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Fluid-rock interaction experiments with andesite at 100℃ for potential carbon storage in geothermal reservoirs

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Deep Underground Science and engineering 2024年第3期3卷 369-382页

作者： grace e.Belshaw elisabeth Steer Yukun Ji Herwin Azis Benyamin Sapiie Bagus Muljadi Veerle Vandeginste School of Chemistry University of NottinghamNottinghamUK Geoenergy Research Centre University of NottinghamNottinghamUK British Geological Survey KeyworthUK State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground engineering China University of Mining and TechnologyXuzhouChina PT Supreme energy JakartaIndonesia Faculty of earth Sciences and Technology Institut Teknologi BandungBandungIndonesia Faculty of engineering University of NottinghamNottinghamUK Department of Materials engineering KU LeuvenCampus BrugesBrugesBelgium

Geothermal energy extraction often results in the release of naturally occurring carbon dioxide(CO_(2))as a *** on carbon storage using volcanic rock types other than basalt under both acidic and elevated temperature conditions has been limited so *** study uses batch reactor experiments at 100℃ to investigate the dissolution of andesite rock samples obtained from an active geothermal reservoir in Sumatra(Indonesia).The samples are subjected to reactions with neutral-pH fluids and acidic fluids,mimicking the geochemical responses upon reinjection of geothermal fluids,either without or with dissolved acidic gases,*** elemental analysis reveals the release of Ca^(2+)ions into the fluids through the dissolution of *** overall dissolution rate of the rock samples is 2.4×10^(–11)to 4.2×10^(–11)mol/(m^(2)·s),based on the Si release during the initial 7 h of the *** dissolution rates are about two orders of magnitude lower than those reported for basaltic rocks under similar reaction *** study offers valuable insights into the potential utilization of andesite reservoirs for effective CO_(2) storage via mineralization.

关键词： andesite carbon sequestration geothermal reservoirs plagioclase dissolution

eco-ableism and access circularity in natural building

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Frontiers of Architectural Research 2024年第2期13卷 235-248页

作者： grace Schleck Lola Ben-Alon Barnard College Department of Architecture New YorkUSA Columbia University Graduate School of Architecture Planningand Preservation(GSAPP)New YorkUSA

The climate crisis disproportionately impacts disabled people. Yet climate-related advocacy, planning, and policymaking often neglect to thoughtfully include disabled people. Responding to this gap, disabled and neurodivergent environmental activists coined the term eco-ableism to describe discrimination and silencing toward disabled and neurodivergent people (i.e., ableism) arising in environmental spaces (i.e., eco-ableism). Relatedly, building operations and construction practices contribute a significant percentage of global, energy-related CO_(2) emissions annually, which calls into question the relationships between the impending climate crisis, disability justice, and architecture. Climate-specific, natural building materials and methods present a potential pathway toward a more sustainable built future: low-carbon, locally sourced, minimally processed, and nontoxic materials. Despite a critical overlap, there is little published research on material access in the production phase and human access in the occupation phase of natural buildings. Applying eco-ableism and material circularity in an architectural framework, this research aims to investigate the gaps and possibilities of access, natural material applications, and resulting US natural buildings informed by scholarship in critical disability studies and semi-structured interviews with natural building professionals.

关键词： eco-ableism Critical disability studies Climate crisis and architecture Naturalmaterialsand methods

Robot-assisted uretero-enteric reimplantation for uretero-enteric anastomotic strictures following robot-assisted radical cystectomy: Surgical approach and outcomes over two decades

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Asian Journal of Urology 2024年第3期11卷 384-390页

作者： Abdul Wasay Mahmood grace Harrington Zhe Jing Qiang Li Ahmed A.Hussein Khurshid A.Guru Department of Urology Roswell Park Comprehensive Cancer CenterElm and Carlton StreetsBuffaloNew YorkNYUSA

Objective:We described the technique and outcomes of robot-assisted repair of uretero-enteric strictures(UeS)following robot-assisted radical cystectomy(RARC)and urinary ***:Retrospective review of our RARC database from November 2005 to August 2023 at Roswell Park Comprehensive Cancer center was *** who developed UeS and ultimately underwent robot-assisted uretero-enteric reimplantation(RUeR)were *** method was used to compute the cumulative incidence recurrence rate of UeS after RUeR.A multivariable regression model was used to identify variables associated with UeS ***:A total of 123(15%)out of 808 RARC patients developed UeS,of whom 52 underwent reimplantation(45 patients underwent RUeR[n=55 cases]and seven patients underwent open ureteroenteric reimplantation).The median time from RARC to UeS was 4.4(interquartile range 3.0e7.0)months,and the median time between UeS and RUeR was 5.2(interquartile range 3.2e8.9)*** 3-year recurrence rate after RUeR is about 29%.On multivariable analysis,longer hospital stay(hazard ratio 1.37,95%confidence interval 1.16e1.61,ped with recurrent UeS after ***:RUeR for UeS after RARC is feasible with durable outcomes although a notable subset of patients experienced postoperative complications and UeS recurrence.

关键词： Stricture Cystectomy Reimplantation Robot-assisted

Prevalence of Drug Resistant Uropathogenic escherichia coli from Immunocompromised Diabetic Patients Attending Selected Health Facilities in Benue State

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Advances in Microbiology 2024年第1期14卷 77-91页

作者： Isaac Ilesanma Adeoti grace Mwuese Gberikon Innocent Okonkwo Ogbonna Tersagh Smart Ichor Department of Microbiology College of Biological Sciences Joseph Sarwuan Tarka University Makurdi Nigeria

escherichia coli is the commonest bacterial uropathogen of UTIs, the commonest infections in immunocompromised diabetic patients. Better understanding of their main resistance mechanisms to commonly used antibacterial agents will help to reduce the burden of this infection. The prevalence of drug resistant uropathogenic escherichia coli isolates from immunocompromised diabetic patients attending selected health facilities in Benue State was investigated. Two hundred and ninety-six midstream urine samples were collected for both study and control diabetic patients. Bacterial isolation was done using semi-quantitative method. Drug resistant escherichia coli were identified as multidrug resistant (MDR), extensive drug resistant (XDR) and pan-drug resistant organisms (PDR). Statistical significance was considered at p e. coli isolates from the study and control subjects with overall prevalence of 20.9% and 8.4% respectively. The isolates were highly resistant to penicillin (ampicillin), monobactam (aztreonam), older quinolone (nalidixic acid) whereas the majority of them showed high susceptibility to aminoglycoside (streptomycin), cephalosporin (cefotaxime) and carbapenem (imipenem). None showed complete susceptibility to all the tested antibiotics. Twenty-five e. coli were identified in this MDR, eight, XDR while 5 were PDR. High numbers of drug resistant e. coli isolates were identified in the study group of which 25 were MDR, 8 XDR while 5 were PDR isolates. High prevalence of UTI and drug resistant isolates occur in diabetic patients with hyperglycemic condition.

关键词： Urinary Tract Infection Immunocompromised Diabetic Mellitus Antibiotic Resistance escherichia coli

Antimalarial potency of the leaf extract of Aspilia africana(Pers.) ***

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Asian Pacific Journal of Tropical Medicine 2012年第2期5卷 126-129页

作者： Akuodor Godwin Christian Amos grace Mfon essien Augustine Dick essien David-Oku Akpan Joseph Linus ezeokpo Basil Chukwuma Department Pharmacology College of Medical SciencesUniversity of CalabarNigeria Department of Pharmacology and Toxicology National Institute for Pharmaceutical Research and Development(NIPRD)AbujaNigeria Department of Biochemistry College of Medical SciencesUniversity of CalabarNigeria Department of Pharmacology and Therapeutics Faculty of Clinical MedicineEbonyi State UniversityAbakalikiNigeria

Objective:To investigate the antimalarial activity of ethanol extract of Aspilin africana (***) ***:The ethanol extract of *** leaf(100-400 mg/kg) was screened for blood schizonticidal effect against chloroquine-sensitive Plasmodium berghei(P. berghei) in mice both in early and established models of antimalarial ***:The leaf extract exhibited significant(Pearly infection and in established infection tests with a considerable mean survival time comparable to that of standard drug,chloroquine(10 mg/kg).Conclusions:The findings show thai ethanol extract of *** leaf possesses potent antiplasmodial activity which justify the use in ethnomedicine and can be developed in malaria therapy.

关键词： Aspilia africana Herbal medicine Plasmodium berghei Mice

Acceptance of COVID-19 vaccine and its related determinants in Nigeria:An online survey

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World Journal of Virology 2024年第4期13卷 89-110页

作者： eyiuche D ezigbo Seyi S enitan esther N Adejumo Abiodun e Durosinmi Richard Y Akele Michael O Dada grace e Itodo Abah M Idoko Okeoghene M edafetanure-Ibeh edwin N Okafor Adedeji A Abdulsalam Oyekan I Oyedoyin Polit U Yelpoji Ogunwola O Opeyemi Ogbuji S Nmesomachi Adesola O Oyekale Chisom B Onyeji Haemostasis and Thrombosis Unit Department of Medical Laboratory SciencesUniversity of NigeriaEnugu CampusEnuguEN 400241Nigeria Department of Medical Laboratory Science School of Public and Allied HealthBabcock UniversityIlishan-RemoOG 121109Nigeria Department of Medical Laboratory Science State HospitalIjebu-OdeOG 120221Nigeria Department of Biomedical Science School of Applied ScienceUniversity of BrightonBrightonES BN24ATUnited Kingdom Department of Microbiology Federal Teaching Hospital LokojaLokojaKO 260006Nigeria Department of Hematology and Blood Group Serology Federal College of Veterinary and Medical Laboratory TechnologyVomPL 930101Nigeria Department of environmental and Occupational Health Texas A and M University School of Public HealthGarlandTX 75049United States Division of Chemical Pathology Department of Medical Laboratory SciencesUniversity of NigeriaEnugu CampusEnuguEN 400102Nigeria School of Molecular Bioscience Sciences College of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowSCO G128QQUnited Kingdom Department of Medical Laboratory Science State Hospital Ijebu-OdeIjebu-OdeOG 360101Nigeria Department of Medical Laboratory Science Faculty of Health Sciences and TechnologyUniversity of JosJosPL 930103Nigeria Department of Medical Laboratory Science Bola Tinubu Health and Diagnostic CenterLagosLA 100102Nigeria Department of Pathology 68 Nigerian Army Reference HospitalYabaLA 1211001Nigeria Department of Medical Laboratory Science Ladoke Akintola University of TechnologyOgbomosoOS 2111105Nigeria

BACKGROUND Vaccine hesitancy is a major challenge in the fight against the coronavirus disease 2019(COVID-19)*** the sociodemographic factors associated with vaccine acceptance among Nigerians is crucial for improving vaccine *** To assess the acceptance rate of COVID-19 vaccine and its related determinants among *** An online cross-sectional survey(observational study)was conducted between February 2021 and May 2021,using a questionnaire hosted on *** invitation to take part in the poll was sent out to participants through social networking platforms.A logistic regression was used to determine which sociodemographic factors were associated with vaccine acceptance *** A total of 1800 persons responded to the survey,a larger proportion of whom were males(53.9%)and within the age group of 21-30 years(29.4%)and earned an average income of less than$500 per month(43.3%).Only 0.56%of participants had a high perceived risk of COVID-19 infection,while only 1.11%had a perceived risk of dying from *** perception rate of the COVID-19 vaccine among participants was 51.1%,while the acceptance rate was 63.9%.There was no significant association between the COVID-19 vaccine acceptance rate and related determinants assessed,particularly age(χ²=3.049,P=0.550),sex(χ²=0.102,P=0.749),average income(χ²=3.802,P=0.875),and religion(χ²=2.819,P=0.420).Participants with chronic conditions demonstrated a higher acceptance rate compared to the general *** Despite the positive perception observed and substantial vaccine acceptance rate among the study participants,more public health interventions are still needed to enhance vaccine acceptability in Nigeria.

关键词： Acceptance COVID-19 Determinants Hesitancy Nigerians Online survey Vaccine

In vivo mouse models to study bile acid synthesis and signaling

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国际肝胆胰疾病杂志:英文版 2023年第5期22卷 466-473页

作者： Anisha Bhattacharya Rulaiha e Taylor grace L Guo Department of Pharmacology and Toxicology Ernest Mario School of PharmacyRutgersThe State University of New JerseyPiscatawayNew JerseyUSA Rutgers Center for Lipid Research RutgersThe State University of New JerseyNew BrunswickNew JerseyUSA environmental and Occupational Health Sciences Institute RutgersThe State University of New JerseyPiscatawayNew JerseyUSA VA New Jersey Health Care System Veterans Administration Medical CenterEast OrangeNew JerseyUSA

The synthesis of bile acids(BAs)is carried out by complex pathways characterized by sequential chemical reactions in the liver through various cytochromes P450(CYP)and other *** the integrity of these pathways is crucial for normal physiological function in mammals,encompassing hepatic and neurological *** on the deficiencies in BA synthesis genes offers valuable insights into the significance of BAs in modulating farnesoid X receptor(FXR)signaling and metabolic *** creating mouse knockout(KO)models,researchers can manipulate deficiencies in genes involved in BA synthesis,which can be used to study human diseases with BA *** KO mouse models allow for a more profound understanding of the functions and regulations of genes responsible for BA ***,KO mouse models shed light on the distinct characteristics of individual BA and their roles in nuclear receptor ***,alterations of BA synthesis genes in mouse models have distinct differences when compared to human diseases caused by the same BA synthesis gene *** review summarizes several mouse KO models used to study BA synthesis and related human diseases,including mice deficient in Cyp7a1,Cyp27a1,Cyp7a1/Cyp27a1,Cyp8b1,Cyp7b1,Cyp2c70,Cyp2a12,and Cyp2c70/Cyp2a12,as well as germ-free mice.

关键词： Bile acid Species difference Farnesoid X receptor Liver diseases

early calcium dysregulation in Alzheimer's disease:setting the stage for synaptic dysfunction

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Science China(Life Sciences) 2011年第8期54卷 752-762页

作者： Shreaya CHAKROBORTY grace e.STUTZMANN Department of Neuroscience Rosalind Franklin University/the Chicago Medical School

Alzheimer's disease(AD) is an irreversible and progressive neurodegenerative disorder with no known cure or clear understanding of the mechanisms involved in the disease *** plaques,neurofibrillary tangles and neuronal loss,though characteristic of AD,are late stage markers whose impact on the most devastating aspect of AD,namely memory loss and cognitive deficits,are still *** studies demonstrate that structural and functional breakdown of synapses may be the underlying factor in AD-linked cognitive *** common element that presents with several features of AD is disrupted neuronal calcium *** intracellular calcium levels are functionally linked to presenilin mutations,Apoe4 expression,amyloid plaques,tau tangles and synaptic *** this review,we discuss the role of AD-linked calcium signaling alterations in neurons and how this may be linked to synaptic dysfunctions at both early and late stages of the disease.

关键词： calcium Alzheimer's neuron synaptic dysfunction plasticity eR ryanodine CICR

Gastroprotective effect of the aqueous leaf extract of Guiera senegalensis in Albino rats

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Asian Pacific Journal of Tropical Medicine 2013年第10期6卷 771-775页

作者： Akuodor GC essien AD David-Oku e Chilaka kC Akpan JL ezeokpo B ezeonwumelu JOC Department of Pharmacology College of Medical SciencesUniversity of Calabar Department of Biochemistry of Medical SciencesUniversity of Calabar Department of Pharmacology and Therapeutic College of Health SciencesNnamdi Azikiwe University Department of Pharmacology and Therapeutic Faculty of Clinical MedicineEbonyi State University School of Pharmacy Kampala International University

Objective:To evaluate the effect of aqueous leaf extract of Guiera senegalensis(***)on gastric mucosal damage using different ulcer ***:Considering the above claims,the present study was undertaken to validate the gastroprotective potential of the aqueous leaf extract of this plant against ethanol,water immersion and Aspirin induced ulcer ***:The leaf extract(50,100 and 200 mg/kg,p.o.)significantly(Pecreased the ulcer index in all assays ***:The results obtained,provide strong evidence of antiulcer activity of the leaf extract of *** and support the traditional uses of the plant for the treatment of ulcer.

关键词： Guiera senegalensis Aqueous extract ethanol Aspirin Stress induced gastric ulcers