Therapeutic effects of herbal formula Huangqisan on metabolic disorders via SREBF1,SCD1 and AMPK signaling pathway

作     者：Ya-lei Liu Zhen-yu Zhou Min Gao Guang Ji Cheng Huang Sheng-jie Fan Ya-lei Liu;Zhen-yu Zhou;Min Gao;Guang Ji;Cheng Huang;Sheng-jie Fan

作者机构：School of PharmacyShanghai University of Traditional Chinese MedicineShanghai 201203China College of PharmacyShanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Institute of Digestive DiseasesLonghua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China 

出 版 物：《Journal of Integrative Medicine》 (结合医学学报（英文版）)

年 卷 期：2021年第19卷第2期

页      面：167-176页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by Shanghai Municipal Planning Commission of Science and Research Fund(Shanghai China No.20174Y0164)to SF 

主　　题：Tradition Chinese medicine Diabetes Hyperlipidemia Obesity Atherosclerosis 

摘      要：Objective:Metabolic syndrome is a complex medical condition that has become an alarming epidemic,but an effective therapy for this disease is still *** use of the herbal formula Huangqisan(HQS)to treat diabetes is documented in the Chinese medical literature as early as 1117 A.D.;however,its therapeutic effects and underlying mechanisms remain ***:To investigate the beneficial effects of HQS on metabolic disorders,high-fat diet-induced obesity(DIO),leptin receptor dysfunction(db/db)and low-density lipoprotein receptor-knockout(LDLR^(-/-))mice were *** mice were treated with either HQS or ***,liver tissue,white fat tissue and brown adipose tissue were harvested at the end of the *** disease-related parameters were evaluated to test effects of HQS against diabetes,obesity and *** arches from LDLR^(-/-)mice were analyzed to investigate the effects of HQS on ***-sequence,quantitative real-time polymerase chain reaction and Western blot were performed to investigate the mechanisms of HQS against metabolic ***:HQS lowered body weight,fasting blood glucose and serum lipid levels and improved glucose tolerance and insulin sensitivity in DIO mice and db/db mice(P0.05).HQS also blocked atherosclerotic plaque formation in LDLR^(^(-/-)) *** suppressed de novo lipid synthesis by reducing the expression of messenger RNA for sterol regulatory element-binding factor 1,stearyl coenzyme A desaturase 1 and fatty acid synthase,and enhancing adenosine 5’-monophosphate-activated protein kinase signaling in both in vivo and in vitro experiments,indicating potential mechanisms for HQS’s activity against ***:HQS is effective for reversing metabolic disorder and has the potential to be used as therapy for metabolic syndrome.