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Pathways of Phosphorus Absorption and Early Signaling between the Mycorrhizal Fungi and Plants

Phyton-International Journal of Experimental Botany 2021年第5期90卷 1321-1338页

作者： griselda madrid-delgado Marcos Orozco-Miranda Mario Cruz-Osorio Ofelia Adriana Hernández-Rodríguez Raúl Rodríguez-Heredia Melchor Roa-Huerta Graciela Dolores Avila-Quezada Facultad de Ciencias Agrotecnológicas Universidad Autónoma de Chihuahua(UACH)Chihuahua31000México Innovak Global Chihuahua31375México

This review highlights the key role that mycorrhizal fungi play in making phosphorus(Pi)more available to plants,including pathways of phosphorus absorption,phosphate transporters and plant-mycorrhizal fungus symbiosis,especially in conditions where the level of inorganic phosphorus(Pi)in the soil is *** fungi colonization involves a series of signaling where the plant root exudates strigolactones,while the mycorrhizal fungi release a mixture of chito-oligosaccharides and liposaccharides,that activate the symbiosis process through gene signaling pathways,and contact between the hyphae and the *** the symbiosis is established,the extraradical mycelium acts as an extension of the roots and increases the absorption of nutrients,particularly phosphorus by the phosphate *** then moves along the hyphae to the plant root/fungus *** transfer of Pi occurs in the apoplectic space;in the case of arbuscular mycorrhizal fungi,Pi is discharged from the arbuscular to the plant’s root symplasm,in the membrane that surrounds the *** is then absorbed through the plant periarbuscular membrane by plant phosphate ***,plants can acquire Pi from soil as a direct absorption *** a result of this review,several genes that codify for high-affinity Pi transporters were *** plants,the main family is Pht1 although it is possible to find others such as Pht2,Pht3,Pho1 and *** in plants,mycorrhizal fungi have genes belonging to the Pht1 *** arbuscular mycorrhizal fungi we found L1PT1,GiPT,MtPT1,MtPT2,MtPT4,HvPT8,ZmPht1,TaPTH1.2,GmosPT and ***1,HcPT2 and BePT have been characterized in ectomycorrhizal *** gene has a different way of expressing *** this review,we present diagrams of the symbiotic relationship between mycorrhizal fungi and the *** knowledge allows us to design solutions to regional problems such as food production in soils with low levels of Pi.

关键词： Interaction,mycorrhiza establishment,symbiosis phosphate uptake

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Association between lifestyle factors and thyroid function in young euthyroid adults

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Food Science and Human Wellness 2024年第1期13卷 265-275页

作者： Elisa Merchan-Ramirez Guillermo Sanchez-delgado Lucas Jurado-Fasoli Francisco M Acosta Manuel Munoz-Torres Jose M.Llamas-Elvira Jonatan R Ruiz Sport and Health University Research Institute(iMUDS) Faculty of Sports ScienceUniversity of GranadaGranada 18016Spain Pennington Biomedical Research Center Baton Rouge 70808USA Faculty of Medicine University of GranadaGranada 18071Spain Turku PET Centre University of TurkuTurku 20500Finland Turku PET Centre Turku University HospitalTurku 20520Finland Biosanitary Research Institute of Granada(Ibs.Granada) Granada 18012Spain CIBERFES Instituto de Salud CarlosⅢMadrid 28029Spain Endocrinology and Nutrition Service University Hospital San CecilioGranada 18016Spain Nuclear Medicine Service "Virgen de las Nieves"University HospitalGranada 18014Spain

Purpose:The present work examines the associations of dietary habits,sedentarism,physical activity(PA)levels and sleep habits,with thyroid function in young euthyroid ***:A total of 105 young euthyroid adults participated in this cross-sectional *** function was determined in fasting conditions(>6 h).Dietary habits were measured by a food frequency questionnaire and three non-consecutive 24 h recalls,and different dietary intake and patterns were then *** time spent in sedentary,PA levels and sleep habits were objectively measured using a wrist-worn ***:Energy and carbohydrate intake were positively associated with thyroid stimulating hormone(TSH)(β=0.222;R^(2)=0.102;P=0.022 andβ=0.425;R^(2)=0.129;P=0.007,respectively)whereas fat intake was negatively associated with TSH(β=-0.428;R^(2)=0.137;P=0.004).Energy intake was also positively associated with free triiodothyronine(β=0.277;R^(2)=0.137;P=0.004).Further,adherence to the Mediterranean diet was negatively related to TSH and free thyroxine(FT4)(β=-0.221;R^(2)=0.113;P=0.020 andβ=-0.268;R^(2)=0.071;P=0.007,respectively).Vigorous-intensity and overall PA were negatively associated with FT4(β=-0.227;R^(2)=0.052;P=0.022 andβ=-0.204;R^(2)=0.042;P=0.041,respectively).In contrast,no associations were found between sleep parameters and thyroid ***:Lifestyle factors such as dietary intake and PA levels seems to be related to thyroid function even in young euthyroid adults.

关键词： Thyroid hormones Dietary intake Sleep Physical activity Euthyroid

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Precision in detecting colon lesions:A key to effective screening policy but will it improve overall outcomes?

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World Journal of Gastrointestinal Endoscopy 2024年第3期16卷 102-107页

作者： Luis Ramon Rabago Maria delgado Galan Department of Gastroenterology Hospital San RafaelMadrid 28016Spain Gastroenterology Department Hospital Severo OchoaLeganes 28914Spain

Colonoscopy is the gold standard for the screening and diagnosis of colorectal cancer,resulting in a decrease in the incidence and mortality of colon ***,it has a 21%rate of missed *** strategies have been devised to increase polyp detection rates and improve their characterization and *** include chromoendoscopy(CE),the use of other devices such as Endo cuffs,and major advances in endoscopic equipment[high definition,magnification,narrow band imaging,i-scan,flexible spectral imaging color enhancement,texture and color enhancement imaging(TXI),etc.].In the retrospective study by Hiramatsu et al,they compared white-light imaging with CE,TXI,and CE+TXI to determine which of these strategies allows for better definition and delimitation of *** concluded that employing CE associated with TXI stands out as the most effective method to *** remains to be demonstrated whether these results are extrapolatable to other types of virtual ***,further investigation is needed in order to ascertain whether this strategy could lead to a reduction in the recurrence of excised lesions and potentially lower the occurrence of interval cancer.

关键词： Colonoscopy screening Interval colorectal cancer Post colonoscopy colorectal cancer chromoendoscopy Virtual chromoendoscopy high-definition whitelight endoscopy Texture and color enhancement imaging Indigo carmine Adenoma Sessile serrated lesion

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Has Coca-Cola treatment become the first-line therapy for gastric bezoars,both in general and specifically for western countries?

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World Journal of Gastrointestinal Endoscopy 2024年第5期16卷 237-243页

作者： Maria delgado Galan Luis Ramon Rabago Department of Gastroenterology Hospital Severo OchoaLeganes 28914Spain Department of Gastroenterology Hospital San RafaelMadrid 28016Spain

Phytobezoars is a rare disease and less common in Western *** stomach is the primary site for these formations,and endoscopic treatment involving fragmentation and extraction has traditionally been the most effective ***,medical treatments using enzymatic and chemical agents,such as cellulase and Coca-Cola,aimed at dissolving the bezoars,have also been utilized,showing varying degrees of resolution ***,the oral dissolution treatment with Coca-Cola has emerged as a promising,simpler,and more costeffective *** study by Liu et al represents an important step in clinical research on this topic,despite some limitations that need addressing for a more comprehensive understanding of its *** considerations for future research include sample size calculation,endoscopic procedure details,outpatient *** treatment,and detailed cost *** study's exclusions,such as patients with upper gastric surgery,phytobezoars older than 14 d,and cases of gastroparesis,limit its applicability to broader populations,especially in Western *** the promising outcomes of the Coca-Cola treatment,it's advocated as a first-line therapy for ***,further research is essential to overcome these *** special situations such as perforation or small bowel obstruction will require surgical treatment.

关键词： Phytobezoars Endoscopic treatment Oral dissolution treatment with Coca-Cola Randomized study Editorial

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Prevalence of Helicobacter pylori infection among patients with esophageal carcinoma

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World Journal of Gastroenterology 2024年第29期30卷 3479-3487页

作者： Miriam López-Gómez Maria Morales Rebeca Fuerte Marta Muñoz Pedro-David delgado-López Jorge Francisco Gómez-Cerezo Enrique Casado Department of Medical Oncology Precision Oncology LaboratoryInfanta Sofía University HospitalSan Sebastián de los Reyes 28231MadridSpain Department of Medical Oncology Infanta Sofía University HospitalSan Sebastián de los Reyes 28702Spain Department of Internal Medicine Infanta Sofía University HospitalSan Sebastián de los Reyes 28703MadridSpain Department of Pathology Infanta Sofía University HospitalSan Sebastián de los Reyes 28702Spain Department of Neurosurgery Burgos University HospitalBurgos 09006Spain Department of Internal Medicine Infanta Sofía University Hospital and Henares University Hospital Foundation for Biomedical Research and InnovationSan Sebastian de los Reyes 28702MadridSpain Department of Medical Oncology Infanta Sofia University Hospital and Henares University Hospital Foundation for Biomedical Research and InnovationSan Sebastian de los Reyes 28702MadridSpain

BACKGROUND Helicobacter pylori(***)is a widespread microorganism related to gastric adenocarcinoma(AC).In contrast,it has been reported that an inverse association exists between *** infection and esophageal *** mechanisms underlying this supposedly protective effect remain *** To determine the prevalence of *** infection in esophageal carcinoma patients,we performed a retrospective observational study of esophageal tumors diagnosed in our *** We retrospectively reviewed the prevalence of *** infection in a cohort of patients diagnosed with esophageal *** or previous proton pump inhibitor(PPI)usage was also *** A total of 89 patients with esophageal carcinoma(69 males,77.5%),with a mean age of 66 years(range,26-93 years)were *** was the most frequent pathological variant(n=47,52.8%),followed by squamous cell carcinoma(n=37,41.6%).Fourteen ACs(29.8%)originated in the gastroesophageal junction and 33(70.2%)in the esophageal ***,54 patients(60.7%)presented at stages III and *** *** infection occurred only in 4 patients(4.5%),3 with AC(6.3%of all ACs)and 1 with squamous cell carcinoma(2.7%of all squamous cell tumors).All patients with previous *** infection had stage *** one patient had received prior *** eradication therapy,whereas 86(96.6%)had received previous or concomitant PPI *** In our cohort of patients,and after histologic evaluation of paraffin-embedded primary tumors,we found a very low prevalence of previous *** *** also reviewed the medical history of the patients,concluding that the majority had received or were on PPI *** minimal prevalence of *** infection found in this cohort of patients with esophageal carcinoma suggests a protective role.

关键词： Helicobacter pylori Eradication Esophageal tumor Dysbiosis Proton pump inhibitors Carcinogenesis Microbiota Incidence

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Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

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Neural Regeneration Research 2024年第8期19卷 1835-1841页

作者： Irene Navarro-Lobato Mariam Masmudi-Martín Manuel F.López-Aranda Juan F.López-Téllez Gloria delgado Pablo Granados-Durán Celia Gaona-Romero Marta Carretero-Rey Sinforiano Posadas María E.Quiros-Ortega Zafar U.Khan Laboratory of Neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of Neurobiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of *** this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM *** findings suggest that BDNF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s ***,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.

关键词： behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling

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Genomic patterns of homozygosity and inbreeding depression in MurcianoGranadina goats

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Journal of Animal Science and Biotechnology 2022年第3期13卷 721-734页

作者： María Gracia Luigi-Sierra Almudena Fernández Amparo Martínez Dailu Guan Juan Vicente delgado Javier FernándezÁlvarez Vincenzo Landi Francesc Xavier Such Jordi Jordana María Saura Marcel Amills Centre for Research in Agricultural Genomics(CRAG) CSIC-IRTA-UAB-UBUniversitat Autònoma de Barcelona08193 BellaterraSpain Departamento de Mejora Genética Animal INIACarretera de la Coruña km 7528040 MadridSpain Departamento de Genética Universidad de Córdoba14071 CórdobaSpain Department of Veterinary Medicine University of Bari“Aldo Moro”62 per Casamassima km.370010 ValenzanoSPItaly Group of Research in Ruminants(G2R) Department of Animal and Food ScienceUniversitat Autònoma de Barcelona(UAB)BellaterraBarcelonaSpain Departament de Ciència Animal i dels Aliments Facultat de VeterinàriaUniversitat Autònoma de Barcelona08193 BellaterraSpain

Background:Inbreeding depression can adversely affect traits related to fitness,reproduction and productive *** current research suggests that inbreeding levels are generally low in most goat breeds,the impact of inbreeding depression on phenotypes of economic interest has only been investigated in a few studies based on genealogical ***:We genotyped 1040 goats with the Goat SNP50 *** information was used to estimate different molecular inbreeding coefficients and characterise runs of homozygosity and homozygosity *** detected38 genomic regions with increased homozygosity as well as 8 ROH hotspots mapping to chromosomes 1,2,4,6,14,16 and *** hundred seventeen goats with available records for dairy traits were analysed to evaluate the potential consequences of inbreeding depression on milk *** regions on chromosomes 8 and 25were significantly associated with inbreeding depression for the natural logarithm of the somatic cell ***,these regions contain several genes related with immunity,such as SYK,IL27,CCL19 and ***,one region on chromosome 2 was significantly associated with inbreeding depression for milk ***:Although genomic inbreeding levels are low in Murciano-Granadina goats,significant evidence of inbreeding depression for the logarithm of the somatic cell count,a phenotype closely associated with udder health and milk yield,have been detected in this *** inbreeding would be expected to augment economic gain by increasing milk yield and reducing the incidence of mastitis,which is one of the main causes of dairy goat culling.

关键词： Goat Inbreeding Milk yield Murciano-Granadina Somatic cell score

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Association between an Incomplete Vaccination Schedule and Nosocomial Sepsis among Children with Cancer

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World Journal of Vaccines 2013年第1期3卷 10-15页

作者： Jesus Reyna-Figueroa Diana PerezPena-Rosas Patricia Galindo-delgado Ana Elena Limon-Rojas Vicente madrid-Marina Program in Public Health Sciences National Institute of Public HealthMexico CityMexico Central South Hospital Petroleos MexicanosMexico CityMexico

Background: Patients with cancer constitute a special group where immunization programs are often interrupted to begin treatment with chemotherapy. Sepsis is one of the main complications in this group. Methods: A hospital-based case-control study matched by age was carried out among subjects ≤ 9 years of age with cancer diagnosis. Children with cancer without sepsis and children with surgical pathology were included as controls;children with sepsis were included as cases. A bivariate logistic regression was used to determine the factors associated to nosocomial sepsis, and odds ratios were calculated with 95% confidence intervals. The percentage of attributable risk was calculated for the variables included in the final model. Results: Nineteen children with cancer and sepsis and 83 controls were included. Twelve (44%) caseshad an incomplete vaccination schedule according to their age. The association force between incomplete schedule and sepsis was 10.1 (95% CI, 3 - 36;p < 0.05). Conclusions: Approximately, 20% to 65% of the cases of serious nosocomial infection can be associated to an incomplete vaccination schedule. Strategies should be implemented to improve the general pediatric population’s vaccination status before a serious disease, such as cancer or another chronic condition preventing the application of vaccines, develops.

关键词： Vaccines Cancer Pediatrics Immunocompromise Association

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Size effects on the tensile strength and fracture toughness of granitic rock in different tests

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第9期15卷 2179-2192页

作者： Ignacio Pérez-Rey Andrea Muñoz-Ibáñez Manuel A.González-Fernández Mauro Muñiz-Menéndez Miguel Herbón Penabad Xian Estévez-Ventosa Jordi delgado Leandro RAlejano Laboratorio de Geotecnia CEDEXMadridSpain CINTECX GESSMin GroupDepartment of Natural Resources and Environmental EngineeringUniversidade de VigoVigoSpain School of Civil Engineering Universidade da CoruñaA CoruñaSpain

This study investigates the tensile failure mechanisms in granitic rock samples at different scales by means of different types of *** do that,we have selected a granitic rock type and obtained samples of different sizes with the diameter ranging from 30 mm to 84 *** samples have been subjected to direct tensile strength(DTS)tests,indirect Brazilian tensile strength(BTS)tests and to two fracture toughness testing *** DTS and fracture toughness were found to consistently grow with sample size,this trend was not clearly identified for BTS,where after an initial grow,a plateau of results was *** is a rather complete database of tensile related properties of a single rock *** if similar databases are rare,the obtained trends are generally consistent with previous scatter and partial experimental ***,different observations apply to different types of rocks and experimental *** differences in variability and mean values of the measured parameters at different scales are critically analysed based on the heterogeneity,granular structure and fracture mechanics *** potential relations between parameters are revised and an indication is given on potential sample sizes for obtaining reliable *** this database with different types of rocks is thought to be convenient to advance towards a better understanding of the tensile strength of rock materials.

关键词： Size effect Tensile strength Fracture toughness Granite Finite fracture mechanics

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Antiproton identification below threshold with the AMS-02 RICH detector

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Chinese Physics C 2017年第5期41卷 158-163页

作者：李紫源 Carlos Jose delgado Mendez Francesca Giovacchini Sadakazu Haino Julia Hoffman School of Physics Sun Yat-Sen University Guangdong 510275 China Institute of Physics Academia Sinica Taipei 11529 China Centro de Investigaciones Energeticas Mediambientales y Tecnologicas (CIEMAT) Madrid E-28040 Spain Physics and Astronomy Department University of Hawaii Hawaii 96822 USA

The Alpha Magnetic Spectrometer（AMS-02）,which is installed on the International Space Station（ISS）,has been collecting data successfully since May *** main goals of AMS-02 are the search for cosmic anti-matter,dark matter and the precise measurement of the relative abundance of elements and isotopes in galactic cosmic *** order to identify particle properties,AMS-02 includes several specialized *** these,the AMS-02 Ring Imaging Cherenkov detector（RICH） is designed to provide a very precise measurement of the velocity and electric charge of *** describe a method to reject the dominant electron background in antiproton identification with the use of the AMS-02 RICH detector as a veto for rigidities below 3 GV.A ray tracing integration method is used to maximize the statistics of  with the lowest possible e background,providing 4 times rejection power gain for e background with respect to only 3% of  signal efficiency *** using the collected cosmic-ray data,e contamination can be well suppressed within 3% with β ≈ 1,while keeping 76% efficiency for  below the threshold.

关键词： RICH cosmic goals isotopes rejection specialized contamination maximize installed suppressed

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