Optimal laboratory testing protocol for patients with acne taking oral isotretinoin
作者机构：Department of DermatologyDongguk University Ilsan HospitalCollege of MedicineDongguk UniversityGoyang 10326South Korea
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2023年第11卷第11期
页 面：2435-2442页
核心收录：
学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学]
基 金：Supported by the Dongguk University Research Program(2021)
主 题：Acne vulgaris Isotretinoin Clinical laboratory techniques Vitamin A Liver
摘 要：BACKGROUND Isotretinoin is a widely prescribed drug for various dermatological conditions,especially *** tests are routinely performed to monitor its side ***,the optimal testing schedule remains *** To evaluate the laboratory monitoring tests and schedules of patients with acne taking isotretinoin to determine the most efficient testing *** We retrospectively reviewed electronic medical records from the Dermatology Department of Dongguk University Ilsan Hospital from 2005 to 2020 for patients prescribed isotretinoin for acne who underwent monthly blood *** Aspartate aminotransferase(AST),alanine aminotransferase(ALT),and trigly-ceride(TG)levels significantly changed between 5 and 6 mo when the total prescription period and dose variables were considered *** high-density lipoprotein level also significantly changed between 5 and 6 ***,low-density lipoprotein(LDL)and total cholesterol levels significantly changed between 1 and 2 *** We recommend testing AST,ALT,and TG levels once every 5 to 6 *** also suggest testing LDL and total cholesterol levels during the first and second months.
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