Antiplasmodial and analgesic activities of Clausena anisata
Antiplasmodial and analgesic activities of Clausena anisata作者机构：Department of Pharmacology and ToxicologyFaculty of PharmacyUniversity of UyoUyoNigeria
出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)
年 卷 期：2012年第5卷第3期
页 面：214-219页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
主 题：Clausena anisata antiplasmodial antimalarial analgesic
摘 要：Objective:Antiplasmodial and analgesic activities of the leaf extract and fractions of Clausena anisata(***) were evaluated for antimalarial and analgesic ***:The crude leaf extract(39-117mg/kg) and fractions(chloroform and acqeous;78mg/kg) of C. anisata were investigated for antiplasmodial activity against chloroquine-sensitive Plasmodium berghei(***) infections in mice using suppressive,prophylactic and curative models and analgesic activity against acetic acid,formalin and heat-induced ***,5 mg/kg and pyrimethamine,1.2mg/kg were used as positive *** films made from tail blood of each mouse were used to assess the level of parasitaemia of the ***:The extract and its fractions dose-dependently reduced parasitaemia induced by chloroquine-sensitive *** in prophylactic,suppressive and curative models in *** reductions were statistically significant(P0.001).They also improved the mean survival time(MST) from 17 to 21 days relative to control(P0.01-0.001).On chemically and thermally-induced pains,the extract inhibited acetic acid and formalin-induced inflammation as well as hot plate-induced pain in *** inhibitions were statistically significant(P0.001) and in a dose-dependent fashion. Conclusions:The antiplasmodial and analgesic effects of this plant may in part be mediated through its chemical constituents and it can be concluded that the *** possess significant antimalarial and analgesic properties.
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