Non-alcoholic Fatty Liver Disease in South Asians:A Review of the Literature

作     者：Sital Singh Gabriela N.Kuftinec Souvik Sarkar 

作者机构：Division of Gastroenterology and Hepatology and Department of Internal MedicineUniversity of CaliforniaDavisUSA Department of Internal MedicineUniversity of CaliforniaDavisUSA 

出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)

年 卷 期：2017年第5卷第1期

页      面：76-81页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Non-alcoholic fatty liver disease(NAFLD) Non-alcoholic steatohepatitis(NASH) South Asia 

摘      要：Non-alcoholic fatty liver disease(NAFLD)and non-alcoholic steatohepatitis(NASH)are national and global *** disease is characterized by a spectrum of liver steatosis(fat deposition),inflammation(in NASH)and *** and specifically NASH can lead to cirrhosis,which carry risks of progression to portal hypertension and hepatocellular carcinoma(HCC).NASH is also associated with higher mortality from cardiovascular *** of the data for NAFLD has been obtained from the perspective of developed nations,although the disease is increasing and threatening to reach epidemic proportions across the *** data is notable for high prevalence of NAFLD in South Asian populations,presumably resulting from a combination of underlying genetic polymorphisms and changes in socio-economic *** is also notable that an‘Asian Paradox has been defined for NAFLD based upon the observation of lower than predefined body mass index(BMI),otherwise termed aslean NAFLD,among this ***,data remains limited in regards to the characteristics of NAFLD/NASH in this *** this article,we present a review of the literature and discuss the prevalence,associated risk factors and burden of HCC in South Asians with NAFLD.