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Antioxidant effect of Lactobacillus fermentum HFY02-fermented soy milk on D-galactose-induced aging mouse model

Food Science and Human Wellness 2022年第5期11卷 1362-1372页

作者： Tiantian Hu Rui Chen Yu Qian Ke Ye Xingyao Long Kun-young park Xin Zhao Chongqing Collaborative Innovation Center for Functional Food Chongqing Engineering Research Center of Functional FoodChongqing Engineering Laboratory for Research and Development of Functional FoodChongqing University of EducationChongqing 400067China Department of General Practice The Third People's Hospital of ChengduChengdu 610036China Department of Food Science and Biotechnology Cha UniversitySeongnam 13488Korea

This study aimed to investigate the antioxidant effect of soybean milk fermented by a new type of Lactobacillus fermentum(LF-HFY02)by using D-galactose induced aging mice ***,the optimal fermentation conditions was screened out by detecting the effects of different fermentation temperature and time on the active components and antioxidant activity of soybean milk in *** then unfermented soybean milk and the soybean milk fermented by different Lactobacillus was given by gavage to D-galactose-induced aging *** activities of GSH,GSH-Px,SOD,CAT and T-AOC in serum,brain and liver of soybean milk fermented by LF-HFY02 were significantly increased,while the content of MDA and the level of AGEs in hippocampal were significantly decreased compared with D-galactose induced *** more,the mRNA expression of GSH and SOD in mouse liver were obviously up-regulated by soybean milk fermented by *** skin tissue structure of mice in the LF-HFY02 fermented soybean milk group was more complete,the collagen fibers were increased and arranged orderly and liver inflammation has improved compared with the model *** Western blot analysis showed that LF-HFY02 effectively upregulated EGFR,SOD and GSH protein expression in mouse *** findings suggest that LF-HFY02 can effectively prevent D-galactose-induced oxidation and aging in mice,and the effect was even better than that of the Lactobacillus delbruechii *** and vitamin ***,LF-HFY02 may be potentially employed as a probiotic *** conclusion,soybean milk fermented by LF-HFY02 can increase the content of antioxidant factors and the activity of antioxidant enzymes by regulating gene and protein expression,and finally inhibit the process of tissue cell peroxidation,and improve the oxidative damage of mouse skin and *** results could provide a basis for the research and development and industrial production of probiotic-related fermented soybean milk products.

关键词： Lactobacillus fermentum HFY02 Fermented soybean milk D-galactose Antioxidant Aging

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Analysis and optimization of nitrile butadiene rubber sealing mechanism of ball valve

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中国有色金属学会会刊：英文版 2009年第B9期19卷 220-224页

作者： young-Chul park Department of Mechanical Engineering Dong-A University

An approach for analyzing and optimizing sealing mechanism of ball valve made of nitrile butadiene rubber(NBR) with finite element method was presented. The Mooney-Rivlin hyperelastic material model was chosen to characterize NBR sealing, as it has been recommended in the similar applications. That is, NBR sealing was modeled as incompressible hyperelasticity, as well as the assumption of isotropic flow. The results illustrate the structural pressure and contact pressure on the contact surface, which shows that the NBR sealing mechanism is very suitable for sealing after dimension optimization.

关键词：橡胶密封丁腈橡胶尺寸优化机制球阀有限元方法材料模型各向同性

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Acquisition of pluripotency in the chick embryo occurs during intrauterine embryonic development via a unique transcriptional network

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Journal of Animal Science and Biotechnology 2018年第3期9卷 574-584页

作者： Jae Yong Han Hyo gun Lee young Hyun park young Sun Hwang Sang Kyung Kim Deivendran Rengaraj Byung Wook Cho Jeong Mook Lim Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences College of Agriculture and Life Sciences Seoul National University Institute for Biomedical Sciences Shinshu University Department of Animal Science and Technology Chung-Ang University Department of Animal Science College of Natural Resources and Life Sciences Pusan National University

Background: Acquisition of pluripotency by transcriptional regulatory factors is an initial developmental event that is required for regulation of cell fate and lineage specification during early embryonic development. The evolutionarily conserved core transcriptional factors regulating the pluripotency network in fishes, amphibians, and mammals have been elucidated. There are also species-specific maternally inherited transcriptional factors and their intricate transcriptional networks important in the acquisition of pluripotency. In avian species, however, the core transcriptional network that governs the acquisition of pluripotency during early embryonic development is not well ***: We found that chicken NANOG(c NANOG) was expressed in the stages between the pre-ovulatory follicle and oocyte and was continuously detected in Eyal-Giladi and Kochav stage I(EGK.I) to X. However, c POUV was not expressed during fol iculogenesis, but began to be detectable between EGK.V and VI. Unexpectedly, c SOX2 could not be detected during fol iculogenesis and intrauterine embryonic development. Instead of c SOX2, c SOX3 was maternally inherited and continuously expressed during chicken intrauterine development. In addition, we found that the pluripotency-related genes such as c ENS-1, c KIT, c LIN28 A, c MYC, c PRDM14, and c SALL4 began to be dramatical y upregulated between *** and ***: These results suggest that chickens have a unique pluripotent circuitry since maternally inherited c NANOG and c SOX3 may play an important role in the initial acquisition of pluripotency. Moreover, the acquisition of pluripotency in chicken embryos occurs at around *** to VI I.

关键词： Avian Embryonic development NANOG Pluripotency Transcriptional factor

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Optimal laboratory testing protocol for patients with acne taking oral isotretinoin

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World Journal of Clinical Cases 2023年第11期11卷 2435-2442页

作者： Yu Jeong park Hui young Shin Woo Kyoung Choi Ai-young Lee Seung Ho Lee Jong Soo Hong Department of Dermatology Dongguk University Ilsan HospitalCollege of MedicineDongguk UniversityGoyang 10326South Korea

BACKGROUND Isotretinoin is a widely prescribed drug for various dermatological conditions,especially *** tests are routinely performed to monitor its side ***,the optimal testing schedule remains *** To evaluate the laboratory monitoring tests and schedules of patients with acne taking isotretinoin to determine the most efficient testing *** We retrospectively reviewed electronic medical records from the Dermatology Department of Dongguk University Ilsan Hospital from 2005 to 2020 for patients prescribed isotretinoin for acne who underwent monthly blood *** Aspartate aminotransferase(AST),alanine aminotransferase(ALT),and trigly-ceride(TG)levels significantly changed between 5 and 6 mo when the total prescription period and dose variables were considered *** high-density lipoprotein level also significantly changed between 5 and 6 ***,low-density lipoprotein(LDL)and total cholesterol levels significantly changed between 1 and 2 *** We recommend testing AST,ALT,and TG levels once every 5 to 6 *** also suggest testing LDL and total cholesterol levels during the first and second months.

关键词： Acne vulgaris Isotretinoin Clinical laboratory techniques Vitamin A Liver

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Atypical progress of frozen shoulder after COVID-19 vaccination:A case report

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World Journal of Clinical Cases 2023年第15期11卷 3637-3642页

作者： Hyun-Seok Jo Hyeong-Min Kim Jae-young Han Hyeng-Kyu park Department of Physical and Rehabilitation Medicine Research Institute of Medical SciencesHeart Research CenterChonnam National UniversityChonnam National University Medical School&HospitalGwangju City 61469South Korea Department of Physical and Rehabilitation Medicine Regional Cardiocerebrovascular CenterCenter for Aging and GeriatricsResearch Institute of Medical SciencesHeart Research CenterChonnam National UniversityChonnam National University Medical School&HospitalGwangju City 61469South Korea

BACKGROUND After vaccination was mandated worldwide,various adverse effects associated with the coronavirus disease 2019(COVID-19)vaccination,including shoulder pain,have been ***,we report a case of new-onset shoulder pain after BNT162b2(Comirnaty,Pfizer-BioNTech)mRNA *** SUMMARY A 50-year-old man visited our rehabilitation center with left shoulder range of motion(ROM)limitation that had persisted for more than 5 *** history included no specific noteworthy events,except *** pain in the patient’s left deltoid muscle appeared 1 day after the second BNT162b2 vaccination and intensified to severe *** patient self-administered aspirin,with which the pain subsided immediately,whereas ROM limitation *** the first visit,the patient complained of dull pain and ROM restriction of the left shoulder(flexion 130°,abduction 110°,and external rotation 40°).Among the diagnostic studies conducted for the evaluation of the shoulder,magnetic resonance imaging showed a thickened coracohumeral *** conduction studies and needle electromyography showed no electrodiagnostic *** patient received comprehensive rehabilitation for 7 mo and had an overall improvement in pain and ROM of the left *** In this case of severe shoulder pain after COVID-19 vaccination that subsided immediately with aspirin treatment,the exact cause and mechanism of pain are ***,the clinical symptoms and diagnostic workups in our report suggest the possibility that the COVID-19 vaccination triggered an immunochemical response that resulted in shoulder pathology.

关键词： COVID-19 Vaccination Adhesive capsulitis Frozen shoulder Mechanism Case report

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Intraoperative sudden arrhythmias in cervical spine surgery adjacent to the stellate ganglion:A case report

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世界临床病例杂志 2023年第24期11卷 5789-5796页

作者： Jong-Hun Seo Su-Yeon Cho Ji-Hwan park Jin-young Seo Hyun-young Lee Dong-Joon Kim Department of Neurosurgery Chosun University HospitalGwangju 61453South Korea Department of Anesthesiology and Pain Medicine Chosun University HospitalGwangju 61453South Korea Department of Anesthesiology and Pain Medicine College of MedicineChosun UniversityGwangju 61453South Korea

BACKGROUND Atrial arrhythmias such as paroxysmal supraventricular tachycardia(PSVT)and atrial flutter(AF)are common in the perioperative *** commonly resolve ***,occasionally,they may continually progress to fatal arrhythmias or cause ***,prompt and appropriate management is *** SUMMARY A 46-year-old female patient diagnosed with cervical C6-7 radiculopathy characterized by decreased sensation in the right third,fourth and fifth fingers underwent C6-7 anterior cervical disc fusion *** showed PSVT and ventricular tachycardia during C6-7 disc ***,the patient remained *** treatment with esmolol and lidocaine for ventricular tachycardia was *** massage and Valsalva maneuver were attempted but PSVT did not *** surgery was paused,and the patient’s fraction of inspired oxygen was set to 100%.Adenosine was administered for pharmacological management of *** arrhythmia temporarily ***,it then transformed into *** was administered,which briefly decreased blood pressure,which immediately *** resumed while the patient was in normal sinus *** was discharged safely on postoperative day 6 without complications or ***,she is living a healthy life without arrhythmia *** Ganglia associated with cardiac arrhythmias in the surgical site should be identified during cervical spine surgery.

关键词： Supraventricular tachycardia Atrial flutter Stellate ganglion Adenosine Diltiazem Case Report

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Solitary acral persistent papular mucinosis nodule:A case report and summary of eight Korean cases

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World Journal of Clinical Cases 2023年第13期11卷 3086-3091页

BACKGROUND Acral persistent papular mucinosis(APPM)is a rare idiopathic subtype of localized lichen *** date,there have been 40 APPM cases reported worldwide;however,only 7 cases have been reported in the Korean *** SUMMARY A 70-year-old man was referred to our hospital with a solitary pinkish nodule on the dorsum of his right *** the absence of symptoms,the patient wanted to know the exact diagnosis;thus,a biopsy was *** examination of a biopsy specimen obtained from the nodule on the dorsum of his hand revealed orthokeratotic hyperkeratosis with patchy parakeratosis,prominent hypergranulosis,and diffuse dissecting mucinous deposition between collagen bundles,along with some bland-looking spindle cells throughout the *** nodule was histologically diagnosed as an APPM,and an intralesional triamcinolone injection(2.5 mg/mL)was started every 2 *** three sessions of treatment,the patient showed marked *** To the best of our knowledge,this is the first case of a Korean APPM presenting as a solitary nodule that showed a marked response to triamcinolone intralesional *** it is a rare disease,we report this case to contribute to future research on the pathogenesis and treatment of APPM.

关键词： Acral persistent papular mucinosis Localized lichen myxedematosus Cutaneous mucinosis Mucin Case report

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Congenital retinal macrovessel with intracranial venous malformation in a pediatric patient: a case report

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International Journal of Ophthalmology(English edition) 2022年第7期15卷 1214-1216页

作者： Hyeon Jin park Sook Hyun Yoon Sook young Kim Donghun Lee Department of Ophthalmology Daegu Catholic University School of MedicineDaegu 42472Republic of Korea

Dear Editor,Congenital retinal macrovessel (CRM) is defined as an abnormal large retinal vessel that encircles the foveal avascular zone (FAZ).Since the first description of a large aberrant vessel crossing the macula by Mauthnerin 1868,there have been several case reports about *** recently,Pichi et alreported clinical manifestations and multimodal retinal imaging of 49 eyes with *** their study,they had identified an association between macrovessel in the retina and venous anomalies of the brain and they emphasized the importance of systemic workups including brain magnetic resonance imaging (MRI).

关键词： venous Congenital malformation

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Evaluation of the safety of anterior capsule staining with trypan blue under air: a retrospective analysis

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 432-437页

作者： young Min park Jong Soo Lee Ji Eun Lee Yeon Ji Jo Ik Soo Byon Sung Who park Centum Bright Light Eye Clinic 20Centum 2-roHaeundaeguBusanKorea 48060Republic of Korea Department of Ophthalmology School of MedicinePusan National University and Medical Research InstitutePusan 49241Republic of Korea

AIM: To evaluate the safety of using 0.03% trypan blue under air for anterior capsule staining in cataract ***: The current study involved a retrospective analysis of the medical records of 86 patients with vitreous hemorrhage, who underwent pars plana vitrectomy and cataract *** patients were classified into two *** trypan blue group(n=45) comprised patients who underwent anterior capsule staining with 0.03% trypan blue under an air *** control group(n=41) comprised of patients who underwent intracameral illuminator-assisted *** status of endothelial cell density(ECD) in both the groups was ***: The trypan blue group displayed significant decline in ECD at 1 mo(7.91% loss, P<0.001) and 3 mo(9.65% loss, P<0.001) after the surgery, whereas no significant changes were observed in the control ***, the number of patients who did not display a postoperative decline in ECD was significantly higher in the control group(43.9%;18 patients) than in the trypan blue group(17.1%;7 patients, P=0.004).CONCLUSION: Anterior capsule staining with trypan blue under the air bubble would not be as safe as the intracameral *** ECD loss might be attributed to the air bubble rather than to the deleterious effects of 0.03% trypan *** studies are required to clarify this.

关键词： anterior capsule cataract endothelium trypan blue vitreous hemorrhage

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Gold nanoparticle-assisted delivery of brain-derived neurotrophic factor to cerebral organoids

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Nano Research 2022年第4期15卷 3099-3105页

作者： Sung Bum park Hye-Jin Cho Sang Rin Moon Kyoung Jin Choi Won Hoon Jung Ki young Kim Byumseok Koh Therapeutics and Biotechnology Division Korea Research Institute of Chemical Technology141 Gajeong-roYuseong-guDaejeon 34114Republic of Korea Chemical Platform Technology Division Korea Research Institute of Chemical Technology141 Gajeong-roYuseong-guDaejeon 34114Republic of Korea

Gold nanoparticle(AuNP)-assisted delivery of proteins/drugs to cells or in vivo systems has long been ***,their interaction with in vivo mimicking organoids is still largely ***,we conjugated brain-derived neurotropic factor(BDNF)to the AuNP surface and monitored how AuNP-BDNF interacts with cerebral *** suggest that AuNP-BDNF can successfully enter cerebral organoids and can be found up to 15.21μm inside cerebral ***-BDNF does not induce significant cytotoxicity to cerebral organoids at concentrations up to 2 nM and increases the expression of 75 genes compared to control cerebral *** data suggest the successful delivery of BDNF through AuNP-BDNF conjugation in cerebral organoids,and the conjugation can affect its differentiation.

关键词： gold nanoparticles cerebral organoids delivery penetration differentiation viability

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