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Cellular & molecular Immunology 2021年第10期18卷 2455-2456页

作者： Swantje I.Hammerschmidt Berislav Bosnjak Günter Bernhardt michaela Friedrichsen Inga Ravens Alexandra Dopfer-Jablonka markus Hoffmann Stefan Pöhlmann georg m.n.behrens Reinhold Förster Institute of Immunology Hannover Medical SchoolHannoverGermany Department for Rheumatology and Immunology Hannover Medical SchoolHannoverGermany Infection Biology Unit German Primate Center-Leibniz Institute for Primate ResearchGöttingenGermany Faculty of Biology and Psychology Georg-August-University GöttingenGöttingenGermany German Center for Infection Research(DZIF) Partner Site Hannover-BraunschweigHannoverGermany German Center for Lung Research(DZL) HannoverGermany Cluster of Excellence RESIST(EXC 2155) Hannover Medical SchoolHannoverGermany

Since the beginning of the COVID-19 pandemic,divergent variants of concern(VoCs)of SARS-CoV-2 have evolved and become the most prevalent SARS-CoV-2 variants in distinct locations at different ***,the Delta variant(B.1.617.2)dominates infection events in large parts of the *** campaigns,however,still use SARS-CoV-2 vaccines based on the spike(S)protein of the original Wuhan virus.

关键词： Delta homologous campaign

Efficient antibody evasion but reduced ACE2 binding by the emerging SARS-CoV-2 variant B.1.640.2

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Cellular & molecular Immunology 2022年第9期19卷 1067-1069页

作者： Prerna Arora Amy Kempf Inga nehlmeier Luise Graichen Sebastian Schulz Anne Cossmann Alexandra Dopfer-Jablonka martin S.Winkler Hans-martin Jäck georg m.n.behrens Stefan Pöhlmann markus Hoffmann Infection Biology Unit German Primate CenterKellnerweg 437077GöttingenGermany Faculty of Biology and Psychology Georg-August-University GöttingenWilhelmsplatz 137073GöttingenGermany Division of molecular Immunology Department of Internal Medicine 3Friedrich-Alexander University of Erlangen-NürnbergGlückstraße 691054ErlangenGermany Department for Rheumatology and Immunology Hannover Medical SchoolCarl-Neuberg-Straße 130625HannoverGermany German Centre for Infection Research(DZIF) Partner Site Hannover-BraunschweigHannoverGermany Centre for Individualised Infection medicine(Ciim) HannoverGermany Department of Anesthesiology University of Göttingen Medical CenterGöttingenGeorg-August University of GöttingenRobert-Koch-Straße 4037075GöttingenGermany

The SARS-CoV-2 spike(S)protein engages ACE2 for cell entry,and the S protein/ACE2 interface is an important target for neutralizing *** the course of the COVID-19 pandemic,SARS-CoV-2 variants have emerged that harbor mutations in the S protein,which confer neutralization resistance and allow viral spread in immunologically nonnaive *** most prominent example is the highly mutated Omicron variant,which infects convalescent or vaccinated individuals with unprecedented efficiency[1,2].

关键词： ACE2 harbor neutral

Host cell entry and neutralisation sensitivity of the SARS-CoV-2 XBB.1.16 lineage

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Cellular & molecular Immunology 2023年第8期20卷 969-971页

作者： Inga nehlmeier Amy Kempf Prerna Arora Anne Cossmann Alexandra Dopfer-Jablonka metodi V.Stankov Sebastian R.Schulz Hans-martin Jäck georg m.n.behrens Stefan Pöhlmann markus Hoffmann Infection Biology Unit German Primate Center—Leibniz Institute for Primate ResearchKellnerweg 437077GöttingenGermany Faculty of Biology and Psychology Georg-August-University GöttingenWilhelmsplatz 137073GöttingenGermany Department of Rheumatology and Immunology Hannover Medical SchoolCarl-Neuberg-Straße 130625HannoverGermany German Centre for Infection Research(DZIF) Partner Site Hannover-BraunschweigCarl-Neuberg-Straße 130625HannoverGermany Division of molecular Immunology Department of Internal Medicine 3Friedrich-Alexander University of Erlangen-NürnbergGlückstraße 691054ErlangenGermany Centre for Individualized Infection medicine(Ciim) Feodor-Lynen-Straße 730625HannoverGermany

Despite previous circulation of the highly transmissible and antibody evasive BA.2.75, BQ.1, XBB.1 and XBB.1.5 lineages, the share of infections caused by the SARS-CoV-2 lineage XBB.1.16 has gradually increased in India in early 2023, resulting in XBB.1.16 being the dominating SARS-CoV-2 lineage in India today. Since a similar trend may also take place in other countries and information on the biological properties of the XBB.1.16 lineage is scarce, we conducted a rapid assessment of the SARS-CoV-2 XBB.1.16 lineage with respect to its ability to enter cells and evade neutralisation by antibodies.

关键词： lineage neutral spite

Profound neutralization evasion and augmented host cell entry are hallmarks of the fast-spreading SARS-CoV-2 lineage XBB.1.5

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Cellular & molecular Immunology 2023年第4期20卷 419-422页

作者： markus Hoffmann Prerna Arora Inga nehlmeier Amy Kempf Anne Cossmann Sebastian R.Schulz Gema morillas Ramos Luis A.manthey Hans-martin Jäck georg m.n.behrens Stefan Pöhlmann Infection Biology Unit German Primate CenterKellnerweg 437077 GöttingenGermany Faculty of Biology and Psychology Georg-August-University GöttingenWilhelmsplatz 137073 GöttingenGermany Department for Rheumatology and Immunology Hannover Medical SchoolCarl-Neuberg-Straße 130625 HannoverGermany Division of molecular Immunology Department of Internal Medicine 3Friedrich-Alexander University of Erlangen-NürnbergGlückstraße 691054 ErlangenGermany German Centre for Infection Research(DZIF) partner site Hannover-BraunschweigCarl-Neuberg-Straße 130625 HannoverGermany Centre for Individualized Infection medicine(Ciim) FeodorLynen-Straße730625 HannoverGermany

Since late 2022, the share of infections caused by the SARS-CoV2 lineage XBB.1.5 has gradually increased in the United States,resulting in XBB.1.5 becoming the dominating SARS-CoV-2lineage in the United States and a similar trend is likely to soontake place also in European countries. However, information onthe virological properties of XBB.1.5 is scarce. Here, weconducted an initial virological assessment of the SARS-CoV-2XBB.1.5 lineage.

关键词： becoming likely lineage

Delta variant(B.1.617.2)sublineages do not show increased neutralization resistance

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Cellular & molecular Immunology 2021年第11期18卷 2557-2559页

作者： Prerna Arora Amy Kempf Inga nehlmeier Luise Graichen Anzhalika Sidarovich martin S.Winkler Sebastian Schulz Hans-martin Jäck metodi V.Stankov georg m.n.behrens Stefan Pöhlmann markus Hoffmann Infection Biology Unit German Primate CenterGöttingenGermany Faculty of Biology and Psychology Georg-August-University GöttingenGöttingenGermany Department of Anesthesiology University of Göttingen Medical CenterGeorg-August University GöttingenGöttingenGermany Division of molecular Immunology Department of Internal Medicine 3Friedrich-Alexander University of Erlangen-NürnbergErlangenGermany Department for Rheumatology and Immunology Hannover Medical SchoolHannoverGermany

The emergence of SARS-CoV-2 variants threatens efforts to control the COVID-19 *** present,the global spread of the Delta(B.1.617.2)variant is responsible for a rapid increase in COVID-19 cases and hospitalizations in... 详细信息

关键词： Delta neutral resistance

The spike protein of SARS-CoV-2 variant A.30 is heavily mutated and evades vaccine-induced antibodies with high efficiency

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Cellular & molecular Immunology 2021年第12期18卷 2673-2675页

作者： Prerna Arora Cheila Rocha Amy Kempf Inga nehlmeier Luise Graichen martin S.Winkler martin Lier Sebastian Schulz Hans-martin Jäck Anne Cossmann metodi V.Stankov georg m.n.behrens Stefan Pöhlmann markus Hoffmann Infection Biology Unit German Primate CenterKellnerweg 437077GöttingenGermany Faculty of Biology and Psychology Georg-August-University GöttingenWilhelmsplatz 137073GöttingenGermany Department of Anesthesiology University of Göttingen Medical CenterGeorg-August University of GöttingenRobert-Koch-Straße 4037075GöttingenGermany Division of molecular Immunology Department of Internal Medicine 3Friedrich-Alexander University of Erlangen-NürnbergGlückstraße 691054ErlangenGermany Department for Rheumatology and Immunology Hannover Medical SchoolCarl-Neuberg-Straße 130625HannoverGermany

The COVID-19 pandemic,caused by SARS-CoV-2,continues to rage in many countries,straining health systems and *** protect against severe disease and death and are considered central to ending the ***-19 vaccines(and SARS-CoV-2 infection)elicit antibodies that are directed against the viral spike(S)protein and neutralize the ***,the emergence of SARS-CoV-2 variants with S protein mutations that confer resistance to neutralization might compromise vaccine efficacy[1].

关键词： antibodies vaccine death

Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods

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Cellular & molecular Immunology 2021年第4期18卷 936-944页

作者： Berislav Bosnjak Saskia Catherina Stein Stefanie Willenzon Anne Katrin Cordes Wolfram Puppe Gunter Bernhardt Inga Ravens Christiane Ritter Christian R.Schultze-Florey nina Godecke Jorg martens Hannah Kleine-Weber markus Hoffmann Anne Cossmann mustafa Yilmaz Isabelle Pink marius m.Hoeper georg m.n.behrens Stefan Pohlm ann Rainer Blasczyk Thomas F.Schulz Reinhold Forster Institute of Immunology Hannover Medical SchoolHannoverGermany lnstitute of Virology Hannover Medical SchoolHannoverGermany Department of Hematology HemostasisOncology and Stem Cell TransplantationHannover Medical SchoolHannoverGermany Institute of Transfusion medicine and Transplant Engineering Hannover Medical SchoolHannoverGermany German Primate Center-Leibniz Institute for Primate Research GottingenGermany Faculty of Biology and Psychology University GottingenGottingenGermany Department of Rheum atology and Immunology Hannover Medical SchoolHannoverGermany Public Health Department HannoverGermany Department of Pneumology and German Centre of Lung Research(DZL) Hannover Medical SchoolHannoverGermany German Center for Infection Research(DZIF) partner site Hannover-BraunschweigHannoverGermany Cluster of Excellence RESIST(EXC 2155) Hannover Medical SchoolHannoverGermany

neutralizing antibodies targeting the receptor-binding domain(RBD)of the SARS-CoV-2 spike(S)block severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)entry into cells via surface-expressed angiotensin-converting enzyme 2(ACE2).We used a surrogate virus neutralization test(sVnT)and SARS-CoV-2 S protein-pseudotyped vesicular stomatitis virus(VSV)vector-based neutralization assay(pVnT)to assess the degree to which serum antibodies from coronavirus disease 2019(COVID-19)convalescent patients interfere with the binding of SARS-CoV-2 S to *** tests revealed neutralizing anti-SARS-CoV-2 S antibodies in the sera of ~90% of mildly and 100% of severely affected COVID-19 convalescent ***,sVnT and pVnT results correlated strongly with each other and to the levels of anti-SARS-CoV-2 S1 IgG and IgA ***,levels of neutralizing antibodies correlated with the duration and severity of clinical symptoms but not with patient *** to pVnT,sVnT is less sophisticated and does not require any biosafety *** this assay is also much faster and cheaper,sVnT will not only be important for evaluating the prevalence of neutralizing antibodies in a population but also for identifying promising plasma donors for successful passive antibody therapy.

关键词： COVID-19 SARS-CoV-2 neutralizing antibody Serum ELISA

Omicron spike protein:a clue for viral entry and immune evasion

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3639-3640页

作者： G.m.n.behrens A.Cossmann m.Hoffmann Department for Rheumatology and Immunology Hannover Medical SchoolHannoverGermany German Centre for Infection Research partner site Hannover-BraunschweigHannoverGermany Ciim Centre for Individualized Infection MedicineHannoverGermany Infection Biology Unit German Primate CenterGöttingen 37077Germany Faculty of Biology and Psychology Georg-August-University GöttingenGöttingenGermany

In a recent study in Science,Bowen et al.1 report that mutations in Omicron sublineage’s spike protein enhance ACE2 binding,impair fusogenicity,and dampen the neutralizing activity of antibodies after vaccination or *** data describe how Omicron and especially the BA.5 variant evade neutralizing antibody responses and argue for using mRnA booster vaccination to increase immunity.

关键词： ACE2 Bowen al.

On the experimental characterization of the fluid volume influence on the friction between rough surfaces

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Friction 2023年第7期11卷 1334-1348页

作者： Lukas STAHL michael mÜLLER georg-Peter OSTERmEYER Institute of Dynamics and Vibrations Technische Universität BraunschweigBraunschweig 37106Germany

The load-bearing behaviour of lubricated contacts depends primarily on the normal force,the relative velocity,and the ***,with the aid of the Stribeck curve,it is usually well possible to characterize whether hydrodynamics,mixed friction,or boundary friction is more likely to be *** fact that the load regime can also depend on the fluid quantity is obvious,but has hardly been systematically investigated so *** for contacts with microscopic roughness,the defined application of a very small amount of fluid is a very challenging *** this paper,a very fundamental study shows how a pin-on-disc tribometer can be used to achieve the transition from dry friction via mixed friction to predominant hydrodynamics by the amount of supplied *** experiments are carried out on samples filed with different *** addition,the simultaneous influence of partial filling and normal force as well as relative velocity is also *** good reproducibility has been practically reached over the entire range of the *** the quantities for the coefficient of friction(COF),it was concluded that close to full filling,a reduction of the fluid quantity has a similar effect on the COF as the reduction of the *** property goes along with the common theory of starved lubricated *** behaviour was not observed to the same extent for the normal *** the vicinity of smaller fluid quantities,the COF increases very rapidly with further reduction in fluid quantity,far more disproportionately than that with reduction in *** a deeper understanding of this problem,various practical issues such as idling or the run-up process in bearings can also be studied in a more focused manner.

关键词： starved lubrication Stribeck curve pin-on-disc tribometer fluid supply experimental studies

App-based assessment of memory functions in patients after transfemoral aortic valve replacement

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Journal of Geriatric Cardiology 2023年第9期20卷 664-672页

作者： Jonathan nübel michael Hauptmann Julika Schön georg Fritz Christian Butter Anja Haase-Fielitz Department of Cardiology University Hospital Heart Centre BrandenburgBrandenburg Medical School(MHB)Theodor FontaneBernauGermany Institute of Biostatistics and Registry Research Brandenburg Medical School Theodor FontaneNeuruppinGermany Faculty of Health Sciences(FGW) Joint Faculty of the University of Potsdamthe Brandenburg Medical School Theodor Fontane and the Brandenburg Technical University Cottbus-SenftenbergCottbusGermany Anesthesia and Intensive Care University Hospital Ruppin Brandenburg(ukrb)Brandenburg Medical School(MHB)Theodor FontaneNeuruppinGermany Department of Anesthesiology Intensive Care and Pain TherapyUniversity Hospital Heart Centre BrandenburgBrandenburg Medical School(MHB)Theodor FontaneBernauGermany Institute of Social medicine and Health System Research Otto von Guericke University MagdeburgGermany

BACKGROUnD Transfemoral aortic valve replacement(TAVR)is the standard treatment for elderly patients with aortic valve *** safe and well-established,there is a risk of intraprocedural hemodynamic instability and silent cerebral embolism,which can lead to a decline in neurocognitive function and *** clinical practice,comprehensive cognitive testing is difficult to ***-assisted digital applications may help to optimize diagnosis and *** neurocognitive function was assessed by validated psychometric tests using“Δelta-App”,which uses artificial intelligence and computational linguistic methods for extraction and *** function was assessed using the‘Consortium to Establish a Registry for Alzheimer’s Disease’(CERAD)word list and digit span task(DST)before TAVR and before hospital *** study is registered in the German Register of Clinical Trials(https://***/search/de/trial/DRKS00020813).RESULTS From October 2020 until march 2022,141 patients were enrolled at University Hospital Heart Centre *** age was 81±6 years,42.6%were *** between the pre-and post-interventional test was on average 6±3 *** function before TAVR was found to be below average in relation to age and educational *** pre-post TAVR comparison showed significant improvements in the wordlist repeat,Pnd wordlist recall test of CERAD,Pno changes in the digital span *** Despite impaired preoperative memory function before TAVR,no global negative effect on memory function after TVAR was *** improvements shown in the word list test should be interpreted as usual learning effects in this task.

关键词： patients impaired valve