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Effects of management of infection source of echinococcosis in Linzhi, Tibet Autonomous Region of China

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Infectious Diseases of Poverty 2021年第2期10卷 105-105页

作者： Ying Wang Bing-Cheng Ma Li-Ying Wang gongsang quzhen Hua-Sheng Pang National institute of Parasitic Diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchWHO Collaborating Center for Tropical DiseasesNational Center for International Research on Tropical DiseasesMOSTKey Laboratory of Parasite and Vector BiologyMOHShanghai 200025China 不详

Background:Echinococcosis is highly endemic in western and northern *** Autonomous Region(TAR)is the most serious prevalent *** is located in southeastern part *** are the primary infection source for the transmission of echinococcosis to humans.A control and prevention campaign based on dog management has been implemented in the past three *** study aims to evaluate the effects of dog management on the infection rate of dogs.

关键词： Echinococcosis Dog management Dog infection Linzhi China

Geographic distribution and prevalence of human echinococcosis at the township level in the Tibet Autonomous Region

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Infectious Diseases of Poverty 2022年第1期11卷 90-90页

作者： Liying Wang gongsang quzhen Min Qin Zehang Liu Huasheng Pang Roger Frutos Laurent Gavotte National Institute of Parasitic Diseases Chinese Centre for Disease Control and Prevention(Chinese Centre for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Centre for International Research On Tropical DiseasesShanghai200025People’s Republic of China 不详

Background Echinococcosis,a zoonotic parasitic disease,is caused by larval stages of cestodes in the Echinococcus *** is highly prevalent in ten provinces/autonomous regions of western and northern *** 2016,an epidemiological survey of Tibet Autonomous Region(TAR)revealed that the prevalence of human echinococcosis was 1.66%,which was much higher than the average prevalence in China(0.24%).Therefore,to improve on the current prevention and control measures,it is important to understand the prevalence and spatial distribution characteristics of human echinococcosis at the township level in *** Data for echinococcosis cases in 2018 were obtained from the annual report system of echinococcosis of Tibet Center for Disease Control and *** had been performed via *** epidemic status of echinococcosis in all townships in TAR was classified according to the relevant standards of population prevalence indices as defined in the national technical plan for echinococcosis *** scan statistics were performed to establish the geographical townships that were most at risk of *** In 2018,a total of 16,009 echinococcosis cases,whose prevalence was 0.53%,were recorded in 74 endemic counties in *** on the order of the epidemic degree,all the 692 townships were classified from high to low *** them,127 townships had prevalence rates≥1%.The high prevalence of human echinococcosis in TAR,which is associated with a wide geographic distribution,is a medical *** 94.65%of the villages and towns reported echinococcosis *** to spatial distribution analysis,the prevalence of human echinococcosis was found to be clustered,with the specific clustering areas being *** cystic echinococcosis primary cluster covered 88 townships,while that of alveolar echinococcosis’s covered 38 *** This study shows spatial distributions of echinococco

关键词： Human echinococcosis Prevalence Geographic distribution Tibet Autonomous Region China

Assessment of echinococcosis control in Tibet Autonomous Region,China

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Infectious Diseases of Poverty 2022年第3期11卷 90-90页

作者： Liying Wang quzhen gongsang Huasheng Pang Min Qin Ying Wang Jingzhong Li Roger Frutos Laurent Gavotte National Institute of Parasitic Diseases Chinese Centre for Disease Control and Prevention(Chinese Centre for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Centre for International Research On Tropical DiseasesShanghai200025China Tibet Center for Disease Control and Prevention NHC Key Laboratory of Echinococcosis Prevention and ControlLhasa850000China 不详

Background:In China the highest prevalence of echinococcosis is in Tibet Autonomous Region(TAR).The government has issued documents and implemented comprehensive prevention and control measures focusing on controlling the source of infection of *** was very important to understand the implementation and effect of infectious source control *** purpose of this study was to examine the implementation of measures to control infectious source(domestic and stray dogs)in TAR and to assess their ***:We collected data on domestic dog registration and deworming and stray dog sheltering in 74 counties/districts in the TAR from 2017 to *** samples from domestic dogs were collected from randomly selected towns to determine Echinococcus infection in dogs using coproantigen *** analyzed the data to compare the canine rate of infection between 2016 and *** data analysis was performed by SPSS statistical to compare dog infection rate in 2016 and 2019 by chi-square test,and ArcGIS was used for ***:From 2017 to 2019,84 stray dog shelters were built in TAR,and accumulatively 446,660 stray or infected dogs were arrested,sheltered,or disposed *** number of domestic dogs went downward,with an increased registration management rate of 78.4%(2017),88.8%(2018),and 99.0%(2019).Dogs were dewormed 5 times in 2017,12 times in 2018,and 12 times in *** dog infection rate was 1.7%(252/14,584)in 2019,significantly lower than 7.3%(552/7564)from the survey of echinococcosis prevalence in Tibet in 2016(P<0.05).Conclusion:Between 2017 and 2019,the number of stray dogs and infection rate of Echinococcus *** domestic dogs decreased significantly,indicating that dogs were effectively controlled as a source of infection in TAR and reflecting a significant decrease in the risk of echinococcosis transmission.

关键词： Echinococcosis Hydatidosis Source of infection Control measure Effect assessment China

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组方藏药治疗肝囊型包虫病的临床疗效观察

中国中西医结合消化杂志 2022年第10期30卷 695-700页

作者：顿珠旦达旦增曲珍白玛米玛卓嘎贡桑曲珍西藏自治区藏医院肝病科拉萨850000 西藏自治区疾病预防控制中心

目的:评价组方藏药治疗肝囊型包虫病的临床疗效及安全性。方法:选择2019年8月—2020年8月收治的西藏那曲索县、巴青县确诊的94例肝囊型包虫病患者为研究对象。通过简单随机抽样方法,纳入口服组方藏药组(52例,观察组)和口服阿苯达唑组(42... 详细信息

目的:评价组方藏药治疗肝囊型包虫病的临床疗效及安全性。方法:选择2019年8月—2020年8月收治的西藏那曲索县、巴青县确诊的94例肝囊型包虫病患者为研究对象。通过简单随机抽样方法,纳入口服组方藏药组(52例,观察组)和口服阿苯达唑组(42例,对照组)进行治疗。6个月后,依据藏医证候积分表评价患者的临床症状改善情况;通过B超检查观察两组患者治疗前后的病灶变化,评价临床疗效;检测治疗前后肝肾功能、血常规改变情况,对其安全性进行评价。结果:治疗后,观察组总有效率为94.23%(49/52),对照组为80.95%(34/42),差异无统计学意义(P>0.05);根据藏医证候积分观察临床症状,观察组治疗后临床症状均有改善,与对照组比较差异有统计学意义(P0.05);安全性评价:治疗后,观察组患者的白细胞、ALT、AST指标低于对照组,差异有统计学意义(P<0.05)。结论:藏药秘诀清凉散、嘎布竹觉、十三味红花丸、驱虫卡擦散组方治疗肝囊型包虫病具有一定的临床疗效,安全性好,具有临床推广价值。

关键词：组方藏药肝囊型包虫病疗效分析

Epidemiological survey of echinococcosis in Tibet Autonomous Region of China

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Infectious Diseases of Poverty 2019年第2期8卷 23-33页

作者： Bin Li gongsang quzhen Chui-Zhao Xue Shuai Han Wei-Qi Chen Xin-Liu Yan Zhong-Jie Li MLinda Quick Yong Huang Ning Xiao Ying Wang Li-Ying Wang Gesang Zuoga Bianba Gangzhu Bing-Cheng Ma Gasong Xiao-Gang Wei Niji Can-Jun Zheng Wei-Ping Wu Xiao-Nong Zhou Tibet Autonomous Region Center for Diseases Control and Prevention Lhasa 850000Tibet Autonomous RegionChina National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesMinistry of Science and TechnologyKey Laboratory of Parasite and Vector BiologyMOHHuangpu DistrictShanghai 200025China Henan Center for Diseases Control and Prevention ZhengzhouShanghai 450000HenanChina Yunnan Institute of Diseases Control and Prevention Kunming 650000YunnanChina Chinese Center for Diseases Control and Prevention ChangpingBeijing 102200China Center for Diseases Control and Prevention AtlantaGA 30328USA Shandong Institute of Parasitic Diseases Jining 272033ShandongChina Lhasa Center for Diseases Control and Prevention Lhasa 850000Tibet Autonomous RegionChina Shigatse Center for Diseases Control and Prevention Sangzhuzi District 857000Tibet Autonomous RegionChina Shannan Center for Diseases Control and Prevention Shannan 856000Tibet Autonomous RegionChina Linzhi Center for Diseases Control and Prevention Linzhi 860000Tibet Autonomous RegionChina Changdu Center for Diseases Control and Prevention Changdu 854000Tibet Autonomous RegionChina Naqu Center for Diseases Control and Prevention Naqu 852000Tibet Autonomous RegionChina Ali Center for Diseases Control and Prevention Ali 859000Tibet Autonomous RegionChina Beijing China

Background:The echinococcosis is prevalent in 10 provinces/autonomous region in western and northern *** survey of echinococcosis in China in 2012 showed the average prevalence of four counties in Tibet Autonomous Region(TAR)is 4.23%,much higher than the average prevalence in China(0.24%).It is important to understand the transmission risks and the prevalence of echinococcosis in human and animals in ***:A stratified and proportionate sampling method was used to select samples in *** selected residents were examined by B-ultrasonography diagnostic,and the faeces of dogs were tested for the canine coproantigen against Echinococcus *** enzyme-linked immunosorbent *** internal organs of slaughtered domestic animals were examined by visual examination and *** awareness of the prevention and control of echinococcosis among of residents and students was investigated using *** data were inputted using double entry in the Epi Info database,with error correction by double-entry comparison,the statistical analysis of all data was processed using SPSS 21.0,and the map was mapped using ArcGIS 10.1,the data was tested by Chi-square test and Cochran-Armitage trend ***:A total of 80384 people,7564 faeces of dogs,and 2103 internal organs of slaughtered domestic animals were *** prevalence of echinococcosis in humans in TAR was 1.66%,the positive rate in females(1.92%)was significantly higher than that in males(1.41%),(X2=30.31,P<0.01),the positive rate of echinococcosis was positively associated with age(X2trend=-423.95,P<0.01),and the occupational populations with high positive rates of echinococcosis were herdsmen(3.66%)and monks(3.48%).The average positive rate of Echinococcus coproantigen in TAR was 7.30%.The positive rate of echinococcosis in livestock for the whole region was 11.84%.The average awareness rate of echinococcosis across the region was 33.39%.Conclusions:A high prevalence of echin

关键词： Tibet Echinococcosis Prevalence Ultrasonography

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西藏日喀则市棘球蚴病传染源控制措施及效果

中国病原生物学杂志 2020年第6期15卷 667-673页

作者：王立英边巴贡桑曲珍庞华胜何伟王莹李景中中国疾病预防控制中心寄生虫病预防控制所世界卫生组织热带病合作中心科技部国家级热带病国际联合研究中心卫生部寄生虫病原与媒介生物学重点实验室上海200025 国家卫生健康委包虫病防治重点实验室日喀则市疾病预防控制中心西藏自治区疾病预防控制中心四川省疾病预防控制中心

目的调查了解西藏日喀则市棘球蚴病传染源控制措施实施情况,评价防治效果。方法调查西藏日喀则市各流行县2017-2019年传染源犬的数量变化、登记管理和驱虫情况以及感染率变化情况并进行比较分析,综合评价防治效果。结果2017-2019年日喀... 详细信息

目的调查了解西藏日喀则市棘球蚴病传染源控制措施实施情况,评价防治效果。方法调查西藏日喀则市各流行县2017-2019年传染源犬的数量变化、登记管理和驱虫情况以及感染率变化情况并进行比较分析,综合评价防治效果。结果2017-2019年日喀则市设立流浪犬收容中心6所,累计抓捕、收容流浪犬或处理染疫犬189992只次,年收容率分别为32.75%、66.13%和99.99%;家养犬分别为50067、42703和38074只,登记管理率分别为36.55%、74.18%和96.16%;犬年均驱虫次数分别为1、10、10次,目前基本实现"犬犬投药、月月驱虫"。2019年犬棘球绦虫感染率为2.27%(41/1803),较2016年棘球蚴病流行情况调查的犬感染率4.83%(94/1945)显著下降(P<0.05)。2019年标化犬感染率为0.70%,较2016年下降85.5%。结论2017-2019年日喀则市流浪犬数量显著减少,家养犬棘球绦虫感染率大幅下降,传染源犬控制效果良好,棘球蚴病传播风险显著降低,实现了日喀则市棘球蚴病3年综合防治目标。

关键词：棘球蚴病包虫病传染源控制措施防治效果

基于游离DNA的棘球蚴病诊断标志物的筛选和应用初探

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中国病原生物学杂志 2020年第6期15卷 674-677,702页

作者：王莹贡桑曲珍庞华胜伍卫平张璟沈玉娟曹建平中国疾病预防控制中心寄生虫病预防控制所国家热带病研究中心世界卫生组织热带病合作中心科技部国家级热带病国际联合研究中心卫生部寄生虫病原与媒介生物学重点实验室上海200025 西藏自治区疾病预防控制中心国家卫生健康委包虫病防治研究重点实验

目的筛选棘球蚴病(包虫病)潜在诊断标志物的游离DNA(cell-free DNA,cfDNA)序列,并初步探讨其诊断价值。方法从西藏自治区采集确诊细粒棘球蚴病患者外周血,分离血浆,提取cfDNA并重测序;对测序数据进行生物信息学分析,并与人参考基因组和... 详细信息

目的筛选棘球蚴病(包虫病)潜在诊断标志物的游离DNA(cell-free DNA,cfDNA)序列,并初步探讨其诊断价值。方法从西藏自治区采集确诊细粒棘球蚴病患者外周血,分离血浆,提取cfDNA并重测序;对测序数据进行生物信息学分析,并与人参考基因组和细粒棘球绦虫基因组综合比对,筛选诊断标志物候选序列;分别以细粒棘球蚴病患者和健康人血浆cfDNA为模板,采用qPCR分析诊断标志物候选序列的特异性和敏感性。结果共采集6份细粒棘球蚴病患者血浆,提取的血浆cfDNA条带较为均一,主要集中于150~200 bp;经重测序和序列比对获得一组候选序列,qPCR分析后初步筛选出一条101碱基的序列,用其检测8例细粒棘球蚴病患者血浆cfDNA,其中5例阳性,敏感性为62.5%;检测健康人血浆的特异性为87.5%(7/8)。结论细粒棘球蚴病患者血浆中存在虫源cfDNA,该序列具有作为诊断标志物的潜在价值。

关键词：棘球蚴病包虫病细粒棘球蚴病诊断标志物游离DNA

National Alveolar Echinococcosis Distribution--China, 2012−2016

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China CDC weekly 2020年第1期2卷 1-7页

作者： Canjun Zheng Chuizhao Xue Shuai Han Zhongjie Li Hu Wang Liying Wang Ying Wang Qian Wang Yu Feng Yanyan Hou Xiao Ma Junying Ma Xiumin Han gongsang quzhen Xiaofeng Jiang Weidong Guo Xianglin Wu Yaming Yang Lei Cao Fanka Li Weiqi Chen Xinliu Yan Shicheng Yu Meihua Fu Qing Yu Ning Xiao Jiangping Cao Jun Yan Weiping Wu Xiao-nong Zhou Division of Infectious Diseases Chinese Center for Disease Control and PreventionBeijingChina National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesMinistry of Science and TechnologyKey Laboratory of Parasite and Vector BiologyMinistry of HealthShanghaiChina Health Commission of Qinghai Province XiningQinghaiChina Sichuan Provincial Center for Disease Control and Prevention ChengduSichuanChina Gansu Provincial Center for Disease Control and Prevention LanzhouGansuChina Xingjiang Uyghur Autonomous Region Center for Disease Control and Prevention UrumqiXinjiangChina Qinhai Institute for Endemic Disease Prevention and Control XiningQinghaiChina Qinghai Provincial People’s Hospital XiningQinghaiChina Tibet Center for Diseases Control and Prevention LhasaTibetChina Inner Mongolia Autonomous Region Center for Diseases Control and Prevention HohhotInner MongoliaChina Ningxia Center for Disease Control and Prevention YinchuanNingxiaChina Yunnan Institute of Parasitic Diseases PuerYunnanChina Shaanxi Provincial Center for Disease Control and Prevention Xi’anShaanxiChina Xinjiang Production and Construction Corps Center for Disease Control and Prevention UrumqiXinjiangChina Henan Provincial Center for Disease Control and Prevention ZhengzhouHenanChina Office of epidemiology Chinese Center for Disease Control and PreventionBeijingChina National Health Commission of the People’s Republic of China BeijingChina.

What is already known about this topic?Both alveolar echinococcosis(AE)and cystic echinococcosis are endemic in China,among which alveolar echinococcosis has a very high mortality *** is added by this report?The survey results showed the prevalence and scope of AE in China and identified high-risk groups including children,monks,herdsmen and illiterate *** the same time,all the cases found in the survey(more than 90%of the patients did not go to the hospital for diagnosis and treatment before survey)were promptly diagnosed and *** are the implications for public health practice?This study provides information for the development of a plan for AE prevention and control and for the implementation of interventions targeted to high-risk populations.

关键词： prevention diagnosis mortality

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智能项圈在包虫病犬驱虫应用中的初步评价

疾病监测 2022年第9期37卷 1216-1222页

作者：杨诗杰马俊英张雪飞王虎马霄多杰才仁车光柱贡桑曲珍庞华胜王威刘玉芳郭帅马万里司晓妹中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心) 世界卫生组织热带病合作中心上海200025 青海省地方病预防控制所青海西宁811602 治多县疾病预防控制中心青海玉树815499 西藏自治区疾病预防控制中心国家卫生健康委包虫病防治研究重点实验室西藏拉萨850002

目的探讨智能项圈在包虫病源头防控中的应用价值。方法采用简单随机抽样分组,智能项圈驱虫组(干预组)的犬佩戴智能项圈,采用物联网技术进行远程管理控制,每月定时自动投放驱虫药饵1次;人工驱虫组(对照组)采用现有人工投放药饵驱虫模式... 详细信息

目的探讨智能项圈在包虫病源头防控中的应用价值。方法采用简单随机抽样分组,智能项圈驱虫组(干预组)的犬佩戴智能项圈,采用物联网技术进行远程管理控制,每月定时自动投放驱虫药饵1次;人工驱虫组(对照组)采用现有人工投放药饵驱虫模式。采用ELISA方法检测犬粪棘球绦虫抗原,SPSS 20.0软件处理数据,广义估算方程(GEE)分析驱虫效果。结果智能项圈驱虫组在驱虫开始、驱虫3个月、6个月、9个月和12个月时项圈佩戴率分别为100.00%(421/421)、96.20%(405/421)、89.31%(376/421)、84.56%(356/421)和94.06%(396/421);累积投药完成率分别为74.36%(313/421)、91.37%(1154/1263)、84.76%(2141/2526)、80.15%(3037/3789)和74.43%(3760/5052)。12次驱虫后,智能项圈驱虫组和人工驱虫组均能显著降低犬粪棘球绦虫抗原阳性率(差异具有统计学意义,χ^(2)=20.723,P=0.014;χ^(2)=26.145,P=0.002)。使用智能项圈驱虫对犬具有更显著的保护作用,其感染风险比人工驱虫组降低27%(95%置信区间0.556~0.959)。结论作为一种新的驱虫工具,智能项圈驱虫维持了较高的驱虫覆盖率和驱虫完成率,有效降低犬棘球绦虫感染风险,值得进一步应用评价。

关键词：包虫病智能项圈犬驱虫物联网