Omicron spike protein:a clue for viral entry and immune evasion

作     者：G.M.N.Behrens A.Cossmann M.Hoffmann 

作者机构：Department for Rheumatology and ImmunologyHannover Medical SchoolHannoverGermany German Centre for Infection Researchpartner site Hannover-BraunschweigHannoverGermany CiiMCentre for Individualized Infection MedicineHannoverGermany Infection Biology UnitGerman Primate CenterGöttingen 37077Germany Faculty of Biology and PsychologyGeorg-August-University GöttingenGöttingenGermany 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2022年第7卷第10期

页      面：3639-3640页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：supported by the German Center for Infection Research(grant no.80018019238,TTU-HIV 04.821,and 04.820) a European Regional Development Fund(ZW7-8515131,ZW7-85151373) 

主　　题：ACE2 Bowen al. 

摘      要：In a recent study in Science,Bowen et al.1 report that mutations in Omicron sublineage’s spike protein enhance ACE2 binding,impair fusogenicity,and dampen the neutralizing activity of antibodies after vaccination or *** data describe how Omicron and especially the BA.5 variant evade neutralizing antibody responses and argue for using mRNA booster vaccination to increase immunity.