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Mono-disperse SrMoO4 nanocrystals:Synthesis,luminescence and photocatalysis

Journal of Materials Science & Technology 2017年第8期33卷 834-842页

作者： Ya-Nan Zhu gan-hong zheng Zhen-Xiang Dai Jing-Jing Mu Zi-Fen Yao Anhui Key Laboratory of Information Materials and Devices School of Physics and Materials SdenceAnhui UniversityHefei 230039China

Well-dispersed uniform SrMoO4 nanocrystals were synthesized by thermal decomposition of a metalorganic salt in the organic solvent under different temperatures（80, 100, 120, 140, and 160？C）. The smallest diameter of these SrMoO4 nanocrystals is only about 2 nm, which is regarded as the smallest values to date. The UV–vis absorbance spectra present that the larger absorption of our samples is mainly distributed in the visible light region and UV light region. The lowest energy gap is found to be 2.71 e V.Such a small gap is ascribed to the introduction of intermediate energy levels, which are due to the surface defects with decreasing the size of nanostrcutrues. The photoluminescence measurement suggests that all these samples exhibit a board and strong emission band in the range from 500 to 700 nm. Through the deconvolution of the photoluminescence spectra, the emission profiles are found to be associated with three various components（green, yellow, and red）. Moreover, the photodegration of methyl blue over our SrMoO4 samples reaches nearly 100% in 120 min. Such a high photodegration may be related to the following aspects. One is related to the size and morphology. Larger surface area leads to more absorption of methyl blue, and the small size nanoparticles lead to the efficient separation of these photogenerated electron-hole pairs. The other is related to the narrow band gap. The small gap is beneficial to more electrons to be excited from the valence band to the conduction band, and eventually more electron-hole pairs are created. Our investigations clearly suggest that thermal decomposition of one metal-organic salt in organic solvent will be a good choice to synthesize the nanoparticles with small size and uniform distribution. Our results also indicate that these SrMoO4 nanoparticles possibly have great potential utilities in photocatalysts.

关键词： SrMoO4 Nanocrystals Luminescence Photocatalyst

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First-principles calculations on spin-polarized transport properties of Mn_4O_4 cluster

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Rare Metals 2015年第1期34卷 45-50页

作者： Zhen-Xiang Dai gan-hong zheng Bing Wang Wei-Wei Wang Yong-Qing Ma Zhi Zeng School of Physics and Materials Science Anhui University Key Laboratory of Materials Physics Institute of Solid State Physics Chinese Academy of Sciences

Taking the Mn404 cluster as a model system, the spin-polarized transport properties of the small cluster system were systematically probed. The theoretical inves- tigations are based on density-functional theory and non- equilibrium Green＇s functional method. The equilibrium transport mechanism is illustrated by the band structure of the electrode, the electronic structure of the Mn404 cluster and the coupling between the cluster and the electrodes. To well understand the non-equilibrium mechanisms, one straightforward and simple band-matching model was proposed. Moreover, such a band-matching model can be extended to well illustrate the transport properties of other nano-scale systems.

关键词： Cluster First-principles Band-matchingmodel Transport mechanism

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YVO_4: Eu^(3+) photoluminescence films with Bi doping

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Rare Metals 2014年第6期33卷 723-726页

作者： Zhen-Xiang Dai Yu-Qin Dong gan-hong zheng Shi-Bing Qian Qian Ma Guang Li Anhui Key Laboratory of Information Materials and Devices School of Physics and Material Science Anhui University

Y0.95-xEu0.05VO4：x Bi3＋（x = 0, 0.02, 0.04,0.06, 0.08, and 0.10 mol） six photoluminescence films were deposited on glass substrates by sol–gel spin-coating method. Their morphology and optical property were investigated. The micrographs for the six samples have no change with Bi3→doping. The emission spectra result shows that a dominant red emission peak at 620 nm, which is due to the Eu3＋electric dipole transition of5D0→7F2,is observed under excitation wavelengths 254 nm. Furthermore, with the content of Bi3→increasing from 0 to0.08 mol, the emission intensity of samples strengthens and reaches a maximum at x = 0.08 mol, then decreases with the doping content to 0.10 mol.

关键词： Photoluminescence film Bi3＋content Emission intensity

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Comprehensive prognostic and immune analysis of sterol Oacyltransferase 1 in patients with hepatocellular carcinoma

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World Journal of Hepatology 2024年第3期16卷 439-451页

作者： Chang-Jiao gan Yue zheng Bin Yang Li-Min Cao Development Research Department National Medical Products Administration Institute of Executive DevelopmentBeijing 100071China School of Medicine Nankai University Affiliated Third Center HospitalTianjin 300070China Tianjin Institute of Hepatobiliary Disease The Third Central Hospital of TianjinTianjin 300170China Department of Science and Technology Tianjin Third Central HospitalTianjin 300170China

BACKGROUND Sterol O-acyltransferase 1(SOAT1)is an important target in the diagnosis and treatment of liver cancer.However,the prognostic value of SOAT1 in patients with hepatocellular carcinoma(HCC)is still not clear.AIM To investigate the correlation of SOAT1 expression with HCC,using RNA-seq and gene expression data of The Cancer Genome Atlas(TCGA)-liver hepatocellular carcinoma(LIHC)and pan-cancer.METHODS The correlation between SOAT1 expression and HCC was analyzed.Cox hazard regression models were conducted to investigate the prognostic value of SOAT1 in HCC.Overall survival and disease-specific survival were explored based on TCGA-LIHC data.Biological processes and functional pathways mediated by SOAT1 were characterized by gene ontology(GO)analysis and the Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis of differentially expressed genes.In addition,the protein-protein interaction network and co-expression analyses of SOAT1 in HCC were performed to better understand the regulatory mechanisms of SOAT1 in this malignancy.RESULTS SOAT1 and SOAT2 were highly expressed in unpaired samples,while only SOAT1 was highly expressed in paired samples.The area under the receiver operating characteristic curve of SOAT1 expression in tumor samples from LIHC patients compared with para-carcinoma tissues was 0.748,while the area under the curve of SOAT1 expression in tumor samples from LIHC patients compared with GTEx was 0.676.Patients with higher SOAT1 expression had lower survival rates.Results from GO/KEGG and gene set enrichment analyses suggested that the PI3K/AKT signaling pathway,the IL-18 signaling pathway,the calcium signaling pathway,secreted factors,the Wnt signaling pathway,the Jak/STAT signaling pathway,the MAPK family signaling pathway,and cell–cell communication were involved in such association.SOAT1 expression was positively associated with the abundance of macrophages,Th2 cells,T helper cells,CD56bright natural killer cells,and Th1 cells,and negatively linked to the abundance of Th17 cells,dendritic

关键词： Sterol O-acyltransferase 1 Hepatocellular carcinoma Prognostic Immune

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The Multiple Roles of Autophagy in Neural Function and Diseases

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Neuroscience Bulletin 2024年第3期40卷 363-382页

作者： Yan-Yan Li zheng-hong Qin Rui Sheng Department of Pharmacology and Laboratory of Aging and Nervous Diseases Jiangsu Key laboratory of Neuropsychiatric DiseasesCollege of Pharmaceutical Sciences of Soochow UniversitySuzhou 215123China

Autophagy involves the sequestration and delivery of cytoplasmic materials to lysosomes,where proteins,lipids,and organelles are degraded and recycled.According to the way the cytoplasmic components are engulfed,autophagy can be divided into macroautophagy,microautophagy,and chaperone-mediated autophagy.Recently,many studies have found that autophagy plays an important role in neurological diseases,including Alzheimer's disease,Parkinson's disease,Huntington's disease,neuronal excitotoxicity,and cerebral ischemia.Autophagy maintains cell homeostasis in the nervous system via degradation of misfolded proteins,elimination of damaged organelles,and regulation of apoptosis and inflammation.AMPK-mTOR,Beclin 1,TP53,endoplasmic reticulum stress,and other signal pathways are involved in the regulation of autophagy and can be used as potential therapeutic targets for neurological diseases.Here,we discuss the role,functions,and signal pathways of autophagy in neurological diseases,which will shed light on the pathogenic mechanisms of neurological diseases and suggest novel targets for therapies.

关键词： Autophagy Neurodegenerative diseases Cerebral ischemia AMPK mTOR Beclin 1 TP53 Endoplasmic reticulum stress

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CNN-LSTM based incremental attention mechanism enabled phase-space reconstruction for chaotic time series prediction

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Journal of Electronic Science and Technology 2024年第2期22卷 77-90页

作者： Xiao-Qian Lu Jun Tian Qiang Liao zheng-Wu Xu Lu gan Bidding and Purchasing Center University of Electronic Science and Technology of ChinaChengdu611731China Yibin Research Institute University of Electronic Science and Technology of ChinaYibin644000China School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu611731China

To improve the prediction accuracy of chaotic time series and reconstruct a more reasonable phase space structure of the prediction network,we propose a convolutional neural network-long short-term memory(CNN-LSTM)prediction model based on the incremental attention mechanism.Firstly,a traversal search is conducted through the traversal layer for finite parameters in the phase space.Then,an incremental attention layer is utilized for parameter judgment based on the dimension weight criteria(DWC).The phase space parameters that best meet DWC are selected and fed into the input layer.Finally,the constructed CNN-LSTM network extracts spatio-temporal features and provides the final prediction results.The model is verified using Logistic,Lorenz,and sunspot chaotic time series,and the performance is compared from the two dimensions of prediction accuracy and network phase space structure.Additionally,the CNN-LSTM network based on incremental attention is compared with long short-term memory(LSTM),convolutional neural network(CNN),recurrent neural network(RNN),and support vector regression(SVR)for prediction accuracy.The experiment results indicate that the proposed composite network model possesses enhanced capability in extracting temporal features and achieves higher prediction accuracy.Also,the algorithm to estimate the phase space parameter is compared with the traditional CAO,false nearest neighbor,and C-C,three typical methods for determining the chaotic phase space parameters.The experiments reveal that the phase space parameter estimation algorithm based on the incremental attention mechanism is superior in prediction accuracy compared with the traditional phase space reconstruction method in five networks,including CNN-LSTM,LSTM,CNN,RNN,and SVR.

关键词： Chaotic time series Incremental attention mechanism Phase-space reconstruction

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Advances in the research and application of neurokinin-1 receptor antagonists

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 91-105页

作者： Xiangyu hong Junjie MA Shanshan zheng Guangyu ZHAO Caiyun FU College of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou310018China

Recently,the substance P(SP)/neurokinin-1 receptor(NK-1R)system has been found to be involved in various human pathophysiological disorders including the symptoms of coronavirus disease 2019(COVID-19).Besides,studies in the oncological field have demonstrated an intricate correlation between the upregulation of NK-1R and the activation of SP/NK-1R system with the progression of multiple carcinoma types and poor clinical prognosis.These findings indicate that the modulation of SP/NK-1R system with NK-1R antagonists can be a potential broad-spectrum antitumor strategy.This review updates the latest potential and applications of NK-1R antagonists in the treatment of human diseases and cancers,as well as the underlying mechanisms.Furthermore,the strategies to improve the bioavailability and efficacy of NK-1R antagonist drugs are summarized,such as solid dispersion systems,nanonization,and nanoencapsulation.As a radiopharmaceutical therapeutic,the NK-1R antagonist aprepitant was originally developed as radioligand receptor to target NK-1R-overexpressing tumors.However,combining NK-1R antagonists with other drugs can produce a synergistic effect,thereby enhancing the therapeutic effect,alleviating the symptoms,and improving patients’quality of life in several diseases and cancers.

关键词： Neurokinin-1 receptor(NK-1R)antagonist Pathophysiological disorder Tumor target Bioavailability Nanoencapsulation Synergistic therapy

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Numerical manifold method for steady-state nonlinear heat conduction using Kirchhoff transformation

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Science China(Technological Sciences) 2024年第4期67卷 992-1006页

作者： ZHANG LiMei KONG Heng zheng hong Key Laboratory of Urban Security and Disaster Engineering Ministry of EducationBeijing University of TechnologyBeijing 100124China Beijing Municipal Construction Co. Ltd.Beijing 100048China

The numerical manifold method(NMM)introduces the mathematical and physical cover to solve both continuum and discontinuum problems in a unified manner.In this study,the NMM for solving steady-state nonlinear heat conduction problems is presented,and heat conduction problems consider both convection and radiation boundary conditions.First,the nonlinear governing equation of thermal conductivity,which is dependent on temperature,is transformed into the Laplace equation by introducing the Kirchhoff transformation.The transformation reserves linearity of both the Dirichlet and the Neumann boundary conditions,but the Robin and radiation boundary conditions remain nonlinear.Second,the NMM is employed to solve the Laplace equation using a simple iteration procedure because the nonlinearity focuses on parts of the problem domain boundaries.Finally,the temperature field is retrieved through the inverse Kirchhoff transformation.Typical examples are analyzed,demonstrating the advantages of the Kirchhoff transformation over the direct solution of nonlinear equations using the NewtonRaphson method.This study provides a new method for calculating nonlinear heat conduction.

关键词： numerical manifold method nonlinear heat conduction temperature-dependent thermal conductivity Kirchhoff transformation convection and radiation boundary conditions

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Effects of orientation on the fatigue crack growth behaviors of the ZK60 magnesium alloy in air and PBS

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Journal of Magnesium and Alloys 2024年第1期12卷 281-294页

作者： Jiaqi Hu zheng Liu Zuoliang Ning hong Gao School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Chemical Process Safety and Equipment Technology Tianjin 300072China

Strong anisotropic corrosion and mechanical properties caused by specimen orientations greatly limit the applications of wrought magnesium alloys.To investigate the influences of specimen orientation,the corrosion tests and(corrosion)fatigue crack growth tests were conducted.The rolled and transverse surfaces of the materials show distinct corrosion rate differences in the stable corrosion stage,but the truth is the opposite for the initial stage of corrosion.In air,specimen orientations have a significant influence on the plastic deformation mechanisms near the crack tip,which results in different fatigue fracture surfaces and cracking paths.Compared with R-T specimens,N-T specimens show a slower fatigue crack growth(FCG)rate in air,which can be attributed to crack closure effects and deformation twinning near the crack tip.The corrosion environment will not significantly change the main plastic deformation mechanisms for the same type of specimen.However,the FCG rate in phosphate buffer saline(PBS)is one order of magnitude higher than that in air,which is caused by the combined effects of hydrogen-induced cracking and anodic dissolution.Owing to the similar corrosion rates at crack tips,the specimens with different orientations display close FCG rates in PBS.

关键词： Magnesium alloy Orientation Corrosion Fatigue crack growth

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Hydrogel loaded with bone marrow stromal cell-derived exosomes promotes bone regeneration by inhibiting inflammatory responses and angiogenesis

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World Journal of Stem Cells 2024年第5期16卷 499-511页

作者： Shuai Zhang Chuan Lu Sheng zheng Guang hong Division for International Collaborative and Innovative Dentistry Tohoku University Graduate School of DentistrySendai 980-8575MiyagiJapan School of Stomatology Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina

BACKGROUND Bone healing is a complex process involving early inflammatory immune regu-lation,angiogenesis,osteogenic differentiation,and biomineralization.Fracture repair poses challenges for orthopedic surgeons,necessitating the search for efficient healing methods.AIM To investigate the underlying mechanism by which hydrogel-loaded exosomes derived from bone marrow mesenchymal stem cells(BMSCs)facilitate the process of fracture healing.METHODS Hydrogels and loaded BMSC-derived exosome(BMSC-exo)gels were charac-terized to validate their properties.In vitro evaluations were conducted to assess the impact of hydrogels on various stages of the healing process.Hydrogels could recruit macrophages and inhibit inflammatory responses,enhance of human umbilical vein endothelial cell angiogenesis,and promote the osteogenic differen-tiation of primary cranial osteoblasts.Furthermore,the effect of hydrogel on fracture healing was confirmed using a mouse fracture model.RESULTS The hydrogel effectively attenuated the inflammatory response during the initial repair stage and subsequently facilitated vascular migration,promoted the formation of large vessels,and enabled functional vascularization during bone repair.These effects were further validated in fracture models.CONCLUSION We successfully fabricated a hydrogel loaded with BMSC-exo that modulates macrophage polarization and angiogenesis to influence bone regeneration.

关键词： Hydrogel Bone marrow mesenchymal stem cells Macrophage polarization Angiogenesis Bone regeneration

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