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Recent advances in platelet engineering for anti-cancer therapies

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Particuology 2022年第5期20卷 2-13页

作者： Yanlin Lv Wei Wei guanghui ma State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Platelets contribute a major role in hemostasis by clumping and coagulation at the site of blood vessel *** light of recent findings of a close relationship between platelets and immunological response,as well as interactions between platelets and cancer cells,novel engineering strategies have emerged for the integration of platelets or platelet membrane(PM)with anti-cancer *** this review,we discuss several recent innovations that use platelets or their membranes to circumvent host immune responses and target tumor cells with high specificity to deliver a range of pharmacological,photothermal,or immunologic agents for eradication of recalcitrant tumor *** specifically,we compare the relative advantages of using whole platelets versus single or hybrid PM to coat nanoparticle *** cargoes range from well-established anti-tumor apoptosis-inducing agents,to relatively new photothermal agents that can induce a feedback cascade in which they induce vascular damage to the tumor which recruits more platelet-or membrane-encapsulated agents to induce further *** also discuss the use of engineered platelets to produce programmed cell death-inducing platelet derived *** review provides an overview and future directions for this promising platelet-based biomimetic approach to anti-cancer therapy.

关键词： Engineering platelets Platelet-mimicking Drug delivery Anti-cancer therapy

Sprayed Pickering emulsion with high antibacterial activity for wound healing

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Progress in Natural Science:materials International 2020年第5期30卷 669-676页

作者： Xieru Bao Jie Wu guanghui ma State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences School of Chemical Engineering University of Chinese Academy of Sciences PLA Key Laboratory of Biopharmaceutical Production and Formulation Engineering Institute of Process Engineering Chinese Academy of Sciences Jiangsu National Synergetic Innovation Center for Advanced materials

Effective treatment of wound injuries can prevent infections and promote healing. In this work, a sprayed Pickering emulsion composed of chitosan nanoparticles, tea tree oil and curcumin was formulated. The shear thinning behaviour allowed this Pickering emulsion to spray even with a high viscosity provided by the aqueous phase containing chitosan nanoparticles. Moreover, the Pickering emulsion could recover to the high viscosity after spraying onto the wounds, leading to the long residence time and intimate contact. In addition, the Pickering emulsion provided a carrier to encapsulate the tea tree oil, which caused sustained-release effects and further strengthened tea tree oil’s antibacterial activity towards the Gram-negative Escherichia coli(E. coli),Gram-positive Staphylococcus aureus(S. aureus) and Gram-positive methicillin-resistant Staphylococcus aureus(MRSA). Besides, this multi-phase system offered a platform to load with hydrophobic curcumin, leading to better synergistic healing effects. Meanwhile, the Pickering emulsion avoided the irritation and toxicity related to surfactants, which was far safer than the classical emulsion especially when used in the defective skin. All these excellent properties endowed this sprayed Pickering emulsion with promising prospects for wound healing.

关键词： Pickering emulsion Wound healing Chitosan nanoparticles High viscosity Antibacterial activity

Engineered self-healing single-cavity microcapsules for pulsatile release of drug delivery

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Particuology 2023年第9期80卷 53-60页

作者： Tong Ye Lingjiao Zou Yishu Wang guanghui ma State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China Division of Molecular Science Graduate School of Science and TechnologyGunma University1-5-1Tenjin-choKiryu376-8515Japan Innovation Academy for Green manufacture Chinese Academy of SciencesBeijing100190China

A wide range of polymer-based drug delivery systems have been reported for the treatment of ***,the dosing regimen of many drugs,such as stimulator of interferon genes agonists,programmed cell death protein-1 antibodies,and coronavirus disease 2019 vaccines,consists of repeatedintratumoral or intramuscular *** repeated administrations may lead to poor adherence,thus resulting in compromised therapeutic outcomes and increased financial ***,we developed a multidose drug delivery platform by engineering polylactic-co-glycolic acid(PLGA)with differentmolecular weights into self-healing single-cavity microcapsules(SSM).This approach showed a flexiblecollocation strategy to achieve customized pulsatile drug release and was fully degradable with ***,this single-injection delivery system contains only PLGA,holding great promise forclinical translation.

关键词： Drug delivery Single-cavity microcapsule Pulsatile release Self-healing microparticle

Recent research and development of PLGA/PLA microspheres/nanoparticles: A review in scientific and industrial aspects

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Frontiers of Chemical Science and Engineering 2019年第1期13卷 14-27页

作者： Feng Qi Jie Wu Hao Li guanghui ma Beijing Nuokangda Pharmaceutical Technology Co. Ltd Beijing 100176 China Department of Mechanical and Aerospace Engineering University of Missouri MO 65211 USA National Key Laboratory of Biochemical Engineering Key Laboratory of Biopharmaceutical Production and Formulation Engineering PLA Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China

Poly(D,L-lactic-co-glycolic acid)(PLGA)/poly (lactic acid)(PLA) microspheres/nanoparticles are one of the most successful drug delivery systems (DDS) in lab and clinic. Because of good biocompatibility and biodegradability, they can be used in various areas, such as longterm release system, vaccine adjuvant, tissue engineering, etc. There have been 15 products available on the US market, but the system still has many problems during development and manufacturing, such as wide size distribution, drug stability issues, and so on. Recently, many new and modified methods have been developed to overcome the above problems. Some of the methods are easy to scale up, and have been available on the market to achieve pilot scale or even industrial production scale. Furthermore, the relevant FDA guidance on the DDS is still incomplete, especially for abbreviated new drug application. In this review, we present some recent achievement of the PLGA/PLA microspheres/nanoparticles, and discuss some promising manufacturing methods. Finally, we focus on the current FDA guidance on the DDS. The review provides an overview on the development of the system in pharmaceutical industry.

关键词： PLGA microspheres drug delivery system stability manufacturing

Concepts, processing, and recent developments in encapsulating essential oils

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Chinese Journal of Chemical Engineering 2021年第2期34卷 255-271页

作者： Qirui Tian Weiqing Zhou Qiong Cai guanghui ma Guoping Lian Department of Chemical and Process Engineering University of SurreyGuildford GU27XHUK State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences School of Chemical SciencesBeijing 100049China Unilever Research Colworth Colworth ParkSharnbrookBedfordshire MK441LQUK

By the virtue of their olfactory,physicochemical,and biological characteristics,essential oils(EOs)have drawn wide attention as additives in daily chemicals like perfume or personal care ***,they are physicochemically unstable and susceptible to degradation or *** offers a feasible strategy to stabilize and prolong release of *** review summarizes the recognized benefits and functional properties of various preparation and characterization methods,wherein innovative fabrication strategies and their formation mechanisms are especially *** in combining detecting/measuring technologies with kinetic modelling are discussed,to give an integral approach of controlling the dynamic release of encapsulated ***,new development trends of EOs capsules are also highlighted.

关键词： Essential oils Encapsulation Sustained release

Formation of biomimetic hierarchical nanostructure in homopolymers and block copolymer ternary blend particles

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Particuology 2022年第5期20卷 98-109页

作者： Shu Kikuchi Ryoka Shoji Shinji Kanehashi guanghui ma Kenji Ogino Graduate School of Bio-Applications and Systems Engineering Tokyo University of Agriculture and Technology2-24-16 NakachoKoganei-shiTokyo 184-8588Japan Institute of Global Innovation Research Tokyo University of Agriculture and Technology2-24-16 NakachoKoganei-shiTokyo 184-8588Japan State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100080China

In order to mimic hierarchical nanostructures in nature,particles of polymer blends consisting of poly(4-butyltriphenylamine)(PBTPA),poly(methyl methacrylate)(PMma)and PBTPA-block-PMma were fabricated by a solvent evaporation *** of the molecular weight and the chemical composition of PBTPA-b-PMma,molecular weights of homopolymers,and the composition of the blend on the morphology were *** polymer blend particle consisting of PBTPA and PMma homopolymers exhibited thermodynamically favored core-shell structure,in which more hydrophilic PMma-shell surrounded *** addition of 10 wt%of PBTPA-b-PMma caused the morphological transition from core-shell toJanus or inversed core-shell,in which PBTPA-shell surrounded PMma-core,depending on the molecular weight of PBTPA segment in *** the molecular weight of PMma segment was higher than that of PMma homopolymer,watermelon-like particles in which small PBTPA domain less than 80 nm dispersed in the PMma domain surrounded by PBTPA shell were *** the ratio of PBTPA-b-PMma increased,the interface of the macrophase separation became *** 50 wt%of the PBTPA-b-PMma,only microphase separation was *** measurement of interfacial tension by pendant drop method demonstrated that PBTPA-b-PMma lower the interfacial tension between PBTPA and the aqueous phase to the value similar to that of PMma with the aqueous phase.

关键词： Microsphere Hierarchical structure Polymer blend Block copolymer Solvent evaporation Phase separation

Aggregating particles on the O/W interface:Tuning Pickering emulsion for the enhanced drug delivery systems

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Aggregate

Aggregate 2022年第2期3卷 3-21页

作者： Yali Ming Yufei Xia guanghui ma State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China

The rational design of drug delivery systems has led to enhanced targeting,increased efficiency,and a reduction of side effects in chemotherapies and *** most biological reactions took place at the interface,particle-stabilized emulsion(Pickering emulsion),may offer major implications for the advanced drug loading,delivery,and controlled *** fact,it is the aggregating particles that determined the multi-level structure,multi-valent cellular interactions,and the multi-functional physiochemical properties in drug delivery.A deeper understanding on the tunable aggregating patterns and properties,as well as the underlying mechanisms,may pave the way for the efficient drug delivery,and also aided the progressing of“Aggregology”beyond molecules to particles,emulsions,and the biomedical ***,the recent development of Pickering emulsions and their applications in drug delivery were thoroughly *** to control over the physiochemical properties were illustrated based on particle properties,energy input,and the choices of continuous and dispersion *** particular,enough emphasis was attached on the structure-effect relationship between the tunable physiochemical properties and the delivery process,such as the multi-level structure for effective loading,flexibility and permeability for enhanced delivery,and the stimuli-responsiveness for the controlled *** channeling the unique interfacial properties and the enhanced drug delivery efficiency,this work may shed light on the rational design of Pickering emulsions for the efficient drug delivery.

关键词： drug delivery system multi-valent interactions particle aggregation Pickering emulsion softness

Statistical learning based facial animation

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第7期14卷 542-550页

作者： Shibiao XU guanghui ma Weiliang MENG Xiaopeng ZHANG National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences

To synthesize real-time and realistic facial animation, we present an effective algorithm which combines image- and geometry-based methods for facial animation simulation. Considering the numerous motion units in the expression coding system, we present a novel simplified motion unit based on the basic facial expression, and construct the corresponding basic action for a head model. As image features are difficult to obtain using the performance driven method, we develop an automatic image feature recognition method based on statistical learning, and an expression image semi-automatic labeling method with rotation invariant face detection, which can improve the accuracy and efficiency of expression feature identification and training. After facial animation redirection, each basic action weight needs to be computed and mapped automatically. We apply the blend shape method to construct and train the corresponding expression database according to each basic action, and adopt the least squares method to compute the corresponding control parameters for facial animation. Moreover, there is a pre-integration of diffuse light distribution and specular light distribution based on the physical method, to improve the plausibility and efficiency of facial rendering. Our work provides a simplification of the facial motion unit, an optimization of the statistical training process and recognition process for facial animation, solves the expression parameters, and simulates the subsurface scattering effect in real time. Experimental results indicate that our method is effective and efficient, and suitable for computer animation and interactive applications.

关键词： Facial animation Motion unit Statistical learning Realistic rendering Pre-integration

A two-pronged strategy utilizing exosomes extracted from antigenpresenting cells to combat hepatitis B

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Nano Research 2024年第10期17卷 9084-9094页

作者： Fumin Hu Dangyang Wang Ting Lu guanghui ma Hua Yue State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing 100190China

Chronic hepatitis B(CHB)is consistently challenging to conquer with numerous complications and *** the effectiveness of antiviral therapies in suppressing hepatitis B virus(HBV)replication,there is an urgent need for novel and more effective treatment *** strategies predominantly emphasize immune activation but still face challenges in sufficiently eliciting T cell *** into account the targeted delivery of nanoparticles to the liver and spleen via intravenous injection,we have proposed a dual-pronged therapeutic strategy based on antigen-presenting cells(APCs)-derived ***,exosomes targeted to the spleen can activate specific immune responses,while those targeted to the liver can modulate or reverse the liver’s immunosuppressive *** immunization,exosome formulations exhibit the remarkable ability to effectively activate APCs,thereby triggering the proliferation of CD8^(+)T ***,they also play an immunoregulatory role by converting M2 macrophages into M1 *** two-pronged therapeutic strategy precisely addresses the issues of T cell dysfunction and immune suppression,both characteristic features of CHB *** combined with Aluminum(Alum)-adjuvanted vaccine,these exosome formulations not only demonstrate a high level of cellular immune response but also secrete specific antibodies comparable to those induced by Alum *** combined approach effectively enhances both cellular and humoral immunity,offering a promising avenue for the development of therapeutic hepatitis B vaccines based on exosome formulations.

关键词： chronic hepatitis B antigen-presenting cells(APCs)-derived exosomes immunoregulatory role two-pronged therapeutic strategy