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Alpha2-adrenergic receptor activation reinstates motor deficits in rats recovering from cortical injury

Neural Regeneration Research 2023年第4期18卷 875-880页

作者： gabriela García-Díaz Laura ERamos-Languren Carmen Parra-Cid Joel Lomelí Sergio Montes Camilo Ríos Antonio Bueno-Nava Ignacio Valencia-Hernández Rigoberto González-Piña Department of Pharmacology Section of Postgraduate Studies and ResearchHigh Medical SchoolInstituto Politécnico NacionalSalvador Díaz MirónAlcaldía Miguel HidalgoMexico CityMexico Department of Neurobiology of Aging and Brain Damage Coordination of Psychobiology and NeurosciencesFaculty of PsychologyNational Autonomous University of MexicoAv.Universidad 3040Col.Copilco UniversidadAlcaldía CoyoacánMexico CityMexico Direction of Research National Institute of Rehabilitation LGIICalz.Mexico-Xochimilco 289Col.Arenal de GuadalupeAlcaldía TlalpanMexico CityMexico Department of Pharmacology Multidisciplinary Academic Unit Reynosa-Aztlan ReynosaAutonomous University of Tamaulipascalle 16 y lago de ChapalaCol.AztlánTamaulipasMexico Department of Neurochemistry National Institute of Neurology and Neurosurgery MVSAv.Insurgentes Sur 3877Col.La FamaAlcaldia TlalpanMexico CityMexico Department of Special Education University of the AmericasPuebla 223Col.RomaAlcaldía CuauhtémocMexico CityMexico

Norepinephrine plays an important role in motor functional recovery after a brain injury caused by ferrous *** of norepinephrine release by clonidine is correlated with motor deficits after motor cortex *** aim of this study was to analyze the role ofα-adrenergic receptors in the restoration of motor deficits in recovering rats after brain *** rats were randomly assigned to the sham and injury groups and then treated with the following pharmacological agents at 3 hours before and 8 hours,3 days,and 20 days after ferrous chloride-induced cortical injury:saline,clonidine,efaroxan(a selective antagonist ofα-adrenergic receptors)and clonidine+*** sensorimotor score,the immunohistochemical staining forα-adrenergic receptors,and norepinephrine levels were *** hours post-injury,the sensorimotor score and norepinephrine levels in the locus coeruleus of the injured rats decreased,and these effects were maintained 3 days ***,20 days later,clonidine administration diminished norepinephrine levels in the pons compared with the sham *** effect was accompanied by sensorimotor *** effects were blocked by *** conclusion,an increase inα-adrenergic receptor levels was observed after *** restores motor deficits in rats recovering from cortical injury,an effect that was prevented by *** underlying mechanisms involve the stimulation of hypersensitiveα-adrenergic receptors and inhibition of norepinephrine activity in the locus *** results of this study suggest thatαreceptor agonists might restore deficits or impede rehabilitation in patients with brain injury,and therefore pharmacological therapies need to be prescribed cautiously to these patients.

关键词： alpha2-adrenoceptors ambulatory behavior clonidine cortical injury efaroxan functional recovery immunohistochemistry motor deficit norepinephrine sensorimotor score

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Tensegrity applied to modelling the motion of viruses

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Acta Mechanica Sinica 2011年第1期27卷 125-129页

作者： Cretu Simona-Mariana Brinzan gabriela-Catalina Faculty of Mechanics University of Craiova Fratii Buzesti National College

A considerable number of viruses’structures have been discovered and more are expected to be *** viruses’symmetries can be observed at the nanoscale *** mechanical models of some viruses realised by scientists are described in this paper,none of which has taken into consideration the internal deformation of subsystems. The authors’models for some viruses’elements are introduced,with rigid and flexible links,which reproduce the movements of viruses including internal deformations of the subunits.

关键词： Viruses · Tensegrity · Structure · Motion

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Gene therapy in Parkinson's disease: targeting the endplasmic reticulum proteostasis network

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Neural Regeneration Research 2015年第7期10卷 1053-1054页

作者： Valentina Castillo gabriela Mercado Claudio Hetz Biomedical Neuroscience Institute Faculty of MedicineUniversity of Chile Program of Cellular and Molecular Biology Center for Molecular Studies of the Cell Institute of Biomedical SciencesUniversity of Chile Department of Immunology and Infectious Diseases Harvard School of Public Health

Parkinson’s disease（PD）is the second most common neurodegenerative disease affecting 1%of the population over 60 years of *** progressive degeneration of dopaminergic neurons at the substantia nigra pars compacta（SNpc）results in a severe and gradual depletion of dopamine content in the striatum,a phenomena that is responsible for the characteristic motor symptoms of this disease.

关键词： gene Gene therapy in Parkinson’s disease targeting the endplasmic reticulum proteostasis network

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Pramipexole, a dopamine D3/D2 receptor-preferring agonist, attenuates reserpine-induced fibromyalgia-like model in mice

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Neural Regeneration Research 2022年第2期17卷 450-458页

作者： Carlos Pereira Martins Rodrigo Sebben Paes gabriela Mantovani Baldasso Eduarda Gomes Ferrarini Rahisa Scussel Rubya Pereira Zaccaron Ricardo Andrez Machado-de-Avila Paulo Cesar Lock Silveira Rafael Cypriano Dutra Laboratory of Autoimmunity and Immunopharmacology Department of Health SciencesCampus AraranguaUniversidade Federal de Santa CatarinaAraranguáSCBrazil Post-Graduate Program of Neuroscience Center of Biological SciencesUniversidade Federal de Santa CatarinaFlorianópolisSCBrazil Laboratory of Experimental Physiopathology Program of Postgraduate in Science of HealthUniversidade do Extremo Sul CatarinenseCriciumaSCBrazil

Fibromyalgia(FM) is a complex pathology described as persistent hyperalgesia including somatic and mood dysfunctions, depression and anxiety. Although the etiology of FM is still unknown, a significant decrease in biogenic amines is a common characteristic in its pathogenesis. Here, our main objective was to investigate the role of dopamine D3/D2 receptor during the reserpine-induced pain in mice. Our results showed that pramipexole(PPX) – a dopaminergic D3/D2 receptor agonist – inhibited mechanical allodynia and thermal sensitivity induced by reserpine. Relevantly, PPX treatment decreased immobility time and increased the number of grooming in the forced swimming test and splash test, respectively. Animals that received PPX remained longer in the open arms than the reserpine group using elevated plusmaze apparatus. The repeated PPX administration, given daily for 4 days, significantly blocked the mechanical and thermal allodynia during FM model, similarly to pregabalin, although it failed to affect the reserpine-induced thermal nociception. Reserpine administration induced significant downregulation of dopamine concentration in the central nervous system, and repeated treatment with PPX restored dopamine levels in the frontal cortex and spinal cord tissues. Moreover, PPX treatment inhibited oxidants production such as DCFH(2′,7′-dichlorodihydrofluorescein) and nitrite, also decreased oxidative damage(carbonyl), and upregulated the activity of superoxide dismutase in the spinal cord. Together, our findings demonstrated the ability of dopamine D3/D2 receptor-preferring agonist in reducing pain and mood dysfunction allied to FM in mice. All experimental protocols were approved by the Universidade Federal de Santa Catarina(UFSC) Ethics Committee(approval No. 2572210218) on May 10, 2018.

关键词： dopamine dopaminergic system fibromyalgia hyperalgesia pain pramipexole reserpine

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On Second Order Degree of Graphs

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Acta Mathematica Sinica,English Series 2012年第1期28卷 171-182页

作者： gabriela ARAUJO-PARDO Camino BALBUENA Mika OLSEN Pilar VALENCIA Instituto de Matemáticas rea de la Investigación CientíficaUniversidad Nacional Autónoma de MxicoCircuito ExteriorCiudad UniversitariaCoyoacan04510 MxicoD.F.Mxico Departament de Matemàtica Aplicada III Universitat Politècnica de CatalunyaC/Jordi Girona 1-3(Edifici C2Despatx 302)08034-BarcelonaSpain Departamento de Matemáticas Aplicadas y Sistemas Universidad Autónoma MetropolitanaCalle Artificios 402o pisoCol.Hidalgo Delegación lvaro Obregón01120 Mxico D.F.Mxico

Given a vertex v of a graph G the second order degree of v denoted as d2（v） is defined as the number of vertices at distance 2 from v. In this paper we address the following question： What axe the sufficient conditions for a graph to have a vertex v such that d2（v） ≥ d（v）, where d（v） denotes the degree of v？ Among other results, every graph of minimum degree exactly 2, except four graphs, is shown to have a vertex of second order degree as large as its own degree. Moreover, every K4^--free graph or every maximal planar graph is shown to have a vertex v such that d2（v） ≥ d（v）. Other sufficient conditions on graphs for guaranteeing this property axe also proved.

关键词： Second order degree K4^-free graph planar graphs

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Hydrogen evolution kinetics on Ni cathodes modified by spontaneous deposition of Ag or Cu

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Journal of Energy Chemistry 2017年第3期26卷 466-475页

作者： Esteban A.Franceschini gabriela I.Lacconi Horacio R.Corti INFIQC-CONICET Departamento de Fisicoquímica–Facultad de Ciencias QuímicasUniversidad Nacional de CórdobaCiudad Universitaria5000 CórdobaArgentina Departamento de Física de la Materia Condensada Centro Atómico ConstituyentesComisión Nacional de Energía AtómicaAv.Gral.Paz 1499(B1650KNA)San MartínBuenos AiresArgentina INQUIMAE-CONICET Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresCiudad UniversitariaPabellón IIC1428EHABuenos AiresArgentina

Nickel modification by spontaneous deposition of transition metals such as Ag and Cu is shown as an economic and simple alternative for the activation of hydrogen evolution reaction（HER） on cathodes in alkaline media. The kinetics of HER is studied on Ni/Ag and Ni/Cu catalysts by cyclic voltammetry and electrochemical impedance spectroscopy（EIS） using a rotating disk electrode（RDE）. Freshly synthesized catalysts, as well as catalysts subjected to a short chronoamperometric ageing procedure, are analyzed and the kinetic and thermodynamic parameters of the HER are obtained. The nickel surface modified with transition metals with an outer shell electronic configuration [xd;（x+1）s;], such as Cu(3d;4s;)and Ag(4d;5s;), shows an improved activity for the HER compared to bare nickel. Furthermore, the Ni/Cu catalyst presents a decreased onset potential. The hydrogen evolution rate, measured as current density at –1.5 V（vs. SCE）, is similar on Ni/Cu and Ni/Ag electrodes.

关键词： Hydrogen evolution reaction Spontaneous deposition Nickel/Silver Nickel/Copper Electrochemical impedance spectroscopy

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Role of vitamin D deficiency and comorbidities in COVID-19

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World Journal of Virology 2022年第1期11卷 85-89页

作者： gabriela Gama Freire Alberca Ricardo Wesley Alberca Department of Microbiology Institute of Biomedical Sciences-University of São PauloSão Paulo 04307-100Brazil Laboratorio de Dermatologia e Imunodeficiencias(LIM-56) Departamento de DermatologiaFaculdade de Medicina FMUSPUniversidade de São PauloSão Paulo 04307-100Brazil

Recent manuscripts described the incidence of vitamin D hypovitaminosis in coronavirus disease 2019(COVID-19)*** D deficiency is also common in patients with comorbidities that are associated with a poor COVID-19 *** ... 详细信息

关键词： COVID-19 SARS-CoV-2 Comorbidities Vitamin D

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Mapping flood and flooding potential indices： a methodological approach to identifying areas susceptible to flood and flooding risk. Case study： the Prahova catchment （Romania）

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Frontiers of Earth Science 2017年第2期11卷 229-247页

作者： Liliana ZAHARIA Romulus COSTACHE Remus PRAVALIE gabriela IOANA-TOROIMAC Faculty of Geography University of Bucharest 1 Nieolae Balcescu Str. 010041 Bucharest Romania National Institute of Hydrology and Water Management 97 Bucuresti-Ploiesti Str. District 1 Bucharest Romania

Given that floods continue to cause yearly significant worldwide human and material damages, flood risk mitigation is a key issue and a permanent challenge in developing policies and strategies at various spatial scales. Therefore, a basic phase is elaborating hazard and flood risk maps, documents which are an essential support for flood risk management. The aim of this paper is to develop an approach that allows for the identification of flash-flood and flood-prone susceptible areas based on computing and mapping of two indices： FFPI （Flash-Flood Potential Index） and FPI （Flooding Potential Index）. These indices are obtained by integrating in a GIS environment several geographical variables which control runoff（in the case of the FFPI） and favour flooding （in the case of the FPI）. The methodology was applied in the upper （mountainous） and middle （hilly） catchment of the Prahova River, a densely populated and socioeconomically well-developed area which has been affected repeatedly by water-related hazards over the past decades. The resulting maps showing the spatialization of the FFPI and FPI allow for the identification of areas with high susceptibility to flash- floods and flooding. This approach can provide useful mapped information, especially for areas （generally large） where there are no flood/hazard risk maps. Moreover, the FFPI and FPI maps can constitute a preliminary step for flood risk and vulnerability assessment.

关键词： flash-flood flooding Flash-flood/FloodingPotential Index Prahova River catchment Romania

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Self-assemblies of plasmonic gold/layered double hydroxides with highly efficient antiviral effect against the hepatitis B virus

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Nano Research 2015年第11期8卷 3512-3523页

作者： gabriela Carja Elena Florentina Grosu Catalina Petrarean Norica Nichita Department of Chemical Engineering Faculty of Chemical Engineering and Environmental Protection Technical University 'Gh. Asachi' of lasi Bd. Mangeron No. 71 lasi 700554 Romania Department of Viral Glycoproteins Institute of Biochemistry of the Romanian Academy Splaiul Independentei 296 Bucharest 060031 Romania

工程建筑群 nanocomposites 明确地指向肝炎 B 病毒(HBV ) 并且克服象有限功效和严肃的副作用那样的治疗很正在质问的电流的限制。第一次，这里，设计 plasmonic 黄金和分层的双氢氧化物 self-assemblies (AuNPs/LDHs ) 的抗病毒的效果... 详细信息

工程建筑群 nanocomposites 明确地指向肝炎 B 病毒(HBV ) 并且克服象有限功效和严肃的副作用那样的治疗很正在质问的电流的限制。第一次，这里，设计 plasmonic 黄金和分层的双氢氧化物 self-assemblies (AuNPs/LDHs ) 的抗病毒的效果被表明，用象为传染 virions 和 subviral 粒子的病毒的复制，汇编，和分泌物的一个模型病毒和导出 hepatoma 的 HepG2.2.215 房间的 HBV。 AuNPs/LDHs 被在小 AuNPs 的一个简单、划算的过程获得(~ 3.5 nm )直接在更大的 LDH nanoparticles 的表面上被获得并且组织(~ 150 nm )由利用 MgLDH 的能力， ZnLDH ，并且在 Au 的水的解决方案表明他们的结构的存储器的 MgFeLDH ( O 2 CCH 3)3。自己组装 AuNPs 和 LDH 的途径被传播估计电子显微镜学(TEM ) ， X 光检查光电子光谱学(XPS ) ，粉末 X 光检查衍射(PXRD ) ，和 UVVis 分析(UVVis ) 。测试的所有 AuNPs/LDHs 减少了数量病毒并且多达 80% 免除对待的房间并且展出了好 cytocompatibility 的 subviral 粒子。AuNPs/MgFeLDH 为整个集中范围与 HBV 分泌物的超过 90% 抑制显示出最高抗病毒的 HBV 反应。HBV 抑制的机制上的初步的研究表明面对 AuNPs/LDHs， HBV 粒子在对待的房间以内被扣押。这些 Au/LDH nanocomposites 的抗病毒、低的细胞毒素的 plasmonic 性质显示他们保持重要潜力为肝炎 B 的处理作为新奇有效治疗学被定制。

关键词：乙型肝炎病毒抗病毒作用纳米金自组装双氢氧化物层状双金属氢氧化物 X射线光电子能谱纳米复合材料

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Low concentrations of atrazine,glyphosate,2,4-dichlorophenoxyacetic acid,and triadimefon exposures have diverse effects on Xenopus laevis organ morphogenesis

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Journal of Environmental Sciences 2010年第9期22卷 1305-1308页

作者： Jenny R.Lenkowski gabriela Sanchez-Bravo Kelly A.McLaughlin Department of Biology Tufts University

Many chemicals are released into the environment, and chemical contamination has been suggested as a contributing factor to amphibian declines. To add to a growing body of knowledge about the impact of individual chemicals on non-target organisms, we examined the specificity of deformities induced by exposure to four pesticides （atrazine, 2,4-dichloropheoxyacetic acid （2,4-D）, triadimefon, and glyphosate） in the model amphibian species, Xenopus laevis. We focused on the period of organ morphogenesis, as it is frequently found to be particularly sensitive to chemical exposure yet also commonly overlooked. We found similar levels of intestine malformations and edemas, as well as disruption of skeletal muscle, in atrazine and triadimefon exposed tadpoles. The effects of 2,4-D were only apparent at the highest concentrations we examined; glyphosate did not induce dramatic malformations at the concentrations tested. While researchers have shown that it is important to understand how chemical mixtures affect non-target organisms, our results suggest that it is first crucial to determine how these chemicals act independently in order to be able to identify consequences of individual pesticide exposure.

关键词： amphibian pesticide organ morphogenesis teratogenesis toxicology Xenopus laevis

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