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Phosphodiesterase 9 localization in cytoplasm and nucleus:the gateway to selective targeting in neuroprotection?

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Neural Regeneration Research 2025年第6期20卷 1701-1702页

作者： giovanni Ribaudo Matteo Giannangeli Margrate Anyanwu Alessandra Gianoncelli Department of Molecular and Translational Medicine University of BresciaBresciaItaly

The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous *** diseases affect more than 50million people *** disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully *** of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3',5'-monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon *** kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them.

关键词： gateway homeostasis preserve

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A New Paradigm in Quantum Fields: The Quantum Oscillator with Semi-Quanta (IQuO) (Part Two)

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Journal of High Energy Physics, Gravitation and Cosmology 2025年第1期11卷 138-164页

作者： giovanni Guido Department of Physics and Mathematics High Scholl C. Cavalleri Parabiago Milano Italy

In this second part of a study about quantum field oscillators with sub-oscillators and semi-quanta (IQuO), it is possible to show that in the initial phase of an interaction between two particles a no-dynamic process of reduction from a non-local to a local state takes place which cannot be described by Hamiltonian. We then describe the coupling of two IQuO of different particle-fields either at one point in space or at two distant points via an intermediary chain of coupled IQuO. The first aspect provides an understanding of the basic processes of creating and annihilating a pair. The second aspect describes the behaviour of two electrically charged particles through a process of phase shifts between the respective IQuO chains (CF1, CF2) implemented in a quantum entanglement via an intermediary chain (CB) of IQuO that originates changes in the direction of the two (CF1, CF2) distance-correlated ones. Thus, the semi-quanta structure of an IQuO and quantum entanglement identify the origin of the empirical law of attraction and repulsion between two electric charges.

关键词： IQuO Quantum Entanglement Phase Fermion Boson Electric Charge

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First SHRIMP Zircon U-Pb Dating Constraints for the Ediacaran Wenghui Biota

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Journal of Earth Science 2025年第1期36卷 102-112页

作者： Mingsheng Zhao Feng Tang giovanni Mussini Yulan Li Heng Zhang Jianshu Chen Linzhi Gao College of Paleontology Shenyang Normal UniversityShenyang 110034China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China Department of Earth Sciences University of CambridgeCambridge CB23EQUnited Kingdom 111 Geological Brigade Guizhou Bureau of Geology and Mineral ResourcesGuiyang 550081China Guizhou Geological Survey Guiyang 550018China

The Ediacaran Period records a significant turning point in the evolution of life on Earth,witnessing the rise to ecological dominance of macroscopic tissue-grade *** Wenghui biota from the Doushantuo Formation of South China hosts abundant multicellular algal macrofossils and problematica,some of which might be closely related to taxa from classic Late Ediacaran assemblages from South Australia and the White Sea biota of ***,a lack of well-resolved isotopic age estimates has hampered efforts to constrain the timing of appearance of the Wenghui biota,obfuscating its significance to our understanding of Ediacaran macroevolution in the aftermath of the Snowball Earth ***,we present the first SHRIMP zircon U-Pb dating results for samples obtained from a laminated tuff ash layer at the base of the Wenghui biota in the Doushantuo Formation,Jiangkou County,Tongren City,Guizhou Province,*** analyses yield an age of 595.4±5.3 Ma for the first appearance of Wenghui biota,suggesting that its appearance postdated that of the Lantian and Weng'an biotas,but preceded that of the Miaohe *** newly obtained age proxies offer an independent test of previous isotopic estimates for the age of the Wenghui biota,providing new chronostratigraphic evidence to map the succession of Ediacaran fossil assemblages on the Yangtze Platform during the Doushantuo *** data suggest that the Lantian,Weng'an,Wenghui,and Miaohe biotas may record a sequence of biotic assemblages attesting to successive phases in the radiation of Ediacaran macroscopic organisms,particularly macroalgae.

关键词： zircon SHRIMP U-Pb dating Wenghui biota Doushantuo Formation Ediacaran system southern China

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Advanced hepatocellular carcinoma treatment strategies:Are transarterial approaches leading the way?

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 22-27页

作者： Stefan Patauner giovanni Scotton Francesca Notte Antonio Frena Department of General and Pediatric Surgery Bolzano Central Hospital-SABESBolzano 39100Trentino-Alto AdigeItaly

Hepatocellular carcinoma(HCC)is a leading cause of cancer-related mortality worldwide,with advanced stages posing significant treatment ***-though hepatic arterial infusion chemotherapy(HAIC)has emerged as a promising modality for treating advanced HCC,particularly in Asian clinical practice,its adoption in Western medicine remains limited due to a lack of large-scale randomized controlled *** editorial reviews and comments on the meta-analysis conducted by Zhou et al,which evaluates the efficacy and safety of HAIC and its combination strategies for advanced *** authors performed a comprehensive meta-analysis of various clinical trials and cohort studies comparing HAIC and its combinations to other first-line treatments,such as sorafenib and transarterial chemoembolization(TACE).In this work,HAIC showed significantly better results regarding overall survival and progression-free survival compared to sorafenib or TACE alone and their *** in combination with lenvatinib,ablation,programmed cell death 1 inhibitors,and radiotherapy further enhanced patient outcomes,indicating a synergistic *** editorial focuses on the critical role of multimodal treatment strategies in managing advanced *** advocates for a paradigm shift towards integrated treatment approaches to enhance survival rates and improve the quality of life in patients with advanced HCC.

关键词： Hepatocellular carcinoma Hepatic arterial infusion chemotherapy Transarterial chemoembolization Sorafenib Combined therapy

Innovative Mechanical Ventilation Control for Enhanced Indoor Air Quality and Energy Efficiency

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Energy Engineering 2025年第3期122卷 861-883页

作者： giovanni Miracco Francesco Nicoletti Vittorio Ferraro Dimitrios Kaliakatsos Department of Mechanical Energy and Management Engineering(DIMEG)University of CalabriaCosenza87036Italy Department of Computer ModellingElectronics and Systems Engineering(DIMES)University of CalabriaCosenza87036Italy

Indoor air quality(IAQ)is often overlooked,yet a poorly maintained environment can lead to significant health issues and reduced concentration and productivity in work or educational *** study presents an innovative control system for mechanical ventilation specifically designed for university classrooms,with the dual goal of enhancing IAQ and increasing energy *** classrooms with distinct construction characteristics were analyzed:one with exterior walls and windows,and the other completely *** each classroom,a model was developed using DesignBuilder software,which was calibrated with experimental data regarding CO_(2) concentration,temperature,and relative humidity *** proposed ventilation system operates based on CO_(2) concentration,relative humidity,and potential for free heating and *** addition,the analysis was conducted for other locations,demonstrating consistent energy savings across different climates and environments,always showing an annual reduction in energy *** demonstrate that mechanical ventilation,when integrated with heat recovery and free cooling strategies,significantly reduces energy consumption by up to 25%,while also maintaining optimal CO_(2) levels to enhance comfort and air *** findings emphasize the essential need for well-designed mechanical ventilation systems to ensure both psychophysical well-being and IAQ in enclosed spaces,particularly in environments intended for extended occupancy,such as ***,this approach has broad applicability,as it could be adapted to various building types,thereby contributing to sustainable energy management practices and promoting healthier indoor *** study serves as a model for future designs aiming to balance energy efficiency with indoor air quality,especially relevant in the post-COVID era,where the importance of indoor air quality has become more widely recognized.

关键词： Indoor air quality mechanical ventilation system innovative control system energy efficiency Energy-Plus simulation

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建筑记忆与当代视野的对话意大利吉隆达酒店

室内设计与装修 2025年第3期 46-52页

作者： giovanni Mecozzi Architetti giovanni Mecozzi Architetti

从意大利拉文纳火车站和港口出发，沿着阿尔曼多·迪亚兹大街朝古老的圣维塔莱大教堂方向走去，在离人民广场不远处就能看到建于文艺复兴时期的瓜奇曼尼宅邸。这是一座保存完好的15世纪建筑，它拥有绘于16世纪城市景致和自然风光的壁画...

从意大利拉文纳火车站和港口出发，沿着阿尔曼多·迪亚兹大街朝古老的圣维塔莱大教堂方向走去，在离人民广场不远处就能看到建于文艺复兴时期的瓜奇曼尼宅邸。这是一座保存完好的15世纪建筑，它拥有绘于16世纪城市景致和自然风光的壁画，以及新古典主义风格的木质天花。

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Factors associated with medical device-related pressure ulcers occurrence in hospital setting: a systematic review protocol

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Frontiers of Nursing 2025年第01期 13-18页

作者： Stefano Trapassi Guya Piemonte Enrico Lumini Lorenzo Righi Christian Ramacciani Isemann Mecheroni Silvana Luisa Bertò Stefania Francioni Fulvia Marini giovanni Becattini Department of Nursing and Midwifery Alta Val d'Elsa Hospital Department of Nursing and Midwifery Santa Maria Annunziata Hospital Department of Nursing and Midwifery Profession University Hospital Careggi Department of Nursing and Midwifery Operation Center Medical Service Department of Nursing and Midwifery Val di Chiana Hospital Department of Nursing and Midwifery Misericordia Hospital Department of Nursing and Midwifery San Donato Hospital

Objective: To identify the principal factors associated with the occurrence and development of medical device-related pressure injuries(MDRPI) in adults admitted to hospitals. MDRPI, a peculiar subtype of pressure injuries(PI), result from the pression exer ted by devices(or their fixation systems) applied for diagnostic and therapeutic purposes. MDRPI represent a serious problem for patients and healthcare systems. Understanding potential risk factors is an important step in implementing effective ***: In this study, we will perform a systematic review; if possible, also a meta-analysis will be performed. The review will follow the preferred reporting items for systematic reviews and meta-analyses(PRISMA) reporting guidelines for systematic reviews. A rigorous literature search will be conducted both in electronic databases(Medline/Pub Med, Embase, CINAHL, Web of Science, Scopus, Cochrane Library) to identify studies published since 2000 and in gray literature for unpublished studies. Pairs of researchers will identify relevant evidence, extract data, and assess risk of bias independently in each eligible study. Factors associated with the occurrence of MDRPI are considered the primary outcome. Secondary outcomes are prevalence and incidence of MDRPI, length of hospital stay, infections, and death. The evidence will be synthesized using the GRADE ***: Results are not currently available as this is a protocol for a systematic ***: This systematic review will identify evidence on risk factors for developing MDRPI. We are confident that the results of this review will help to improve clinical practice and guide future research.

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来源：博看期刊

Factors associated with medical device-related pressure ulcers occurrence in hospital setting:a systematic review protocol

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Frontiers of Nursing 2025年第1期12卷 13-18页

作者： Stefano Trapassi Guya Piemonte Enrico Lumini Lorenzo Righi Christian Ramacciani Isemann Mecheroni Silvana Luisa Bertò Stefania Francioni Fulvia Marini giovanni Becattini Department of Nursing and Midwifery Alta Val d’Elsa HospitalPoggibonsi 53036Italy Department of Nursing and Midwifery Santa Maria Annunziata HospitalBagno a Ripoli 50012Italy Department of Nursing and Midwifery Profession University Hospital CareggiFlorence 50134Italy Department of Nursing and Midwifery Operation Center Medical ServiceSiena 53100Italy Department of Nursing and Midwifery Val di Chiana HospitalMontepulciano 53045Italy Department of Nursing and Midwifery Misericordia HospitalGrosseto 58100Italy Department of Nursing and Midwifery San Donato HospitalArezzo 52100Italy

Objective: To identify the principal factors associated with the occurrence and development of medical device-related pressure injuries (MDRPI) in adults admitted to hospitals. MDRPI, a peculiar subtype of pressure injuries (PI), result from the pression exerted by devices (or their fixation systems) applied for diagnostic and therapeutic purposes. MDRPI represent a serious problem for patients and healthcare systems. Understanding potential risk factors is an important step in implementing effective interventions. Methods: In this study, we will perform a systematic review;if possible, also a meta-analysis will be performed. The review will follow the preferred reporting items for systematic reviews and meta-analyses (PRISMA) reporting guidelines for systematic reviews. A rigorous literature search will be conducted both in electronic databases (Medline/PubMed, Embase, CINAHL, Web of Science, Scopus, Cochrane Library) to identify studies published since 2000 and in gray literature for unpublished studies. Pairs of researchers will identify relevant evidence, extract data, and assess risk of bias independently in each eligible study. Factors associated with the occurrence of MDRPI are considered the primary outcome. Secondary outcomes are prevalence and incidence of MDRPI, length of hospital stay, infections, and death. The evidence will be synthesized using the GRADE methodology. Results: Results are not currently available as this is a protocol for a systematic review. Conclusions: This systematic review will identify evidence on risk factors for developing MDRPI. We are confident that the results of this review will help to improve clinical practice and guide future research.

关键词： incidence medical devices pressure injury pressure ulcer prevalence risk factor

Development and validation of a decision algorithm for eyelid reconstruction following oncological resection

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World Journal of Transplantation 2025年第2期15卷 309-319页

作者： giovanni Miotti Davide Quaglia Federico Cesare Novati Pier Camillo Parodi Martina Grando Carlo Salati Leopoldo Spadea Caterina Gagliano Mutali Musa Marco Zeppieri Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Medical Surgical and Health SciencesPlastic and Reconstructive Surgery UnitUniversity of TriesteTrieste 34123Italy Department of Internal Medicine Azienda Sanitaria Friuli OccidentaleSan Vito al Tagliamento 33078Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I“Sapienza”University of RomeRome 00142Italy Department of Medicine and Surgery University of Enna“Kore”Enna 94100Italy Mediterranean Foundation“G.B.Morgagni” Catania 95125Italy Department of Optometry University of BeninBenin 300283Nigeria Department of Ophthalmology Centre for Sight AfricaNkpor 434112Nigeria

BACKGROUND Eyelid reconstruction is an intricate process,addressing both aesthetic and functional aspects post-trauma or oncological *** concerns and oncological radicality guide personalized *** complex anatomy,involving anterior and posterior lamellae,requires tailored reconstruction for optimal *** To formulate an eyelid reconstruction algorithm through an extensive literature review and to validate it by juxtaposing surgical outcomes from Cattinara Hos-in dry eye and tears,which may lead to long-term consequences such as chronic conjunctivitis,discomfort,or *** prevent this issue,scars should be oriented vertically or perpendicularly to the free eyelid margin when the size of the tumor *** employing a malar flap to repair a lower eyelid defect,the malar incision must ascend diagonally;this facilitates enhanced flap advancement and mitigates ectropion by restricting vertical ***-quently,it is imperative to maintain that the generated tension remains consistently horizontal and never vertical[9].Lagophthalmos is a disorder characterized by the inability to completely close the eyelids,leading to corneal exposure and an increased risk of keratitis or ulceration;it may arise following upper eyelid *** avert this issue,it is essential to preserve a minimum of 1 cm of skin between the superior edge of the excision and the inferior boundary of the *** may occur in cancers involving the lacrimal puncta,requiring their *** previously stated,when employing a glabellar flap to rectify medial canthal abnormalities,it is essential to prevent a trapdoor effect or thickening of the flap relative to the eyelid skin to which it is *** about our proposed algorithm enco-mpass limited sample sizes and possible publication biases in existing *** investigations ought to examine long-term results to further refine the *** research should evaluate t

关键词： Cartilage grafts Decision algorithm Eyelid lamella grafts Eyelid reconstruction Flap transplantation Graft transplantation Mucosa grafts