Molecular basis of COVID-19,ARDS and COVID-19-associated ARDS:Diagnosis pathogenesis and therapeutic strategies

作     者：PRIYADHARSHINI THANJAVUR SRIRAMAMOORTHI GAYATHRI GOPAL SHIBI MURALIDAR SAI RAMANAN ESWARAN DANUSH NARAYAN PANNEERSELVAM BHUVANESWARAN MEIYANATHAN SRICHANDRASEKAR THUTHIKKADU INDHUPRAKASH SENTHIL VISAGA AMBI 

作者机构：Biopharmaceutical Research LabAnusandhan Kendra-1SASTRA Deemed-to-be UniversityThanjavur613401India School of Chemical and BiotechnologySASTRA Deemed-to-be UniversityThanjavur613401India 

出 版 物：《BIOCELL》 (生物细胞（英文）)

年 卷 期：2023年第47卷第11期

页      面：2335-2350页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：SASTRA Deemed-to-be University  Tamil Nadu  India 

主　　题：ARDS SARS-CoV-2 Variants Pathogenesis Risk factors Vaccines 

摘      要：The novel coronavirus pneumonia(COVID-19)is spreading worldwide and threatening people *** routes by which SARS-CoV-2 causes lung injury have grown to be a major concern in the scientific community since patients with new Coronavirus,severe acute respiratory syndrome coronavirus(SARS-CoV-2)have a high likelihood of developing acute respiratory distress syndrome(ARDS)in severe *** mortality rate of COVID-19 has increased over the period due to rapid spread,and it becomes crucial to understand the disease epidemiology,pathogenic mechanisms,and suitable treatment *** is a respiratory disorder and is one of the clinical manifestations observed in patients with severe *** this scenario,it is important to address this problem to develop suitable treatment *** review attempts to present the prevalence of ARDS in COVID-19 patients and their predictive causes and risk factors,highlighting the contrasting features of COVID-19-induced ARDS with typical *** review also presents insights into the association between SARS-CoV-2 and lung damage while exploring the potential COVID-19 mechanisms in ARDS from the perspective of the angiotensin-converting enzyme 2 protein,cytokine storm,immune responses,and other signaling *** review also discusses the diagnosis strategies,pathogenesis,risk factors,and treatment options of COVID-19-related ARDS.