Comprehensive prognostic and immune analysis of sterol Oacyltransferase 1 in patients with hepatocellular carcinoma

作     者：Chang-Jiao Gan Yue Zheng Bin Yang Li-Min Cao 

作者机构：Development Research DepartmentNational Medical Products Administration Institute of Executive DevelopmentBeijing 100071China School of MedicineNankai University Affiliated Third Center HospitalTianjin 300070China Tianjin Institute of Hepatobiliary DiseaseThe Third Central Hospital of TianjinTianjin 300170China Department of Science and TechnologyTianjin Third Central HospitalTianjin 300170China 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2024年第16卷第3期

页      面：439-451页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by the Tianjin Municipal Project of Science and Technology,No.21ZXGWSY00040 and the Tianjin Health Research Project,No.TJWJ2022QN043 

主　　题：Sterol O-acyltransferase 1 Hepatocellular carcinoma Prognostic Immune 

摘      要：BACKGROUND Sterol O-acyltransferase 1(SOAT1)is an important target in the diagnosis and treatment of liver ***,the prognostic value of SOAT1 in patients with hepatocellular carcinoma(HCC)is still not *** To investigate the correlation of SOAT1 expression with HCC,using RNA-seq and gene expression data of The Cancer Genome Atlas(TCGA)-liver hepatocellular carcinoma(LIHC)and *** The correlation between SOAT1 expression and HCC was *** hazard regression models were conducted to investigate the prognostic value of SOAT1 in *** survival and disease-specific survival were explored based on TCGA-LIHC *** processes and functional pathways mediated by SOAT1 were characterized by gene ontology(GO)analysis and the Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis of differentially expressed *** addition,the protein-protein interaction network and co-expression analyses of SOAT1 in HCC were performed to better understand the regulatory mechanisms of SOAT1 in this *** SOAT1 and SOAT2 were highly expressed in unpaired samples,while only SOAT1 was highly expressed in paired *** area under the receiver operating characteristic curve of SOAT1 expression in tumor samples from LIHC patients compared with para-carcinoma tissues was 0.748,while the area under the curve of SOAT1 expression in tumor samples from LIHC patients compared with GTEx was *** with higher SOAT1 expression had lower survival *** from GO/KEGG and gene set enrichment analyses suggested that the PI3K/AKT signaling pathway,the IL-18 signaling pathway,the calcium signaling pathway,secreted factors,the Wnt signaling pathway,the Jak/STAT signaling pathway,the MAPK family signaling pathway,and cell–cell communication were involved in such ***1 expression was positively associated with the abundance of macrophages,Th2 cells,T helper cells,CD56bright natural killer cells,and Th1 cells,and negatively