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ABAQUS有限元分析软件在滚动轴承故障诊断中的仿真应用

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机械设计与制造 2024年第5期399卷 22-27页

作者：郑国刚戴光泽张敏男西南交通大学材料科学与工程学院四川成都610031

通过ABAQUS有限元仿真分析软件对圆柱滚子轴承进行了动力学仿真,运用仿真结果分析了预设工况下轴承的载荷分布规律。运用线弹性力学的相关理论,研究了滚子裂纹缺陷的发展机理,并由此对滚子剥落故障的形成进行了很好的解释。对比分析了... 详细信息

通过ABAQUS有限元仿真分析软件对圆柱滚子轴承进行了动力学仿真,运用仿真结果分析了预设工况下轴承的载荷分布规律。运用线弹性力学的相关理论,研究了滚子裂纹缺陷的发展机理,并由此对滚子剥落故障的形成进行了很好的解释。对比分析了正常运行状态与故障运行状态下轴承动能与应力的变化规律,分析了故障状态轴承工作的不利影响。利用提取得到的仿真冲击振动信号,运用FFT变换方式进行了振动信号的相关处理,对预制单部件故障频率进行了较为准确提取,初步研究了复合故障对轴承运行的不利影响,为实际工程应用中轴承故障诊断奠定了一定的仿真理论依据。

关键词：有限元仿真故障诊断滚动轴承

Small interfering RNA-mediated knockdown of Notch1 in lung T cells of asthmatic mice affects T cell differentiation

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Chinese Medical Journal 2009年第21期122卷 2647-2651页

作者： GUO Xue-jun zhou min REN Lian-ping YANG min HUANG Shao-guang XU Wei-guo Department of Respiratory Medicine Ruijin Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200025 China Department of Respiratory Medicine Xinhua Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200092 China Department of Respiratory Medicine Shanghai Third Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200092 China

Background The immunologic response to allergens mediated by T lymphocytes is an incipient key element in the pathogenesis of asthma, and Thl/Th2 balance is regarded as the core of asthma pathogenesis. Notch is a single-pass transmembrane receptor protein that regulates differentiation, proliferation and apoptosis in a broad range of cells. It is considered that the Notch signal pathway works in every stage of T cell development and differentiation. Whether the pathway of asthma pathogenesis is related to Notch1 remains unknown. This study is aimed to investigate whether the pathway of asthma pathogenesis is related to Notch1 by examining the effect of knockdown of the Notch1 gene by small interfering RNA on T cell differentiation. Methods An OVA-induced asthma mouse model was established. The expression of Notch1 in the tissue and T cells of the lung from asthmatic mice was detected by RT-PCR and Western blotting. The expression of Notch1 and cytokine interleukin （IL）-4 and interferon （IFN）-γ in activated lung T cells was detected by RT-PCR and enzyme-linked immunosorbent assay after blocking Notch1 by small interfering RNA. Results The mRNA and protein expression of Notch1 increased significantly both in the lung tissue and lung T cells of asthmatic mice （both P 〈0.05）. IL-4 decreased and IFN-y increased significantly in active lung T cells after Notch1 was blocked by Notchl-specific small interfering RNA （IL-4：（2.51±0.51） pg/ml vs 0.64±0.27） pg/ml protein; IFN-γ：（21.72±4.24） pg/ml vs （39.79±4.09） pg/ml protein, P 〈0.05）. Conclusion This study demonstrated that the Notch1 signal might play a role in the pathogenesis of asthma by its involvement in Thl/Th2 differentiation.

关键词： asthma Notchl receptor T-lymphocytes small interfering RNA

Treatment of Epilepsy with Bipolar Electro-coagulation： An Analysis of Cortical Blood Flow and Histological Change in Temporal Lobe

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Chinese Medical Journal 2015年第2期128卷 210-215页

作者： Zhi-Qiang Cui Guo-ming Luan Jian zhou Feng Zhai Yu-guang Guan min Bao Department of Neurosurgery Sanbo Brain Hospital Capital Medical University Beijing 100093 China Department of Neurosurgery Chinese People's Liberation Army General Hospital Chinese People's Liberation Army Postgraduate Medical School Beijing 100853 China

Background：Bipolar electro-coagulation has a reported efficacy in treating epilepsy involving functional cortex by pure electro-coagulation or combination with ***,the mechanisms of bipolar electro-coagulation are not completely *** studied the acute cortical blood flow and histological changes after bipolar electro-coagulation in 24 patients with intractable temporal lobe ***：Twenty-four patients were consecutively enrolled,and divided into three groups according to the date of *** regional cortical blood flow （rCBF）,electrocorticography,the depth of cortex damage,and acute histological changes （H and E staining,neuronal staining and neurofilament （NF） staining） were analyzed before and after the *** t-test analysis was used to compare the rCBF before and after the ***：The rCBF after coagulation was significantly reduced （P 〈 0.05）.The spikes were significantly reduced after *** the temporal cortex,the depth of cortical damage with output power of 2-9 W after electro-coagulation was 0.34 ± 0.03,0.48 ± 0.06,0.69 ± 0.06,0.84 ± 0.09,0.98 ± 0.08,1.10 ± 0.1 l,1.11 ± 0.09,and 1.22 ± 0.11 mm,*** with output power of 4-5 W completely damaged the neurons and NF protein in the molecular layer,external granular layer,and external pyramidal ***：The electro-coagulation not only destroyed the neurons and NF protein,but also reduced the *** concluded that the injuries caused by electro-coagulation would prevent horizontal synchronization and spread of epileptic discharges,and partially destroy the epileptic focus.

关键词： Acute Histological Change Bipolar Electro-coagulation Electrocorticography Regional Cortical Blood Flow Temporal Lobe Epilepsy

Therapeutic effects of herbal formula Huangqisan on metabolic disorders via SREBF1,SCD1 and AMPK signaling pathway

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Journal of Integrative Medicine 2021年第2期19卷 167-176页

作者： Ya-lei Liu Zhen-yu zhou min Gao guang Ji Cheng Huang Sheng-jie Fan School of Pharmacy Shanghai University of Traditional Chinese MedicineShanghai 201203China College of Pharmacy Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Institute of Digestive Diseases Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China

Objective:Metabolic syndrome is a complex medical condition that has become an alarming epidemic,but an effective therapy for this disease is still *** use of the herbal formula Huangqisan(HQS)to treat diabetes is documented in the Chinese medical literature as early as 1117 A.D.;however,its therapeutic effects and underlying mechanisms remain ***:To investigate the beneficial effects of HQS on metabolic disorders,high-fat diet-induced obesity(DIO),leptin receptor dysfunction(db/db)and low-density lipoprotein receptor-knockout(LDLR^(-/-))mice were *** mice were treated with either HQS or ***,liver tissue,white fat tissue and brown adipose tissue were harvested at the end of the *** disease-related parameters were evaluated to test effects of HQS against diabetes,obesity and *** arches from LDLR^(-/-)mice were analyzed to investigate the effects of HQS on ***-sequence,quantitative real-time polymerase chain reaction and Western blot were performed to investigate the mechanisms of HQS against metabolic ***:HQS lowered body weight,fasting blood glucose and serum lipid levels and improved glucose tolerance and insulin sensitivity in DIO mice and db/db mice(P<0.05).HQS also blocked atherosclerotic plaque formation in LDLR^(^(-/-)) *** suppressed de novo lipid synthesis by reducing the expression of messenger RNA for sterol regulatory element-binding factor 1,stearyl coenzyme A desaturase 1 and fatty acid synthase,and enhancing adenosine 5’-monophosphate-activated protein kinase signaling in both in vivo and in vitro experiments,indicating potential mechanisms for HQS’s activity against ***:HQS is effective for reversing metabolic disorder and has the potential to be used as therapy for metabolic syndrome.

关键词： Tradition Chinese medicine Diabetes Hyperlipidemia Obesity Atherosclerosis

A LFD-RAA-Based Rapid Detection Method for Pseudomonas syringae pv. tabaci

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Agricultural Science & Technology 2024年第2期25卷 38-43页

作者： XIAO Yan-song LI Hong-guang LI Si-jun WU Wen-xin zhou Lu-su ZHONG Jie SU Jia-en YANG Zhi-juan Chenzhou Tobacco Company Hunan Provincial Tobacco CorporationChenzhou 423000PRC Guiyang Branch of Chenzhou Tobacco Company Hunan Provincial Tobacco CorporationChenzhou 424400PRC College of Plant Protection Hunan Agricultural UniversityChangsha 410128PRC Dali Tobacco Company Yunnan Provincial Tobacco CorporationDali 671000PRC

This study aimed to achieve rapid detection of Pseudomonas syringae ***,the pathogen of tobacco wildfire *** specific primers and probes for recombinase-aided amplification(RAA)were designed with HrpZ as the target *** was then combined with the lateral flow dipstick(LFD)to establish a LFD-RAA-based rapid detection system for the ***,the detection performance of the established method was *** results showed that the LFDRAA method had high *** amplification could be completed after 25 min of reaction at 39℃.The sensitivity of the established method reached 0.0001 ng/μL,which was superior to that of PCR ***,the LFD-RAA method could quickly detect *** *** from tobacco leaves,demonstrating field *** sum up,the LFD-RAA method established in this study can be applied in the rapid detection and early diagnosis of tobacco wildfire disease.

关键词： Tobacco wildfire disease Recombinase-aided amplification Detection

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降雨条件下凋落物层的水力特性研究

节水灌溉 2024年第4期 91-96,104页

作者：陶雪卿魏琛琛孙光辉邢伟民扬州大学水利科学与工程学院江苏扬州225000 长江科学院农业水利研究所武汉430010

凋落物层水力特性能够显著影响坡地产流过程。选取不同凋落物组合(5 cm落叶层+5 cm分解层、10 cm落叶层),雨型(递增、递减和均匀)以及两种坡度(15°、20°),采用人工模拟降雨试验,对凋落物渗漏水和侧向径流水量进行分析。结果表明:①降... 详细信息

凋落物层水力特性能够显著影响坡地产流过程。选取不同凋落物组合(5 cm落叶层+5 cm分解层、10 cm落叶层),雨型(递增、递减和均匀)以及两种坡度(15°、20°),采用人工模拟降雨试验,对凋落物渗漏水和侧向径流水量进行分析。结果表明:①降雨强度越大,凋落物渗漏达到稳定所需时间越少,稳定渗漏率越大。②相同雨型及坡度条件下,平均渗漏率表现为5 cm落叶层+5 cm分解层>10 cm落叶层,侧向径流率表现为5 cm落叶层+5 cm分解层<10 cm落叶层。③与均匀雨型相比,5 cm落叶层+5 cm分解层递增雨型和递减雨型处理平均渗漏率减少了10.8%~36.4%,平均侧向产流率增加了14.3%~19.0%。各雨型基本表现为均匀雨型平均渗漏率最大且平均侧向产流率最小,递增和递减雨型处理没有显著性差异。④相同凋落物组合和雨型条件下,与15°相比,20°处理凋落物平均渗漏率减小了4.3%~35.9%(P<0.05),侧向径流率增大了6.0%~20.3%(P<0.05)。

关键词：凋落物径流渗漏雨型坡度

大黄蛰虫丸通过NF-κB信号通路调节动脉粥样硬化大鼠血脂及炎症相关指标水平

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中国老年学杂志 2024年第12期44卷 2917-2921页

作者：王转转顾民华李光智余洪海南省中医院海南海口570203

目的探究大黄蛰虫丸(DHZCW)调控核转录因子(NF)-κB信号通路对动脉粥样硬化(AS)大鼠血脂及炎症相关指标水平的影响及机制。方法60只SD大鼠随机抽取12只作为NC组,余48只通过腹腔注射大剂量维生素(Vit)D3的方式构建AS大鼠模型,并将其随机... 详细信息

目的探究大黄蛰虫丸(DHZCW)调控核转录因子(NF)-κB信号通路对动脉粥样硬化(AS)大鼠血脂及炎症相关指标水平的影响及机制。方法60只SD大鼠随机抽取12只作为NC组,余48只通过腹腔注射大剂量维生素(Vit)D3的方式构建AS大鼠模型,并将其随机分为AS组、DHZCW低、中、高剂量组,每组12只。其中DHZCW低、中、高剂量组分别予以1.0、2.0、3.0 g/kg DHZCW灌胃,NC组及AS组均予以等量生理盐水灌胃。观察各组1、3、7 w时的体质量变化及7 w时血管内皮组织形态变化,比较各组血清三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、白细胞介素(IL)-1β、IL-6、肿瘤坏死因子(TNF)-α水平及p-p65、p65、p-NF-κB抑制蛋白(IκB)α、IκBα蛋白表达。结果在3、7 w时,AS组、DHZCW各剂量组体质量均较NC组明显减少(P<0.05)。在7 w时,DHZCW各剂量组体质量均较AS组明显增加,DHZCW高、中剂量组体质量较DHZCW低剂量组明显降低(P<0.05)。AS组血清TG、TC、LDL-C、IL-1β、IL-6、TNF-α水平及p-p65/p65、p-IκBα/IκBα比值均较NC组明显增加,HDL-C水平较NC组明显减少(P<0.05)。DHZCW各剂量组血清TG、TC、LDL-C、IL-1β、IL-6、TNF-α水平及p-p65/p65、p-IκBα/IκBα比值均较AS组明显减少,HDL-C水平较AS组明显增加(P<0.05);且DHZCW中、高剂量组血清TG、TC、LDL-C、IL-1β、IL-6、TNF-α水平及p-p65/p65、p-IκBα/IκBα比值均较DHZCW低剂量组明显减少,HDL-C水平较DHZCW低剂量组明显增加(P<0.05)。结论DHZCW可通过抑制NF-κB通路降低AS大鼠血脂水平及炎症反应,发挥抗AS的作用。

关键词：大黄蛰虫丸核转录因子(NF)-κB 动脉粥样硬化血脂炎症

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类别特征约束的多目标域表情识别方法

计算机工程与科学 2024年第5期46卷 836-845页

作者：范琪王善敏刘成广刘青山南京信息工程大学自动化学院江苏南京210044 南京航空航天大学计算机科学与技术学院江苏南京211100 南京信息工程大学计算机学院江苏南京210044 南京邮电大学计算机学院江苏南京210023

表情识别FER方法通常会受到采集环境和受试者区域、种族等因素的影响。为了提升FER方法的泛化性能,无监督的域自适应表情识别方法UDA-FER成为了研究热点。现有的UDA-FER方法普遍存在2个问题:(1)仅关注对目标域的识别率,导致方法从源域... 详细信息

表情识别FER方法通常会受到采集环境和受试者区域、种族等因素的影响。为了提升FER方法的泛化性能,无监督的域自适应表情识别方法UDA-FER成为了研究热点。现有的UDA-FER方法普遍存在2个问题:(1)仅关注对目标域的识别率,导致方法从源域迁移至目标域后,对源域的识别率急剧下降;(2)仅研究基于单个目标域的UDA-FER方法,将现有方法直接应用于多个目标域会导致方法识别率骤降。为解决上述问题,提出了一种类别特征约束的多目标域表情识别方法MTD-FER,实现FER向多个目标域的连续迁移。为了保持对源域的识别率并提高对多个目标域的识别率,MTD-FER设计了类别自适应的伪标签标记CAPL模块和类别特征约束CWFC模块,挑选目标域高质量的样本标记为伪标签,并对齐各个域同类样本的特征,缓解连续迁移导致的灾难性遗忘问题。以RAF-DB为源域,FER-2013和ExpW为目标域,进行大量的实验,证明了MTD-FER的有效性。实验结果表明,与基准方法相比,MTD-FER在多次迁移后,源域识别率提升6.36%,与迁移之前基本持平;在各个目标域性能均有所提升,其中FER-2013性能提升了27.33%,ExpW性能提升了3.03%。

关键词：人脸表情识别无监督域自适应多目标域类别自适应的伪标签类别特征约束

Porous carbon nanofibers derived from low-softening-point coal pitch towards all-carbon potassium ion hybrid capacitors

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Rare Metals 2022年第11期41卷 3706-3716页

作者： guang-Yuan Wang Xiao-Hong Wang Jin-Feng Sun Ya-min Zhang Lin-Rui Hou Chang-zhou Yuan School of Materials Science and Engineering University of JinanJinan250022China

Potassium ion hybrid capacitors(PIHC)have promising applications in medium and large-scale energy storage systems due to their high energy/power density,abundant potassium resource and low ***,the slow kinetics of battery-type anodes originating from the large-size K+results in a mismatch between the two electrodes,rendering the modest energy density of ***,we first develop an electrospinning strategy to successfully synthesize fibrous precursor by using the HNO_(3)pre-oxidized low-softening-point coal pitch as the low-cost raw *** further carbonization or KOH activation,the two types of carbon nanofibers(CNF)are fabricated as anode and cathode materials,respectively,towards the dual-carbon PIHC *** to its threedimensional interconnected porous conducting network and large layer spacing,the resulted CNF anode material is endowed with high reversible capacities,excellent rate and long cycle ***,the activated CNF cathode with a large surface area of 2169 m^(2)·g^(-1)exhibits excellent capacitive performance.A PIHC constructed with the two fibrous electrodes delivers an energy density of110.0 Wh·kg^(-1)at 200.0 W kg^(-1),along with a capacitance retention of 83.5%after 10,000 cycles at 1.0 A·g^(-1).The contribution here provides a cost-efficiency avenue and platform for advanced dual-carbon PIHC.

关键词： Potassium ion hybrid capacitors(PIHC) Low-softening-point coal pitch Carbon nanofibers(CNF) Dual-carbon devices Long durability