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Journal of Plant Ecology 2013年第4期6卷 298-304页

作者： gurbir s.bhullar Peter J.Edwards Harry Olde Venterink Institute of Integrative Biology ETH ZurichUniversitätstrasse 168092 ZurichSwitzerland

Aims and Methods Vascular plants are known to influence the production,transport and oxidation of methane in wetland soils,but these processes are not well *** plants grown in intact peat cores,we compared the influence upon methane emissions of 20 forb and graminoid species from European *** measured plant-mediated transport of methane(conduit or chimney effect)using a novel agar-sealing technique that prevented methane exchange from the bare soil to the *** Findings the plant-mediated transport(chimney effect)represented between 30%and almost 100%of the total methane flux,with graminoids exhibiting greater internal transport than *** general,plants with less dense root tissues and a relatively larger root volume exhibited a larger chimney *** species(12 out of 20)signif-icantly reduced methane emissions compared to bare soil and only one species,succisa pratensis,increased *** suggest that characterising vegetation in terms of plant functional traits and plant processes offers an effective method for estimating methane emis-sions from ***,we found no correlation between the magnitude of the chimney effect and the overall influence of different plant species on methane *** introducing a useful tool to study plant-mediated transport,this work suggests that characterising vegetation in terms of functional traits could improve estimates of methane emissions from wetlands,which in turn could help in designing mitigation strategies.

关键词： functional group graminoid forb agar-sealing conduit gas transportreceived

Targeting gut microbiota in osteoporosis:impact of the microbial based functional food ingredients

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Food science and Human Wellness 2024年第1期13卷 1-15页

作者： Pauline Duffuler Khushwant s.bhullar Jianping Wu Department of Agricultural Food&Nutritional science University of AlbertaEdmonton T6G 2P5Canada

Osteoporosis is the most common bone disorder,characterized by low bone mineral density and microarchitectural deterioration of the bone tissue,which increases the susceptibility to *** the past decade,emerging research findings reported the implication of gut microbiota on bone health and osteoporosis *** patients or individuals with a lower bone mineral density exhibit an alteration of the gut microbiota at several taxonomic *** reports demonstrate that gut microbiota regulates bone metabolism through the modulation of the gut function(mineral availability and absorption,gut integrity),the immune system,and the endocrine ***,based on the vital role of gut microbiota on bone health,it has emerged as a novel therapeutic target for the prevention of bone loss and the treatment of ***-based functional food ingredients,such as probiotics,prebiotics,synbiotics,and fermented foods,have been developed to alter the gut microbiota composition and function and thus,to provide benefits to the host bone *** promising initial results,microbial-based therapies are still under ***,additional animal studies and clinical trials are needed to understand the interactions between gut microbiota and bone metabolism before further applications.

关键词： Dysbiosis Bone health Probiotic Prebiotic Fermented food synbiotic

Dietary peptides in aging:Evidence and prospects

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Food science and Human Wellness 2020年第1期9卷 1-7页

作者： Khushwant s.bhullar Jianping Wu Department of Agricultural Food and Nutritional ScienceUniversity of AlbertaEdmontonABCanada Department of Pharmacology University of AlbertaEdmontonABCanada

With improvements in healthcare and lifestyle,the proportion of the aging population is rising steadily across the *** physiological functions are altered during aging and resemble those occurring in disease conditions involving metabolic and mitochondrial ***,there is an urge to better develop dietary or medicinal interventions targeting the mechanisms underlying aging and aging-related *** reports indicate that in geroscience,dietary interventions such as bioactive peptides to slow aging are a matter of’when’rather than’if’.Leading targets for peptides include the metabolic-mitochondrial pathway accompanied by improved nutrient *** of these pathways diminish aging biomarkers in various model organisms and confers protection against a growing list of age-related *** derived bioactive peptides are characterized modulators of these pathways,while some verified in vivo and even clinically approved,and numerous others are under *** brief review focuses on the latest scientific advances in understanding the anti-aging ability of bioactive peptides as well as delineates the possible future directions in this process.

关键词： Dietary peptides Anti-aging Aging biomarkers

Olfactory receptor gene evolution is unusually rapid across Tetrapoda and outpaces chemosensory phenotypic change

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Current Zoology 2020年第5期66卷 505-514页

作者： Laurel R.Yohe Matteo Fabbri Michael Hanson Bhart-Anjan s.bhullar Department of Earth&Planetary science Peabody Museum of Natural HistoryYale UniversityNew HavenCT06511USA

Chemosensation is the most ubiquitous sense in animals,enacted by the products of complex gene families that detect environmental chemical cues and larger-scale sensory structures that process these *** there is a general conception that olfactory receptor(OR)genes evolve rapidly,the universality of this phenomenon across vertebrates,and its magnitude,are *** supposed correlation between molecular rates of chemosensory evolution and phenotypic diversity of chemosensory systems is largely *** combine comparative genomics and sensory morphology to test whether OR genes and olfactory phenotypic traits evolve at faster rates than other genes or *** published genomes,we identified ORs in 21 tetrapods,including amphibia ns,reptiles,birds,and mammals and compared their rates of evolution to those of orthologous non-OR protein-coding *** found that,for all clades investigated,most OR genes evolve nearly an order of magnitude faster than other protein-coding genes,with many OR genes showing signatures of diversifying selection across nearly all taxa in this *** rapid rate of evolution suggests that chemoreceptor genes are in "evolutionary overdrive,"perhaps evolving in response to the ever-changing chemical space of the *** obtain complementary morphological data,we stained whole fixed specimens with iodine,μCT-scanned the specimens,and digitally segmented chemosensory and nonchemosensory brain *** then estimated phenotypic variation within traits and among *** we found considerable variation in chemosensory structures,they were no more diverse than nonchemosensory *** suggest chemoreceptor genes evolve quickly in reflection of an ever-changing chemical space,whereas chemosensory phe no types and processing regions are more conserved because they use a standardized or constrained architecture to receive and process a range of chemical cues.

关键词： chemosensation diversifying selection olfaction olfactory bulb olfactory receptor tetrapod

Navigating the complexities of perianal Crohn’s disease:Diagnostic strategies,treatment approaches,and future perspectives

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World Journal of Gastroenterology 2024年第44期30卷 4745-4753页

作者： Jai P singh Maryam Aleissa Ernesto R Drelichman Vijay K Mittal Jasneet s.bhullar Department of surgery-Colon and Rectal surgery Ascension Providence HospitalSouthfieldMI 48075United States Department of surgery-Colon and Rectal surgery Ascension Providence HospitalMichigan State University College of Human MedicineSouthfieldMI 48075United States Department of surgery Ascension Providence HospitalMichigan State University College of Human MedicineSouthfieldMI 48075United States

This article discusses the literature review article by Pacheco et al published in July 2024;the authors provided good reviews of perianal Crohn’s disease(CD),and challenges faced by clinicians in the ***,characterized by its chronic and relapsing nature,is an idiopathic condition that can involve any segment of the gastrointestinal *** disease impacts up to 40%of patients with CD,with perianal fistulas constituting up to 80%of perianal *** CD can be highly incapacitating and profoundly diminish the overall well-being of *** management focuses on controlling the perianal sepsis and treating luminal *** are crucial to the treatment approach,and results have been *** surgery focuses on controlling the sepsis,with more definitive treatments being fistula surgery,fecal diversion,and proctectomy as the last *** manuscript briefly describes the burden of CD,the challenges posed by perianal CD,and the role of different treatment modalities from colorectal surgeon’s perspective.

关键词： Crohn’s disease Perianal Fistula Fistulotomy Biologics stem cell therapy

Prediction of Crohn's disease aggression through NOD2/CARD15 gene sequencing in an Australian cohort

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World Journal of Gastroenterology 2014年第17期20卷 5008-5016页

作者： Maneesha bhullar Finlay Macrae Gregor Brown Margie smith Ken sharpe Department of Colorectal Medicine and Genetics 3 CentreThe Royal Melbourne HospitalParkville 3052Australia Department of Molecular Genetics CMR Room 204PathologyThe Royal Melbourne HospitalParkville 3052Australia Department of statistics University of MelbourneParkville 3050Australia

AIM: To investigate the association between mutations in oligomerisation domain 2/caspase recruitment domains 15 (NOD2/CARD15) and the natural history of Crohn’s disease (CD) to identify patients who would benefit fr... 详细信息

关键词： Inflammatory bowel disease, Oligomerisation domain 2/caspase recruitment domains 15, Genotyping, Crohn’ s disease, Natural history

Auxetic Behavior of Flat and Curved Indenters into a Half-space

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材料科学与工程（中英文A版） 2012年第5期2卷 436-441页

作者： s.K. bhullar J.L. Wegner A. Mioduchowski Department of Mechanical Engineering University of Victoria Victoria B.C. Canada VSW 3P6 Department of Mechanical Engineering University of Alberta Edmonton AB Canada T6G 2G8

Outcomes and efficacy of magnetic resonance imaging-compatible sacral nerve stimulator for management of fecal incontinence: A multi-institutional study

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World Journal of Radiology 2024年第2期16卷 32-39页

作者： Binit Katuwal Amy Thorsen Kunal Kochar Ryba bhullar Ray King Ernesto Raul Drelichman Vijay K Mittal Jasneet singh bhullar Department of surgery Ascension Providence HospitalMichigan State University College of Human MedicineSouthfieldMI 48075United States Department of Colon and Rectal surgery Alina Health Abbott Northwestern HospitalMinneapolisMN 55407United States Colon and Rectal surgery Advocate Illinois MasonicPark RidgeIL 60068United States Volunteer student Department of ResearchAscension Providence HospitalSouthfieldMI 48075United States Colon and Rectal surgery University of WisconsinMadisonWI 53715United States General and Colorectal surgery Ascension Providence HospitalMichigan State University College of Human MedicineSouthfieldMI 48075United States Department of surgery Department of Medical EducationAscension Providence HospitalMichigan State University College of Human MedicineSouthfieldMI 48075United States

BACKGROUND Fecal incontinence(FI)is an involuntary passage of fecal matter which can have a significant impact on a patient’s quality of *** modalities of treatment exist for *** nerve stimulation is a well-established treatment for *** the increased need of magnetic resonance imaging(MRI)for diagnostics,the In-terstim which was previously used in sacral nerve stimulation was limited by MRI *** MRI-compatible Interstim was approved by the United states Food and Drug Administration in August 2020 and has been widely *** To evaluate the efficacy,outcomes and complications of the MRI-compatible *** Data of patients who underwent MRI-compatible Medtronic Interstim placement at UPMC Williamsport,University of Minnesota,Advocate Lutheran General Hospital,and University of Wisconsin-Madison was pooled and *** demographics,clinical features,surgical techniques,complications,and outcomes were *** the Reporting of Observational studies in Epidemiology(sTROBE)cross-sectional reporting guidelines were *** seventy-three patients had the Interstim *** mean age was 63.29±12.2 ***-seven(78.1%)patients were females and forty-two(57.5%)patients had *** addition to incontinence,overlapping symptoms included diarrhea(23.3%),fecal urgency(58.9%),and urinary incontinence(28.8%).Fifteen(20.5%)patients underwent Peripheral Nerve Evaluation before proceeding to definite implant ***-two(43.8%)patients underwent rechargeable Interstim ***(4.1%)patients needed removal of the *** of the external lead connection was observed in 7(9.6%)patients after the stage I *** explanation for one patient was due to ***(9.6%)patients had other complications like nerve pain,hematoma,infection,lead fracture,and *** mean follow-up was 6.62±3.5 ***-eight(93.2%)patients reported significant improvement of symptoms on

关键词： Fecal incontinence sacral nerve stimulation Interstim Magnetic resonance imaging sacral neuromodulation

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心脏插管术

国际内科双语杂志（中英文） 2006年第12期6卷 23-26,52-54页

作者： Ted s N Lo gurbir Bhatia Jim Nolan 陈益和（译）纪宝华（校）英国西中部地区心脏病学的注册专家英国特伦特河畔斯托克市的北斯塔福德郡大学医院心胸中心的心脏病学顾问医师不详

随着技术的发展和仪器的微型化。

关键词：心脏插管术经桡动脉微型化