Interaction between cannabinoid and nucleotide systems as a new mechanism of signaling in retinal cell death

作     者：Hércules R. Freitas Ricardo A. M. Reis Ana L. M. Ventura Guilherme R. Franca 

作者机构：Laboratory of Neurochemistry Institute of Biophysics Carlos Chagas Filho Universidade Federal do Rio de Janeiro Rio de Janeiro RJ Brazil School of Health Sciences Centro Universitário IBMR Rio de Janeiro RJ Brazil Laboratory of Neurochemistry Institute of Biology Universidade Federal Fluminense Niterói RJ Brazil Biomedical Institute Departament of Physiological Sciences/ Pharmacology Universidade Federal do Estado do Rio de Janeiro Rio de Janeiro RJ Brazil 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2019年第14卷第12期

页      面：2093-2094页

核心收录：

学科分类：10[医学] 

基　　金：supported by Coordenaqao de Aperfeigoamento dePessoal de Nivel Superior (CAPES),No.oo1 and PROCAD-2013(both to RAM) Conselho Nacional de Desenvolvimento Cientificoe Tecnologico (CNPq),No.303018/2016-0 (to ALMV) FundacaoCarlos Chagas Filho de Amparo a Pesquisa do Estado do Rio deJaneiro (FAPERJ),No.2016/02 (to GRF) Instituto Nacional de Cienciae Tecnologia de Neurociencia Translacional (INNT/INCT),No.465346/2014-6 (to RAMR) 

主　　题：Interaction nucleotide systems cell death 

摘      要：Nervous system emerges from complex signaling interactions where extrinsic (neurotransmitters and trophic factors, among others) and intrinsic factors (transcription factors) interplay in the developing tissue to control gene activity promoting chronic changes in cell genesis, migration, differentiation and death. The retinal microenvironment is regulated by a broad variety of chemicals, including endocannabinoids and nucleotides that modulate embryonic progenitor-neuron-Müller glia signaling in very early developing or pathophysiological conditions.