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Congenital hyperinsulinism:Role of fluorine-18L-3, 4 hydroxyphenylalanine positron emission tomography scanning

World Journal of Radiology 2014年第6期6卷 252-260页

作者： Jaya Sujatha gopal-Kothapani Khalid Hussain Department of Paediatric Endocrinology Royal Manchester Children’s Hospital Manches-ter M13 9WL United Kingdom Department of Paediatric Endocrinology Great Ormond Street Hospital for Children NHS Trust and the Institute of Child Health University College London London WC1N 1EH United Kingdom Developmental Endocrinology Research Group Molecular Genetics Unit Institute of Child Health University College London London WC1N 1EH United Kingdom

Congenital hyperinsulinism(CHI) is a rare but complex heterogeneous disorder caused by unregulated secre-tion of insulin from the β-cells of the pancreas leading to severe hypoglycaemia and neuroglycopaenia. Swift diagnosis and institution of appropriate management is crucial to prevent or minimise adverse neurodevel-opmental outcome in children with CHI. Histologically there are two major subtypes of CHI, diffuse and focal disease and the management approach will significantly differ depending on the type of the lesion. Patients with medically unresponsive diffuse disease require a near total pancreatectomy, which then leads on to the de-velopment of iatrogenic diabetes mellitus and pancre-atic exocrine insufficiency. However patients with focaldisease only require a limited pancreatectomy to re-move only the focal lesion thus providing complete cure to the patient. Hence the preoperative differentiation of the histological subtypes of CHI becomes paramount in the management of CHI. Fluorine-18L-3, 4-hydroxy-phenylalanine positron emission tomography(18F-DOPA-PET) is now the gold standard for pre-operative differentiation of focal from diffuse disease and locali-sation of the focal lesion. The aim of this review article is to give a clinical overview of CHI, then review the role of dopamine in β-cell physiology and finally discuss the role of 18F-DOPA-PET imaging in the management of CHI.

关键词： Congenital hyperinsulinism Fluorine-18L-3,4-hydroxyphenylalanine positron emission tomography Focal congenital hyperinsulinism Diffuse congenital hyperinsulinism Ectopic congenital hyperinsulinism Standardized uptake value

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阿片样物质介导多潘立酮和西沙必利对小鼠的镇痛作用(英文)

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Acta Pharmacologica Sinica 2002年第1期23卷 25-28页

作者： Isabella TOPNO,Mohammed ASAD,Deepak gopal SHEWADE,Chanolean SHASHINDRAN,Subramanyan RAMASWAMY Department of Pharmacology Jawaharlal Institute of Post-graduate Medical Education and Research Pondicherry-605006 India Department of Pharmacology Jawaharlal Institute of Post-graduate Medical Education and Research Pondicherry-605006 India Department of Pharmacology Jawaharlal Institute of Post-graduate Medical Education and Research Pondicherry-605006 India Department of Pharmacology Jawaharlal Institute of Post-graduate Medical Education and Research Pondicherry-605006 India Department of Pharmacology Jawaharlal Institute of Post-graduate Medical Education and Research Pondicherry-605006 India

To study the anti-nociceptive effect of domper-idone and cisapride in mice. METHODS: Initially, the effect of these drugs on motor activity was tested using rotarod. The anti-nociception was tested using chemical and mechanical assay. In the chemical assay, the number of abdominal constrictions either in the saline treated animals or in the domperidone/cisapride (1, 5, or 10 mg/kg either po or ip) treated mice, were recorded for a period of 30 min after acetic acid challenge (10 mLAg, of 0.6 % acetic acid ip). In the tail clip assay, the time taken by the mouse to make attempts to dislodge the bulldog clamp placed at the tail (reaction time) was recorded with a cut off time of 30 s. The role of opioid pathways was examined by pretreating the animals with naloxone (1 mg/kg, ip) 30 min prior to domperidone and cisapride. RESULTS: Domperidone and cisapride, both reduced the number of abdominal constrictions when given orally or intraperitoneally. Domperidone (5 mg/kg) inhibited it to the extent of 57.0 % a

关键词：多潘立酮西沙必利镇痛药醋酸类纳洛酮

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High level of soluble expression and purification of catalytically active native UDP-galactose 4-epimerase of <i>Aeromonas hydrophila</i>in <i>E. coli</i>

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Advances in Bioscience and Biotechnology 2011年第6期2卷 397-403页

作者： Keshav gopal Shivani Agarwal Aparna Dixit 不详

The ubiquitous Aeromonas hydrophila is responsible for several pathological conditions in fish and human. Like most gram negative bacteria, its virulence relies on outer membrane lipopolysachharide (LPS). The Leloir pathway enzyme UDP-galactose 4-epimerase (GalE), plays an important role in the LPS biosynthesis, and therefore is a potential drug target. We have earlier carried out extensive biochemical and biophysical studies with histidine-tagged recombinant GalE. However, for effective drug design it is desirable to understand the structure-function relation of a protein in its native form without any additional sequences or tags. In the present study, we report the high level expression, purification and characterization of recombinant GalE (rGalE) of Aeromonas hydrophila in its native form in E coli. The rGalE expressed as a soluble protein was purified to near homogeneity. From 1 L of shake flask culture ~15 mg of purified rGalE was obtained. The purified protein was biologically active with Km and Kcat values of 0.7 mM and 28.8 s–1, respectively. The enzyme exhibited a temperature and pH optima of 37。C and 7 - 9, respectively. Thus, the present study employed for soluble expression and purification of functionally active rGalE without any tag bypasses the need for cumbersome strategies associated with removal of tag from purified protein.

关键词： Tag-Less GalE Aeromonas hydrophila Recombinant Expression Kcat

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Semiconductor metal oxide compounds based gas sensors： A literature review

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Frontiers of Materials Science 2015年第1期9卷 14-37页

作者： Sunil Jagannath PATIL Arun Vithal PATIL Chandrakant Govindrao DIGHAVKAR Kashinath Shravan THAKARE Ratan Yadav BORASE Sachin Jayaram NANDRE Nishad gopal DESHPANDE Rajendra Ramdas AHIRE Department of Physics S. G. Patil Arts Science & Commerce College Sakri-424304 Dist. Dhule India Department of Physics L. V. H. College Panchavati Nashik-422003 India Thin and Thick film Laboratory M. S. G. College Malegaon Camp Malegaon-423105 Dist. Nashik India Department of Physics Uttamrao Patil College Dahivel Dist-Dhule India Department of Physics Shivaji University Kolhapur-416004 India

This paper gives a statistical view about important contributions and advances on semiconductor metal oxide （SMO） compounds based gas sensors developed to detect the air pollutants such as liquefied petroleum gas （LPG）, H2S, NH3, CO2, acetone, ethanol, other volatile compounds and hazardous gases. Moreover, it is revealed that the alloy/composite made up of SMO gas sensors show better gas response than their counterpart single component gas sensors, i.e., they are found to enhance the 4S characteristics namely speed, sensitivity, selectivity and stability. Improvement of such types of sensors used for detection of various air pollutants, which are reported in last two decades, is highlighted herein.

关键词： gas sensor semiconductor metal oxide (SMO) sensitivity air pollutant gas response

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Molecular basis of COVID-19,ARDS and COVID-19-associated ARDS:Diagnosis pathogenesis and therapeutic strategies

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BIOCELL 2023年第11期47卷 2335-2350页

作者： PRIYADHARSHINI THANJAVUR SRIRAMAMOORTHI GAYATHRI gopal SHIBI MURALIDAR SAI RAMANAN ESWARAN DANUSH NARAYAN PANNEERSELVAM BHUVANESWARAN MEIYANATHAN SRICHANDRASEKAR THUTHIKKADU INDHUPRAKASH SENTHIL VISAGA AMBI Biopharmaceutical Research Lab Anusandhan Kendra-1SASTRA Deemed-to-be UniversityThanjavur613401India School of Chemical and Biotechnology SASTRA Deemed-to-be UniversityThanjavur613401India

The novel coronavirus pneumonia(COVID-19)is spreading worldwide and threatening people *** routes by which SARS-CoV-2 causes lung injury have grown to be a major concern in the scientific community since patients with new Coronavirus,severe acute respiratory syndrome coronavirus(SARS-CoV-2)have a high likelihood of developing acute respiratory distress syndrome(ARDS)in severe *** mortality rate of COVID-19 has increased over the period due to rapid spread,and it becomes crucial to understand the disease epidemiology,pathogenic mechanisms,and suitable treatment *** is a respiratory disorder and is one of the clinical manifestations observed in patients with severe *** this scenario,it is important to address this problem to develop suitable treatment *** review attempts to present the prevalence of ARDS in COVID-19 patients and their predictive causes and risk factors,highlighting the contrasting features of COVID-19-induced ARDS with typical *** review also presents insights into the association between SARS-CoV-2 and lung damage while exploring the potential COVID-19 mechanisms in ARDS from the perspective of the angiotensin-converting enzyme 2 protein,cytokine storm,immune responses,and other signaling *** review also discusses the diagnosis strategies,pathogenesis,risk factors,and treatment options of COVID-19-related ARDS.

关键词： ARDS SARS-CoV-2 Variants Pathogenesis Risk factors Vaccines

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Controlled Mobility Time Synchronization for WSNs

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Wireless Sensor Network 2017年第1期9卷 1-15页

作者： gopal Chand Gautam Narottam Chand Kaushal Department of Computer Science & Engineering National Institute of Technology Hamirpur Hamirpur India

One of the important aspects in wireless sensor networks is time synchronization. Many applications such as military activity monitoring, environmental monitoring and forest fire monitoring require highly accurate time synchronization. Time synchronization assures that all the sensor nodes in wireless sensor network have the same clock time. It is not only essential for aforementioned applications but it is mandatory for TDMA scheduling and proper duty cycle coordination. Time synchronization is a challenging problem due to energy constraints. Most of the existing synchronization protocols use fixed nodes for synchronization, but in the proposed synchronization, algorithm mobile nodes are used to synchronize the stationary nodes in the sensing field. In this paper, we propose a new time synchronization algorithm, named controlled mobility time synchronization (CMTS) with the objective to achieve the higher accuracy while synchronizing the nodes. The proposed approach is used in this paper to synchronize the nodes externally by using the mobile nodes. Simulation results exhibit that proposed controlled mobility time synchronization increases the synchronization precision and reduces the energy consumption as well as synchronization error by reducing the collisions and retransmissions.

关键词： Wireless Sensor Network Time Synchronization Mobility Offset Energy

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器质性心脏病在STEMI患者中的发生率及其临床关联性

器质性心脏病在STEMI患者中的发生率及其临床关联性

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作者： gopal Suwal 吉林大学

学位级别：硕士

背景:心肌梗死(MI)是全世界内发病率和死亡率最高的疾病之一。心肌梗死通常是由于冠状动脉在斑块破裂或侵蚀的部位发生血栓导致血管闭塞所致。怀疑或确诊为急性心肌缺血或梗死的患者可诊断为急性冠脉综合征(ACS)。非ST段抬高型心肌梗死(... 详细信息

背景:心肌梗死(MI)是全世界内发病率和死亡率最高的疾病之一。心肌梗死通常是由于冠状动脉在斑块破裂或侵蚀的部位发生血栓导致血管闭塞所致。怀疑或确诊为急性心肌缺血或梗死的患者可诊断为急性冠脉综合征(ACS)。非ST段抬高型心肌梗死(NSTEMI),不稳定型心绞痛和ST段抬高型心肌梗死(STEMI)是ACS的三种类型。ST段抬高型心肌梗死(STEMI)是由心肌缺血的典型症状、持续性ST段抬高的心电图改变(STE)以及其后继发的心肌损伤标志物水平改变三者共同定义的临床综合征。在标准条件下进行诊断时,STEMI的诊断标准为心电图表现为至少有两个相邻导联ST段抬高≥1mm(0.1mV)以及心肌损伤标志物升高。心电图(ECG)是针对心肌梗死患者的初步检查,心肌损伤标志物的血液检查可以证明患者患有心肌梗死。而超声心动图检查(ECHO)由于可以进一步诊断心肌梗死的早期和晚期并发症,从而被认为是对于所有急性心肌梗死患者而言具有诊断意义的诊断性检查项目。超声心动图检查是一种非侵入性的诊断技术,它可以提供有关心脏功能和血液动力学的信息并且对患有AMI机械并发症的患者进行病情评估。AMI的主要机械并发症分别是心室游离壁破裂、室间隔破裂和乳头肌破裂伴严重的二尖瓣反流。器质性心脏病是指患者先天即有缺陷或后天获得性缺陷或两者兼有的,并因此而导致心脏瓣膜或心腔的完整性遭到损害的一类疾病。STEMI的机械并发症可导致器质性心脏病的发生。大多数AMI患者并发乳头肌破裂,从而导致严重的二尖瓣反流(MR),并最终导致右心衰竭和三尖瓣反流(TR)。因此在STEMI的严重并发症中,MR和TR是主要的两种器质性疾病。目的:这项研究的目的是通过研究超声心动图报告从而确定STEMI患者的器质性病变,即缺血性二尖瓣关闭不全、主动脉瓣关闭不全和三尖瓣关闭不全的患病率。方法:2018年1月、2月、3月和4月在吉林大学第一附属医院出现STEMI的所有358名患者均纳入了本次研究。这些数据收集于患者的病历资料,包括年龄、性别、所累及的心肌壁,以及患者患有糖尿病、高血压和(或)脑梗塞的既往史。患者的住院时长在其出院后进行计算。该研究中的基线调查在患者入院后即进行,研究中涉及的超声心动图报告患者为入院后7天内完成的第一批超声心动图报告。而重症患者的超声心动图是在入院后7天内在床旁进行采集的。我们在此次研究中重新定义了术语“器质性心脏病”:超声心动图彩色多普勒检查显示心脏的任意瓣膜(即二尖瓣,主动脉瓣或三尖瓣)反流面积≥4cm的STEMI患者即被视为患有器质性心脏病。患者总共分为两组:任意瓣膜均返流,且反流面积≥4cm的器质性心脏病组和反流面积<4cm的反流性非器质性心脏病组,即:将患者分为二尖瓣关闭不全“MR”组和非二尖瓣关闭不全“非MR”组:MR患者为二尖瓣反流面积≥4cm的患者,而非MR患者为反流面积<4cm的患者;主动脉瓣关闭不全“AR”组和非主动脉瓣关闭不全“非AR”组:AR患者为主动脉瓣反流面积≥4cm的患者,而非AR患者为反流面积<4cm的患者;三尖瓣关闭不全“TR”组和非三尖瓣关闭不全“非TR”组:TR患者为三尖瓣反流面积≥4cm的患者,而非TR患者为反流面积<4cm的患者。。本实验采用SPSS 21对收集的数据进行分析。连续变量使用平均值±标准差表示,分类变量表示为频率(百分比)。使用配对t检验比较连续测量。卡方分析用于比较分类变量。双侧P值<0.05被认为具有统计学意义。结果:本研究纳入的样本总共包括358名STEMI患者,其中男性患者为258位(72.1%),女性患者为100位(27.9%)。在这358名STEMI患者中共有162例(45.3%)表现为下壁ST段抬高型心肌梗死,194例(54.2%)表现为前壁ST段抬高型心肌梗死,另外2例(0.6%)表现为非前壁或下壁ST段抬高型心肌梗死。358名STEMI患者中有高血压病史的患者为158例(44.1%),有糖尿病史的患者为90例(25.1%),有脑梗死病史的患者为14例(3.9%)。共有71名患者(19.8%)患有严重心血管不良事件(MACE)。3例STEMI患者(0.837%)在入院当天死亡,6例STEMI患者(1.67%)在30天内死亡。在随访期内共有13例患者(3.63%)死亡,其中10例STEMI患者(76.92%)死于心源性原因。有7例患者(1.96%)再次发生了心肌梗塞。共有59例STEMI患者(16.48%)于首次住院后再次住院,其中由于中风导致住院的有6例(1.67%),由于心力衰竭再次入院的患者有7例(1.95%)。STEMI患者的平均年龄为(58.72±11.429)岁,STEMI患者的住院时间为(7.16±2.995)天。白细胞计数平均值为13.35±2.307(10/L)。心脏肌钙蛋白I的平均值

关键词： STEMI 乳头肌破裂器质性心脏病缺血性二尖瓣关闭不全三尖瓣关闭不全

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Analysis of Aquifer Characteristics and Groundwater Quality in Southwest Punjab, India

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Journal of Earth Science and Engineering 2014年第10期4卷 597-604页

作者： Rajinder Pal Singh Chopra gopal Krishan Hydro-geological and Hydro-chemical Division Punjab Water Resources and Environment Directorate Chandigarh 160017India Hydrological lnvestigations Division National Institute of Hydrology Roorkee 247667 Uttarakhand lndia IGB-Groundwater Resilience Project British Geological Survey NERC Nottingham NG12 5GG UK

A study was conducted in eight districts, viz., Faridkot, Moga, Ferozepur, Muktsar, Bathinda, Mansa, Barnala and Sangrur in south-western part of the Punjab, India to characterize aquifer strata by preparing a fence diagram depicting sub-surface strata and distribution of groundwater quality. The sub-surface lithology drilled upto a depth of 60 m reveal the presence of top most layer of impervious strata comprising of clay upto the depth of 2 m to 5 m which impedes the percolation of surface runoff into the soil leading to surface flooding and water logging even in areas having saturated zone beyond the depth of 5 m. Thick pervious strata of 45 m to 50 m thickness is encountered in central and south-sentral part of the study area comprising of Bathinda, Muktsar and Mansa districts which at certain places are separated by one or two thin layers of impervious or semi-pervious strata comprising of clay and sand occasionally associated with ＂kankar＂ of thickness ranging between 2 m to 5 m. The northern, western and eastern parts, however, exhibit three to four layered pervious zones ranging in thickness from 5 m to 25 m separated by thin layers of impervious and semi pervious strata. The groundwater quality in about 6% of the study area in eight districts is fit, 18% is marginal and 76% is unfit for irrigation purpose.

关键词： Groundwater aquifer characteristics quality depth southwest Punjab.

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Modelling the potential risk zone of Lantana camara invasion and response to climate change in eastern India

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Ecological Processes 2022年第1期11卷 142-154页

作者： Sharad Tiwari S.N.Mishra Dharmendra Kumar Basant Kumar S.N.Vaidya Brojo gopal Ghosh Sk Mujibar Rahaman Masjuda Khatun Sanjoy Garai Amit Kumar Institute of Forest Productivity LalgutwaRanchi 835303JharkhandIndia Department of IT Govt.of JharkhandJharkhand Space Application CentreRanchiIndia Department of Geoinformatics Central University of JharkhandRanchi 835205JharkhandIndia

Background:The aim of this study is to elucidate the potential risk zones prone to the invasion of perennial ornamental plant Lantana camara,which is native to South America and has invasive tendency in Jharkhand,eastern India,for present(2020)and the future(2050)climatic conditions under four different Representative Concentration Pathways scenarios(RCPs).We analysed the current distribution pattern of *** in the plateau region of eastern India and identified potentially suitable habitats prone to its further infestation in the future under the climate change ***:Results showed the presence of *** invasion in~13%of the geographical area of Jharkhand,Cho-tanagpur plateau which may expand up to 20–26%by 2050 depending upon emission scenarios as characterised by the four *** for the current scenario suggests the dominance of *** in sub-zone V(12.77%under high risk zones(HRZ)and 9.5%under critical risk zones(CRZ))followed by sub-zones IV(6.7%:HRZ;4.19%:CRZ)and VI(2.49%:HRZ;2.14%:CRZ).Future projection(2050)indicates a possible expansion of its distribution range across all agro-climatic sub-zones with dominance in sub-zones V and *** Bio_4(temperature seasonality)was observed as the most contributing factor for the distribution of *** for current and future scenarios across all *** habitat for *** mostly occurred under natural vegetation(66.05%of CRZ and 60.71%of HRZ)and agriculture landscape(29.51%of CRZ and 34.48%of HRZ).Conclusions:The study provides an insight of invasion of *** in the plateau region of eastern India,and reveals wide distribution across all the agro-climatic sub-zones of Jharkhand,mostly in open and disturbed areas under natural vegetation and agriculture *** projections for the year 2050 suggest a continuous increase in the expansion range of invasion across Jharkhand and call for urgent initiatives to combat its further invasion.

关键词： Climate change Forest Invasion Lantana camara Maxent RCPs

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基于CRC铸造法和Pandat理论计算的Mg-10Zn-（0-7）Al合金热裂敏感性研究

基于CRC铸造法和Pandat理论计算的Mg-10Zn-（0-7）Al合金热裂敏感...

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作者： Vinodh gopal 上海交通大学

学位级别：硕士

目前按汽车行业处于从汽油车到混合动力汽车之间的过渡阶段,更有必要继续研究轻合金的开发,以将其集成到白色车身应用中。压铸是汽车零部件生产中常见的制造工艺之一。尽管目前对Mg-Zn-(x)Al合金中消除mg17a12相来改善力学性能和铸造性... 详细信息

目前按汽车行业处于从汽油车到混合动力汽车之间的过渡阶段,更有必要继续研究轻合金的开发,以将其集成到白色车身应用中。压铸是汽车零部件生产中常见的制造工艺之一。尽管目前对Mg-Zn-(x)Al合金中消除mg17a12相来改善力学性能和铸造性能的研究报道较多,但铝含量对mg-10zn等高锌合金热裂敏感系数的影响研究较少,对热裂曲线的特性解释不充分。高锌合金被认为能完全抑制mg17a12相的形成,因此研究锌含量较多的镁合金的热烈性能有很好的前景。热裂是合金在铸件和焊接过程中常见的缺陷,尤其是含锌镁合金铸件中的一个主要问题。本文研究了mg-10zn合金的热裂,研究了不同铝含量(wt%)对mg-10zn合金裂的影响。通过设置不同的初始模具温度(280°C,320°C,350°C),运用装备有加载包,热电偶和数据管理系统的约束杆铸造法,分析了凝固过程中的体积收缩力曲线。实验结果表明,铝的加入降低了镁-10zn合金的热裂敏感系数。通过画热裂敏感系数与铝含量的函数关系图,得出了线性向下坡度线。热裂发生对应的载荷力值(di)大小顺序是ZA107>ZA105>ZA102>Mg-10Zn,因此合金的热裂敏感系数为ZA107

关键词：热裂敏感系数 mg-10zn-(x)Al镁合金收缩力和温度曲线固体分数(fs) kou标准

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