检索结果-南通市图书馆

B cell development is critically dependent on NFATc1 activity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2019年第5期16卷 508-520页

作者： Sabrina Giampaolo gabriela Wojcik Stefan Klein-Hessling Edgar Serfling Amiya K.Patra Department of Molecular Pathology Institute of PathologyUniversity of WürzburgJosef Schneider-Str.297080 WürzburgGermany Institute of Translational and Stratified Medicine Faculty of Medicine and DentistryUniversity of PlymouthPlymouth PL68BUUK Comprehensive Cancer Center Mainfranken University of WürzburgJosef Schneider-Str.697080 WürzburgGermany

B cell development in bone marrow is a precisely regulated complex *** successive stages of differentiation,which are regulated by a multitude of signaling pathways and an array of lineage-specific transcription factors,the common lymphoid progenitors ultimately give rise to mature B *** to early thymocyte development in the thymus,early B cell development in bone marrow is critically dependent on IL-7 *** this IL-7-dependent stage of differentiation,several transcription factors,such as E2A,EBF1,and Pax5,among others,play indispensable roles in B lineage specification and *** recent studies have implicated several other transcription factors in B cell development,the role of NFATc1 in early B cell developmental stages is not ***,using multiple gene-manipulated mouse models and applying various experimental methods,we show that NFATc1 activity is vital for early B cell *** of NFATc1 activity in pro-B cells suppresses EBF1 expression,impairs immunoglobulin gene rearrangement,and thereby preBCR formation,resulting in defective B cell ***,deficiency in NFATc1 activity arrested the pro-B cell transition to the pre-B cell stage,leading to severe B cell *** findings suggest that,along with other transcription factors,NFATc1 is a critical component of the signaling mechanism that facilitates early B cell differentiation.

关键词： Differentiation EBF1 NFATc1 Pro-B Pre-B

Algorithms for Computing Some Invariants for Discrete Knots

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics 2013年第11期4卷 1526-1530页

作者： gabriela Hinojosa David Torres Rogelio Valdez Facultad de Ciencias Universidad Autónoma del Estado de Morelos Cuernavaca México

Given a cubic knot K, there exists a projection? of the Euclidean space R3?onto a suitable plane ?such that p(K) is a knot diagram and it can be described in a discrete way as a cycle permutation. Using this fact, we develop an algorithm for computing some invariants for K: its fundamental group, the genus of its Seifert surface and its Jones polynomial.

关键词： Cubic Knots Discrete Knots Algorithms

Medical management of symptomatic severe aortic stenosis in patients non-eligible for transcatheter aortic valve implantation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2020年第11期17卷 704-709页

作者： gabriela Silvia Gheorghe Andreea Simona Hodorogea Andrei Cristian Dan Gheorghe Ioan Tiberiu Nanea Ana Ciobanu University of Medicine and Pharmacy Carol Davila BucharestProf.Dr.Th.Burghele HospitalBucharestRomania

1 Transcatheter aortic valve implantation in symptomatic severe aortic stenosis: where do we stand? Aortic stenosis occurs in 2%-9% of patients over the age of 65, the most common cause being degenerative.^([1,2]) The preferred treatment in symptomatic severe aortic stenosis(SAS) is surgical aortic valve replacement(SAVR), but in the elderly, the surgical risk can be greater than the benefit.([3]).

关键词： Angiotensin-converting enzyme inhibitors Beta-blockers Calcium channel blockers Diuretics Symptomatic severe aortic stenosis Transcatheter aortic valve implantation

Application of polyurethane geocomposites to help maintain track geometry for high-speed ballasted railway tracks

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第11期13卷 836-849页

作者： Peter Keith WOODWARD Abdellah EL KACIMI Omar LAGHROUCHE gabriela MEDERO Meysam BANIMAHD Institute for Infrastructure and Environment School of the Built EnvironmentHeriot-Watt UniversityEdinburghEH14 4ASUK

There are many issues surrounding the performance of critical assets on high-speed ballasted railway *** assets like switch & crossings and bridge transitions high track forces can be produced resulting in higher ballast settlements and hence track *** latter result in higher track forces and hence more settlement,leading to the need for increased track maintenance to ensure comfort and *** technologies for solving issues like ballast movement under high-speed loading regimes are ***,a technique that has been well used across the UK and now increasingly overseas to stabilise and reinforce ballasted railway tracks is the application of in-situ polyurethane polymers,termed *** paper discusses how this technique can be used to solve these types of long-standing issues and presents actual polymer application profiles at two typical critical sites,namely a junction and a transition onto concrete slab-track.

关键词： Railways Polyurethanes Geocomposites Modelling High-speed

Successful Treatment with ¹⁷⁷Lutetium-Dotatate and Maintenance Octreotide in a Patient with Esthesioneuroblastoma with Central Nervous System Invasion: Case Report and Review of the Literature

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

International Journal of Otolaryngology and Head & Neck Surgery 2023年第1期12卷 8-20页

作者： gabriela Dombrowski Laura Fernandes Ferreira Dalcin Francisco Assis Coelho Patricia Massucheto Ledesma Daniel Herchenhorn Department of Clinical Oncology Instituto D’Or de Pesquisa e Ensino Rio de Janeiro Brazil Clínica de Diagnóstico por Imagem CDPI DASA Instituto D’Or de Pesquisa e Ensino Rio de Janeiro Brazil Clínica de Medicina Nuclear Villela Pedras Clínica de Diagnóstico por Imagem CDPI DASA Rio de Janeiro Brazil

This article presents a case of a patient with relapsed esthesioneuroblastoma (ENB), an aggressive rare tumor that arises from the specialized sensory epithelial olfactory cells in the skull base area, which was initially treated with endoscopic surgery, followed by adjuvant radiotherapy. After local relapse, new surgical approaches and subsequent lines of platin-based chemotherapy were performed. A PET-CT with 68GALIUM DOTATATOC (PET-DOTATOC) showed intense uptake of disease, compatible with the presence of somatostatin receptors, in the face, nodes, liver, bones, and meningeal area. Treatment with 4 cycles of 177Lutetium-Dotatate was performed, followed by maintenance octreotide, with a major radiological and clinical response that is lasting more than 1 year after treatment. This article describes a rare case of a skull-base tumor, with multiple recurrences, in which disease control was achieved with a targeted Peptide Receptor Radionuclide Therapy (PRRT) with 177Lutetium-Dotatate, and discusses factors that could influence the incorporation of this form of therapy. Previous case reports proved the potential efficacy of this therapy usually given for low-grade neuroendocrine tumors and will be carefully reviewed.

关键词： Esthesioneuroblastoma Olfactory Neuroblastoma Peptide Receptor Radionuclide Therapy PRRT 177Lutetium

Oxidative stress, antioxidants and intestinal calcium absorption

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第16期23卷 2841-2853页

作者： gabriela Diaz de Barboza Solange Guizzardi Luciana Moine Nori Tolosa de Talamoni Laboratorio“Dr.Fernando Canas” Cátedra de Bioquímica y Biología MolecularFacultad de Ciencias MédicasINICSA(CONICET-Universidad Nacional de Córdoba)Pabellón ArgentinaCiudad UniversitariaCórdoba 5000Argentina

The disequilibrium between the production of reactive oxygen(ROS) and nitrogen(RNS) species and their elimination by protective mechanisms leads to oxidative stress. Mitochondria are the main source of ROS as by-products of electron transport chain. Most of the time the intestine responds adequately against the oxidative stress, but with aging or under conditions that exacerbate the ROS and/or RNS production, the defenses are not enough and contribute to developing intestinal pathologies. The endogenous antioxidant defense system in gut includes glutathione(GSH) and GSH-dependent enzymes as major components. When the ROS and/or RNS production is exacerbated, oxidative stress occurs and the intestinal Ca2+ absorption is inhibited. GSH depleting drugs such as DLbuthionine-S,R-sulfoximine, menadione and sodium deoxycholate inhibit the Ca2+ transport from lumen to blood by alteration in the protein expression and/or activity of molecules involved in the Ca2+ transcellular and paracellular pathways through mechanisms of oxidative stress, apoptosis and/or autophagy. Quercetin, melatonin, lithocholic and ursodeoxycholic acids block the effect of those drugs in experimental animals by their antioxidant, anti-apoptotic and/or anti-autophagic properties. Therefore, they may become drugs of choice for treatment of deteriorated intestinal Ca2+ absorption under oxidant conditions such as aging, diabetes, gut inflammation and other intestinal disorders.

关键词： Transcellular and paracellular Ca2+pathways DL-buthionine-S R-sulfoximine Menadione Sodium deoxycholate Lithocholic acid Ursodeoxycholic acid Melatonin

Are extrafloral nectaries efficient against herbivores? Herbivory and plant defenses in contrasting tropical species

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Plant Ecology 2020年第4期13卷 423-430页

作者： Cássio Cardoso Pereira Maria gabriela Boaventura Gislene Carvalho de Castro Tatiana Cornelissen Departamento de Genética Ecologia e EvoluçãoUniversidade Federal de Minas Gerais31270-910 Belo HorizonteMGBrazil Departamento de Ciências Naturais Universidade Federal de São João del-Rei36301-160 São João del-ReiMGBrazil

植物用于防御的资源有限,而那些具有生物防御的物种,其叶片可能会较少地用于其他类型的防御。我们比较了机械防御能力较弱,但具有花外蜜腺的植物,与没有花外蜜腺但叶片更有韧性的植物是否更不容易被取食。我们通过分析文献数据,调查有... 详细信息

植物用于防御的资源有限,而那些具有生物防御的物种,其叶片可能会较少地用于其他类型的防御。我们比较了机械防御能力较弱,但具有花外蜜腺的植物,与没有花外蜜腺但叶片更有韧性的植物是否更不容易被取食。我们通过分析文献数据,调查有无花外蜜腺的植物被取食的情况。在巴西南部的热带稀树草原植被中,我们采集了6种热带植物的叶片数据,并测定了被取食情况和比叶面积。我们进一步评估了有无花外蜜腺的物种之间以及植物之间被取食情况和比叶面积的差异。为了检验动物取食与叶片韧性之间的关系,我们对单株平均被取食情况和平均叶片韧性进行了回归。研究结果表明,植物表现出不同程度的叶片损伤,但没有蚂蚁防御的植物因被取食造成的叶面积损失最大。不同植物的机械防御水平也不相同。无花外蜜腺的植株更坚韧,比叶面积值更小。虽然无花外蜜腺的植物有更多的坚硬叶片,但这种机械防御不足以损害和/或减少食草动物的取食,这表明由蚂蚁形成的生物防御可能比用于与叶片适口性相关的机械防御更有效。

关键词：蚂蚁生物防御动物取食叶片适口性比叶面积

Non-alcoholic Fatty Liver Disease in South Asians:A Review of the Literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2017年第1期5卷 76-81页

作者： Sital Singh gabriela N.Kuftinec Souvik Sarkar Division of Gastroenterology and Hepatology and Department of Internal Medicine University of CaliforniaDavisUSA Department of Internal Medicine University of CaliforniaDavisUSA

Non-alcoholic fatty liver disease(NAFLD)and non-alcoholic steatohepatitis(NASH)are national and global *** disease is characterized by a spectrum of liver steatosis(fat deposition),inflammation(in NASH)and *** and specifically NASH can lead to cirrhosis,which carry risks of progression to portal hypertension and hepatocellular carcinoma(HCC).NASH is also associated with higher mortality from cardiovascular *** of the data for NAFLD has been obtained from the perspective of developed nations,although the disease is increasing and threatening to reach epidemic proportions across the *** data is notable for high prevalence of NAFLD in South Asian populations,presumably resulting from a combination of underlying genetic polymorphisms and changes in socio-economic *** is also notable that an‘Asian Paradox'has been defined for NAFLD based upon the observation of lower than predefined body mass index(BMI),otherwise termed as"lean NAFLD",among this ***,data remains limited in regards to the characteristics of NAFLD/NASH in this *** this article,we present a review of the literature and discuss the prevalence,associated risk factors and burden of HCC in South Asians with NAFLD.

关键词： Non-alcoholic fatty liver disease(NAFLD) Non-alcoholic steatohepatitis(NASH) South Asia

Arylated analogues of cypronazole: fungicidal effect and activity on human fibroblasts. Docking analysis and molecular dynamics simulations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Products and Bioprospecting 2022年第1期12卷 107-120页

作者： Natividad Herrera Cano Sebastian A.Andujar Cristina Theoduloz Daniel A.Wunderlin Ana N.Santiago Guillermo Schmeda-Hirschmann Ricardo D.Enriz gabriela E.Feresin Instituto de Biotecnología Facultad de IngenieríaUniversidad Nacional de San JuanCONICET-CCT San JuanAv.Libertador General San Martín1109(O)5400 San JuanArgentina Facultad de Química Bioquímica y Farmacia-IMIBIO-SL(CONICET)Universidad Nacional de San LuisChacabuco 9155700 San LuisArgentina Laboratorio de Cultivo Celular Facultad de Ciencias de la SaludUniversidad de TalcaCasilla 7473460000 TalcaChile ICYTAC CONICET and Universidad Nacional de CórdobaFacultad de Ciencias QuímicasDepartamentoQuímica OrgánicaCiudad UniversitariaBv.Juan Filloy s/n5000 CórdobaArgentina INFIQC CONICET and Universidad Nacional de CórdobaFacultad de Ciencias QuímicasDepartamento Química OrgánicaCiudad UniversitariaHaya de La Torre S/N5000 CórdobaArgentina Laboratorio de Química de Productos Naturales Instituto de Química de Recursos NaturalesUniversidad de TalcaCasilla 7473460000 TalcaChile

Triadimefon(TDM)and cyproconazole(CPZ)are two triazoles widely used as *** azoles were synthe-sised starting from commercial TDM and *** compounds were evaluated against phytopathogenic filamentous fungi,including Aspergillus fumigatus(AF),***(AN),***(AU),***(AJ),***(AT),Fusarium oxyspo-rum and Botrytis cinerea isolated from grapevine in the province of San Juan,*** of the synthesised compounds(1-(Biphenyl-4-yloxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one,1;2-(Biphenyl-4-yl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol,3;3-Cyclopropyl-2-(4’-fluorobiphenyl-4-yl)-1-(1H-1,2,4-triazol1-yl)butan-2-ol,4)presented remarkable in vitro fungicidal properties,with better effects than TDM and CPZ on some of the target *** was assessed using human lung fibroblasts *** 1,with IC50 values of 389.4μM,was less toxic towards MRC-5 human lung fibroblasts than commercial TDM(248.5μM)and CPZ(267.4μM).Docking analysis and molecular dynamics simulations suggest that the compounds present the same interaction in the binding pocket of the CYP51B enzyme and with the same amino acids as *** derivatives investigated could be considered broad-spectrum but with some selectivity towards imperfect fungi.

关键词： Azoles Antifungal cytotoxicity Conformational and electronic analysis