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A Dietar. Supplement Jinghuosu Amelior.tes r.pr.ductive Damage Induced by Tr.pter.gium Glycosides

Chinese Jour.al of Integr.tive Medicine 2024年第4期30卷 330-338页

作者： MA Jing SUN Bo TE Li-ger HUANG Xin ZUO Xin HAN Xiao-ke WANG Shu-song Hebei Key Labor.tor. of r.pr.ductive Medicine Hebei Institute of Reproductive HealthHebei Reproductive Health HospitalShijiazhuang(050071)China Gr.duate School of Hebei Medical Univer.ity Shijiazhuang(050017)China School of Chemistr. and Mater.als Science Hebei Normal UniversityShijiazhuang(050024)China Xingtai Infer.ility Specialist Hospital XingtaiHebei Province(054000)China

Objective To deter.ine the possible pr.tective effects of Jinghuosu,a dietar. supplement(DS),on tr.pter.gium glycosides(TG)-induced r.pr.ductive system injur. in r.ts and its under.ying *** A r.pr.ductive damage model was established in r.ts by feeding of ***-eight male Spr.gue Dawley r.ts wer. r.ndomly divided into 4 gr.ups using a r.ndom number.table(n=7 in each):contr.l(C)gr.up,model(M)gr.up,DS gr.up and L-car.itine(LC)*** in M,DS and LC gr.ups r.ceived 40 mg/kg TGs *** fr.m the 5th week,after.administr.tion of TGs for.4 h ever. day,r.ts in DS and LC gr.ups wer. administer.d with 2.7 g/kg DS and 0.21 g/kg LC,r.spectively,for.pr.tective tr.atment over.the next 4 *** in Gr.up C continued to r.ceive the contr.l ***-eosin staining was used for.histopathological analysis of r.t testicular.***-linked immunosor.ent assay was per.or.ed to measur. alkaline phosphatase(ALP),lactate dehydr.genase,alcohol dehydr.genase,total antioxidant capacity(T-AOC),super.xide dismutase,glutathione per.xidase(GSH-Px),and malondialdehyde(MDA)*** assay was used to deter.ine the ser.m testoster.ne *** r.al-time PCr.and Wester. blotting wer. conducted to analyze the expr.ssion of genes and pr.teins r.lated to the testoster.ne synthesis pathway and the nuclear.factor.er.thr.id 2-r.lated factor.2/heme oxygenase 1 antioxidant *** Or.l administr.tion of TGs induced significant incr.ases in the testicular.levels of zinc tr.nspor.er.1 and MDA(Pthe other.hand,sper. concentr.tion,sper. motility,and ser.m testoster.ne,ser.m zinc,testicular.zinc,Zr.-,Ir.-like pr.tein 1,ALP,luteinizing hor.one(LH)r.ceptor.ster.idogenic acute r.gulator. pr.tein,Cytochr.me P450 family 11 subfamily A member.1,3β-hydr.xyster.id dehydr.genase 1 T-AOC,GSH-Px,nuclear.factor.er.thr.id 2-r.lated factor.2,heme oxygenase-1 and NAD(P)H:quinone oxidor.ductase 1 levels decr.ased following TG

关键词： dietar. supplement Jinghuosu tr.pter.gium glycosides r.pr.ductive damage infer.ility

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Subpopulations of r.gulator. T cells ar. associated with subclinical ather.scler.tic plaques,levels of ldL,and car.ior.spir.tor. fitness in the elder.y

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Jour.al of Spor. and Health Science 2024年第3期13卷 288-296,I0002页

作者： Tim Böttr.ch Pascal Bauer.Vincent Gr.βer.Magdalena Huber.Har.mann r.ifer.Tor.ten Fr.ch Svenja Nolte ther.sa Dombr.wski Fr.nz Cemic Natascha Sommer.r.ber. r.ngseis Klaus Eder.Kar.ten Kr.ger Chr.stopher.Weyh Depar.ment of Exer.ise Physiology and Spor.s ther.py Institute of Sports ScienceJustus-Liebig-UniversityGiessen 35394Germany Depar.ment of Car.iology and Angiology Justus-Liebig-University GiessenGiessen 35392Germany Institute for.Systems Immunology Center for Tumor und ImmunologyMarburg 35032Germany th Mittelhessen Department of Computer ScienceUniversity of Applied Sciences GiessenGiessen 35390Germany Depar.ment of Inter.al Medicine Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Giessen 35394Germany Excellence Cluster.Car.io-Pulmonar. Institute(CPI) Justus-Liebig UniversityGiessen 35394Germany Institute of Animal Nutr.tion and Nutr.tion Physiology Justus-Liebig-University GiessenGiessen 35390Germany

Backgr.und:Ather.scler.sis for.s the pathological basis for.the development of car.iovascular.*** pathological pr.cesses initially develop without clinically r.levant symptoms,the identification of ear.y mar.er. in the subclinical stage plays an impor.ant r.le for.initiating ear.y *** is evidence that r.gulator. T cells(Tr.gs)ar. involved in the development of ***,the pr.sent study aimed to identify and investigate associations with Tr.gs and their.subsets in a cohor. of healthy elder.y individuals with and without subclinical ather.scler.tic plaques(SAP).In addition,var.ous lifestyle and r.sk factor.,such as car.ior.spir.tor. fitness,wer. investigated as associated ***:A cr.ss-sectional study was per.or.ed in 79 par.icipants(male:n=50;age=63.6±3.7 year.;body mass index=24.9±3.1 kg/m2;mean±SD)who had no pr.vious diagnosis of chr.nic disease and wer. not taking *** of the car.tids to identify SAP,car.iovascular.function measur.ment for.vascular.assessment and a car.ior.spir.tor. fitness test to deter.ine peak oxygen uptake wer. ***,tests wer. conducted to assess blood lipids and deter.ine glucose *** of Tr.gs and their.subtypes(r.sting(r.r.gs)and effector.memor.(mTr.gs))was per.or.ed by 8-chanel flow *** wer. categor.zed accor.ing to ather.scler.tic plaque *** and logistic r.gr.ssion models wer. used to analyze associations between ***:SAP was detected in a total of 29 *** par.icipants with plaque wer. older.64.8±3.6 year. vs.62.9±3.5 year.)and had higher.per.pher.l systolic blood pr.ssur.(133.8±14.7 mmHg vs.125.8±10.9 mmHg).the par.icipants with SAP wer. char.cter.zed by a lower.per.entage of r.r.gs(28.8%±10.7%vs.34.6%±10.7%)and a higher.per.entage of mTr.gs(40.3%±14.7%vs.30.0%±11.9%).Multiple logistic r.gr.ssion identified age(odds r.tio(Or.=1.20(95%confidence inter.al(95%CI):1.011.42))and

关键词： Car.ior.spir.tor. fitness Elder.y r.gulator. T cells Subclinical ather.scler.sis

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Inhibitor. activity of polysacchar.de extr.cts fr.m thr.e kinds of edible fungi on pr.lifer.tion of human hepatoma smMC-7721 cell and mouse implanted S180 tumor

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Wor.0} Jour.al of Gastr.enter.logy 1999年第5期5卷 404-407页

作者： Jiang sm Xiao ZM Xu ZH Shandong Nor.al Univ Dept Biol Provincial Key Lab Anim Stress Jinan 250014 Shandong Prov Peoples R China Univ Heidelber. D-6900 Heidelberg Germany

AIM To deter.ine the activities ofpolysacchar.de extr.cts fr.m Flammulina velutipes (Cur.. ex Fr. ) Sing (FV), Lentinusedodes (LE) and Agar.cus bispor.s Sing (AB)on the pr.lifer.tion of human hepatoma smMC-7721 cells in vitr. and on mouse implanted S-180tumor. in *** the polysacchar.de extr.cts wer. isolated fr.m the fr.it bodies of FV, LE and AB by the methods of hot-water.extr.ction, Sevag’sr.moval of pr.teins, ethanol pr.cipitation,tr.psin digestion and ethanol fr.ctionalpr.cipitation. Human hepatoma smMC-7721 cells wer. tr.ated with 50 mg/L Polysacchar.de extr.cts, and the mitosis index, mitochondr.a activity and cell pr.lifer.tion wer. detected at differ.nt times in both contr.l and exper.mental gr.ups. the mice with S-180 implanted tumor. wer. injected with the polysacchar.de extr.cts at 24 mg/ kg body weight for.9 d and the tumor.eight was measur.d on the 15th *** the mitosis index of hepatoma cells in vitr. could be significantly decr.ased by tr.atment with the polysacchar.de extr.cts fr.mthe thr.e kinds of edible fungi (P thecell number. and mitochondr.a activity of smMC7721 cells tr.ated with polysacchar.de extr.cts wer. lower.than those in contr.l gr.ups (P the inhibition r.tes of polysacchar.de extr.cts against implanted S-180 tumor. in mice wer. 52.8%, 56.6% and 51 .9% r.spectivelycompar.d with that in c0ntr.l ***0N the POIysacchar.de extr.ctsfr.m the thr.e kinds of edible fungi could inhibitnot only the Cultur.d malignant cells in vitfO butalso impIanted Sl80 tum0r.i0 vivo.

关键词： polysacchar.de, edible fungi liver neoplasm car.inoma, hepatocellular smMC7721, tumor cell, cultur.d implanted tumor. S-180 cell pr.lifer.tion

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一步浸渍合成具有多重孔隙的铸型炭体(英文)

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新型炭材料 2003年第4期18卷 265-270页

作者：陆安慧 Jan-Henr.k smtt Mika Lindn Fer.i Schüth Max-Planck-Institut für.Kohlenfor.chung Kaiser-Wilhelm-Platz 1D-45470 Mülheim an der Ruhr Max-Planck-Institut für.Kohlenfor.chung Kaiser-Wilhelm-Platz 1 D-45470 Mülheim an der Ruhr

　以多孔块状硅体为模板,通过一步浸渍、炭化、酸处理工艺,制备出结构可控、孔隙联通且具有多重孔隙的铸型炭体。分别采用氮吸附技术、高分辨透射电镜和扫描电镜对模板硅、硅碳复合物及相应炭体进行了结构表征。从微米尺度分析,该炭体... 详细信息

　以多孔块状硅体为模板,通过一步浸渍、炭化、酸处理工艺,制备出结构可控、孔隙联通且具有多重孔隙的铸型炭体。分别采用氮吸附技术、高分辨透射电镜和扫描电镜对模板硅、硅碳复合物及相应炭体进行了结构表征。从微米尺度分析,该炭体是由高度联接的枝状结构单元为骨架构筑而成。与模板硅相比较,此炭体是硅体的正复本。从纳米尺度分析,这种炭体枝状骨架是由分布均匀且相互连接的中孔构成,此中孔及其孔壁对应于模板硅的孔壁及中孔,是多孔硅的负复本。此外构成中孔的炭骨架本体又含有大量炭化过程产生的微孔。因此该法合成的铸型炭具有孔隙高度发达和结构层层嵌套的特点。

关键词：铸型炭体一步浸渍法合成多重孔隙结构表征

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Char.cter.zation of the Dr.sophila Atlastin Inter.ctome r.veals VCP as a Functionally r.lated Inter.ctor

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Jour.al of Genetics and Genomics 2013年第6期40卷 297-306页

作者： Niamh C.O'Sullivan Nina Dr.ger Cahir.J.O'Kane 4th Floor Burlington Danes BuildingDepartment of MedicineImperial College LondonW12 ONNUnited Kingdom Depar.ment of Genetics University of CambridgeDowning StreetCambridge CB2 3EHUnited Kingdom

At least 25 genes,many involved in tr.fficking,localisation or.shaping of membr.ne or.anelles,have been identified as causative genes for.the neur.degener.tive disor.er.her.ditar. spastic par.plegia（HSP）.One of the most commonly mutated HSP genes,atlastin-1, encodes a dynamin-like GTPase that mediates homotypic fusion of endoplasmic r.ticulum（Er. ***,the molecular.mechanisms of atlastin-1-r.lated membr.ne fusion and axonopathy r.main *** better.under.tand its mode of action,we used affinity pur.fication coupled with mass spectr.metr. to identify pr.tein inter.ctor. of atlastin in *** of 72 identified pr.teins r.vealed that the atlastin inter.ctome contains many pr.teins involved in pr.tein pr.cessing and tr.nspor.,in addition to pr.teins with r.les in mr.A binding,metabolism and mitochondr.al *** highest confidence inter.ctor.fr.m mass spectr.metr. analysis, the ubiquitin-selective AAA-ATPase valosin-containing pr.tein（VCP）,was validated as an atlastin-inter.cting pr.tein,and VCP and atlastin showed over.apping subcellular.***,VCP acted as a genetic modifier.of atlastin：loss of VCP par.ially suppr.ssed an eye phenotype caused by atlastin over.xpr.ssion,wher.as over.xpr.ssion of VCP enhanced this *** inter.ctions between atlastin and VCP suggest a functional r.lationship between these two pr.teins,and point to potential shar.d mechanisms between HSP and other.for.s of neur.degener.tion.

关键词： Endoplasmic r.ticulum Her.ditar. spastic par.plegias Atlastin Valosin-containing pr.tein

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新技术、新工具对汽车和发动机开发过程的影响

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汽车与新动力 2001年第6期33卷 16-18+39页

作者： Oligschlger U Wagner.th 黄镇平

技术进步为发展用于汽车和发动机开发的新工具开辟了道路,这一方面提供了优化整个工作流程的机会,另一方面也提供了改进单项任务的机会。介绍了开发过程的实际现状和工具发展的新方向,最后给出了对未来的展望。ADAPT-SIM是驾驶员和车辆... 详细信息

技术进步为发展用于汽车和发动机开发的新工具开辟了道路,这一方面提供了优化整个工作流程的机会,另一方面也提供了改进单项任务的机会。介绍了开发过程的实际现状和工具发展的新方向,最后给出了对未来的展望。ADAPT-SIM是驾驶员和车辆模拟的一种工具,其开发主要适于ECU应用,但也可用于其他的动态试验项目。这一工具的引用可获得更好的试验可控制性,因而也可获得更好的重复性。

关键词：汽车汽车发动机开发新技术新工具

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Anthr.x:an update

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Asian Pacific Jour.al of Tr.pical Biomedicine 2011年第6期1卷 496-501页

作者： Kamal sm r.shid AKM M Bakar.MA Aliad MA Depar.ment of Medicine Khulna Medical College Depar.ment of Paediatr.cs Khulna Medical College Depar.ment of Gastr.enter.logy khulna Medical College

Anthr.x is a zoonotic disease caused by Bacillus *** is potentially fatal and highly contagious *** ar. the natur.l *** acquir. the disease incidentally by contact with infected animal or.animal *** the 18th centur. an epidemic destr.yed appr.ximately half of the sheep in *** 1900 human inhalational anthr.x occur.d spor.dically in the United *** 1979 an outbr.ak of human anthr.x occur.d in Sver.lovsk of Soviet *** continued to r.pr.sent a wor.0} wide *** incidence of the disease has decr.ased in developed countr.es as a r.sult of vaccination and impr.ved industr.al *** anthr.x clinically pr.sents in thr.e for.s,***,gastr.intestinal and *** 95%of human anthr.x is cutaneous and 5%is *** anthr.x is ver. r.r.(less than 1%).Inhalational for. is used as a biological war.far. agent. Penicillin,cipr.floxacin(and other.quinolones),doxicyclin,ampicillin,***, clar.thr.mycin,vancomycin,chlor.mphenicol,r.fampicin ar. effective antimicr.bials. Antimicr.bial ther.py for.60 days is *** anthr.x vaccine is available. Administr.tion of anti-pr.tective antigen(PA) antibody in combination with cipr.floxacin pr.duced 90%-100%*** combination of CPG-adjuvanted anthr.x vaccine adsor.ed(AVA) plus dalbavancin significantly impr.ved sur.ival.

关键词： Anthr.x Bacillus anthr.cis Zoonotic disease Contagious disease Cutaneous anthr.x Inhalational anthr.x Gastr.intestinal anthr.x Human anthr.x

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Dir.ct extr.sion of thin Mg wir.s for.biomedical applications

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Tr.nsactions of Nonfer.ous Metals Society of China 2020年第2期30卷 373-381页

作者： K.TESAŘ K.BALÍK Z.SUCHAr.A A.JÄger depar.ment of mater.als faculty of nuclear sciences and physical engineeringczech technical university in praguetrojanova 13prague12000czech republic depar.ment of dielectr.cs institute of physicsczech academy of sciencesna slovance 2prague18221czech republic depar.ment of composites and car.on mater.als institute of rock structure and mechanicsczech academy of sciencesv holešovičkách 41prague18209czech republic depar.ment of mechanics faculty of civil engineeringczech technical university in praguethákurova 7prague16629czech republic

Biodegr.dable wir.s,able to pr.vide load-bear.ng suppor. for.var.ous biomedical applications,ar. the novel tr.nds in cur.ent biomater.al r.sear.h.A thin 99.92%Mg wir. with a diameter.of 250μm was pr.par.d via dir.ct extr.sion with an extr.me r.duction r.tio of 1:*** total imposed str.in in a single pr.cessing step was *** was car.ied out at elevated temper.tur.s in the r.nge fr.m 230 to 310℃and with var.ous r.m speeds r.nging fr.m^0.2 to^0.5 mm/*** r.sulting wir.s show ver. good mechanical pr.per.ies which var. with extr.sion *** tr.e tensile str.ss at r.om temper.tur. r.aches^228 MPa and ductility r.aches^13%.the pr.posed single-step dir.ct extr.sion can be an effective method for.the pr.duction of Mg wir.s in sufficient quantities for.*** fr.ctogr.phic analysis r.vealed that failur. of the wir.s may be closely connected with inclusions(e.g.,Mg O par.icles).the r.sults ar. essential for.deter.ining the optimal pr.cessing conditions of hot extr.sion for.thin Mg *** smaller.gr.in size,as the outcome of the lower.extr.sion temper.tur.,is identified as the main par.meter.affecting the tensile pr.per.ies of the wir.s.

关键词： biomedical mater.als mechanical pr.per.ies fr.ctur. nonfer.ous metals magnesium

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Ghr.lin inhibits viscer.l affer.nt activation of catecholamine neur.ns in the solitar. tr.ct nucleus

Ghrelin inhibits visceral afferent activation of catecholami...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： sm Appleyar. Pr.gr.m in Neur.science Department of Veterinary Comparative AnatomyWashington State University School of Life Science Northeast Normal University

＜正＞Br.instem A2/C2 catecholamine（CA） neur.ns in the solitar. tr.ct nucleus（NTS） ar. thought to play an impor.ant r.le in the contr.l of food intake and other.homeostatic *** have pr.viously demonstr.ted that these neur.ns,which send extensive pr.jections to br.in r.gions involved in the r.gulation of appetite,ar. str.ngly and dir.ctly activated by solitar. tr.ct（ST） viscer.l ***,a potent or.xigenic peptide r.leased fr.m the stomach,is pr.posed to act in par. thr.ugh modulating NTS CA neur.ns but the under.ying cellular.mechanisms ar. ***,we identified CA neur.ns using tr.nsgenic mice that expr.ss enhanced gr.en fluor.scent pr.tein dr.ven by the tyr.sine hydr.xylase pr.moter.th-EGFP）.We then deter.ined how ghr.lin modulates th-EGFP neur.ns using patch-clamp techniques in a hor.zontal br.in slice *** inhibited the fr.quency of spontaneous glutamate inputs（spontaneous EPSCs） onto th-EGFP neur.ns,including cholecystokinin-sensitive neur.ns,an effect blocked by the GHSr. antagonist,*** r.sulted in a decr.ase in the basal fir.ng r.te of NTS th-EGFP neur.ns,an effect blocked by the glutamate antagonist *** also dose-dependently inhibited the amplitude of ST affer.nt-evoked EPSCs（ST-EPSCs） in th-EGFP NTS neur.ns,decr.asing the success r.te for.ST-evoked action *** addition,ghr.lin decr.ased the fr.quency of mini-EPSCs suggesting its actions ar. pr.synaptic to r.duce glutamate ***,inhibition by ghr.lin of the ST-EPSCs was significantly incr.ased by an 18 h *** r.sults demonstr.te a potential mechanism by which ghr.lin inhibits NTS th neur.ns thr.ugh a pathway whose r.sponsiveness is incr.ased dur.ng fasting.

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r.r. ear.h element geochemistr. of Post-to Neo-ar.hean shales fr.m Singhbhum mobile belt, Easter. India: implications for.tectonic setting and paleo-oxidation conditions

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Chinese Jour.al Of Geochemistr. 2015年第3期34卷 401-409页

作者： Akhtar.r.Mir Depar.ment of Ear.h Sciences University of Kashmir

In the pr.sent study, tr.ce element(including r.r. ear.h element) chemical data has been inter.r.ted with the aim to decipher.the tectonic setting and paleo-r.dox conditions of the Post- to Neo-ar.hean shales fr.m the Singhbhum Mobile Belt, easter. India. the data show moder.te enr.chment of compatible elements [such as Cu(avg. 59.28 ppm), Ni(avg. 59.49 ppm), V(avg.234.24 ppm) and Cr.avg. 181.23 ppm)] r.lative to the Post-Ar.hean Austr.lian Shale. their.chondr.te nor.alized light r.r. ear.h elements ar. moder.tely fr.ctionated [(La/sm)Nr.nges fr.m 2.21 to 5.78], wher.as heavy r.r. ear.h elements show a near.y flat patter. [(Gd/Lu)Nr.nges fr.m0.74 to 1.68]; this indicates that the r.r. ear.h element(r.E) concentr.tions, r.ther.than being sever.ly affected by the diagenesis and weather.ng pr.cesses, decr.ased gr.dually fr.m Gd to Lu. the Post-Ar.hean Austr.lian Shale nor.alized multi-element diagr.m shows the slight enr.chment of Cr. V, Zr. Y, U and Sc, wher.as Sr. Pb, Hf and th ar. depleted. the notable negative anomaly of Sr.indicates the least accumulation of plagioclase, which is also suppor.ed by the negative Eu-anomaly in these *** La–th–Sc and th–Zr.Sc tectonic setting diagr.ms indicate their.continental ar. setting. the geochemical par.meter., such as U/th, V/Cr. Ni/Co, and Cu/Zn, indicate that these shales wer. deposited under.oxic to anoxic envir.nmental conditions.

关键词：稀土元素地球化学特征新太古代页岩印度构造意义氧化条件移动氧化还原条件

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