Recent advances in platelet engineering for anti-cancer therapies
作者机构：State Key Laboratory of Biochemical EngineeringInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China
出 版 物：《Particuology》 (颗粒学报（英文版）)
年 卷 期：2022年第20卷第5期
页 面：2-13页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the National Natural Science Foundation of China(grant Nos.21821005,21907096 and 82072406) National Key R&D Program of China(grant No.2017YFA0207900) Strategic Priority Research Program of the Chinese Academy of Sciences(grant No.XDB29040303)
主 题：Engineering platelets Platelet-mimicking Drug delivery Anti-cancer therapy
摘 要：Platelets contribute a major role in hemostasis by clumping and coagulation at the site of blood vessel *** light of recent findings of a close relationship between platelets and immunological response,as well as interactions between platelets and cancer cells,novel engineering strategies have emerged for the integration of platelets or platelet membrane(PM)with anti-cancer *** this review,we discuss several recent innovations that use platelets or their membranes to circumvent host immune responses and target tumor cells with high specificity to deliver a range of pharmacological,photothermal,or immunologic agents for eradication of recalcitrant tumor *** specifically,we compare the relative advantages of using whole platelets versus single or hybrid PM to coat nanoparticle *** cargoes range from well-established anti-tumor apoptosis-inducing agents,to relatively new photothermal agents that can induce a feedback cascade in which they induce vascular damage to the tumor which recruits more platelet-or membrane-encapsulated agents to induce further *** also discuss the use of engineered platelets to produce programmed cell death-inducing platelet derived *** review provides an overview and future directions for this promising platelet-based biomimetic approach to anti-cancer therapy.
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