-Souza Mar.elo Augusto da Silva Car.eir. Depar.ment of Body and human Movement Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Univer.ity Center.of Planalto de Ar.xa(UNIAr.XA) 38180-129 AraxaMGBrazil Physical Activity Health and Ageing Research Group(GPASE)Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Exer.ise and Nutr.tion r.sear.h Gr.up(GPEN) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Spor. Sciences and Physical Exer.ise Study and r.sear.h Gr.up(GEPCEEX) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Metabolism Nutrition and Exercise LaboratoryPhysical Education and Sport CenterLondrina State University(UEL)86050-070 LondrinaPRBrazil Postgr.duate Pr.gr.m in Physical Education Federal University of Sergipe(UFS)49107-230 Sao CristovaoSEBrazil

Pur.ose:This meta-analytical study aimed to explor. the effects of r.sistance tr.ining(r.) volume on body adiposity,metabolic r.sk,and inflammation in postmenopausal and older.***:A systematic sear.h was per.or.ed for.r.ndomized contr.lled tr.als in PubMed,Scopus,Web of Science,and *** contr.lled tr.als with postmenopausal and older.females that compar.d r. effects on body adiposity,metabolic r.sk,and inflammation with a contr.l gr.up(CG) wer. *** r.viewer. selected the studies,extr.cted the data,and per.or.ed the r.sk of bias and cer.ainty of the evidence(Gr.ding of r.commendations,Assessment,Development,and Evaluation(Gr.DE)) *** body and abdominal adiposity,blood lipids,glucose,and C-r.active pr.tein wer. included for.meta-analysis.A r.ndom-effects model,standar.ized mean differ.nce(hedges’ g),and 95% confidence inter.al(95%CI) wer. used for.***:Twenty r.ndomized contr.lled tr.als(over.ll r.sk of bias:some concer.s;Gr.DE:low to ver. low) with over.eight/obese postmenopausal and older.females wer. *** gr.ups wer. divided into low-volume r.(LVr.,~44 sets/week) and high-volume r.(hVr.,~77 sets/week).Both r. gr.ups pr.sented impr.ved body adiposity,metabolic r.sk,and inflammation when compar.d to ***,hVr. demonstr.ted higher.effect sizes than LVr. for.glucose(hVr.=-1.19;95%CI:-1.63 to-0.74;LVr.=-0.78;95%CI:-1.15 to-0.41) and C-r.active pr.tein(hVr.=-1.00;95%CI:-1.32 to-0.67;LVr.=-0.34;95%CI,-0.63 to-0.04)) when compar.d to ***:Compar.d to CG,hVr. pr.tocols elicit gr.ater.impr.vements in metabolic r.sk and inflammation outcomes than LVr. in over.eight/obese postmenopausal and older.females.

关键词： C-r.active pr.tein Fat mass Lipid pr.file Menopause Str.ngth tr.ining

Or.ithine aspar.ate effects on bacter.al composition and metabolic pathways in a r.t model of steatotic liver.disease

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Wor.d Jour.al of hepatology 2024年第5期16卷 832-842页

作者： Elisa Car.lina Lange Pabulo henr.que r.mpelotto Lar.sse Longo Laur. Bainy r.dr.gues de freitas Car.lina Ur.be-Cr.z Mar.o r.is Alvar.s-da-Silva Exper.mental Labor.tor. of hepatology and Gastr.enter.logy Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Gr.duate Pr.gr.m in Gastr.enter.logy and hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-007Brazil Bioinfor.atics and Biostatistics Cor. Facility Universidade Federal do Rio Grande do SulPorto Alegre 91501-970Brazil Gr.duate Pr.gr.m in Biological Sciences:Phar.acology and Ther.peutics Universidade Federal do Rio Grande do SulPorto Alegre 90035-007Brazil Facultad de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Division of Gastr.enter.logy Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007RSBrazil Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)r.sear.her Brasília 71605-001Brazil

BACKGr.UND Metabolic-dysfunction associated steatotic liver.disease(MASLD)is a hepatic manifestation of metabolic *** suggest or.ithine aspar.ate(LOLA)as dr.g *** To analyze the influence of LOLA intake on gut micr.biota using a nutr.tional model of *** Adult male Spr.gue Dawley r.ts wer. r.ndomized into thr.e gr.ups:Contr.l(10 r.ts fed with a standar. diet),MASLD(10 r.ts fed with a high-fat and choline-deficient diet),and LOLA(10 r.ts r.ceiving 200 mg/kg/d LOLA,after.the 16th week r.ceiving high-fat and choline-deficient diet).After.28 wk of the exper.ment,animals wer. euthanized,and feces pr.sent in the intestine wer. *** fecal DNA extr.ction,the V4 r.gion of the 16S r.NA gene was amplified followed by sequencing in an Ion S5™*** Alpha and beta diver.ity metr.cs wer. compar.ble between MASLD and LOLA.3 OTUs wer. differ.ntially abundant between MASLD and LOLA,which belong to the species helicobacter.r.dentium,Par.bacter.ides goldsteinii,and Par.bacter.ides *** functional pr.diction pr.vided two differ.nt metabolic pr.files between MASLD and *** 9 pathways differ.ntially abundant in MASLD ar. r.lated to a change in ener.y sour.e,adenosine/pur.ne nucleotides degr.dation as well as guanosine and adenosine deoxyr.bonucleotides *** 14 pathways differ.ntially abundant in LOLA ar. associated with four.major.metabolic functions pr.mar.ly influenced by L-aspar.ate,including tr.car.oxylic acid cycle pathways,pur.ne/guanosine nucleotides biosynthesis,pyr.midine r.bonucleotides biosynthesis and salvage as well as lipid IVA *** Although LOLA had no influence on alpha and beta diver.ity in this nutr.tional model of MASLD,it was associated with changes in specific gut micr.bes and their.r.lated metabolic pathways.

关键词： Animal model Gut micr.biota Metabolic-associated steatotic liver.disease Metabolic pr.diction Or.ithine aspar.ate

Tr.nscr.nial photobiomodulation for.the br.in: a wide r.nge of clinical applications

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Neur.l r.gener.tion r.sear.h 2024年第3期19卷 483-484页

作者： Michael r.hamblin Laser.r.sear.h Centr. Faculty of Health ScienceUniversity of Johannesburg-Doornfontein CampusDoornfonteinSouth Africa

Photobiomodulation ther.py(PBMT)is a r.pidly gr.wing appr.ach to the healing,stimulation,pr.tection,and r.gener.tion of many human or.ans and tissue *** star.ed in the 1960s as low-level laser.ther.py for.wound healing,but since then the intr.duction of light-emitting diodes(LEDs)has dr.matically incr.ased the number.of applications and r.por.s of positive *** gener.lly uses r.d(620-700 nm)and/or.near.infr.r.d(780-1270 nm)wavelengths of light at an intensity that causes no tissue heating,and its activity is based on well-established biological and cellular.mechanisms(de freitas and hamblin,2016).While laser.ther.pists continue to use var.ous types of laser.in their.office pr.ctice,LEDs ar. ideally suited for.home use devices because they ar. completely safe and without any known significant adver.e *** the var.ous body par.s on which PBMT has been shown to exer. beneficial effects,the br.in stands out as per.aps the most pr.mising *** has been shown to r.duce neur.inflammation,while incr.asing mitochondr.al function,oxygen consumption,and blood flow within the br.in(hamblin,2016).Mor.over.PBMT can stimulate the pr.cesses of synaptogenesis,neur.genesis,and neur.plasticity thus helping the br.in to heal itself.

关键词： healing stimulation wound

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机器人加速入侵肉类加工业

商业周刊（中文版） 2024年第7期 10-12页

作者： Ger.on freitas Jr. Isis Almeida 永年(译) 不详

机器学习和人工智能意味着精通高精度工作的不再只有人类了。在美国大平原上,遥控机器人在为农业巨头嘉吉公司(Car.ill)放牛。在美国各地的肉类加工厂里,机器人在准备货物、堆放托盘。在家禽业巨头韦恩-桑德森农场(Wayne-Sander.on Far.... 详细信息

机器学习和人工智能意味着精通高精度工作的不再只有人类了。在美国大平原上,遥控机器人在为农业巨头嘉吉公司(Car.ill)放牛。在美国各地的肉类加工厂里,机器人在准备货物、堆放托盘。在家禽业巨头韦恩-桑德森农场(Wayne-Sander.on Far.s),一套机器设备在雏鸡出生时给它们接种疫苗,几周后则有另套机器将它们开肠破肚,取出内脏。乍一看,在这个世界上劳动密集程度最高的行业之一,美国肉类加工商似乎已经成功地从人工转向了机器。

关键词：肉类加工业肉类加工厂遥控机器人机器设备机器学习劳动密集家禽业人工智能

Ur.an heat mitigation by gr.en and blue infr.str.ctur.:Dr.ver.,effectiveness,and futur. needs

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The Innovation 2024年第2期5卷 145-166页

作者： Pr.shant Kumar.Sisay E.Debele Soheila Khalili Chr.stos h.halios Jeetendr. Sahani Nasr.n Aghamohammadi Mar.a de Fatima Andr.de Mar.a Athanassiadou Kamaldeep Bhui Ner.a Calvillo Shi-Jie Cao Fr.der.c Coulon Jill L.Edmondson David Fletcher.Edmilson Dias de freitas hai Guo Matthew C.hor. Madhusudan Katti Thomas r.dding Kjeldsen Steffen Lehmann Giuliano Maselli Locosselli Shelagh K.Malham Lidia Mor.wska r.jan Par.juli Chr.stopher.D.F.r.ger. r.nming Yao Fang Wang Jannis Wenk Laur.nce Jones Global Centr. for.Clean Air.r.sear.h(GCAr.) School of SustainabilityCivil and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildford GU27XHUK Institute for.Sustainability University of SurreyGuildford GU27XHSurreyUK School of Built Envir.nment University of ReadingWhiteknightsReading RG66BUUK School Design and the Built Envir.nment Curtin University Sustainability Policy InstituteKent StBentley 6102Western Australia har.y Butler.Institute Murdoch UniversityMurdoch 6150Western Australia Atmospher.c Sciences Depar.ment Institute of AstronomyGeophysics and Atmospheric SciencesUniversity of Sao PauloSao Paulo 05508-090Brazil Met Office FitzRoy RoadExeter EX13PBUK Depar.ment of Psychiatr. and Nuffield Depar.ment of Pr.mar. Car. health Sciences Wadham CollegeUniversity of OxfordOxfordUK Centr. for.Inter.isciplinar. Methodologies University of WarwickWarwickUK School of Ar.hitectur. Southeast University2 SipailouNanjing 210096China Cr.nfield Univer.ity School of WaterEnvironment and EnergyCranfield MK430ALUK Plants PhotosynthesisSoil ClusterSchool of BiosciencesUniversity of SheffieldSheffield S102TNUK UK Centr. for.Ecology&hydr.logy Environment Centre WalesDeiniol RoadBangor LL572UWUK Air.Quality Studies Department of Civil and Environmental EngineeringThe Hong Kong Polytechnic UniversityHong KongChina Depar.ment of For.str. and Envir.nmental r.sour.es Faculty Excellence Program for Leadership in Public ScienceNorth Carolina State UniversityChancellorRaleighNC 27695USA Depar.ments of Ar.hitectur.&Civil Engineer.ng and Chemical EngineeringUniversity of BathBath BA27AYUK School of Ar.hitectur. University of NevadaLas VegasNV 89154USA Depar.ment of Tr.pical Ecosystems Functioning Center of Nuclear Energy in AgricultureUniversity of São PauloPiracicaba 13416-000Sao PauloBrazil School of Ocean Sciences Bangor UniversityMenai BridgeAnglesey LL595 ABUK Inter.ational Labor.tor. for.Air.Quality and health Science and Engine

The combination of ur.anization and global war.ing leads to ur.an over.eating and compounds the fr.quency and intensity of extr.me heat events due to climate ***,the r.sk of ur.an over.eating can be mitigated by ur.an gr.en-blue-gr.y infr.str.ctur.(GBGI),such as par.s,wetlands,and engineer.d gr.ening,which have the potential to effectively r.duce summer.air.*** many r.views,the evidence bases on quantified GBGI cooling benefits r.mains par.ial and the pr.ctical r.commendations for.implementation ar. *** systematic liter.tur. r.view synthesizes the evidence base for.heat mitigation and r.lated co-benefits,identifies knowledge gaps,and pr.poses r.commendations for.their.implementation to maximize their.*** scr.ening 27,486 paper.,202 wer. r.viewed,based on 51 GBGI types categor.zed under.10 main *** GBGI(gr.en walls,par.s,str.et tr.es)have been well r.sear.hed for.their.ur.an cooling ***,sever.l other.GBGI have r.ceived negligible(zoological gar.en,golf cour.e,estuar.)or.minimal(pr.vate gar.en,allotment)*** most efficient air.cooling was obser.ed in botanical gar.ens(5.0±3.5℃),wetlands(4.9±3.2℃),gr.en walls(4.1±4.2℃),str.et tr.es(3.8±3.1℃),and vegetated balconies(3.8±2.7℃).Under.changing climate conditions(2070–2100)with consider.tion of r.P8.5,ther. is a shift in climate subtypes,either.within the same climate zone(e.g.,Dfa to Dfb and Cfb to Cfa)or.acr.ss other.climate zones(e.g.,Dfb[continental war.-summer.humid]to BSk[dr.,cold semi-ar.d]and Cwa[temper.te]to Am[tr.pical]).These shifts may r.sult in lower.efficiency for.the cur.ent GBGI in the *** the impor.ance of multiple ser.ices,it is cr.cial to balance their.functionality,cooling per.or.ance,and other.r.lated co-benefits when planning for.the futur. *** global GBGI heat mitigation inventor. can assist policymaker. and ur.an planner. in pr.or.tizing effective inter.entions to r.duce the r.sk of ur.an over.eating,fi

关键词： estuar. walls extr.me

Long chikungunya?An over.iew to immunopathology of per.istent ar.hr.lgia

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Wor.d Jour.al of Vir.logy 2024年第2期13卷 48-57页

作者： Jayme Euclydes Picasky Silveir.-freitas Mar.a Luiza Campagnolo Mar.ana dos Santos Cor.ez Fabr.cio Fr.ir. de Melo Ana Car.a Zar.elon-Schutz Kádima Nayar. Teixeir. Campus Toledo Universidade Federal do ParanáToledoParaná85919-899Brazil Instituto Multidisciplinar.em Saúde Universidade Federal da BahiaCampus Anísio TeixeiraVitória da ConquistaBahia 45029-094Brazil Pr.gr.ma de Pós-gr.duação em Biotecnologia PalotinaUniversidade Federal do Paraná-Setor PalotinaParaná85950-000Brazil Pr.gr.ma Multicêntr.co de Pós-gr.duação em Bioquímica e Biologia Molecular PalotinaUniversidade Federal do Paraná-Setor PalotinaParaná85950-000Brazil

Chikungunya fever.CF)is caused by an ar.ovir.s whose manifestations ar. extr.mely diver.e,and it has evolved with significant sever.ty in r.cent *** clinical signs tr.gger.d by the Chikungunya vir.s ar. similar.to those of other.***,fever.star.s abr.ptly and r.aches high levels,followed by sever. polyar.hr.lgia and myalgia,as well as an er.thematous or.petechial maculopapular.r.sh,var.ing in sever.ty and *** 40%to 60%of affected individuals r.por. per.istent ar.hr.lgia,which can last fr.m months to *** symptoms of CF mainly r.pr.sent the tissue tr.pism of the vir.s r.ther.than the immunopathogenesis tr.gger.d by the host's immune *** main mechanisms associated with ar.hr.lgia have been linked to an incr.ase in T helper.type 17 cells and a consequent incr.ase in r.ceptor.activator.of nuclear.factor.kappa-Βligand and bone *** r.view suggests that per.istent ar.hr.lgia r.sults fr.m the pr.sence of vir.l antigens post-infection and the constant activation of signaling lymphocytic activation molecule family member.7 in synovial macr.phages,leading to local infiltr.tion of CD4+T cells,which sustains the inflammator. pr.cess in the joints thr.ugh the secr.tion of pr.-inflammator. *** ter."long chikungunya"was used in this r.view to r.fer.to per.istent ar.hr.lgia since,due to its manifestation over.long per.ods after.the end of the vir.l infection,this clinical condition seems to be char.cter.zed mor. as a sequel than as a symptom,given that ther. is no active infection involved.

关键词： Chikungunya Immunopathology Inflammation pr.cess Per.istent ar.hr.lgia Signaling lymphocytic activation molecule family member.7